TY -的T1 nontuber的相似特征culous mycobacterial pulmonary disease in men and women JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00252-2019 VL - 54 IS - 1 SP - 1900252 AU - Holt, Michael R. AU - Kasperbauer, Shannon H. AU - Koelsch, Tilman L. AU - Daley, Charles L. Y1 - 2019/07/01 UR - //www.qdcxjkg.com/content/54/1/1900252.abstract N2 - The characteristics of nontuberculous mycobacterial pulmonary disease (NTM-PD) in individuals without clinically apparent predisposing factors have been described in female-predominant cohorts. Phenotypic characteristics are advanced age, tall stature, slender body habitus, right middle lobe (RML)- and/or lingula-predominant nodular bronchiectasis, and increased frequencies of scoliosis, pectus excavatum (PEX) and mitral valve prolapse [1–3]. Increased rates of cystic fibrosis transmembrane conductance regulator (CFTR), immune, ciliary and connective tissue gene mutations, and abnormal α1-antitrypsin (α1-AT) phenotypes have also been reported [4, 5]. The phenotypic archetype of NTM-PD in men is upper lobe cavitation in a middle-aged smoker. We hypothesised that the characteristics of male patients without pre-existing structural lung disease and immunocompromise resemble those of female patients.In a retrospective study of patients with nontuberculous mycobacterial pulmonary disease in the absence of clinically apparent risk factors, men and women shared phenotypic and other characteristics but lesser disease severity was observed in men http://bit.ly/2YAV7QBThank you to Douglas C. Everett (Division of Biostatistics and Bioinformatics, NJH) for his advice regarding the statistical analysis. Data used for this study were downloaded from the NJH Research Database, supported by NJH. ER -