TY - JOUR T1 - LCI在CF - N2或SF6患儿中?JF -欧洲呼吸杂志JO -欧洲呼吸J DO - 10.1183/1393003.congress-2017。PA1839 VL - 50 IS -补充61 SP - PA1839 AU - Stahl, Mirjam AU - Joachim, Cornelia AU - Wielpütz, Mark AU - Mall, Marcus Y1 - 2017/09/01 UR - //www.qdcxjkg.com/content/50/suppl_61/PA1839.abstract N2 - MBW已被证明可检测CF肺病引起的早期肺功能损害。我们已经能够证明，在临床稳定的儿童CF患者中，LCI升高与肺部MRI扫描的形态改变和灌注缺陷相关。目前，MBW的执行方法是使用100%的O2从肺中冲洗出常驻N2，或者使用含有SF6的气体混合物。最近发表的数据表明，用N2-MBW测量的LCI值高于同时使用SF6-MBW测量的LCI值。原因尚不清楚，与其他检测CF引起的肺部变化的方法的比较缺失。因此，我们调查了16名年龄为2.5±0.7岁的CF学龄前儿童，使用N2-和SF6-MBW(均使用Exhalyzer D, Eco Medics, Duernten, CH)，并按照指南在水合氯醛镇静下进行胸部MRI检查。N2-LCI为9.1±2.6，比SF6-LCI(6.9±0.8)高2.2±2.3个单位(P<0.01)。与Lindblad等人(海报NACFC 2016)的数据相比，我们人群中的N2-FRC和CEV高于SF6-FRC和-CEV(均为P<0.001)，而两种气体之间的VT没有显著差异。 LCI values from both gas methods correlated with each other and with MRI scores, there were no significant differences between the N2-LCI – MRI correlation and the SF6-LCI – MRI correlation. Concordance of results (normal – pathologic) from both methods MRI (pathologic, score ≥1) and MBW (pathologic, N2-LCI ≥8.08 or SF6-LCI ≥7.68 (ULN of control population)) was higher between N2-LCI and the typical changes in MRI in this age group than between SF6-LCI and MRI. Hence, despite confirmation of higher N2-LCI compared to SF6-LCI in children with CF, the reason and clinical meaning remain unclear. ER -