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[(Allergic)-333.9(bronchopulmonary)-333.9(aspergillosis)-330.1(in)-332.6(cystic)-330.1(f)-2.8(ibrosis.)]TJ
6.0623 -1.0319 TD
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[(A)-330.8(E)0.3(uropean)-332.4(epidemiological)-331.5(study)]TJ
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[(G.)-314.1(Mastella)]TJ
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5.0801 0 TD
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(*)Tj
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[(,)-313.9(M)0(.)-319(Rainisio)]TJ
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[(,)-313.9(H.K.)-319.9(Harms)]TJ
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[(,)-319.1(M.E.)-313.5(Hodson)]TJ
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6.3992 0 TD
(**)Tj
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[(,)-313.9(C)0(.)-320.2(Koch)]TJ
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(##)Tj
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[(,)-319.1(J)0(.)-315.7(Navarro)]TJ
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10.959 0 0 10.959 451.105 651.628 Tm
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[(,)-319.1(B)0(.)-315.3(Strandvik)]TJ
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(***)Tj
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1.5002 0 TD
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[(S.G.)-329.3(McKenzie)]TJ
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(###)Tj
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T*
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T*
[(Cystic)-336(Fibr)32.9(osis.)]TJ
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(#)Tj
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[(ERS)-327.9(Journals)-335.6(Ltd)-334.6(2000.)]TJ
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[(from)-302.7(a)-303(hypersensitivity)-314.5(response)-304.6(to)]TJ
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[(Aspergillus)-311.7(fumigatus,)]TJ
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T*
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T*
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[(*Dept)-455.7(of)-465.5(Pulmonary)-457.3(and)-462.2(Digestive)-452.3(Dis-)]TJ
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[(eases)-358.7(of)-358.8(Developmen)11.8(tal)-367.3(Age,)-356.9(Cystic)-359.8(Fib-)]TJ
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[(rosis)-399.9(Center)35.8(,)-397.3(V)99.2(erona,)-392(Italy)63.5(.)]TJ
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(#)Tj
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[(Statistics)-401.6(for)]TJ
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[(Research)-596.9(SFR)-598.6(Ltd,)-602.3(Basel,)-599.3(Switzerlan)9.3(d.)]TJ
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(Children)Tj
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[(Dept,)-663(Royal)-664.2(Brompton)-659.4(National)-666.6(Heart)]TJ
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[(&)-531.7(Lung)-520.7(Hospital,)-525.5(London,)-522.5(UK.)]TJ
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[(of)-451.2(Paediatrics,)-447.5(Rigshospitalet,)-448.9(University)]TJ
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[(Hospital,)-319.2(Copenhagen,)-321(Denmar)11.7(k.)]TJ
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(\302)Tj
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(Hos-)Tj
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[(pital,)-215.1(Paris,)-216.6(France.)-429.4(***Dept)-216.8(of)-216.5(Pediatric)9.7(s,)]TJ
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[(Oestra)-119.7(University)-109.9(Hospital,)-112.9(Go)]TJ
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[(\310)-83.5(teborg,)-108.8(Swe-)]TJ
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(den.)Tj
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[(mann-La)-327.8(Roche)-326.5(Ltd,)-324.9(Basel,)-329(Switzerland.)]TJ
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[(Corresponde)11.8(nce:)-333.4(G.)-333.7(Mastella,)-335.1(Cystic)-331.4(Fib-)]TJ
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[(rosis)-592(Center)-597.2(Ospedale)-590.8(Civile)-595.8(Maggiore)]TJ
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[(Piazzale)-229.6(Stefani)-227.8(1)-232.7(37126)-231.3(V)106.3(erona)-229.5(Italy)-235.3(Fax:)]TJ
T*
[(39)-330.1(458072042)]TJ
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[(Keywords)11.5(:)-334.6(Aller)11.2(gic)-329.4(bronchopul)12.4(monary)]TJ
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[(asper)18.3(gillosis,)-207.5(cystic)-211.8(fibrosis,)-210.2(lung)-207.4(function)12.9(,)]TJ
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[(mixed)-325.5(model)]TJ
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[(Received:)-327.9(June)-326.1(30)-330.1(1999)]TJ
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[(Accepted)-325.4(after)-331.6(revision)-329.8(March)-321.1(19)-330.1(2000)]TJ
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[(The)-685.3(Epidemiologic)-680.2(Registry)-690.1(of)-693.1(Cystic)]TJ
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[(Fibrosis)-799.2(\(ERCF\))-794.3(Advisory)-800.3(Board,)-796.1(an)]TJ
T*
[(independe)12.5(nt)-858.9(team)-852.9(of)-849.6(academics)-847.7(who)]TJ
0 -1.067 TD
[(manage)-404.3(the)-414.8(ERCF)-406.9(with)-418.6(comple)12(te)-416.9(editor)15.8(-)]TJ
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[(ial)-509.6(freedom,)-495(would-like)-507.1(to)-503.2(acknowledg)12.1(e)]TJ
0 -1.067 TD
[(financial)-582.9(support)-579.4(from)-589.8(F)75.4(.)-589.4(Hof)17.8(fmann-La)]TJ
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[(Roche,)-282.7(Basel,)-286.3(Switzerlan)9.3(d)-289.6(for)-292.8(funding)-279.5(the)]TJ
T*
[(ERCF)76.8(.)]TJ
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[(Al)14.9(le)18.4(r)20.4(g)0(i)18.9(c)-433.7(br)19.6(on)15.5(ch)20.8(op)15.5(ul)18.9(mo)18.1(na)15.1(ry)-418.5(as)19.6(pe)15.1(r)20.4(g)0(i)18.9(l)0(l)16.5(o)0(s)14.4(i)0(s)-420.5(\()0(A)21.4(B)0(P)97(A)0(\))-422.5(i)0(s)-420.5(a)]TJ
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21.9428 0 TD
(A.)Tj
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[(Asper)23.4(gillus)]TJ
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[(A.)-215.8(flav)-8.2(us)]TJ
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(,)Tj
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[(A.)-221.5(nidulans)]TJ
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(,)Tj
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[(A.)-221.5(niger)]TJ
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[(as)-333.2(wel)-9(l)-333.2(a)0(s)-333.2(other)-338.2(fungi)-343.5([2].)]TJ
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[(pe)15.1(rm)16.5(it)22.2(te)12.8(d)-199.9(t)0(h)18.9(e)-200.3(pr)13.9(es)19.6(en)15.1(t)-202.3(s)0(t)17.7(u)0(d)21.2(y)73.2(.)-205.2(T)12.2(he)-195.4(ma)17.7(in)-191.7(ai)18.4(m)-203.1(o)0(f)-196.6(t)0(h)18.9(i)0(s)-192.9(s)0(t)17.7(u)0(d)15.5(y)-199.9(wa)16.9(s)]TJ
0 -1.0528 TD
[(to)-191.7(es)13.9(ta)18.4(bl)18.9(is)17.7(h)-199.9(t)0(h)13.2(e)-200.3(pr)19.6(ev)15.1(al)18.5(en)15.1(ce)-190.1(of)-190.9(AB)12.6(P)91.1(A)-198.2(in)-197.4(C)11.6(F)79.7(.)-199.6(S)0(e)15.9(c)0(o)20.8(n)0(d)15.5(a)0(r)19.2(y)-205.6(ai)18.4(ms)]TJ
0 -1.0471 TD
[(we)16.9(re)-339.3(to)-339.7(de)20.8(sc)13.9(ri)17.3(be)-337.7(th)18.9(e)-348.3(c)0(l)18.4(i)0(n)18.9(i)0(c)18.4(a)0(l)-340.1(c)0(o)20.8(n)0(d)15.5(i)0(t)16.5(i)0(o)18.9(n)0(s)-338.5(t)0(h)18.9(a)0(t)-340.1(c)0(a)20.4(n)-347.9(be)-337.7(as)19.6(so)14.4(-)]TJ
0 -1.0528 TD
[(ci)18.4(at)18.4(ed)-252.3(wi)14.9(th)-248.6(AB)18.3(P)91.1(A)-260.8(an)20.8(d)-262.5(t)0(o)-248.6(e)0(x)20.8(p)0(l)13.2(o)0(r)19.6(e)-257.2(th)18.9(e)-262.9(p)0(o)21.2(s)0(s)13.2(i)13.9(bl)13.2(e)-257.2(i)0(n)18.9(f)0(l)17.3(u)0(e)15.1(n)0(c)20.8(e)-262.9(of)]TJ
0 -1.0471 TD
[(AB)18.3(P)91.1(A)-232.3(on)-217.8(th)18.9(e)-228.8(p)0(r)13.9(o)0(g)21.2(r)0(e)13.5(s)0(s)18.9(i)0(o)18.9(n)-228.4(of)-219.4(lu)18.9(ng)-223.5(di)18.9(se)19.6(as)13.9(e.)-217.8(In)-219.4(th)18.9(e)-228.8(E)0(R)12.4(C)11.6(F)-227.6(t)0(h)13.2(e)]TJ
0 -1.0527 TD
[(di)18.9(ag)15.1(no)21.2(si)17.7(s)-309.2(o)0(f)-299(A)12.4(BP)97(A)-306.3(i)0(s)-295.3(d)0(e)15.1(f)0(i)17.3(n)0(e)20.8(d)-308.1(ac)14.7(co)20.8(rd)13.9(i)13.9(n)0(g)-297.4(t)0(o)-299.8(t)0(h)18.9(e)-308.5(ab)20.8(ov)15.5(e)-308.5(c)0(r)19.2(i)0(-)]TJ
T*
[(te)18.4(ri)17.3(a)-325.5(a)0(n)15.1(d)-319.4(ot)13.2(he)20.8(r)-326.7(r)0(e)19.2(c)0(o)15.1(m)0(m)14.9(e)0(n)20.8(d)0(a)15.1(t)0(i)16.5(o)0(n)21.2(s)0(.)]TJ
/F6 1 Tf
6.7718 -3.1583 TD
[(Patients)-346.7(and)-330.8(method)-13.1(s)]TJ
/F4 1 Tf
-6.7718 -2.0998 TD
[(Data)-339.4(ascertainm)-13.8(ent)-335.1(and)-338(quality)-337.2(contr)26.4(ol)]TJ
/F3 1 Tf
1.0015 -2.0998 TD
[(Th)17.1(e)-467.8(E)12.2(RC)17.5(F)-466.6(i)0(s)-460.3(a)0(n)-457.2(i)0(n)18.9(t)0(e)18.4(r)0(n)19.6(a)0(t)12.8(i)0(o)18.9(n)0(a)20.8(l)-469.8(ob)21.2(se)13.9(rv)19.6(at)18.4(io)18.9(na)15.1(l)-464.1(d)0(a)15.1(t)0(a)18.4(b)0(a)15.1(s)0(e)]TJ
-1.0015 -1.0471 TD
[(in)18.9(it)16.5(ia)18.4(te)18.4(d)-245.5(i)0(n)-231.5(E)0(u)17.1(r)0(o)13.9(p)0(e)-229.6(b)0(y)-234.8(F)79.7(.)-239.4(H)0(o)17.3(f)20.4(fm)16.5(an)15.1(n-)19.6(La)-233.7(Ro)16.5(ch)15.1(e)-240.2(L)0(t)14.7(d)-239.8(in)-237.2(19)21.2(94)15.5(.)]TJ
0 -1.0528 TD
[(Co)16.5(un)21.2(tr)11.6(i)13.9(e)0(s)-264.9(w)0(e)16.9(r)0(e)-265.3(e)0(l)18.4(i)0(g)18.9(i)0(b)18.9(l)0(e)-266.1(t)0(o)-260(p)0(a)15.1(r)0(t)17.3(i)13.9(ci)12.8(pa)20.8(te)-266.1(if)-261.6(th)18.9(e)-268.6(l)0(o)13.2(c)0(a)20.4(l)-270.6(co)15.1(mp)18.1(an)15.1(y)]TJ
