PT -期刊文章盟Bajwah塞布丽娜AU - Davies, Joanna M. AU - Tanash, Hanan AU - Currow, David C. AU - Oluyase, Adejoke O. AU - Ekström, Magnus TI - Safety of benzodiazepines and opioids in interstitial lung disease: a national prospective study AID - 10.1183/13993003.01278-2018 DP - 2018 Dec 01 TA - European Respiratory Journal PG - 1801278 VI - 52 IP - 6 4099 - //www.qdcxjkg.com/content/52/6/1801278.short 4100 - //www.qdcxjkg.com/content/52/6/1801278.full SO - Eur Respir J2018 Dec 01; 52 AB - Safety concerns are a barrier to prescribing benzodiazepines (BDZs) and opioids in interstitial lung disease (ILD). We therefore examined the association of BDZs and opioids on risk of admission to hospital and death.We conducted a population-based longitudinal cohort study of fibrotic ILD patients starting long-term oxygen therapy in Sweden between October 2005 and December 2014. Effects of BDZs and opioids on rates of admission to hospital and mortality were analysed using Fine–Gray and Cox regression while adjusting for potential confounders.We included 1603 patients (61% females). BDZs were used by 196 (12%) patients and opioids were used by 254 (15%) patients. There was no association between BDZs and increased admission. Treatment with high- versus low-dose BDZs was associated with increased mortality (subdistribution hazard ratio (SHR) 1.46, 95% CI 1.08–1.98 versus 1.13, 95% CI 0.92–1.38). Opioids showed no association with increased admission. Neither low-dose opioids (≤30 mg·day−1 oral morphine equivalent) (SHR 1.18, 95% CI 0.96–1.45) nor high-dose opioids (>30 mg·day−1 oral morphine equivalent) (SHR 1.11, 95% CI 0.89–1.39) showed association with increased mortality.This first ever study to examine associations between BDZ and opioid use and harm in ILD supports the use of opioids and low-dose BDZs in severely ill patients with respiratory compromise.This first ever study to examine associations between benzodiazepine and opioid use and harm in ILD supports the use of opioids and low-dose benzodiazepines in severely ill patients with respiratory compromise http://ow.ly/yBfZ30lXCKu