T*
[(af)24.9(fi)17.3(li)22.2(at)12.8(e)-399.5(h)0(a)20.8(d)-399.1(su)20(f)14.7(f)0(i)17.3(c)0(i)18.5(e)0(n)15.1(t)-395.8(av)15.1(ai)18.5(la)18.4(bl)18.9(e)-399.5(m)0(a)17.7(n)0(p)15.5(o)0(w)17.3(e)0(r)-390.5(a)0(n)15.1(d)-399.1(fi)17.3(na)20.8(nc)15.1(ia)18.4(l)]TJ
0 -1.0471 TD
[(re)19.2(so)14.4(ur)19.6(ce)14.7(s)-383.2(t)0(o)-379.5(s)0(u)20(p)0(p)15.5(o)0(r)19.6(t)0(-)17.3(i)0(n)18.9(i)0(t)16.5(i)0(a)18.4(t)0(i)16.5(o)0(n)-377.1(o)0(f)-378.7(t)13.9(he)-377.5(Re)16.1(gi)18.9(st)17.7(ry)76.5(.)-381.7(C)0(l)14.1(i)0(n)18.8(i)0(c)18.4(s)-388.9(in)]TJ
0 -1.0527 TD
[(th)18.9(es)13.9(e)-223.1(c)0(o)20.8(u)0(n)15.5(t)0(r)17.3(i)0(e)18.4(s)-223.9(w)12.4(e)0(r)13.5(e)-223.1(el)18.4(ig)18.9(ib)18.9(le)-214.9(to)-214.5(pa)15.1(rt)17.3(ic)18.4(ip)18.9(at)18.4(e)-223.1(i)0(f)-216.1(t)0(h)18.9(e)0(y)-212.5(d)0(e)15.1(l)0(i)16.5(v)0(e)20.8(r)0(e)13.5(d)]TJ
0 -1.0471 TD
[(sp)20(ec)14.7(ia)18.4(li)16.5(ze)14.7(d)-393.4(c)0(a)14.7(r)0(e)-384.8(t)0(o)]TJ
/F8 1 Tf
7.853 0 TD
(>)Tj
/F3 1 Tf
0.5406 0 TD
[(10)-388.5(CF)-386.7(pa)15.1(ti)16.5(en)20.8(ts)-392.1(an)20.8(d)-399.1(w)12.4(er)13.5(e)-393.8(w)0(i)14.9(l)0(l)16.5(i)0(n)18.8(g)-399.1(to)]TJ
-8.3936 -1.0527 TD
[(su)20(bm)12.4(it)-370.5(de)20.8(fi)11.6(ne)20.8(d)-382(c)0(l)18.4(i)0(n)18.9(i)0(c)18.4(a)0(l)-374.2(d)0(a)15.1(t)0(a)-368.5(c)0(o)15.1(l)0(l)16.5(e)0(c)20.4(t)0(e)18.4(d)-382(fr)18(om)-374.6(ea)14.7(ch)-371.8(of)-367.3(th)13.2(ei)18.4(r)]TJ
0 -1.0471 TD
[(pa)15.1(ti)22.2(en)15.1(ts)-318.1(at)-311.6(no)15.5(rm)16.5(al)-317.3(cl)18.4(in)18.9(ic)-317.3(vi)18.9(si)17.7(ts)17.7(.)]TJ
1.0015 -1.0528 TD
[(In)19.6(it)16.5(ia)12.8(l)13.9(l)0(y)75.8(,)-353.2(da)20.8(ta)-345.7(we)16.9(re)-345(co)15.1(ll)22.2(ec)14.7(te)18.4(d)-353.6(o)0(n)-343(p)0(a)15.1(p)0(e)20.8(r)-355.2(fo)13.9(rm)16.5(s)-349.1(t)0(h)13.2(a)0(t)-340.1(w)0(e)11.2(r)0(e)]TJ
-1.0015 -1.0471 TD
[(se)19.6(nt)-237.2(to)-237.2(Qu)17.3(in)18.9(ti)16.5(le)18.4(s)-246.7(G)0(m)14.2(b)0(H)-238.8(\()0(N)21.4(e)0(u)-240.9(I)0(s)18.4(e)0(n)20.8(b)0(u)15.5(r)20.4(g,)-234.5(Ge)16.9(rm)10.8(an)20.8(y\))-236.4(fo)19.6(r)-247.1(d)0(a)15.1(t)0(a)]TJ
0 -1.0528 TD
[(en)15.1(tr)17.3(y)73.2(,)-410.1(qu)15.5(al)18.4(it)16.5(y)-416.2(c)0(o)20.8(n)0(t)18.9(r)0(o)13.9(l)-412.9(an)15.1(d)-410.5(a)0(s)19.6(s)0(i)17.7(g)0(n)15.5(m)0(e)17.7(n)0(t)-407.9(o)0(f)-401.5(p)0(r)13.9(e)0(f)19.2(e)0(r)13.5(r)0(e)19.2(d)-416.2(t)13.9(e)0(r)13.5(m)0(s)]TJ
0 -1.0471 TD
[(\(c)19.2(od)15.5(in)18.9(g\))-287.7(of)-287.7(CF)17.3(TR)-289.2(mu)18.1(ta)12.8(ti)16.5(on)21.2(s,)-286.9(me)17.7(di)13.2(ca)20.4(ti)16.5(on)15.5(s,)-286.9(ad)20.8(ve)15.1(rs)18.4(e)-297.1(e)0(v)20.8(e)0(n)15.1(t)0(s)]TJ
0 -1.0528 TD
[(an)15.1(d)-313.8(c)0(a)14.7(u)0(s)20(e)0(s)-310.4(o)0(f)-310.4(d)0(e)15.1(a)0(t)18.4(h)0(.)-308.4(Q)0(u)17.3(i)0(n)18.9(t)0(i)16.5(l)0(e)12.8(s)-314.9(su)14.4(bj)18.9(ec)20.4(te)12.8(d)-313.7(t)0(h)13.2(e)-314.2(da)15.1(ta)-311.6(to)]TJ
/F8 1 Tf
20.7762 0 TD
(>)Tj
/F3 1 Tf
0.5406 0 TD
[(40)15.5(0)]TJ
-21.3168 -1.0471 TD
[(co)15.1(nt)18.9(ex)20.8(t)-344.6(a)0(n)20.8(d)-342.2(co)15.1(ns)20(is)17.7(te)18.4(nc)15.1(y)-342.2(c)0(h)20.8(e)0(c)14.7(k)0(s)-332.8(a)0(n)20.8(d)-342.2(is)17.7(su)14.4(ed)-332(qu)21.2(er)13.5(ie)18.4(s)-343.4(t)0(o)-328.3(t)0(h)13.2(e)]TJ
25.1977 66.1583 TD
[(su)14.4(bm)18.1(it)16.5(ti)16.5(ng)-354.3(ce)20.4(nt)13.2(re)-356.3(w)12.4(h)0(e)15.1(r)0(e)-356.3(n)0(e)20.8(c)0(e)14.7(s)0(s)18.8(a)0(r)13.5(y)-359.3(to)-356.7(cl)18.4(ar)13.5(if)17.3(y)-365(i)13.9(nc)15.1(on)15.5(si)17.7(st)17.7(en)20.8(-)]TJ
0 -1.0471 TD
[(ci)12.8(es)19.6(.)-347.5(I)0(n)-338.9(1)0(9)15.5(9)0(7)-337.3(a)-348.3(tr)17.3(an)20.8(si)17.7(ti)16.5(on)-337.3(wa)16.9(s)-349.1(m)0(a)17.7(d)0(e)-343.4(t)0(o)-334(r)0(e)13.5(m)0(o)18.1(t)0(e)-340.1(d)0(a)15.1(t)13.9(a)-348.3(e)0(n)15.1(t)0(r)17.2(y)]TJ
0 -1.0528 TD
[(\(R)14.9(DE)13.2(\))-451.9(u)0(s)20(i)0(n)18.8(g)-456(In)19.6(te)18.4(rn)13.9(et)-442.5(te)18.5(ch)15.1(no)21.2(lo)13.2(gy)83.8(.)-455.6(T)12.2(he)-445.8(da)20.8(ta)-448.2(en)20.8(tr)17.3(y)-456(f)0(o)19.6(r)0(m)16.5(s)]TJ
0 -1.0471 TD
[(we)16.9(re)-345(re)13.5(cr)19.2(ea)14.7(te)18.4(d)-353.6(i)0(n)-345.3(J)0(a)19.6(v)0(a)-343.4(s)0(c)13.9(r)0(i)17.3(p)0(t)-339.7(a)0(n)15.1(d)-353.6(th)18.9(e)-354(p)0(r)19.6(e)0(-)13.5(e)0(x)20.8(i)0(s)17.7(t)0(i)16.5(n)0(g)-343(q)0(u)15.5(a)0(l)18.5(i)0(t)16.5(y)]TJ
0 -1.0528 TD
[(as)13.9(su)20(ra)13.5(nc)20.8(e)-234.5(c)0(h)15.1(e)0(c)20.4(k)0(s)-230.3(\()0(i)17.3(n)0(c)20.8(l)0(u)13.2(d)0(i)18.9(n)0(g)-223.5(l)0(o)18.9(n)0(g)15.5(i)0(t)16.5(u)0(d)21.2(i)0(n)13.2(a)0(l)-226.2(c)0(h)20.8(e)0(c)14.7(k)0(s)20(\))-235.7(an)15.1(d)-234.1(m)0(o)18.1(s)0(t)]TJ
0 -1.0471 TD
[(of)-373(th)18.8(e)-382.4(c)0(o)20.8(d)0(i)18.8(n)0(g)-371.4(w)0(e)16.9(r)0(e)-373.4(b)0(u)21.2(i)0(l)16.5(t)-378.7(in)18.9(to)-373.8(th)18.8(e)-382.4(R)11.6(DE)-373.8(sy)20(st)17.7(em)-375(to)-368.1(en)15.1(su)20(re)]TJ
0 -1.0528 TD
[(hi)13.2(gh)-434(da)20.8(ta)-436.8(qu)15.5(al)18.5(it)16.5(y)73.2(.)-444.2(P)11.4(a)0(r)19.2(t)0(i)16.5(c)0(i)12.8(p)0(a)20.8(t)0(i)16.5(n)0(g)-434(c)0(e)14.7(n)0(t)18.9(r)0(e)19.2(s)-445.8(we)16.9(re)-436(gi)18.9(ve)15.1(n)-438.9(c)0(o)15.1(n)0(-)]TJ
0 -1.0471 TD
[(tr)17.3(ol)13.2(le)18.4(d)-217(a)0(c)20.4(c)0(e)14.7(s)0(s)-208.8(t)0(o)-208.8(t)13.9(he)-212.5(da)20.8(ta)-209.2(en)15.1(tr)17.3(y)-217(s)0(c)19.6(r)0(e)19.2(e)0(n)15.1(s)-218.2(at)-203.5(ww)13.4(w)69.3(.)0(e)21.2(r)0(c)13.5(f)0(.)20(o)0(r)25.3(g)-211.3(an)15.1(d)]TJ
0 -1.0527 TD
[(th)13.2(e)-285.7(l)0(o)18.9(c)0(a)14.7(l)0(l)16.5(y)-285.3(en)15.1(te)18.4(re)19.2(d)-291(d)0(a)20.8(t)0(a)-283.1(w)12.4(er)13.5(e)-285.7(s)0(u)14.4(b)0(m)18.1(i)0(t)16.5(t)0(e)18.5(d)-285.3(in)-282.7(en)20.8(cr)13.5(yp)21.2(te)18.4(d)-291(f)0(o)19.6(r)0(m)]TJ
T*
[(to)-311.2(S)11.4(p)0(i)18.9(d)0(e)15.1(r)-315.3(Ne)16.9(tw)14.9(or)19.6(k)-313.8(A)0(G)-311(\()0(O)15.7(t)0(e)18.5(l)0(f)17.3(i)0(n)18.9(g)0(e)15.1(n)0(,)-302.7(S)0(w)12.4(i)0(t)16.5(z)0(e)20.4(r)0(l)17.3(a)0(n)15.1(d)0(\))-304.7(f)0(o)19.6(r)-321(su)20(b-)]TJ
0 -1.0471 TD
[(se)13.9(qu)21.2(en)15.1(t)-321.8(t)0(r)17.3(a)0(n)15.1(s)0(f)18.4(e)0(r)-316.5(t)0(o)-316.9(Q)0(u)17.3(i)0(n)18.9(t)0(i)16.5(l)0(e)18.4(s)0(.)]TJ
1.0015 -1.0528 TD
[(Da)11.2(t)13.9(a)-473.5(an)15.1(al)18.5(ys)20(is)-466(wa)16.9(s)-474.3(u)0(n)21.2(d)0(e)15.1(r)-474.7(t)13.9(h)0(e)-468.6(c)0(o)20.8(n)0(t)18.9(r)0(o)13.9(l)-469.8(of)-464.1(an)-462.9(Ad)17.3(vi)13.2(so)20(ry)]TJ
-1.0015 -1.0471 TD
[(Bo)16.5(ar)13.5(d)-313.7(c)0(o)15.1(m)0(p)18.1(r)0(i)17.3(s)0(e)19.6(d)-319.4(of)-304.7(th)13.2(e)-314.1(a)0(u)15.1(t)0(h)18.8(o)0(r)19.6(s)-314.9(of)-310.4(th)18.8(is)-306.7(ma)12(nu)21.2(sc)13.9(ri)17.3(pt)-305.5(an)15.1(d)-313.8(a)0(t)]TJ
0 -1.0527 TD
[(no)-257.6(t)13.9(i)0(m)15.7(e)-262.9(we)16.9(re)-253.9(pe)15.1(rs)18.4(on)15.5(al)-249(pa)15.1(ti)16.5(en)20.8(t)-264.9(d)0(a)20.8(t)0(a)-254.7(a)0(v)15.1(a)0(i)18.4(l)0(a)18.4(b)0(l)18.9(e)-262.9(to)-254.3(Ho)17.3(f)20.4(f)0(m)16.5(a)0(n)15.1(n)0(-)]TJ
0 -1.0471 TD
[(La)-319(R)11.6(o)0(c)15.1(h)0(e)-314.9(L)0(t)14.7(d)0(.)]TJ
/F4 1 Tf
0 -3.1526 TD
[(Pat)-8.8(ients)-334.5(and)-338(cystic)-341.8(fibr)25.1(osis)-332.2(c)-6.9(entr)27.1(es)]TJ
/F3 1 Tf
1.0015 -2.0998 TD
[(A)-220.9(t)0(o)18.8(t)0(a)18.4(l)-213.7(of)-208(12)15.5(,4)21.6(47)-206.4(CF)-210.3(pa)20.8(ti)16.5(en)15.1(ts)-204.3(we)16.9(re)-208.4(en)20.8(ro)13.9(ll)16.5(ed)-206.8(i)13.9(n)-217(th)18.9(e)-217.4(E)0(R)18.1(C)0(F)]TJ
-1.0015 -1.0527 TD
[(by)-291.8(13)-297.4(D)12.4(e)0(c)14.7(e)0(m)17.7(b)0(e)15.1(r)-298.3(19)15.5(97)-291.8(\(5)19.6(,9)15.9(67)-291.7(fe)19.2(ma)17.7(le)12.8(s)-297.9(\()0(4)13.9(8)0(%)18.9(\))0(,)-293(m)0(e)17.7(d)0(i)18.9(a)0(n)-292.2(a)0(g)15.1(e)]TJ
0 -1.0471 TD
[(12)-229.2(yr)14(s,)-224.3(ag)15.1(e)-234.5(r)0(a)13.5(n)0(g)21.2(e)-240.2(fr)18(om)-226.6(0\261)15.5(62)-223.5(yr)13.9(s\))18.4(.)-239.4(P)11.4(at)18.4(ie)18.4(nt)13.2(s)-235.3(w)0(e)16.9(r)0(e)-231.1(e)0(n)20.8(r)0(o)19.6(l)0(l)16.5(e)0(d)-229.6(i)0(n)]TJ
0 -1.0527 TD
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-14.9263 -1.0471 TD
[(ti)16.5(me)-448.9(of)-452.7(ea)14.7(ch)-445.8(re)13.5(po)21.2(rt)17.3(ed)-451.5(vi)18.9(si)17.7(t.)-453.1(T)12.2(h)0(e)-451.5(E)0(R)18.1(C)0(F)-455(p)0(o)21.2(p)0(u)15.5(l)0(a)18.4(t)0(i)16.5(o)0(n)-451.1(w)0(a)16.9(s)]TJ
0 -1.0528 TD
[(st)17.7(ra)19.2(ti)16.5(fi)17.3(ed)-394.6(by)-394.2(th)18.8(e)-405.2(a)0(b)20.8(s)0(e)13.9(n)0(c)20.8(e)0(/)18.5(p)0(r)13.9(e)0(s)19.6(e)0(n)15.1(c)0(e)-389.3(o)0(f)-395.8(A)0(B)18.3(P)91.1(A.)-392(Th)17.1(e)-405.2(A)0(B)18.3(P)91.1(A)]TJ
0 -1.0471 TD
[(po)15.5(si)17.7(ti)22.2(ve)-571(su)20(bp)15.5(op)21.2(ul)18.9(at)18.4(io)13.2(n)-575.5(w)12.4(as)-566.5(se)13.9(le)18.4(ct)18.5(ed)-565.3(us)14.4(i)13.9(n)0(g)-570.6(i)13.9(nf)13.9(or)19.6(ma)17.7(ti)16.5(on)]TJ
0 -1.0528 TD
[(fr)18(om)-374.6(al)18.4(l)-378.7(v)0(i)18.9(s)0(i)17.7(t)0(s)17.7(.)-381.7(In)19.6(di)18.9(vi)13.2(du)21.2(al)-374.2(ev)20.8(en)15.1(ts)-369.3(an)15.1(d)-376.3(m)0(e)17.7(d)0(i)13.2(c)0(a)20.4(l)-378.7(co)15.1(nd)21.2(it)16.5(io)13.2(ns)]TJ
0 -1.0471 TD
[(we)16.9(re)-219.8(co)20.8(ns)14.4(id)18.9(er)19.2(ed)-218.2(pr)13.9(es)19.6(en)15.1(t)-225.1(i)0(f)-221.7(t)0(h)18.9(e)0(y)-218.2(w)0(e)16.9(r)0(e)-219.8(r)0(e)19.2(c)0(o)15.1(r)0(d)19.6(e)0(d)-218.2(a)0(t)-220.6(l)0(e)18.4(a)0(s)19.6(t)-230.8(on)21.2(ce)]TJ
0 -1.0528 TD
[(du)15.5(ri)17.3(ng)-314.5(th)18.8(e)-325.5(o)0(b)21.2(s)0(e)13.9(r)0(v)19.6(a)0(t)18.4(i)0(o)18.9(n)-325.1(pe)15.1(ri)17.3(od)-314.5(fo)19.6(r)-326.7(e)0(a)20.4(c)0(h)-314.9(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(.)]TJ
1.0015 -1.0471 TD
[(Sp)16.3(ir)17.3(om)18.1(et)18.5(ri)17.3(c)-416.6(t)0(e)18.4(s)0(t)17.7(s)0(,)-400.7(p)0(e)15.1(r)0(f)18(o)0(r)13.9(m)0(e)17.7(d)-410.5(us)14.4(in)18.9(g)-410.5(e)0(i)18.4(t)0(h)13.2(e)0(r)-401.9(a)-416.6(be)20.8(ll)16.5(-s)18.4(pi)18.9(ro)13.9(-)]TJ
-1.0015 -1.0527 TD
[(me)17.7(te)18.4(r)-309.7(o)0(r)-299(a)-308.5(pn)21.2(eu)15.1(mo)18.1(ta)18.4(ch)15.1(og)21.2(ra)13.5(ph)-297.4(fo)19.6(ll)16.5(ow)17.3(in)18.9(g)-308.1(t)0(h)18.9(e)-308.5(E)12.2(R)0(S)-301.4(c)0(r)19.2(i)0(t)16.5(e)0(r)19.2(i)0(a)12.8(,)]TJ
T*
[(we)16.9(re)-231.2(re)19.2(co)15.1(rd)19.6(ed)-235.2(at)-231.9(fo)19.6(ll)16.5(ow)17.3(-u)19.6(p)-239.8(v)0(i)18.9(s)0(i)17.7(t)0(s)17.7(,)-239.4(wh)17.3(et)12.8(he)20.8(r)-241.4(p)0(a)15.1(t)13.9(ie)12.8(nt)18.9(s)-241(w)12.4(er)13.5(e)-240.2(i)0(n)]TJ
0 -1.0471 TD
[(st)17.7(ab)15.1(le)-340.1(cl)18.5(in)18.9(ic)12.8(al)-340.1(si)17.7(tu)18.9(at)12.8(i)13.9(o)0(n)-343(o)0(r)-344.6(n)0(o)21.2(t)0(.)-345(F)11.4(EV)]TJ
7.97 0 0 7.97 201.033 667.049 Tm
(1)Tj
9.963 0 0 9.963 208.516 667.049 Tm
[(an)20.8(d)-353.6(F)11.4(VC)-345.9(w)12.4(e)0(r)13.5(e)-348.3(ca)14.7(l-)]TJ
-15.08 -1.0528 TD
[(cu)15.1(la)18.4(te)18.4(d)-211.3(a)0(s)-202.3(p)0(e)20.8(r)0(c)13.5(e)0(n)20.8(t)0(a)12.8(g)0(e)20.8(s)-212.5(of)-202.3(th)18.9(e)-211.7(p)0(r)19.6(e)0(d)15.1(i)0(c)18.4(t)0(e)18.4(d)-211.3(va)15.1(lu)18.9(es)19.6(,)-210.9(a)0(c)14.7(c)0(o)20.8(r)0(d)13.9(i)0(n)18.9(g)-211.3(to)]TJ
0 -1.0471 TD
(K)Tj
6.974 0 0 6.974 65.367 646.129 Tm
0.0001 Tc
[(NU)21.7(DSO)20.9(N)]TJ
9.963 0 0 9.963 97.512 646.129 Tm
0 Tc
[(et)-340.1(al)18.5(.)-353.2([)0(2)19.6(4].)-356.3(This)-363.6(stand)-7.8(ardizatio)-11.1(n)-359.3(algor)-8.2(ithm)-363.8(was)]TJ
-3.9379 -1.0527 TD
[(adopte)-7.8(d)-268.2(t)0(o)-271.4(make)-274.5(the)-272.5(results)-276.2(compa)-7.8(rable)-276.1(with)-273.5(those)-275.2(of)-270.6(the)]TJ
0 -1.0471 TD
[(United)-673.8(State)-8.6(s)-662.1(Cys)-8.2(tic)-667.6(Fibros)-9(is)-665.2(Foun)-8(dation)-669.8(and)-668.5(other)]TJ
0 -1.0527 TD
[(epidem)-10.9(iologic)-200.7(registries)-203.2(which)-198.3(are)-198.2(in)-191.7(p)-6.5(rogress)-199.1(in)-191.7(USA)-202.8(and)]TJ
0 -1.0471 TD
[(Canad)-9.3(a)-274.3([12].)-285.5(The)-280(initial)-285.1(FEV)]TJ
7.97 0 0 7.97 174.954 604.29 Tm
(1)Tj
9.963 0 0 9.963 181.644 604.29 Tm
[(was)-281(used)-283.5(to)-277.1(deter)-8.6(mine)-282.1(the)]TJ
-12.3826 -1.0528 TD
[(severi)-10.6(ty)-334(of)-333.2(the)-335.1(disea)-8.2(se)-333.2(in)-339.7(patients)]TJ
/F11 1 Tf
13.8736 0 TD
($)Tj
/F3 1 Tf
0.8365 0 TD
[(6)-336.5(yrs)-335.1(of)-333.2(age.)]TJ
-13.7085 -1.0471 TD
[(Th)17.1(e)-382.4(v)0(a)20.8(l)0(i)16.5(d)-382(ER)18.1(CF)-375.3(po)15.5(pu)21.2(la)18.4(ti)16.5(on)-371.4(wa)16.9(s)-383.2(d)0(e)15.1(f)0(i)17.3(n)0(e)20.8(d)-382(ac)14.7(co)20.8(rd)13.9(in)18.9(g)-382(t)0(o)]TJ
-1.0015 -1.0527 TD
-0.0171 Tc
[(t)-17.1(h)1.8(e)-422.3(p)-17.1(ar)-17.1(ti)-17.1(cu)-17.1(la)-17.1(r)-419(a)-17.1(n)3.7(a)-17.1(ly)-17.1(si)-17.1(s)-414.8(p)-17.1(er)-17.1(fo)-17.1(rm)-17.1(ed)-17.1(.)-416.6(F)-5.7(o)-17.1(r)-418.6(t)-17.1(h)1.8(e)-422.3(g)-17.1(en)-17.1(o)4.1(t)-17.1(yp)-17.1(e)-417.4(c)-17.1(or)3.3(-)]TJ
0 -1.0471 TD
0 Tc
[(re)19.2(la)12.8(ti)22.2(on)15.5(,)-358.9(o)0(n)21.2(l)0(y)-351(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-352.2(w)0(i)20.6(t)0(h)-351(a)-359.7(kn)15.5(ow)17.3(n)-359.3(g)0(e)20.8(n)0(o)15.5(t)0(y)18.9(p)0(e)-349.1(w)0(e)16.9(r)0(e)-350.7(a)0(n)15.1(a)0(-)]TJ
0 -1.0528 TD
[(ly)18.9(se)13.9(d;)-299.8(fo)13.9(r)-309.7(t)0(h)18.9(e)-314.2(mi)15.7(cr)19.2(ob)15.5(io)18.9(lo)18.9(gi)13.2(ca)20.4(l)-310.4(a)0(n)15.1(a)0(l)18.4(y)0(s)14.4(i)0(s)17.7(,)-307.7(on)15.5(ly)-305.5(pa)20.8(ti)16.5(en)15.1(t)13.9(s)-314.9(wi)14.9(th)]TJ
0 -1.0471 TD
[(at)-328.7(le)18.4(as)14(t)-333.2(o)0(n)15.5(e)-336.9(va)15.1(li)16.5(d)-336.5(s)0(p)20(u)0(t)18.9(u)0(m)-329(c)0(u)15.1(l)0(t)16.5(u)0(r)19.6(e)-336.9(we)16.9(re)-333.6(i)13.9(n)0(c)15.1(l)0(u)18.9(d)0(e)15.1(d)0(;)-328.3(f)0(o)19.6(r)-338.1(lu)18.9(ng)]TJ
0 -1.0527 TD
[(fu)19.6(nc)15.1(ti)16.5(on)-291.7(an)20.8(al)18.4(ys)14.4(is)17.7(,)-296.3(t)0(h)18.9(e)-302.8(av)20.8(ai)18.5(la)12.8(bi)18.9(li)16.5(ty)-288.4(of)-293.3(F)11.4(E)0(V)]TJ
7.97 0 0 7.97 220.479 531.042 Tm
(1)Tj
9.963 0 0 9.963 227.452 531.042 Tm
[(or)-293.3(F)11.4(V)0(C)-294.7(v)0(a)20.8(l)0(u)13.2(e)0(s)]TJ
-16.9806 -1.0471 TD
[(in)-220.2(pa)15.1(ti)16.5(en)20.8(ts)]TJ
/F11 1 Tf
4.2281 0 TD
(#)Tj
/F3 1 Tf
0.8251 0 TD
[(6)-234.1(y)0(r)19.6(s)-229.6(of)-225.1(ag)20.8(e)-234.5(w)0(e)16.9(r)0(e)-219.8(c)0(r)13.5(i)0(t)22.2(i)0(c)12.8(a)0(l)18.4(,)-228(ho)15.5(we)16.9(ve)20.8(r)37.5(,)-228(va)15.1(li)16.5(d)-228.4(l)0(u)18.9(n)0(g)]TJ
-5.0532 -1.0528 TD
[(fu)19.6(nc)15.1(ti)16.5(on)-382.8(da)15.1(ta)-385.6(we)16.9(re)-390.5(on)21.2(ly)-385.2(av)15.1(ai)18.4(la)18.4(bl)13.2(e)-393.8(i)0(n)-385.2(a)-399.5(fe)19.2(w)-397.3(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)17.7(.)-393(F)11.4(o)0(r)]TJ
0 -1.0471 TD
[(Ig)19.6(G,)-255.5(th)18.9(e)-262.9(m)0(e)17.7(a)0(n)-252.3(o)0(f)-253.5(a)0(l)18.4(l)-264.9(va)20.8(li)16.5(d)-262.5(v)0(a)20.8(l)0(u)13.2(e)0(s)-247.8(f)0(o)13.9(r)-258.4(a)-262.9(s)0(u)14.4(b)0(j)18.9(e)0(c)20.4(t)-264.9(w)12.4(a)0(s)-253.5(u)0(s)14.4(e)0(d)-252.3(i)0(n)]TJ
0 -1.0527 TD
[(th)18.9(e)-496.3(a)0(n)15.1(a)0(l)18.5(y)0(s)14.4(i)0(s)17.7(.)-495.5(F)11.4(o)0(r)-492.5(t)0(h)18.9(e)-496.2(we)16.9(ig)18.9(ht)-493.3(z-)19.2(sc)19.6(or)13.9(es)-486.8(\(t)17.3(he)-491.3(st)17.7(an)20.8(da)15.1(rd)19.6(iz)18.4(ed)]TJ
0 -1.0471 TD
[(we)16.9(ig)18.8(ht)-442.1(fo)13.9(r)-446.2(a)0(g)15.1(e)-450.7(an)20.8(d)-450.3(s)0(e)13.9(x)0(:)-436.4(t)0(h)13.2(e)-450.7(z-)19.2(sc)19.6(or)14(e)-450.7(c)0(o)20.8(r)0(r)18(e)0(s)13.9(p)0(o)21.2(n)0(d)15.5(s)-451.5(t)13.9(o)-450.3(th)13.2(e)]TJ
0 -1.0528 TD
[(st)17.7(an)15.1(da)20.8(rd)-407.2(de)15.1(vi)18.9(at)18.5(io)18.9(n)-416.2(f)0(r)18(o)0(m)-408.7(t)0(h)18.9(e)-416.6(me)17.7(an)-406(of)-407.2(th)18.9(e)-416.6(r)0(e)19.2(f)0(e)19.2(r)0(e)13.5(n)0(c)20.8(e)-416.6(po)15.5(p-)]TJ
0 -1.0471 TD
[(ul)18.9(at)18.4(io)13.2(n\))19.6(,)-205.2(t)0(h)18.9(e)-206(ag)20.8(e)-206(i)0(n)-197.4(m)0(o)18.1(n)0(t)18.9(h)0(s)-196.2(w)0(a)16.9(s)-206.8(co)20.8(mp)12.4(le)18.4(te)18.4(d)-205.6(u)0(s)20(i)0(n)18.9(g)-205.6(th)18.9(e)-206(d)0(a)15.1(t)0(e)-197.8(o)0(f)]TJ
0 -1.0528 TD
[(ea)14.7(ch)-223.9(vi)18.9(si)17.7(t)-242.1(a)0(n)20.8(d)-234.1(th)13.2(e)-234.5(d)0(a)15.1(t)0(e)-226.2(o)0(f)-225.1(b)0(i)13.2(r)0(t)17.3(h)0(,)-223.1(a)0(n)15.1(d)-234.1(wa)16.9(s)-235.3(u)0(s)14.4(e)0(d)-229.6(t)13.9(og)15.5(et)18.4(he)15.1(r)-235.7(w)0(i)14.9(t)0(h)]TJ
0 -1.0471 TD
[(ac)14.7(t)13.9(u)0(a)15.1(l)-350.3(we)16.9(ig)18.8(ht)-345.3(to)-339.7(de)15.1(ri)17.3(ve)-337.7(th)13.2(e)-348.3(z)0(-)19.2(s)0(c)13.9(o)0(r)19.6(e)-354(fr)18(om)-340.4(se)13.9(x-)19.6(sp)20(ec)14.7(if)17.3(ic)-340.1(re)13.5(f-)]TJ
0 -1.0527 TD
[(er)19.2(en)15.1(ce)-241.3(va)15.1(l)13.9(u)0(e)15.1(s)-252.3(pu)21.2(bl)18.9(is)17.7(he)15.1(d)-251.2(b)0(y)-240.5(t)0(h)18.9(e)-251.6(W)83.4(o)0(r)13.9(l)13.9(d)-251.2(He)16.9(al)18.4(th)-242.9(Or)27.1(ga)15.1(ni)18.9(za)14.7(t)13.9(i)0(o)13.2(n)]TJ
0 -1.0471 TD
[(\(W)18.5(HO)13.4(\))-429.2([)0(2)19.6(5].)-430.3(The)-445(mean)-439.5(value)-445.2(was)-440.3(compu)-7.4(ted)-443.3(using)-439.9(all)]TJ
0 -1.0527 TD
[(valid)-373.2(values)-373.1(for)-369.7(a)-365.4(subje)-7.8(ct.)-368.9(The)-371(antibiot)-10.3(ic)-368.5(treatmen)-11.1(t)-367.3(ana-)]TJ
0 -1.0471 TD
[(lysis)-210.1(was)-212.7(perfor)-9.8(med)-210.7(by)-206.4(class)-9.4(ifying)-215.8(the)-209.9(antibiot)-10.3(ic)-209.2(regimens)]TJ
0 -1.0528 TD
[(on)-325.9(the)-329.4(basis)-327.7(of)-327.5(their)-329.2(inte)-8.2(nsity)58.5(,)]TJ
/F4 1 Tf
12.3713 0 TD
(i.e.)Tj
/F3 1 Tf
1.5364 0 TD
[(in)-322.6(order)-331.8(of)-327.5(decreas)-9.7(ing)]TJ
-13.9077 -1.0471 TD
[(intensit)-11.5(y:)-225.8(prophyl)-9.3(axis,)-229.3(co)-7.6(ntinuous)-234(use;)-229(prophyl)-9.3(axis,)-229.3(inte)-8.2(r-)]TJ
0 -1.0528 TD
[(mitten)-9.6(t)-299.1(use;)-308.6(only)-301.3(for)-307.1(respirato)-11.1(ry)-304.7(tract)-306.9(infection)-312.3(exacerba)-9.7(-)]TJ
0 -1.0471 TD
[(tions.)-289(Any)-290.7(patient)-292.1(with)-290.6(more)-287(than)-290.4(one)-287.2(antibiot)-10.3(ic)-283.2(regim)-11.3(en)]TJ
0 -1.0527 TD
[(was)-366.3(consi)-7.8(dered)-370.4(to)-362.4(belong)-371.6(to)-362.4(the)-369.3(most)-368.3(intense)-370.6(of)-361.6(the)-369.3(re-)]TJ
T*
[(porte)-8.2(d)-416.2(classes.)-422.6(Ant)-8.6(i-)]TJ
/F4 1 Tf
8.4505 0 TD
[(As)-6.8(per)30.3(gillus)]TJ
/F3 1 Tf
4.9053 0 TD
[(anti)-8.2(biotics)-423.8(were)-419.1(itr)-8.6(aco-)]TJ
-13.3557 -1.0471 TD
[(nazole)-338.2(or)-338.9(ampho)-7.4(tericin.)]TJ
/F4 1 Tf
0 -2.5607 TD
[(Statist)-10.4(ical)-338.3(analysis)]TJ
/F3 1 Tf
1.0015 -1.6503 TD
[(Th)17.1(e)-433.7(m)0(i)15.7(x)0(e)15.1(d)-433.3(mo)18.1(de)20.8(l)-435.6(a)0(n)15.1(a)0(l)18.4(y)0(s)20(i)0(s)-426.2([)0(2)13.9(6)0(,)-433.6(27],)-448.1(which)-448.7(has)-447.7(been)]TJ
-1.0015 -1.0471 TD
[(used)-334.7(to)-328.3(study)-331.7(the)-335.1(influence)-338.8(of)-333.2(ABP)80.9(A)-329.1(o)0(n)-331.6(decli)-9.4(ne)-326.3(of)-333.2(lung)]TJ
0 -1.0527 TD
[(funct)-8.2(ion,)-318(is)-312.4(an)-320.6(extension)-320.9(of)-316.1(mul)-7.8(tiple)-318.7(regres)-9.8(sion)-313.9(ana)-8.8(lysis.)]TJ
0 -1.0471 TD
[(Althoug)-8.3(h)-262.5(i)0(t)-262.4(i)0(s)-261.2(a)-257.2(compl)-9.7(ex)-258(co)-7.6(mputation,)-268.3(it)-262.4(enable)-8.2(s)-258(the)-266.8(esti-)]TJ
0 -1.0528 TD
[(mation)-576.3(of)-566.5(indi)-7.8(vidual)-573.1(and)-566.1(popula)-7.4(tion)-571.2(regres)-9.8(sion)-570(para-)]TJ
T*
[(meters)-298.2(even)-294.1(in)-288.4(the)-295.3(presen)-8.2(ce)-292.6(of)-287.7(unev)-9.1(enly)-290.4(spaced)-297.2(repeat)-9.8(ed)]TJ
0 -1.0471 TD
[(meas)-8.2(ures.)]TJ
1.0015 -1.0527 TD
[(Th)17.1(e)-274.3(i)0(n)13.2(t)13.9(en)15.1(ti)16.5(on)-263.3(wa)11.2(s)-275.1(t)0(o)-265.7(m)0(o)18.1(d)0(e)15.1(l)-276.3(th)18.9(e)-274.3(F)0(E)17.9(V)]TJ
7.97 0 0 7.97 211.635 206.646 Tm
(1)Tj
9.963 0 0 9.963 218.381 206.646 Tm
[(pe)20.8(rc)13.5(en)20.8(t)-276.3(p)0(r)13.9(e)0(d)20.8(i)0(c)18.4(t)0(e)12.8(d)]TJ
-16.0701 -1.0471 TD
[(va)15.1(lu)18.9(e)-257.2(a)0(t)-249(a)-262.9(gi)18.9(ve)20.8(n)-262.5(a)0(g)20.8(e)-262.9(us)20(in)18.9(g)-256.8(a)0(n)-252.3(i)0(n)18.9(i)0(t)16.5(i)0(a)18.4(l)-259.2(se)13.9(ve)20.8(ri)17.3(ty)-254.3(sc)19.6(or)19.6(e)-262.9(\()0(s)18.4(e)0(v)20.8(e)0(r)13.5(e)0(:)]TJ
0 -1.0527 TD
-0.0114 Tc
[(FE)-11.4(V)]TJ
7.97 0 0 7.97 76.705 185.726 Tm
0 Tc
(1)Tj
/F8 1 Tf
9.963 0 0 9.963 87.307 185.726 Tm
(<)Tj
/F3 1 Tf
0.5406 0 TD
[(40)15.5(%;)-655(mo)18.1(de)15.1(ra)19.2(te)12.8(:)-663.3(F)11.4(EV)]TJ
7.97 0 0 7.97 183.572 185.726 Tm
(1)Tj
9.963 0 0 9.963 194.173 185.726 Tm
[(40)21.2(\2616)15.5(9%)18.9(;)-663.2(m)0(i)15.7(l)0(d)18.9(:)-668.9(F)11.4(E)0(V)]TJ
7.97 0 0 7.97 281.424 185.726 Tm
(1)Tj
/F11 1 Tf
9.963 0 0 9.963 58.28 175.294 Tm
($)Tj
/F3 1 Tf
0.8251 0 TD
[(70)15.5(%\))17.3(,)-336.1(a)0(g)20.8(e)-342.6(gr)19.6(ou)15.5(ps)-327.1(at)-328.7(th)18.9(e)-336.9(s)0(t)17.7(a)0(r)13.5(t)-333.2(of)-333.2(t)13.9(h)0(e)-332(o)0(b)21.2(s)0(e)13.9(r)0(v)19.6(a)0(t)18.4(i)0(o)13.2(n)-336.5(pe)20.8(ri)17.3(od)]TJ
-0.8251 -1.0528 TD
(\()Tj
/F8 1 Tf
0.313 0 TD
(<)Tj
/F3 1 Tf
0.5463 0 TD
-0.0161 Tc
[(6)-227.4(y)-16.1(rs)-16.1(,)-217.6(6)-16.1(\2611)-16.1(2)-222.5(y)-16.1(rs)-16.1(,)-223.3(1)-16.1(3\261)-16.1(1)5.1(7)-233.1(y)-16.1(r)3.5(s)-234.3(o)-16.1(r)]TJ
/F11 1 Tf
11.3071 0 TD
0 Tc
($)Tj
/F3 1 Tf
0.8251 0 TD
[(18)-206.4(yr)19.6(s\))18.4(,)-216.6(a)0(g)15.1(e)-211.7(at)-209.2(th)18.9(e)-217.4(t)0(i)16.5(m)0(e)-209.9(o)0(f)]TJ
-12.9915 -1.0471 TD
[(ob)15.5(se)19.6(rv)19.6(at)12.8(i)13.9(o)0(n)-405.6(a)0(n)15.1(d)-410.5(pr)19.6(es)14(en)20.8(ce)14.7(/a)18.4(bs)20(en)15.1(ce)-406.4(of)-401.5(AB)18.3(P)91.1(A)-414.4(as)-407.2(fi)17.3(xe)20.8(d)-410.5(e)0(f)13.5(-)]TJ
0 -1.0528 TD
[(fe)19.2(ct)12.8(s,)-520.2(an)20.8(d)-530(a)0(g)15.1(e)-524.7(an)15.1(d)-530(a)0(n)-519.8(i)0(n)18.9(t)0(e)18.4(r)0(c)13.5(e)0(p)20.8(t)-532.4(\(t)17.3(he)-519.8(in)18.9(te)18.4(rs)12.8(ec)20.4(ti)16.5(on)-519.4(po)15.5(in)18.9(t)]TJ
0 -1.0471 TD
[(be)15.1(tw)20.6(ee)14.7(n)-478.8(t)0(h)18.9(e)-479.2(re)13.5(gr)19.6(es)13.9(si)17.7(on)-468.2(li)16.5(ne)-468.6(an)15.1(d)-478.8(t)0(h)18.9(e)-479.2(y-)14(ax)20.8(is)17.7(\))-480.4(a)0(s)-475.4(r)0(a)19.2(n)0(d)15.5(o)0(m)]TJ
0 -1.0528 TD
[(ef)24.9(fe)19.2(ct)18.4(s.)-332.4(Al)14.9(l)-338.9(E)0(R)18.1(C)0(F)-335.5(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)-329.5(w)0(i)14.9(t)0(h)-328.3(a)0(t)-334.4(l)0(e)18.4(a)0(s)13.9(t)-338.9(tw)14.9(o)-336.5(F)0(E)17.9(V)]TJ
7.97 0 0 7.97 254.948 122.967 Tm
(1)Tj
9.963 0 0 9.963 262.318 122.967 Tm
[(me)17.7(as)13.9(-)]TJ
-20.4803 -1.0471 TD
[(ur)19.6(em)12(en)20.8(ts)-335.2(af)19.2(te)18.4(r)-343.8(t)0(h)18.9(e)-342.6(in)18.9(it)16.5(ia)18.4(l)-344.6(o)0(n)21.2(e)-342.6(\(w)15.7(hi)18.9(ch)-332(wa)16.9(s)-343.4(n)0(o)15.5(t)-338.9(us)14.4(ed)-332(in)-328.3(th)13.2(e)]TJ
25.1977 66.1583 TD
[(an)15.1(al)18.4(ys)14.3(i)13.9(s)0(\))-379.9(w)12.4(er)13.5(e)-382.4(i)0(n)18.9(c)0(l)18.5(u)0(d)15.5(e)0(d)20.8(.)-387.3(H)12.4(o)0(w)11.6(e)0(v)20.8(e)0(r)47.7(,)-381.6(du)15.5(e)-382.4(t)0(o)-373.8(t)0(h)18.8(e)-382.4(ve)15.1(ry)-373(la)18.5(r)14.7(g)0(e)]TJ
0 -1.0471 TD
[(nu)15.5(mb)18.1(er)-447.4(of)-447(ob)21.2(se)13.9(rv)19.6(at)18.4(io)18.8(ns)14.4(,)-449.9(t)0(h)18.9(e)-456.4(fu)19.6(ll)-450.1(da)20.8(ta)18.4(ba)15.1(se)-447(co)20.8(ul)18.8(d)-456(n)0(o)21.2(t)-458.4(be)]TJ
0 -1.0528 TD
[(an)15.1(al)18.4(ys)14.3(ed)-229.6(an)15.1(d)-239.8(t)0(h)18.9(e)-240.2(mo)18.1(de)15.1(l)-242.1(w)0(a)16.9(s)-241(fi)17.3(tt)16.5(ed)-229.6(in)18.8(de)15.1(pe)15.1(nd)21.2(en)15.1(tl)16.5(y)-239.8(t)0(o)-231.5(t)0(w)14.9(e)0(l)18.4(v)0(e)]TJ
0 -1.0471 TD
[(su)14.4(bp)21.2(op)15.5(ul)18.9(at)18.4(io)13.2(ns)20(,)-495.5(d)0(e)15.1(f)0(i)17.3(n)0(e)15.1(d)-495.8(by)-490.9(th)18.9(e)-501.9(i)13.9(ni)13.2(ti)16.5(al)-488(se)19.6(ve)15.1(ri)17.3(ty)-487.6(an)15.1(d)-495.8(a)0(g)15.1(e)]TJ
0 -1.0528 TD
[(su)14.4(bg)21.2(ro)14(up)21.2(s.)-343.8(Th)17.1(is)-346.5(i)13.9(n)0(v)15.5(o)0(l)18.9(v)0(e)15.1(d)-347.9(th)13.2(e)-348.3(p)0(r)13.9(e)0(s)19.6(e)0(n)15.1(c)0(e)20.4(/)0(a)12.8(b)0(s)20(e)0(n)20.8(c)0(e)-343.8(o)0(f)-344.6(A)0(B)12.6(P)96.7(A)]TJ
0 -1.0471 TD
[(an)15.1(d)-416.2(a)0(g)15.1(e)-416.6(\(a)19.2(s)-417.4(f)0(i)17.3(x)0(e)15.1(d)-416.2(ef)24.9(fe)19.2(ct)18.5(s\))12.8(,)-415.8(a)0(n)20.8(d)-421.9(an)-406(in)18.9(te)18.5(rc)13.5(ep)20.8(t)-418.6(a)0(n)15.1(d)-416.2(ag)15.1(e)-416.6(\()0(a)19.2(s)]TJ
0 -1.0528 TD
[(ra)13.5(nd)21.2(om)-272.1(ef)30.6(fe)13.5(ct)18.4(s\))-266.1(on)15.5(l)13.9(y)67.5(.)-273.5(T)0(h)17.1(e)-274.3(go)15.5(al)-266.1(of)-264.9(th)13.2(is)-266.9(an)20.8(al)12.8(ys)20(is)-266.9(wa)16.9(s)-275.1(p)0(u)15.5(r)0(e)19.2(l)0(y)]TJ
0 -1.0471 TD
[(de)15.1(sc)19.6(ri)17.3(pt)13.2(iv)18.9(e,)-320.2(an)15.1(d)-330.8(t)13.9(he)-326.3(re)19.2(su)20(lt)16.5(s)-332(o)0(f)-321.8(s)0(t)17.7(a)0(t)18.4(i)0(s)17.7(t)0(i)16.5(c)0(a)14.7(l)-327.5(te)12.8(st)17.7(s)-326.3(a)0(r)13.5(e)-331.2(re)19.2(po)15.5(rt)17.3(ed)]TJ
0 -1.0527 TD
[(on)15.5(ly)-254.3(fo)19.6(r)-264.1(f)0(o)19.6(r)0(m)16.5(a)0(l)-254.7(r)0(e)19.2(a)0(s)13.9(o)0(n)21.2(s)0(.)-252.7(I)0(n)-253.5(f)0(a)13.5(c)0(t)18.4(,)-262.1(du)21.2(e)-262.9(t)0(o)-254.3(t)0(h)18.9(e)-262.9(un)15.5(us)20(ua)15.1(l)13.9(l)0(y)-254.3(l)0(a)18.5(r)14.7(ge)]TJ
T*
[(nu)15.5(mb)18.1(er)-310.8(of)-304.7(pa)15.1(ti)16.5(en)20.8(ts)-306.7(in)-311.2(ea)20.4(ch)-309.2(of)-310.4(t)13.9(h)0(e)-309.2(a)0(n)15.1(a)0(l)18.5(y)0(s)20(e)0(s)13.9(,)-313.4(st)17.7(at)18.5(is)17.7(ti)16.5(ca)14.7(l)-316.1(s)0(i)17.7(g)0(-)]TJ
0 -1.0471 TD
[(ni)13.2(fi)17.3(ca)20.4(nc)15.1(e)-308.5(c)0(a)20.4(n)-308.1(be)-297.8(re)19.2(ac)14.7(he)20.8(d)-308.1(i)0(n)-299.8(c)0(a)20.4(s)0(e)13.9(s)-303.6(wh)17.3(er)13.5(e)-308.5(t)0(h)18.9(e)-308.5(re)19.2(su)20(lt)16.5(s)-309.2(a)0(r)19.2(e)-308.5(of)]TJ
0 -1.0528 TD
[(no)-314.5(cl)12.8(in)18.8(ic)18.4(al)-317.3(re)19.2(le)18.4(va)15.1(nc)15.1(e.)]TJ
1.0015 -1.0471 TD
[(Du)11.6(ra)19.2(ti)16.5(on)-473.8(of)-464.1(fo)19.6(ll)16.5(ow)17.3(-u)19.6(p)-484.5(f)0(o)19.6(r)-486.1(th)18.8(e)-484.9(m)0(i)15.7(x)0(e)20.8(d)-484.5(mo)18.1(de)15.1(l)-481.2(a)0(n)15.1(a)0(l)18.5(y)0(s)20(i)0(s)]TJ
-1.0015 -1.0527 TD
[(ra)13.5(ng)21.2(ed)-223.9(fr)18(om)-226.6(1\261)21.2(45)-223.5(mo)18.1(nt)18.9(hs)14.4(,)-228(w)0(i)14.9(t)0(h)-220.2(a)-234.5(m)13.2(e)0(d)15.1(i)0(a)18.5(n)-234.1(of)-219.4(25)-223.5(mo)18.1(nt)18.8(hs)-224.7(fo)19.6(r)]TJ
0 -1.0471 TD
[(bo)15.5(th)-407.9(th)18.8(e)-422.3(A)12.4(BP)97(A)-414.4(a)0(n)15.1(d)-416.2(no)15.5(n-)19.6(AB)12.6(P)96.8(A)-420.1(gr)19.6(ou)15.5(ps)20(.)-421.5(T)12.2(he)-411.7(nu)21.2(mb)12.4(er)-407.6(of)]TJ
0 -1.0527 TD
[(FE)17.9(V)]TJ
7.97 0 0 7.97 327.742 614.721 Tm
(1)Tj
9.963 0 0 9.963 335.509 614.721 Tm
[(me)12(as)19.6(ur)19.6(em)12(en)20.8(ts)-375(pe)20.8(r)-383.6(p)0(e)20.8(r)0(s)12.8(o)0(n)-371.4(r)0(a)19.2(n)0(g)15.5(e)0(d)-371.8(f)0(r)18(o)0(m)-368.9(3)0(\261)15.5(4)0(5)15.5(,)-376(wi)14.9(th)]TJ
-2.629 -1.0471 TD
[(me)12(di)18.9(an)-349.1(va)15.1(lu)18.9(es)-350.3(of)-350.3(7)-359.3(a)0(n)15.1(d)-359.3(6)-359.3(f)0(o)19.6(r)-360.9(th)18.9(e)-359.7(A)0(B)18.3(P)91.1(A)-363.2(a)0(n)20.8(d)-359.3(no)15.5(n-)19.6(AB)12.6(P)96.7(A)]TJ
0 -1.0528 TD
[(gr)13.9(ou)21.2(ps)14.4(,)-324.7(r)0(e)19.2(s)0(p)20(e)0(c)14.7(t)0(i)16.5(v)0(e)20.8(l)0(y)81.5(.)]TJ
/F6 1 Tf
9.8617 -2.5551 TD
[(Res)-7.8(ults)]TJ
/F4 1 Tf
-9.8617 -1.5478 TD
[(Aller)19.8(gic)-335.1(br)31.4(onchopul)-8.9(mona)-7(ry)-333.2(asper)21.8(gillosis)-342.4(pr)31.4(evalen)-8.2(ce)]TJ
/F3 1 Tf
1.0015 -2.0998 TD
[(Th)17.1(e)-439.3(d)0(i)13.2(a)0(g)20.8(n)0(o)15.5(s)0(i)17.7(s)-440.1(of)-429.9(AB)18.3(P)91.1(A)-357.5(wa)16.9(s)-440.1(r)0(e)13.5(p)0(o)21.2(r)0(t)17.3(e)0(d)-434.4(f)0(o)19.6(r)-440.5(96)21.2(7)-444.6(o)0(f)-429.9(t)0(h)18.9(e)]TJ
-1.0015 -1.0527 TD
[(12)15.5(,4)15.9(47)-286.1(CF)-295.7(pa)20.8(ti)16.5(en)15.1(ts)17.7(;)-299.1(a)0(n)-292.2(o)0(v)21.2(e)0(r)13.5(a)0(l)18.4(l)-299.1(AB)18.3(P)91.1(A)-300.6(pr)14(ev)20.8(al)18.4(en)15.1(ce)-292.6(of)-287.7(7.)15.9(8%)]TJ
0 -1.0471 TD
[(\(9)13.9(5%)-493.3(co)15.1(nf)19.6(id)18.9(en)15.1(ce)-497.4(i)13.9(n)0(t)13.2(e)0(r)19.2(v)0(a)15.1(l)-503.9(\(C)20.6(I\))-499.8(7.)21.6(3\261)15.5(8.)21.6(3\))13.9(.)-501.2(H)0(o)17.3(w)0(e)16.9(v)0(e)15.1(r)43.2(,)-506.8(p)0(r)19.6(e)0(-)]TJ
0 -1.0527 TD
[(va)15.1(le)18.4(nc)15.1(e)-428(v)0(a)20.8(r)0(i)17.3(e)0(d)-423(g)0(r)19.6(e)0(a)14.7(t)0(l)16.5(y)-427.6(be)20.8(tw)14.9(ee)14.7(n)-427.6(c)0(o)20.8(u)0(n)15.5(t)0(r)17.3(i)0(e)18.4(s)-428.8(an)15.1(d)-427.6(i)0(n)18.8(d)0(i)18.9(v)0(i)13.2(d)0(u)21.2(a)0(l)]TJ
0 -1.0471 TD
[(ce)14.7(nt)18.9(re)13.5(s.)-207.2(Pr)14.7(ev)20.8(al)18.5(en)15.1(ce)-212.9(of)-213.7(A)12.4(B)0(P)97(A)-220.9(ra)19.2(ng)15.5(ed)-212.5(fr)18(om)-209.5(2.)15.9(1%)-208.8(in)-214.5(S)11.4(w)0(e)16.9(d)0(e)15.1(n)]TJ
0 -1.0528 TD
[(to)-345.3(13)15.5(.6)21.6(%)-355.9(i)0(n)-345.3(B)11.6(el)12.8(gi)18.9(um)-346.1(\(t)17.3(ab)20.8(le)-345.7(1\),)-356.3(and)-361.2(from)-367.9(0\26127)-8.7(%)-361.6(for)-364(the)]TJ
0 -1.0471 TD
[(bigger)-299.2(centr)-8.6(es)-293.3(\()]TJ
/F4 1 Tf
6.2425 0 TD
(i.e.)Tj
/F3 1 Tf
1.5023 0 TD
[(those)-298(with)]TJ
/F11 1 Tf
4.4443 0 TD
($)Tj
/F3 1 Tf
0.8365 0 TD
[(50)-291.7(pati)-8.2(ents;)-294.7(n)]TJ
/F8 1 Tf
5.4345 0 TD
(=)Tj
/F3 1 Tf
0.552 0 TD
[(73\).)-300.2(Sim-)]TJ
-19.0121 -1.0527 TD
[(ilar)-726.8(varia)-8.6(bility)-725.4(was)-724.8(also)-724(apparen)-8.1(t)-720.2(within)-727(individua)-8.7(l)]TJ
0 -1.0471 TD
[(cou)-8.4(ntries.)]TJ
1.0015 -1.0528 TD
[(AB)12.6(P)91.1(A)-124.2(wa)16.9(s)-212.5(a)0(l)18.4(m)0(o)18.1(s)0(t)-204.3(e)0(q)20.8(u)0(a)15.1(l)0(l)16.5(y)-205.6(pr)13.9(ev)20.8(al)12.8(en)20.8(t)-208(i)0(n)-203.1(m)0(a)17.7(l)0(e)12.8(s)-206.8(\(5)19.6(09)15.5(/6)18.9(48)15.5(0,)]TJ
-1.0015 -1.0471 TD
[(7.)15.9(9%)18.9(\))-469(a)0(n)15.1(d)-467.4(fe)19.2(ma)12(l)13.9(e)0(s)-464.1(\()0(4)19.6(5)0(8)15.5(/)0(5)18.9(9)0(6)21.2(7)0(,)-462.1(7)0(.)21.6(7)0(%)13.2(\))0(.)-458(I)0(t)-460.7(w)0(a)16.9(s)-468.6(li)16.5(tt)16.5(l)13.9(e)-473.5(re)19.2(p-)]TJ
0 -1.0528 TD
[(re)13.5(se)19.6(nt)18.9(ed)-292.2(in)-288.4(pa)15.1(ti)16.5(en)20.8(ts)]TJ
/F8 1 Tf
7.8928 0 TD
(<)Tj
/F3 1 Tf
0.5463 0 TD
[(6)-296.7(y)0(r)19.6(s)-303.6(ol)18.9(d,)-285.7(bu)15.5(t)-299.1(w)0(a)16.9(s)-297.9(re)19.2(po)15.5(rt)17.3(ed)-292.2(in)-288.4(~1)18.1(0%)]TJ
-8.4391 -1.0471 TD
[(of)-412.8(ol)18.9(de)15.1(r)-417.8(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)-409.1(\()]TJ
/F8 1 Tf
7.3863 0 TD
(<)Tj
/F3 1 Tf
0.5463 0 TD
[(6)-416.2(y)0(r)19.6(s)-423.1(56)21.2(/3)18.9(15)15.5(0,)-410.9(1.)21.6(7%)13.2(;)-418.6(6)0(\261)21.2(1)0(2)-411.3(y)0(r)19.6(s)-423.1(32)21.2(0/)]TJ
-7.9326 -1.0528 TD
[(32)15.5(23)15.5(,)-393(9)0(.)21.6(0)0(%)13.2(;)-395.8(13)21.2(\2611)15.5(8)-393.4(y)0(r)19.6(s)-400.3(23)21.2(7/)18.9(18)15.5(79)21.2(,)-398.7(1)39.1(1.)21.6(2%)13.2(;)]TJ
/F11 1 Tf
17.2594 0 TD
($)Tj
/F3 1 Tf
0.8251 0 TD
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[(un)15.5(de)15.1(rw)21.4(en)15.1(t)-378.7(l)0(u)18.8(n)0(g)-371.4(t)0(r)17.3(a)0(n)15.1(s)0(p)20(l)0(a)18.4(n)0(t)13.2(a)0(t)18.5(i)0(o)18.9(n)-382(t)13.9(h)0(a)15.1(n)-382(t)13.9(h)0(o)15.5(s)0(e)-373(i)0(n)-368.1(t)0(h)18.9(e)-382.4(ge)20.8(ne)15.1(ra)19.2(l)]TJ
0 -1.0528 TD
[(CF)-318.4(po)15.5(pu)21.2(la)18.4(ti)16.5(on)-314.5(\(t)17.3(ab)15.1(le)-317.3(4\).)]TJ
1.0015 -1.0471 TD
[(Pa)15.9(ti)16.5(en)15.1(ts)-238.4(wi)14.9(th)-242.9(AB)18.3(P)91.1(A)-255.1(re)19.2(ce)14.7(iv)18.9(ed)-240.9(mo)18.1(re)-242.5(re)13.5(sp)20(ir)17.3(at)18.4(or)14(y)-251.2(t)0(h)18.8(e)0(r)19.2(a)0(p)15.1(i)0(e)18.4(s)]TJ
-1.0015 -1.0528 TD
[(th)13.2(an)-343.4(th)13.2(os)20(e)-359.7(w)12.4(it)16.5(ho)15.5(ut)-345.3(AB)12.6(P)91.1(A)12.4(,)-358.9(i)0(n)-351(p)0(a)20.8(r)0(t)17.3(i)0(c)18.4(u)0(l)13.2(a)0(r)53.4(,)-358.9(or)19.6(al)-351.4(an)20.8(d)-359.3(i)0(n)18.9(h)0(a)15.1(l)0(e)18.4(d)]TJ
0 -1.0471 TD
[(co)15.1(rt)17.3(ic)18.4(os)14.4(te)18.4(ro)19.6(id)18.9(s,)-212.9(bu)15.5(t)-219.4(a)0(l)18.5(s)0(o)-213.3(b)0(r)19.6(o)0(n)15.5(c)0(h)15.1(o)0(d)21.2(i)0(l)16.5(a)0(t)18.5(o)0(r)13.9(s)0(,)-207.2(d)0(o)15.5(r)0(n)19.6(a)0(s)14(e)-217.4(al)12.8(fa)-208.4(\(P)14.7(ul)18.8(-)]TJ
0 -1.0528 TD
[(mo)12.4(zy)20.8(me)]TJ
/F5 1 Tf
3.3631 0 TD
(1)Tj
/F3 1 Tf
0.9958 0 TD
[(\))-434.8(a)0(n)20.8(d)-433.3(co)15.1(nt)18.9(in)18.9(uo)15.5(us)-423.8(an)15.1(ti)16.5(bi)18.9(ot)18.8(ic)-425.4(th)18.9(er)13.5(ap)20.8(y)-433.3(\()0(t)17.3(a)0(b)15.1(l)0(e)-425.4(5\).)]TJ
-4.359 -1.0471 TD
[(Con)-7(versely)57(,)-256.5(ABP)75.2(A)-175.4(was)-258.2(more)-264.3(prevalent)-264.8(in)-260(patients)-265.6(treated)]TJ
0 -1.0527 TD
[(routi)-10.2(nely)-404.2(with)-404.4(continu)-10.5(ous)-401.8(antibiot)-10.3(ic)-402.6(therapy)-408.5(\(804/8191;)]TJ
T*
[(1)27.7(1.0%\))-496.8(than)-495.2(in)-487.6(those)-497.2(recei)-9(ving)-494.8(intermitt)-12.5(ent)-494.5(antibiotics)]TJ
0 -1.0471 TD
[(\(5.7%\))-265.8(or)-259.2(antibiot)-10.3(ics)-256.7(for)-261.6(exacerba)-9.7(tion)-7.8(s)-252.3(only)-261.5(\(3.6%\))-9.7(.)-256.5(Only)]TJ
0 -1.0528 TD
[(26.2)-8.4(%)-282(o)0(f)-282(ABP)80.9(A)-283.5(patients)-288.4(\(253/)-7.8(967\))-283.5(were)-288.2(treated)-286.1(with)-284.9(the)]TJ
0 -1.0471 TD
[(anti)-8.2(-)]TJ
/F4 1 Tf
1.8096 0 TD
[(Asper)29.1(gillus)]TJ
/F3 1 Tf
4.7971 0 TD
[(anti)-8.2(biotics,)-316.1(itr)-8.7(aconazol)-10.1(e)-308.5(o)-6.5(r)-309.7(ampho)-7.4(tericin)]TJ
-6.6067 -1.0527 TD
[(\(1.4%)-223.6(of)-219.4(those)-224(without)-227(ABP)80.9(A)-135.6(were)-219.9(also)-223.3(treated)-223.5(wi)-7.8(th)-214.5(these)]TJ
0 -1.0471 TD
[(anti)-8.2(biotics\))-10.7(.)]TJ
/F4 1 Tf
0 -2.39 TD
[(Infl)-9.4(uence)-329.4(of)-328.3(alle)-8.2(r)32.2(gic)-329.4(br)25.7(onchopul)-8.9(monary)-334.5(asper)27.5(gillosi)-10.4(s)-326.3(o)0(n)]TJ
0 -1.0471 TD
[(lung)-341.2(function)-338(de)-7.6(cline)]TJ
/F3 1 Tf
1.0015 -1.6503 TD
[(Re)16.1(gr)14(es)19.6(si)17.7(on)-240.5(an)20.8(al)12.8(ys)20(is)-238.4(of)-236.4(pe)15.1(rc)19.2(en)15.1(t)-247.8(p)0(r)19.6(e)0(d)-240.9(F)11.4(EV)]TJ
7.97 0 0 7.97 478.034 574.526 Tm
(1)Tj
9.963 0 0 9.963 484.441 574.526 Tm
[(in)-237.2(AB)12.6(P)91.1(A)-243.7(an)15.1(d)]TJ
-17.5781 -1.0528 TD
[(no)15.5(n-)19.6(AB)12.6(P)91.1(A)-243.7(pa)20.8(ti)16.5(en)20.8(ts)-238.4(wa)16.9(s)-241(p)0(e)15.1(r)0(f)18(o)0(r)19.6(m)0(e)17.7(d)-245.5(us)20(in)13.2(g)-239.8(t)0(h)18.8(e)-245.9(mi)15.7(xe)20.8(d)-245.5(m)0(o)18.1(d)0(e)20.8(l)]TJ
0 -1.0471 TD
[(an)15.1(al)18.4(ys)14.3(i)13.9(s)0(,)-338.1(a)0(s)19.6(s)0(u)20(m)0(i)15.7(n)0(g)-331.6(l)0(i)16.5(n)0(e)15.1(a)0(r)19.2(i)0(t)16.5(y)73.2(,)-341.8(f)0(o)13.9(r)-338.1(th)13.2(e)-342.6(t)0(h)18.9(r)0(e)19.2(e)-342.6(se)19.6(ve)15.1(ri)17.3(ty)-334(gr)19.6(ou)15.5(ps)]TJ
0 -1.0528 TD
[(st)17.7(ra)13.5(ti)16.5(fi)17.3(ed)-326.3(fo)19.6(r)-338.1(a)0(g)15.1(e)0(.)-325.9(I)0(n)-327.5(s)0(u)14.3(b)0(g)21.2(r)0(o)13.9(u)0(p)21.2(s)-337.7(of)-327.5(pa)15.1(ti)16.5(en)20.8(ts)]TJ
/F8 1 Tf
17.1456 0 TD
(<)Tj
/F3 1 Tf
0.5463 0 TD
[(6)-336.5(y)0(r)19.6(s)-337.7(of)-327.5(ag)15.1(e,)]TJ
-17.6919 -1.0471 TD
[(an)15.1(al)18.4(ys)14.3(i)13.9(s)-497(wa)16.9(s)-497(n)0(o)21.2(t)-492.5(po)15.5(ss)18.8(ib)18.9(le)-488(du)15.5(e)-490.6(t)0(o)-487.6(t)0(h)18.8(e)-496.2(sm)16.9(al)18.4(l)-492.5(n)0(u)15.5(m)0(b)18.1(e)0(r)-487.2(o)0(f)]TJ
0 -1.0528 TD
[(pa)15.1(ti)16.5(en)20.8(ts)-517.3(wi)14.9(th)-516.1(va)15.1(li)16.5(d)-524.3(v)0(a)20.8(l)0(u)13.2(e)0(s)19.6(.)-523.9(Th)17.1(e)-524.7(r)0(e)13.5(s)0(u)20(l)0(t)16.5(s)-525.5(de)15.1(mo)18.1(ns)20(tr)17.3(at)12.8(ed)-514.1(a)]TJ
0 -1.0471 TD
[(ma)12(r)20.4(g)0(i)18.9(n)0(a)15.1(l)0(l)16.5(y)-268.2(mo)18.1(re)-265.3(ra)19.2(pi)18.9(d)-273.9(d)0(e)20.8(c)0(l)12.8(i)0(n)18.8(e)-268.6(in)-265.7(F)11.4(E)0(V)]TJ
7.97 0 0 7.97 458.305 511.767 Tm
(1)Tj
9.963 0 0 9.963 464.995 511.767 Tm
[(by)-257.6(ag)15.1(e)-268.6(i)0(n)-265.7(t)0(h)18.8(e)-268.6(no)15.5(n-)]TJ
-15.6262 -1.0527 TD
[(AB)12.6(P)91.1(A)-255.1(pa)20.8(ti)16.5(en)15.1(ts)-244.1(th)13.2(an)-246.6(in)-242.9(th)13.2(e)-251.6(A)0(B)12.6(P)91.1(A)-255.1(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)-244.1(i)0(n)-248.6(s)0(e)14(v)0(e)20.8(r)0(a)19.2(l)-259.2(of)-247.8(th)18.9(e)]TJ
0 -1.0471 TD
[(su)14.4(bg)21.2(ro)14(up)21.2(s)-337.7(a)0(n)20.8(a)0(l)12.8(y)0(s)20(e)0(d)-326.3(\()0(f)18(i)0(g)18.9(.)-336.1(1;)-334(tabl)-8.2(e)-342.6(6\).)-350.6(Regress)-9.2(ion)-346.1(analysis)]TJ
0 -1.0528 TD
[(of)-583.6(percent)-585.3(pred)-579.8(FEV)]TJ
7.97 0 0 7.97 400.082 480.359 Tm
(1)Tj
9.963 0 0 9.963 409.833 480.359 Tm
[(in)-578.7(the)-579.8(ABP)75.2(A)-579.4(and)-577.4(non-A)-9.3(BP)85.6(A)]TJ
-10.0893 -1.0471 TD
[(pati)-8.2(ents)-291.6(after)-294.7(the)-289.6(introduct)-10.3(ion)-289.2(of)-293.3(a)-285.7(quadrat)-10.1(ic)-288.8(term)-295.1(for)-290(age)]TJ
0 -1.0528 TD
[(was)-354.9(able)-353.4(to)-351(summari)-11.5(ze)-349.5(the)-352.2(general)-357.7(trend)-8.2(s)-349.1(i)0(n)-351(FEV)]TJ
7.97 0 0 7.97 511.483 459.439 Tm
(1)Tj
9.963 0 0 9.963 518.91 459.439 Tm
(over)Tj
-21.038 -1.0471 TD
[(the)-386.3(follow)-9.2(-up)-385.2(period)-384.5(of)-384.4(the)-386.3(study)-383(\(table)-387.3(6\),)-384.8(but)-385.9(did)-380.3(not)]TJ
0 -1.0527 TD
[(ident)-9(ify)-393.2(imp)-7.8(ortant)-398.3(dif)10.8(ference)-10.1(s)-394.6(between)-399.8(ABP)80.9(A)-391.7(and)-395.3(non-)]TJ
0 -1.0471 TD
[(ABP)75.2(A)-556.7(pati)-8.2(ents)-559(wi)-7.8(th)-555.9(respec)-8.6(t)-560.8(t)0(o)-561.6(FEV)]TJ
7.97 0 0 7.97 465.335 428.088 Tm
(1)Tj
9.963 0 0 9.963 474.86 428.088 Tm
[(decline)-563.3(in)-561.6(any)]TJ
-16.6164 -1.0528 TD
[(severi)-10.6(ty)-339.7(group.)-347.2(Only)-345.1(differences)-342.7(for)-341.2(the)-346.5(intercept)-346.9(values)]TJ
0 -1.0471 TD
[(wer)-8.2(e)-558.8(demon)-7.4(strated,)-571.8(which)-562.5(suppor)-7.4(ted)-562.8(the)-562.8(poorer)-565.8(lung)]TJ
0 -1.0527 TD
[(funct)-8.2(ion)-294.9(levels)-295.9(in)-294.1(the)-295.3(ABP)80.9(A)-294.9(subpopu)-6.5(lation)-296.6(already)-295.1(iden-)]TJ
0 -1.0471 TD
[(tif)-8.6(ied)-335.1(by)-331.6(c)-6.9(ross-sect)-11.1(ional)-339(analysis.)]TJ
/F6 1 Tf
9.1675 -2.39 TD
[(Discu)-10.9(ssion)]TJ
/F3 1 Tf
-8.1659 -1.6503 TD
[(Th)17.1(is)-375(is)-375(t)13.9(h)0(e)-377.5(s)0(e)19.6(c)0(o)15.1(n)0(d)-371.4(e)0(x)20.8(t)0(e)18.4(n)0(s)14.4(i)0(v)18.9(e)-382.4(ep)20.8(id)13.2(em)17.7(io)18.9(lo)18.9(gi)18.9(ca)14.7(l)-378.7(s)0(t)12(u)0(d)21.2(y)-382(of)]TJ
-1.0015 -1.0527 TD
[(AB)12.6(P)91.1(A)-477(in)-464.8(CF)-472.1(to)-470.5(be)-468.6(pu)21.2(bl)18.9(is)17.7(he)15.1(d)-478.8(r)0(e)19.2(c)0(e)14.7(n)0(t)18.9(l)0(y)-464.8([)0(1)13.9(2].)-475.8(The)-490.5(large)]TJ
ET
1 i 
58.28 756.907 227.168 -0.51 re
f
58.28 740.466 227.168 -0.51 re
f
58.28 638.816 227.168 -0.454 re
f
BT
/F2 1 Tf
8.966 0 0 8.966 58.28 770.74 Tm
[(Table)-331.9(1.)-336.7(\261)-333.2(Prevalence)-1086.5(of)-1089.1(allergic)-1093.2(bronchopulmonary)]TJ
0 -1.0559 TD
[(aspergillosis)-332.9(\(ABPA\))-337.1(by)-332.7(country)]TJ
/F3 1 Tf
0 -1.7072 TD
[(Country)-5423.2(CF)-331.1(population)-1576.2(ABP)83.5(A%)-2000.8(95%)-334.1(CI)]TJ
0 -2.0043 TD
[(Austria)-8592.9(169)-4380.3(5.3)-2891.5(2.5\2619.9)]TJ
0 -1.0559 TD
[(Belgium)-8499.2(44)-3963.5(13.6)-2891(5.2\26127.4)]TJ
T*
[(Denmark)-7810.9(320)-4380.3(3.4)-2891.5(1.7\2616.1)]TJ
T*
[(France)-8228.2(2935)-4461.9(7.4)-2891.5(6.5\2618.4)]TJ
0 -1.0496 TD
[(Germany)-7229.2(3070)-3994.1(1)32.1(1.5)-2392(10.4\26112.7)]TJ
0 -1.0559 TD
[(Ireland)-8706.9(621)-3912.4(1)32.1(1.0)-2891.5(8.6\26113.7)]TJ
T*
[(Netherlands)-6718.8(353)-4380.3(6.8)-2891.5(4.4\2619.9)]TJ
T*
[(Sweden)-8350.9(424)-4380.3(2.1)-2891.5(1.0\2614.0)]TJ
T*
[(United)-333.6(Kingdom)-4309.9(451)33.1(1)-4311.7(6.0)-2891.5(5.3\2616.7)]TJ
T*
[(All)-335.3(countries)-5281.5(12447)-4379.2(7.8)-2891.5(7.3\2618.3)]TJ
0 -1.9475 TD
[(CF:)-332.9(cystic)-337.6(fibrosis;)-335.7(95%)-334.1(CI:)-335.3(95%)-334.1(confidence)-338.8(interval.)]TJ
ET
58.28 294.293 476.504 -0.454 re
f
86.343 269.915 52.498 -0.283 re
f
136.743 269.915 92.466 -0.283 re
f
227.112 269.915 106.469 -0.283 re
f
332.164 269.915 106.469 -0.283 re
f
437.216 269.915 97.568 -0.283 re
f
254.438 248.258 79.143 -0.283 re
f
359.49 248.258 79.143 -0.283 re
f
464.542 248.258 70.243 -0.283 re
f
58.28 227.849 476.504 -0.51 re
f
58.28 126.198 476.504 -0.454 re
f
BT
/F2 1 Tf
8.966 0 0 8.966 58.28 308.126 Tm
[(Table)-331.9(2.)-336.7(\261)-333.2(Prevalence)-245.5(of)-241.9(allergic)-246(bronchopulmonary)-241.7(aspergillosis)-250.7(\(ABPA\))-242.3(by)-244.2(initial)-246.8(forced)-245.9(expiratory)-242.5(volume)-245.2(in)-241.7(one)-247.1(second)]TJ
0 -1.0559 TD
(\(FEV)Tj
7.173 0 0 7.173 78.746 298.658 Tm
(1)Tj
8.966 0 0 8.966 82.715 298.658 Tm
[(\))-330.9(and)-335.7(age)]TJ
/F3 1 Tf
0.4047 -1.7072 TD
[(CF)-337.4(Population)]TJ
2.6809 -1.0559 TD
(n)Tj
5.0836 1.0559 TD
[(Mean)-333.3(FEV)]TJ
7.173 0 0 7.173 196.044 283.351 Tm
(1)Tj
8.966 0 0 8.966 202.62 283.351 Tm
(%)Tj
-4.0846 -1.0559 TD
[(\(95%)-334.5(CI\))]TJ
11.6152 1.0559 TD
(FEV)Tj
7.173 0 0 7.173 286.979 283.351 Tm
(1)Tj
/F8 1 Tf
8.966 0 0 8.966 269.688 273.883 Tm
(<)Tj
/F3 1 Tf
0.5501 0 TD
(40%)Tj
11.2168 1.0559 TD
(FEV)Tj
7.173 0 0 7.173 392.031 283.351 Tm
(1)Tj
8.966 0 0 8.966 370.545 273.883 Tm
(40\26170%)Tj
11.7416 1.0559 TD
(FEV)Tj
7.173 0 0 7.173 492.605 283.351 Tm
(1)Tj
/F11 1 Tf
8.966 0 0 8.966 474.066 273.883 Tm
($)Tj
/F3 1 Tf
0.8346 0 TD
(70%)Tj
-47.2069 -1.3594 TD
(Age)Tj
0 -1.0559 TD
[(yrs)-2675.2(All)-891.7(ABP)83.5(A)]TJ
10.7742 1.0559 TD
(No)Tj
-0.6765 -1.0559 TD
[(ABP)77.1(A)-2468.7(ABP)83.5(A)]TJ
9.7246 1.0559 TD
(No)Tj
-0.6765 -1.0559 TD
[(ABP)83.5(A)-3284.4(ABP)77.1(A)]TJ
12.3929 1.0559 TD
(No)Tj
-0.6765 -1.0559 TD
[(ABP)83.5(A)-3290.7(ABP)83.5(A)]TJ
12.3929 1.0559 TD
(No)Tj
-0.6766 -1.0559 TD
[(ABP)77.1(A)-2784.9(ABP)83.5(A)]TJ
-20.3598 -2.1118 TD
[(Y)92(e)0(s)-961(%)-1365.7(95%)-334.1(CI)-3975.5(Y)92(e)0(s)-961(%)-1365.7(95%)-334.1(CI)-3975.5(Y)92(e)0(s)-714.5(%)-866.2(95%)-334.1(CI)]TJ
/F8 1 Tf
-22.2187 -1.998 TD
(<)Tj
/F3 1 Tf
0.5501 0 TD
[(6)-2459.1(1015)-1313.1(42)-3065.6(91)]TJ
8.517 -1.0559 TD
(\(89.5\26192.5\))Tj
6.4873 1.0559 TD
(78.7)Tj
-1.4479 -1.0559 TD
(\(73.2\26184.2\))Tj
6.0763 1.0559 TD
[(7)-2010.2(0)-1599.2(0)-1719.3(0\26141.0)-1638(141)-1256.7(15)-979(8.4)-969.3(4.6\26114.0)-1261(825)-1263.1(29)-719.8(3.4)-729(2.3\2614.8)]TJ
-20.1827 -2.1119 TD
[(6\26112)-1509.1(3284)-1060.2(306)-2439.1(79.8)]TJ
9.0671 -1.0559 TD
(\(79.0\26180.6\))Tj
6.4873 1.0559 TD
(70.1)Tj
-1.4479 -1.0559 TD
(\(68.0\26172.2\))Tj
5.5768 1.0559 TD
[(136)-1256.7(16)-726.1(10.5)-722.2(6.1\26116.5)-1261(731)-1010.2(132)-472.7(15.3)-475.6(13.0\26117.9)-792.6(21)32.6(1)32.1(1)-789.9(158)-472.7(7.0)-729(6.0\2618.1)]TJ
-19.6832 -2.1118 TD
[(13\26117)-1009.1(2004)-1060.2(228)-2439.1(68.5)]TJ
9.0671 -1.0559 TD
(\(67.4\26169.6\))Tj
6.4873 1.0559 TD
(60.1)Tj
-1.4479 -1.0559 TD
(\(57.3\26162.9\))Tj
5.5768 1.0559 TD
[(272)-1256.7(52)-726.1(16.1)-475.6(12.2\26120.5)-1007.6(633)-1256.7(92)-726.1(12.7)-475.6(10.4\26115.3)-1007.6(871)-1263.1(84)-719.8(8.8)-476.1(7.1\26110.8)]TJ
/F11 1 Tf
-19.6832 -2.1055 TD
($)Tj
/F3 1 Tf
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(Candida)Tj
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T*
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[(Asper)28.5(gillus)]TJ
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T*
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T*
[(ABP)83.5(A)-7596.6(295/954)-3122.3(30.9)-2372.5(28.0\26134.0)]TJ
/F4 1 Tf
-0.3351 -1.0559 TD
[(S.)-331.2(maltophilia)]TJ
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0.3351 -1.0559 TD
[(No)-331.1(ABP)83.5(A)-5548(798/10886)-3039.1(7.3)-2954.7(6.8\2617.8)]TJ
T*
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[(B.)-334.7(cepacia)]TJ
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T*
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[(No)-331.1(ABP)83.5(A)-5295.1(5329/10886)-2374.7(49.0)-2372.5(48.0\26149.9)]TJ
T*
[(ABP)83.5(A)-7596.6(459/954)-3122.3(48.1)-3498(51.3)]TJ
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0 -1.0559 TD
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T*
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T*
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T*
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T*
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[(P)123.5(.)-521.4(aeruginosa)]TJ
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[(S.)-211.1(aur)25.6(eus)]TJ
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[(phomonas)-335.5(maltophilia)]TJ
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BT
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T*
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[(complication/number)-511.8(of)-499.5(patients)-509.6(in)-500.9(the)-500.1(given)-505.5(class;)-503.2(n/N)-503.7(%:)]TJ
T*
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T*
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(468)Tj
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T*
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T*
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T*
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T*
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[(alle)-8.6(rgens)-462.2(ha)-7.6(ve)-468.6(been)-476.2(ident)-9(ified:)-474.7(secret)-11(ed)-474.3(and)]TJ
-4.3931 -1.0641 TD
[(cytopl)-9.7(asmic)-210.5(proteins.)-207.9(Se)-6.8(creted)-208.9(allergens)-203.4(may)-205(b)-6.5(e)-200.3(recogni)-10.1(z-)]TJ
0 -1.0698 TD
[(ed)-394.6(by)-399.9(serum)-402.8(IgE)-395(of)]TJ
/F4 1 Tf
8.587 0 TD
[(A.)-397.9(fumigat)-10.7(us)]TJ
/F3 1 Tf
5.1784 0 TD
[(-sensitized)-407.7(individua)-8.7(ls)]TJ
-13.7654 -1.0641 TD
[(with)-267.8(or)-264.9(without)-272.5(ABP)80.9(A,)-266.8(whereas)-269.3(nonsecr)-8.9(eted)-268(cytoplasm)-11.1(ic)]TJ
T*
[(allergens)-220.5(may)-222.1(b)-6.5(e)-217.4(recogni)-10.1(zed)-225(only)-221.7(by)-223.5(serum)-226.4(IgE)-224.2(from)-225.6(AB-)]TJ
T*
[(P)79.7(A)-414.4(pati)-8.2(ents)-416.7([32].)-422(By)-416(u)-6.5(sing)-416.3(such)-420.1(alle)-8.6(rgens,)-411.4(distinct)-421.2(IgE)]TJ
T*
[(respon)-7.8(ses)-249.8(to)]TJ
/F4 1 Tf
5.1272 0 TD
[(A.)-250(fum)-8.6(igatus)]TJ
/F3 1 Tf
5.2751 0 TD
[(ha)-7.6(ve)-246.6(been)-254.2(found)-250.1(in)-254.3(CF)-250.2(patients)]TJ
-10.4023 -1.0641 TD
[(with)-205.2(ABP)80.9(A)-203.9(\(against)]TJ
/F4 1 Tf
8.0692 0 TD
[(rAsp)-197.3(f)]TJ
/F3 1 Tf
2.5437 0 TD
[(4)-199.9(and)]TJ
/F4 1 Tf
2.3388 0 TD
[(rAsp)-203(f)]TJ
/F3 1 Tf
2.5437 0 TD
[(6)-199.9(antigens\))-208.7(or)-202.3(sim-)]TJ
-15.4954 -1.0641 TD
(ple)Tj
/F4 1 Tf
1.3999 0 TD
[(A.)-193.1(fumigatus)]TJ
/F3 1 Tf
5.1613 0 TD
[(allergy)-183.2(\(agai)-8.6(nst)]TJ
/F4 1 Tf
6.2425 0 TD
[(rAsp)-191.7(F)]TJ
/F3 1 Tf
2.8623 0 TD
[(1)-188.6(and)]TJ
/F4 1 Tf
2.3217 0 TD
[(rAsp)-191.7(F)]TJ
/F3 1 Tf
2.8623 0 TD
[(3)-188.6(an-)]TJ
-20.8502 -1.0641 TD
[(tigens\))-314.9([22,)-311.6(34]\).)-308.2(Di)-7.8(ff)12.4(erent)-8.6(iation)-313.7(of)-310.4(the)-306.7(two)-310.2(condit)-9.7(ions)-308.2(is)]TJ
0 -1.0698 TD
[(fundam)-9.7(ental)-197.2(because)-195.9(of)-196.6(different)-193.6(therapeuti)-11.9(c)-189(imp)-7.8(lication)-10.7(s.)]TJ
1.0015 -1.0471 TD
[(Th)17.1(er)19.2(e)-393.8(a)0(r)19.2(e)-388.1(on)15.5(ly)-379.5(a)-388.1(l)0(i)16.5(m)0(i)15.7(t)0(e)18.4(d)-393.4(nu)21.2(mb)18.1(er)-384.8(of)-378.7(re)13.5(po)21.2(rt)17.3(s)-388.9(i)0(n)-385.2(t)13.9(he)-383.2(li)16.5(t-)]TJ
-1.0015 -1.0641 TD
[(er)19.2(at)12.8(ur)19.6(e)-291.4(t)0(h)18.9(a)0(t)-283.1(h)0(a)15.1(v)0(e)-280.8(a)0(d)20.8(d)0(r)13.9(e)0(s)19.6(s)0(e)13.9(d)-291(t)13.9(h)0(e)-286.5(p)0(r)19.6(e)0(v)15.1(a)0(l)18.4(e)0(n)20.8(c)0(e)-286.9(o)0(f)-282(A)0(B)18.3(P)91.1(A)-289.2(a)0(t)-283.2(a)0(n)]TJ
T*
[(ea)14.7(rl)17.3(y)-239.8(a)0(g)15.1(e)-240.2(in)-231.5(CF)85.6(,)-239.4(d)0(e)15.1(s)0(p)20(i)0(t)16.5(e)-240.2(ev)15.1(id)18.9(en)20.8(ce)-235.7(th)18.9(at)-237.6(an)-229.6(im)15.7(mu)12.4(ne)-229.6(re)13.5(sp)20(on)15.5(se)]TJ
T*
(to)Tj
/F4 1 Tf
1.343 0 TD
[(A.)-574.3(fu)18.9(mi)14.9(ga)21.2(tu)18.9(s)]TJ
/F3 1 Tf
5.8499 0 TD
[(us)14.4(ua)20.8(ll)16.5(y)-581.2(d)0(e)15.1(v)0(e)20.8(l)0(o)18.9(p)0(s)-577.5(v)0(e)20.8(r)0(y)-572.2(e)0(a)14.7(r)0(l)17.3(y)-581.2(in)-573(th)18.9(es)13.9(e)]TJ
-7.1929 -1.0641 TD
[(pa)15.1(ti)22.2(en)15.1(ts)-261.2([1)13.9(0,)-262.9(12)21.2(,)-273.5(2)0(1)15.5(])0(.)-258.8(O)0(u)11.6(r)-269.8(da)15.1(ta)-260.4(sh)14.4(ow)-261.5(th)18.9(at)-266.1(AB)12.6(P)96.8(A)-277.8(ca)20.4(n)-273.9(a)0(f)30.6(f)0(e)13.5(c)0(t)]TJ
0 -1.0698 TD
[(ev)15.1(en)-280.8(pa)15.1(t)13.9(i)0(e)12.8(n)0(t)18.9(s)]TJ
/F8 1 Tf
5.4402 0 TD
0 Tw
(<)Tj
/F3 1 Tf
0.5406 0 TD
[(6)-296.7(y)0(r)19.6(s)-292.2(of)-282(ag)15.1(e)-291.4(\()0(5)19.6(6)0(/)18.9(3)0(1)15.5(5)0(0)-280.4(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)17.7(\))0(.)-287.3(I)0(n)-282(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)]TJ
/F11 1 Tf
-5.9808 -1.0641 TD
($)Tj
/F3 1 Tf
0.8251 0 TD
[(6)-325.1(y)0(r)19.6(s)-326.3(of)-316.1(ag)20.8(e,)-314.5(pr)13.9(ev)20.8(al)18.5(en)15.1(ce)-315.3(is)-318.1(co)20.8(ns)14.4(i)13.9(s)0(t)12(e)0(n)20.8(t)0(l)16.5(y)-325.1(~)13.2(1)0(0)15.5(%)0(.)]TJ
0.1764 -1.0471 TD
[(An)-255.8(at)18.5(te)18.4(mp)18.1(t)-264.9(t)0(o)-254.3(c)0(o)20.8(r)0(r)12.4(e)0(l)18.5(a)0(t)18.4(e)-262.9(th)18.9(e)-262.9(p)0(r)19.6(e)0(v)15.1(a)0(l)18.4(e)0(n)15.1(c)0(e)-252.7(o)0(f)-253.5(A)0(B)18.3(P)91.1(A)-260.8(p)0(h)15.5(e)0(n)15.1(o)0(-)]TJ
-1.0015 -1.0641 TD
[(ty)18.9(pe)-457.2(wi)14.9(th)-453.5(CF)17.3(TR)-459.9(ge)20.8(no)15.5(ty)18.9(pe)-457.2(wa)16.9(s)-462.9(p)0(e)15.1(r)0(f)18(o)0(r)13.9(m)0(e)17.7(d)-461.7(by)-456.8(gr)14(ou)21.2(pi)18.9(ng)]TJ
T*
[(pa)15.1(ti)22.2(en)15.1(ts)-340.8(wi)20.6(th)-339.7(a)-348.3(k)0(n)15.5(o)0(w)17.3(n)-347.9(ge)15.1(no)21.2(ty)18.9(pe)-343.4(i)13.9(n)0(t)13.2(o)-347.9(th)18.9(e)-348.3(f)0(o)19.6(u)0(r)-338.9(m)0(o)12.4(s)0(t)-335.1(c)0(o)15.1(m)0(-)]TJ
0 -1.0698 TD
[(mo)18.1(n)-501.5(g)0(r)19.6(o)0(u)15.5(p)0(s)-492.1(f)0(o)19.6(u)0(n)15.5(d)-501.5(am)17.7(on)15.5(g)-495.8(t)0(h)13.2(e)-496.2(ER)12.4(C)11.6(F)-500.8(pa)15.1(ti)16.5(en)20.8(ts)-494.5(\()]TJ
/F10 1 Tf
19.8543 0 TD
(D)Tj
/F3 1 Tf
0.6601 0 TD
-0.0135 Tc
[(F5)-13.5(08)-13.5(/)]TJ
/F10 1 Tf
-20.5144 -1.0641 TD
0 Tc
(D)Tj
/F3 1 Tf
0.6601 0 TD
-0.0135 Tc
[(F5)-13.5(08)-13.5(,)]TJ
/F10 1 Tf
2.6006 0 TD
0 Tc
(D)Tj
/F3 1 Tf
0.6601 0 TD
-0.0135 Tc
[(F5)-13.5(08)-13.5(/)5.4(G)-13.5(5)3.8(5)-13.5(I)6.1(D)-13.5(,)]TJ
/F10 1 Tf
5.5767 0 TD
0 Tc
(D)Tj
/F3 1 Tf
0.6601 0 TD
[(F5)16.3(08)21.2(/G)14.9(54)15.5(2X)17.3(,)]TJ
/F10 1 Tf
5.7588 0 TD
(D)Tj
/F3 1 Tf
0.6601 0 TD
-0.0128 Tc
[(F5)-12.8(08)-12.8(/)6.1(N)-12.8(1)4.5(3)-12.8(0)8.4(3)-12.8(K\))-12.8(.)]TJ
-16.5766 -1.0641 TD
0 Tc
[(Th)17.1(e)-473.5(r)0(e)19.2(m)0(a)17.7(i)0(n)13.2(i)13.9(ng)-468.2(pa)20.8(ti)16.5(en)15.1(t)13.9(s)-474.3(we)16.9(re)-464.5(gr)19.6(ou)15.5(pe)15.1(d)-467.4(i)0(n)13.2(t)0(o)-459.2(t)0(w)14.9(o)-473.1(cl)18.4(as)19.6(se)13.9(s:)]TJ
/F10 1 Tf
T*
(D)Tj
/F3 1 Tf
0.6601 0 TD
-0.0165 Tc
[(F5)-16.5(08)-16.5(/o)-16.5(th)-16.5(er)-508.2(a)-16.5(n)4.3(d)-512.3(o)-16.5(th)-16.5(er)-16.5(/o)-16.5(th)-16.5(er)49.4(.)-512(N)-16.5(o)-500(s)-16.5(ig)-16.5(ni)-16.5(fi)-16.5(ca)-16.5(nt)-509(d)-16.5(i)2.4(f)3.9(f)-16.5(er)-16.5(en)-16.5(ce)-16.5(s)]TJ
-0.6601 -1.0641 TD
0 Tc
[(we)16.9(re)-316.5(ob)15.5(se)19.6(rv)19.6(ed)-314.9(be)15.1(tw)14.9(ee)20.4(n)-325.1(g)0(e)15.1(n)0(o)21.2(t)0(y)18.9(p)0(e)15.1(s)0(.)]TJ
/F4 1 Tf
25.1977 42.2239 TD
[(Aller)19.8(gic)-693.6(br)31.4(onchopul)-8.9(mona)-7(ry)-691.7(asper)27.5(gillosi)-10.4(s)-690.5(associ)-9.7(ations)]TJ
0 -1.0584 TD
[(with)-342.6(clinical)-340.8(condit)-9.7(ions)]TJ
/F3 1 Tf
1.0015 -2.0998 TD
[(AB)12.6(P)91.1(A)-129.9(wa)16.9(s)-212.5(g)0(e)15.1(n)0(e)20.8(r)0(a)13.5(l)0(l)16.5(y)-211.3(as)13.9(so)20(ci)18.5(at)18.5(ed)-206.8(wi)14.9(th)-203.1(a)-217.4(p)0(o)21.2(o)0(r)13.9(e)0(r)-202.7(n)0(u)15.5(t)0(r)17.3(i)0(t)16.5(i)0(o)18.8(n)0(a)20.8(l)]TJ
-1.0015 -1.0584 TD
[(st)17.7(at)12.8(us)-224.7(\(l)17.3(ow)17.3(er)-225.5(bo)21.2(dy)-223.5(we)16.9(ig)13.2(ht)-220.2(z-)13.5(sc)19.6(or)19.6(e\))13.5(,)-233.7(s)0(l)17.7(i)0(g)18.9(h)0(t)18.9(l)0(y)-225.8(h)0(i)18.9(g)0(h)15.5(e)0(r)-225.5(c)0(o)20.8(n)0(c)15.1(e)0(n)20.8(-)]TJ
0 -1.0527 TD
[(tr)17.3(at)12.8(io)18.9(ns)-310(of)-310.4(se)19.6(ru)14(m)-316.9(I)0(g)13.9(G)-317.7(\(a)13.5(n)-313.8(i)0(n)13.2(d)0(i)18.9(c)0(a)20.4(t)0(i)16.5(o)0(n)-314.5(o)0(f)-310.4(g)0(r)19.6(e)0(a)14.7(t)13.9(er)-310.8(in)13.2(fl)17.3(am)17.7(ma)17.7(-)]TJ
0 -1.0584 TD
[(ti)16.5(on)15.5(\),)-230.4(a)-240.2(p)0(o)21.2(o)0(r)14(e)0(r)-231.2(r)0(e)19.2(s)0(p)20(i)0(r)17.3(a)0(t)12.8(o)0(r)19.6(y)-239.8(fu)19.6(nc)15.1(ti)16.5(on)-229.2(\(l)17.3(ow)17.3(er)-231.2(F)11.4(E)0(V)]TJ
7.97 0 0 7.97 491.357 470.154 Tm
(1)Tj
9.963 0 0 9.963 497.707 470.154 Tm
[(an)20.8(d)-239.8(F)0(V)12.4(C)11.6(\))]TJ
-18.9097 -1.0584 TD
[(an)15.1(d)-564.1(a)-570.2(hi)18.9(gh)15.5(er)-555.5(ra)13.5(te)-556.3(of)-560.8(re)19.2(sp)14.4(ir)17.3(at)18.4(or)19.6(y)-569.8(t)0(r)17.3(a)0(c)20.4(t)-572.2(co)20.8(lo)18.8(ni)13.2(za)20.4(ti)16.5(on)-559.2(by)]TJ
0 -1.0527 TD
[(pa)15.1(th)18.8(og)15.5(en)20.8(s.)]TJ
1.0015 -1.0528 TD
[(As)16.1(so)14.4(ci)18.5(at)18.4(io)18.9(n)-365(w)12.4(it)16.5(h)-359.3(i)0(m)15.7(p)0(a)15.1(i)0(r)17.3(e)0(d)-349.1(l)0(u)18.9(n)0(g)-354.3(f)0(u)19.6(n)0(c)15.1(t)0(i)16.5(o)0(n)-348.7(i)0(s)-352.2(o)0(f)-350.2(i)0(n)18.9(t)0(e)12.8(r)0(e)19.2(s)0(t)17.7(.)]TJ
-1.0015 -1.0527 TD
[(Pa)15.9(ti)16.5(en)15.1(t)13.9(s)-206.8(w)12.4(i)0(t)16.5(h)-205.6(AB)18.3(P)91.1(A)-203.9(ha)20.8(d,)-194.6(on)-195(av)20.8(er)13.5(ag)20.8(e,)-195(a)-200.3(1)0(0)15.5(%)-202.3(lo)18.9(we)16.9(r)-207.2(F)11.4(EV)]TJ
7.97 0 0 7.97 522.255 428.145 Tm
(1)Tj
9.963 0 0 9.963 528.264 428.145 Tm
(%)Tj
-21.9769 -1.0584 TD
[(pr)13.9(ed)-314.9(th)18.9(an)-314.9(th)18.8(os)20(e)-325.5(w)0(i)14.9(t)0(h)18.9(o)0(u)15.5(t)-321.8(AB)18.3(P)91.1(A)0(.)-312.4(I)0(n)-316.1(a)0(d)15.1(d)0(i)18.8(t)0(i)16.5(o)0(n)21.2(,)-324.7(pa)15.1(t)13.9(i)0(e)12.8(n)0(t)18.9(s)-320.6(wi)14.9(th)]TJ
T*
[(FE)17.9(V)]TJ
7.97 0 0 7.97 327.742 407.055 Tm
(1)Tj
/F11 1 Tf
9.963 0 0 9.963 335.338 407.055 Tm
($)Tj
/F3 1 Tf
0.8251 0 TD
[(70)21.2(%)-367.3(o)0(f)-350.2(t)0(h)18.8(e)-359.7(pr)13.9(ed)20.8(ic)18.4(te)12.8(d)-359.3(v)0(a)20.8(l)0(u)13.2(e)-359.7(we)16.9(re)-350.7(le)18.4(ss)-356.7(fr)18(eq)20.8(ue)15.1(nt)18.8(ly)]TJ
-3.4371 -1.0527 TD
[(af)24.9(fe)19.2(ct)12.8(ed)-303.5(by)-303.1(AB)18.3(P)91.1(A)-312(\(7)14(%\))-307.1(t)13.9(h)0(a)15.1(n)-313.8(th)18.9(e)-314.2(o)0(t)18.9(h)0(e)15.1(r)0(s)18.4(,)-313.4(wh)17.3(il)16.5(e)-314.1(i)13.9(n)-313.7(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)]TJ
0 -1.0584 TD
[(wi)14.9(th)-299.8(F)11.4(E)0(V)]TJ
7.97 0 0 7.97 348.094 386.022 Tm
(1)Tj
/F8 1 Tf
9.963 0 0 9.963 355.068 386.022 Tm
(<)Tj
/F3 1 Tf
0.5463 0 TD
[(70)15.5(%)-304.7(o)0(f)-299(t)0(h)18.8(e)-302.8(pr)13.9(ed)20.8(ic)12.8(t)13.9(e)0(d)-297.8(v)0(a)15.1(l)0(u)18.9(e)-308.5(A)12.4(B)0(P)97(A)-306.3(ca)14.7(n)-302.4(r)0(e)19.2(a)0(c)14.7(h)]TJ
-5.1386 -1.0584 TD
[(pe)15.1(ak)-548.2(fr)18(eq)15.1(ue)15.1(nc)20.8(ie)18.4(s)-559.6(o)0(f)-549.4(1)0(3)15.5(\261)0(1)21.2(6)0(%)-555.9(i)0(n)-550.2(a)0(d)20.8(o)0(l)18.9(e)0(s)13.9(c)0(e)20.4(n)0(t)18.9(s)-559.6(\(t)17.3(ab)15.1(le)-550.6(2\).)]TJ
0 -1.0527 TD
[(Po)-6.4(orer)-359.5(lung)-358.2(function)-360(in)-356.7(CF)-358.3(pati)-8.2(ents)-359.8(with)-358.9(ABP)80.9(A)-357.5(o)0(r)-355.9(sen-)]TJ
0 -1.0584 TD
[(sit)-8.2(ization)-354.7(to)]TJ
/F4 1 Tf
5.093 0 TD
[(A.)-352.4(fum)-8.6(igatus)]TJ
/F3 1 Tf
5.48 0 TD
[(has)-356.7(been)-351(report)-10.6(ed)-349.1([10,)-357.1(23].)-351.4(In)]TJ
-10.573 -1.0527 TD
[(CF)-466.4(it)-467.2(is)-466(unclear)-471.5(whether)-469.3(ABP)80.9(A)-465.6(i)0(s)-466(respon)-7.8(sible)-465.4(for)-466.4(the)]TJ
0 -1.0584 TD
[(deter)-8.6(ioration,)-402.6(more)-400.8(severe)-401.2(lung)-398.1(impa)-9(irment)-401.4(predisposes)]TJ
T*
[(pati)-8.2(ents)-240.3(to)-237.2(ABP)75.2(A,)-238.4(or)-242.1(some)-241.1(other)-241.5(clin)-8.2(ical)-241.9(feature)-245.4(underlies)]TJ
0 -1.0527 TD
[(both)-455(condit)-9.7(ions.)-450.9(The)-456.4(absence)-457.7(of)-452.7(complete)-459.1(clinical)-460.7(and)]TJ
0 -1.0584 TD
[(imm)-11(unological)-214.7(pati)-8.2(ent)-209.9(histori)-9.6(es)-208(prior)-219.9(to)-208.8(their)-215.4(enrolment)-216.3(in)]TJ
T*
[(the)-568.4(ERCF)-567.8(means)-572.3(that)-565.9(these)-571.6(data)-569.6(cannot)-565.4(an)-7.6(swer)-567.8(this)]TJ
0 -1.0527 TD
[(que)-8.4(stion.)]TJ
1.0015 -1.0528 TD
[(A)-226.6(g)0(r)19.6(e)0(a)14.7(t)0(e)18.5(r)-218.6(fr)12.4(eq)20.8(ue)15.1(nc)20.8(y)-222.7(o)0(f)-213.7(p)0(a)15.1(t)13.9(ho)15.5(ge)15.1(ni)18.9(c)-223.1(b)0(a)20.8(c)0(t)18.4(e)0(r)13.5(i)0(a)18.4(l)-219.4(co)15.1(lo)18.9(ni)18.8(za)14.7(ti)16.5(on)]TJ
-1.0015 -1.0527 TD
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T*
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T*
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T*
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T*
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(1)Tj
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0 -1.0528 TD
[(ad)15.1(mi)21.4(ni)13.2(st)17.7(er)19.2(ed)15.1(.)-387.3(A)0(l)14.9(l)-390.1(of)-384.4(th)18.9(e)-393.8(c)0(o)20.8(m)0(m)14.9(o)0(n)-382.8(t)0(h)18.9(e)0(r)13.5(a)0(p)20.8(i)0(e)18.4(s)-394.6(us)20(ed)-383.2(to)-379.5(tr)17.3(ea)14.7(t)]TJ
0 -1.0471 TD
[(lu)18.9(ng)-200.7(di)18.9(se)13.9(as)19.6(e)-206(i)0(n)-203.1(C)11.6(F)-210.5(w)0(e)16.9(r)0(e)-202.7(a)0(d)20.8(m)0(i)15.7(n)0(i)18.9(s)0(t)17.7(e)0(r)13.5(e)0(d)-195.4(t)0(o)-203.1(c)0(o)20.8(n)0(s)14.4(i)0(d)18.9(e)0(r)19.2(a)0(b)15.1(l)0(y)-197.4(m)0(o)12.4(r)0(e)]TJ
0 -1.0527 TD
[(AB)18.3(P)91.1(A)-266.5(pa)20.8(ti)16.5(en)15.1(t)13.9(s)-263.7(th)18.9(an)-252.3(th)13.2(os)20(e)-262.9(w)0(i)14.9(t)0(h)18.9(o)0(u)21.2(t)-264.9(AB)18.3(P)91.1(A)0(.)-255.5(O)12.4(ra)13.5(ll)16.5(y-)19.6(ad)15.1(mi)21.4(ni)13.2(s-)]TJ
0 -1.0471 TD
[(te)18.4(re)13.5(d)-199.9(c)0(o)20.8(r)0(t)17.3(i)0(c)18.4(o)0(s)14.4(t)0(e)18.4(r)0(o)19.6(i)0(d)13.2(s)-201.1(ar)19.2(e)-200.3(g)0(e)15.1(n)0(e)20.8(r)0(a)13.5(l)0(l)22.2(y)-205.6(re)19.2(co)20.8(mm)14.9(en)15.1(de)15.1(d)-199.9(f)0(o)19.6(r)-201.5(AB)18.3(P)91.1(A)]TJ
0 -1.0528 TD
[(in)-277.1(no)21.2(n-)13.9(C)11.6(F)-284.5(pa)15.1(ti)16.5(en)20.8(ts)-278.2([2)19.6(7])-287.7(as)-293.3(well)-296.7(a)-6.9(s)-292.2(in)-294.1(CF)-295.7(pati)-8.2(ents)-297.2([1)31(1,)-297.1(16,)]TJ
0 -1.0471 TD
[(18,)-360.4(19])-362.4(in)-356.7(order)-365.9(to)-362.4(control)-364.9(acute)-365.9(exacerba)-9.7(tions)-362.6(and)-361.2(pre-)]TJ
0 -1.0528 TD
[(vent)-347.3(pe)-7.6(rmanent)-354.7(lung)-346.9(damag)-7.8(e.)-348.7(Notably)53.9(,)-341.8(only)-352.6(56%)-346.1(of)-350.2(the)]TJ
0 -1.0471 TD
[(ABP)80.9(A)-232.3(patients)-237.2(received)-233.6(oral)-229.4(corti)-10.6(costeroids)-233.4(whi)-8.6(le)-226.2(75%)-232.3(of)]TJ
0 -1.0527 TD
[(them)-236.6(recei)-9(ved)-230.3(inhal)-9(ed)-229.6(corti)-10.6(costeroids)-11.5(.)-228(Howeve)-13.2(r)31.8(,)-228(the)-238.4(latter)]TJ
0 -1.0471 TD
[(route)-383.8(of)-378.7(adminis)-9.1(tration)-384.4(was)-383.4(also)-376.9(comm)-9.7(only)-381(used)-380.2(in)-379.5(the)]TJ
0 -1.0528 TD
[(non-A)-9.3(BP)85.6(A)-226.6(pati)-8.2(ents)-223.3(\(39%\))-9.4(.)-222.3(There)-226.6(h)-6.5(a)0(s)-225.1(been)-225.8(no)-223.5(eviden)-7.8(ce)-224.3(to)]TJ
0 -1.0471 TD
[(date)-524.1(of)-521(the)-522.9(effectiveness)-523(of)-521(inhaled)-523.1(co)-7.6(rticosteroid)-12.5(s)-519.8(i)0(n)]TJ
0 -1.0528 TD
[(contr)-8.2(olling)-364.5(ABP)75.2(A)-363.2(i)0(n)-362.4(C)0(F)68.5(.)-364.6(The)-365.3(great)-8.6(er)-362(use)-368.1(of)-361.6(conti)-9(nuous)]TJ
0 -1.0471 TD
[(antibiot)-10.3(ics)-296.5(and)-292.9(dornas)-7.8(e)-291.4(alfa)-298.1(in)-294.1(pati)-8.2(ents)-291.6(wi)-7.8(th)-294.1(ABP)80.9(A)-294.9(prob-)]TJ
0 -1.0528 TD
[(ably)-250.5(confi)-8.2(rms)-252.9(the)-249.8(great)-8.6(er)-248.2(severi)-10.5(ty)-248.6(of)-247.8(lung)-255.8(disease)-256(in)-248.6(these)]TJ
0 -1.0471 TD
[(patien)-10.1(ts,)-329.8(but)-334.7(one)-332.7(could)-331(also)-337.1(argue)-324.9(that)-332.6(conti)-9(nuous)-335.1(expo-)]TJ
0 -1.0528 TD
[(sure)-268(to)-265.7(antibiotics)-272.7(may)-267.6(predispose)-270.9(to)-265.7(fungal)-270.7(colonizati)-12.7(on.)]TJ
/F4 1 Tf
0 -3.0103 TD
[(Influence)-668.8(of)-664(aller)29.7(g)-6.5(i)0(c)-658.7(b)0(r)31.4(onch)-9.1(opulmonar)-8.7(y)-661.3(asper)27.5(gillosi)-10.4(s)]TJ
0 -1.0471 TD
[(on)-337.3(lung)-335.5(function)-343.7(decline)]TJ
/F3 1 Tf
1.0015 -2.0998 TD
[(De)16.9(sp)14.4(i)13.9(t)0(e)-493.7(t)0(h)13.2(e)-501.9(re)19.2(la)18.4(ti)16.5(ve)15.1(ly)-493.3(sh)20(or)19.6(t)-503.9(p)0(e)15.1(r)0(i)17.3(o)0(d)-490.9(o)0(f)-481.1(f)0(o)13.9(l)0(l)16.5(o)0(w)17.3(-)0(u)19.6(p)0(,)-490.5(t)0(h)13.2(e)]TJ
-1.0015 -1.0527 TD
[(lo)18.9(ng)15.5(it)16.5(ud)21.2(in)18.9(al)-300.2(as)19.6(pe)15.1(ct)-294.5(of)-299(th)18.9(is)-301(st)17.7(ud)21.2(y)-308.1(h)0(a)15.1(s)-303.6(pr)19.6(ov)15.5(id)18.9(ed)-297.8(so)14.4(m)13.2(e)-308.5(in)18.9(te)12.8(r)20.4(-)]TJ
0 -1.0471 TD
[(es)19.6(ti)16.5(ng)-428.3(in)18.9(si)17.7(gh)21.2(t)-435.6(i)0(n)18.9(t)0(o)-430.7(i)13.9(nd)15.5(ep)15.1(en)20.8(de)15.1(nt)-425(ef)30.6(fe)13.5(ct)18.5(s)-434.4(o)0(f)-424.2(A)0(B)12.6(P)96.8(A)-437.2(o)0(n)-422.6(t)0(h)13.2(e)]TJ
0 -1.0528 TD
[(pr)19.6(og)15.5(re)19.2(ss)13.2(i)13.9(o)0(n)-490.9(o)0(f)-486.8(p)0(u)15.5(l)0(m)15.7(o)0(n)21.2(a)0(r)13.5(y)-495.8(di)18.9(se)19.6(as)13.9(e)-496.2(i)0(n)-487.6(C)0(F)91.3(.)-495.5(In)-492.5(t)13.9(h)0(e)-491.3(c)0(r)19.2(o)0(s)14.4(s)0(-)]TJ
0 -1.0471 TD
[(se)19.6(ct)12.8(io)18.9(na)20.8(l)-208(p)0(a)20.8(r)0(t)-199(o)0(f)-196.6(t)0(h)18.9(e)-206(pr)19.6(es)14(en)20.8(t)-208(s)0(t)17.7(u)0(d)21.2(y)67.5(,)-205.2(i)0(t)-194.1(h)0(a)15.1(s)-201.1(be)15.1(en)-195.4(de)20.8(mo)12.4(ns)20(tr)17.3(at)18.4(ed)]TJ
0 -1.0527 TD
[(th)18.9(at)-197.8(AB)18.3(P)91.1(A)-203.9(is)-198.6(ge)20.8(ne)15.1(ra)19.2(ll)16.5(y)-205.6(a)0(s)19.6(s)0(o)14.4(c)0(i)18.4(a)0(t)18.4(e)0(d)-195.4(w)0(i)14.9(t)0(h)-197.4(a)-200.3(po)15.5(or)19.6(er)-197(pu)15.5(lm)15.7(on)21.2(ar)13.5(y)]TJ
0 -1.0471 TD
[(st)17.7(at)18.4(us)14.4(,)-210.9(a)0(l)18.5(t)0(h)18.9(o)0(u)15.5(g)0(h)-200.7(a)-217.4(si)17.7(gn)21.2(if)17.3(ic)12.8(an)20.8(t)-213.7(c)0(a)14.7(u)0(s)20(a)0(l)-203.5(r)0(e)19.2(l)0(a)12.8(t)0(i)16.5(o)0(n)21.2(s)0(h)20(i)0(p)-208.8(i)0(s)-204.3(y)0(e)20.8(t)-213.7(to)-203.1(be)]TJ
0 -1.0528 TD
[(es)19.6(ta)12.8(bl)18.9(is)17.7(he)20.8(d.)-314.1(T)12.2(h)0(i)18.9(s)-320.6(is)-312.4(pa)20.8(rt)17.3(ly)-311.2(su)14.4(pp)21.2(or)13.9(te)18.4(d)-319.4(b)0(y)-308.8(o)0(t)18.9(h)0(e)15.1(r)-315.3(st)17.7(ud)15.5(ie)18.4(s)-320.6([)0(1)19.6(0)0(,)]TJ
T*
[(12)15.5(,)-319.1(2)0(3)15.5(])0(.)]TJ
1.0015 -1.0471 TD
[(Th)17.1(e)-484.9(m)0(i)15.7(x)0(e)15.1(d)-484.5(mo)18.1(de)15.1(l)-486.8(r)0(e)19.2(g)0(r)19.6(e)0(s)14(s)0(i)17.7(o)0(n)-473.8(a)0(n)15.1(a)0(l)18.4(y)0(s)20(i)0(s)-477.4(w)0(a)16.9(s)-485.7(un)15.5(ab)15.1(l)13.9(e)-490.6(to)]TJ
-1.0015 -1.0527 TD
[(de)15.1(mo)18.1(ns)20(tr)17.3(at)18.4(e)-234.5(s)0(u)20(b)0(s)20(t)0(a)12.8(n)0(t)18.9(i)0(a)18.4(l)-230.8(or)-219.4(cl)18.4(in)13.2(ic)18.4(al)18.5(ly)-220.2(re)13.5(le)18.4(va)20.8(nt)-225.8(di)18.9(f)20.4(f)0(e)19.2(r)0(e)13.5(n)0(c)20.8(e)0(s)-225.1(i)0(n)]TJ
0 -1.0471 TD
[(th)18.9(e)-297.1(r)0(a)13.5(t)0(e)18.4(s)-297.9(of)-287.7(FE)12.2(V)]TJ
7.97 0 0 7.97 123.647 196.214 Tm
0 Tw
(1)Tj
9.963 0 0 9.963 130.62 196.214 Tm
[(de)15.1(cl)18.5(in)18.9(e)-297.1(b)0(e)15.1(t)0(w)20.6(e)0(e)14.7(n)-296.7(AB)12.6(P)96.8(A)-300.6(an)15.1(d)-296.7(n)0(o)15.5(n)0(-)19.6(A)0(B)18.3(P)91.1(A)]TJ
-7.2611 -1.0527 TD
[(pa)15.1(ti)22.2(en)15.1(ts)-443.3(fo)13.9(r)-451.9(a)0(n)15.1(y)-450.3(of)-447(th)18.9(e)-450.7(a)0(g)15.1(e)-456.4(by)-439.7(se)13.9(ve)20.8(ri)17.3(ty)-447.8(su)20(bg)15.5(ro)19.6(up)15.5(s)-451.5(c)0(o)15.1(n)0(-)]TJ
0 -1.0471 TD
[(si)17.7(de)15.1(re)19.2(d.)-371(In)-373(so)14.4(me)-375(su)20(bg)21.2(ro)13.9(up)21.2(s,)-372.2(ty)13.2(pi)18.9(ca)20.4(ll)16.5(y)-382(i)0(n)-373.8(t)0(h)18.9(e)-382.4(ad)15.1(ul)18.9(t)-384.4(g)0(r)19.6(o)0(u)15.5(p)]TJ
0 -1.0528 TD
[(wi)14.9(th)-487.6(se)13.9(ve)20.8(re)-492.9(im)15.7(pa)15.1(ir)17.3(me)17.7(nt)18.9(,)-501.2(t)0(h)18.9(e)-501.9(re)19.2(gr)14(es)19.6(si)17.7(on)-490.9(li)16.5(ne)15.1(s)-497(a)0(r)13.5(e)-496.2(in)18.9(di)13.2(s-)]TJ
0 -1.0471 TD
[(ti)16.5(ng)21.2(ui)13.2(sh)20(ab)15.1(le)18.4(,)-455.6(w)0(h)17.3(e)0(r)13.5(e)0(a)20.4(s)-457.2(in)-453.5(ot)18.9(he)20.8(r)-463.3(s)0(u)20(b)0(g)21.2(r)0(o)13.9(u)0(p)21.2(s)0(,)-451.9(i)0(n)18.9(c)0(l)18.4(u)0(d)15.5(i)0(n)18.9(g)-456(th)13.2(e)]TJ
0 -1.0528 TD
[(ad)15.1(ol)18.9(es)19.6(ce)14.7(nt)-328.3(an)20.8(d)-336.5(a)0(d)15.1(u)0(l)18.9(t)-333.2(gr)13.9(ou)21.2(ps)-327.1(wi)14.9(th)-328.3(mo)18.1(de)15.1(ra)19.2(te)-328.7(lu)18.9(ng)-331.6(fu)19.6(nc)20.8(ti)16.5(on)]TJ
0 -1.0471 TD
[(im)15.7(pa)20.8(ir)17.3(me)12(nt)18.9(,)-336.1(F)11.4(EV)]TJ
7.97 0 0 7.97 126.992 133.455 Tm
(1)Tj
9.963 0 0 9.963 134.305 133.455 Tm
[(de)20.8(cl)12.8(in)18.9(e)-336.9(s)0(e)19.6(e)0(m)17.7(s)-337.7(to)-328.3(be)-326.3(mo)18.1(re)-327.9(ra)13.5(pi)18.9(d)-336.5(i)0(n)-322.6(t)0(h)13.2(e)]TJ
-7.631 -1.0528 TD
[(pa)15.1(ti)22.2(en)15.1(ts)-238.4(wi)14.9(th)18.9(ou)21.2(t)-247.8(A)0(B)12.6(P)91.1(A)12.4(.)-245.1(Th)17.1(e)-251.6(r)0(e)19.2(s)0(u)20(l)0(t)16.5(s)-246.7(of)-242.1(t)13.9(h)0(i)13.2(s)-246.7(an)20.8(al)18.4(ys)14.4(is)-238.4(ar)19.2(e)-245.9(n)0(o)15.5(t)]TJ
0 -1.0471 TD
[(co)15.1(nc)20.8(lu)18.9(si)17.7(ve)-332(an)15.1(d)-336.5(a)-342.6(lo)18.9(ng)21.2(er)-333.6(pe)20.8(ri)11.6(od)-325.9(of)-333.2(ob)21.2(se)13.9(rv)19.6(at)18.4(io)13.2(n,)-325.5(co)15.1(mb)18.1(in)18.8(ed)]TJ
25.1977 48.1591 TD
[(wi)14.9(th)-271.4(th)18.8(e)-280(e)0(v)20.8(a)0(l)18.5(u)0(a)15.1(t)0(i)16.5(o)0(n)-269(o)0(f)-270.6(o)0(t)18.9(h)0(e)20.8(r)-281.2(va)15.1(ri)17.3(ab)20.8(le)18.4(s)-280.8(i)0(n)18.8(v)0(o)15.5(l)0(v)18.9(e)0(d)-269.4(i)0(n)-265.7(t)0(h)13.2(e)-274.3(de)15.1(c-)]TJ
0 -1.0527 TD
[(li)16.5(ne)-314.9(of)-316.1(pu)15.5(lm)15.7(on)21.2(ar)13.5(y)-319.4(f)0(u)13.9(n)0(c)20.8(t)0(i)16.5(o)0(n)15.5(,)-324.7(i)13.9(s)-326.3(ne)15.1(ce)20.4(ss)18.8(ar)13.5(y)73.2(.)]TJ
1.0015 -1.0471 TD
[(In)-236.4(co)15.1(nc)20.8(lu)13.2(si)17.7(on)21.2(,)-245.1(t)0(h)18.9(i)0(s)-232.7(s)0(t)17.7(u)0(d)15.5(y)-245.5(en)20.8(ab)15.1(le)18.5(d)-245.5(t)0(h)18.9(e)-240.2(au)15.1(th)18.8(or)13.9(s)-241(t)0(o)-237.2(e)0(s)19.6(t)0(i)16.5(m)0(a)17.7(t)0(e)]TJ
-1.0015 -1.0528 TD
-0.0165 Tc
[(t)-16.5(h)-3.3(e)-359.1(v)-16.5(a)4.3(r)-16.5(ia)-16.5(bl)-16.5(e)-350.9(p)-16.5(re)-16.5(va)-16.5(le)-16.5(nc)-16.5(e)-348.9(o)-16.5(f)-349.7(a)-16.5(ll)-16.5(er)3.9(g)-16.5(i)2.4(c)-359.1(b)-16.5(ro)-16.5(n)4.7(c)-16.5(ho)-16.5(pu)-16.5(lm)-16.5(on)-16.5(ar)-16.5(y)-349.7(a)-16.5(s-)]TJ
0 -1.0471 TD
0 Tc
[(pe)15.1(r)20.4(g)0(i)18.9(l)0(l)16.5(o)0(s)14.3(i)0(s)-221.3(i)0(n)-225.8(c)0(y)15.1(s)0(t)17.7(i)0(c)-226.2(f)0(i)17.3(b)0(r)19.6(o)0(s)14.4(i)0(s)-221.3(i)0(n)-225.8(c)0(o)15.1(u)0(n)21.2(t)0(r)17.3(i)0(e)12.8(s)-229.6(of)-230.7(w)12.4(e)0(s)14(t)0(e)18.4(r)0(n)19.6(,)-233.7(ce)14.7(nt)18.8(ra)19.2(l)]TJ
0 -1.0528 TD
-0.0165 Tc
[(a)-16.5(n)-1.4(d)-415.6(n)-16.5(or)-16.5(th)-16.5(er)-16.5(n)-406.6(E)-16.5(ur)-16.5(op)-16.5(e.)-415.2(I)-16.5(t)-409(h)-16.5(a)-1.4(s)-416.8(b)-16.5(ee)-16.5(n)-405.4(d)-16.5(em)-16.5(on)-16.5(st)-16.5(ra)-16.5(te)-16.5(d)-405.4(t)-16.5(ha)-16.5(t)-407.8(t)-16.5(hi)-16.5(s)]TJ
0 -1.0471 TD
0 Tc
[(co)15.1(mp)18.1(li)16.5(ca)14.7(ti)22.2(on)-229.2(is)-227(as)13.9(so)20(ci)18.4(at)18.5(ed)-229.6(wi)14.9(th)-225.8(a)-234.5(p)0(o)15.5(o)0(r)19.6(e)0(r)-231.1(c)0(l)18.5(i)0(n)18.9(i)0(c)18.4(a)0(l)-231.9(c)0(o)20.8(n)0(d)15.5(i)0(t)16.5(i)13.9(on)15.5(.)]TJ
0 -1.0527 TD
[(A)-266.5(l)13.9(on)15.5(gi)18.9(tu)18.9(di)13.2(na)20.8(l)-264.9(a)0(p)20.8(p)0(r)19.6(o)0(a)15.1(c)0(h)-252.3(u)0(s)20(i)0(n)13.2(g)-256.8(a)-262.9(m)0(i)15.7(x)0(e)20.8(d)-262.5(mo)18.1(de)15.1(l)-259.2(m)0(u)18.1(l)0(t)16.5(i)0(p)18.8(l)0(e)-254.7(r)0(e)19.2(-)]TJ
0 -1.0471 TD
[(gr)13.9(es)19.6(si)17.7(on)-388.5(an)15.1(al)18.5(ys)14.4(is)-386.4(wa)16.9(s)-400.3(u)0(n)15.5(a)0(b)20.8(l)0(e)-391.3(t)0(o)-390.9(c)0(o)15.1(n)0(f)19.6(i)0(r)17.3(m)-402.3(an)-388.9(in)18.9(de)15.1(pe)20.8(nd)15.5(en)20.8(t)]TJ
0 -1.0528 TD
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>>
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