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391.011 644.145 0.51 -170.362 re
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BT
/F1 1 Tf
14.944 0 0 14.944 98.646 729.297 Tm
0.0207 Tc
[(Exhaled)-332.7(n)-2.6(itric)-330.2(o)-2.6(xide)-330.2(in)-332.7(asthmatic)-334(children)-332.7(exposed)-336.5(to)]TJ
3.6799 -1.0319 TD
[(relevant)-332.9(a)0(llergens:)-332.9(e)3.7(ffect)-332.9(of)-332.9(flunisolide)]TJ
/F2 1 Tf
10.959 0 0 10.959 103.691 676.516 Tm
0 Tc
[(G.L.)-329.5(Piacentini)]TJ
/F3 1 Tf
6.5337 0 TD
0 Tw
(*)Tj
/F2 1 Tf
0.4966 0 TD
[(,)-334.6(A)0(.)-330.8(Bodini)]TJ
/F3 1 Tf
4.6507 0 TD
(*)Tj
/F2 1 Tf
0.5018 0 TD
[(,)-329.4(S)0(.)-336(Costella)]TJ
/F3 1 Tf
5.4836 0 TD
(**)Tj
/F2 1 Tf
0.9984 0 TD
[(,)-329.4(L)0(.)-331(Vicentini)]TJ
/F3 1 Tf
5.5301 0 TD
(*)Tj
/F2 1 Tf
0.5018 0 TD
[(,)-334.6(P)0(.)-330.8(Mazzi)]TJ
/F3 1 Tf
4.4955 0 TD
(*)Tj
/F2 1 Tf
0.4966 0 TD
[(,)-334.6(Y)0(.)-330.8(Suzuki)]TJ
/F3 1 Tf
4.8783 0 TD
(*)Tj
/F2 1 Tf
0.5018 0 TD
(,)Tj
-22.6844 -1.0243 TD
[(D.)-330.5(Peroni)]TJ
/F3 1 Tf
4.2006 0 TD
(*)Tj
/F2 1 Tf
0.5018 0 TD
[(,)-334.6(A.L.)-330.7(Boner)]TJ
/F3 1 Tf
5.3801 0 TD
(*)Tj
/F4 1 Tf
8.966 0 0 8.966 58.28 634.677 Tm
[(Exhaled)-368.6(nitric)-365.5(oxide)-372.4(in)-361.8(asthmatic)-373.5(childr)28.9(en)-365.5(exposed)-363.7(to)-368.1(r)30.9(elevant)-367.2(aller)28.4(gens:)-366.1(effect)-370.1(of)-368.1(fluni-)]TJ
0 -1.0559 TD
[(solide.)-283.8(G.L.)-278.6(Piacentini,)-282.2(A.)-284.1(Bodini,)-280(S.)-280.6(Costella,)-283.5(L.)-279.2(V)72.9(icentini,)-286.1(P)129.8(.)-281.1(Mazzi,)-283.8(Y)84.1(.)-281.1(Suzuki,)-281.4(D.)-283.9(Per)35(oni,)]TJ
T*
[(A.L.)-335.7(Boner)105.6(.)]TJ
/F5 1 Tf
4.8939 0 TD
(#)Tj
/F4 1 Tf
0.999 0 TD
[(ERS)-334.2(Journals)-335.6(Ltd)-334.6(2000.)]TJ
/F6 1 Tf
-5.893 -1.0559 TD
[(ABSTRACT)66.7(:)-443.1(Inhaled)-438.1(corticosteroids)-441.5(ar)13.9(e)-448.2(capable)-438.1(of)-448.9(r)13.4(educing)-443(the)-446.7(level)-444.4(of)-442.6(exhaled)]TJ
T*
[(nitric)-291.7(oxide)-289(\(expiratory)-293.8(nitric)-291.7(oxide)-295.4(fraction)-289.2(\(F)]TJ
7.173 0 0 7.173 236.636 596.806 Tm
(E,NO)Tj
8.966 0 0 8.966 253.871 596.806 Tm
[(\)\))-291.8(in)-290.8(asthmatic)-296.9(patients)-289.2(in)-290.8(a)-290.4(dose-)]TJ
-21.814 -1.0622 TD
[(dependent)-349(fashion.)-348.8(The)-349.3(aim)-342.8(of)-347.7(this)-348.9(study)-350.9(was)-344.4(to)-347.7(evaluate)-351.5(whether)-338.6(or)-346.5(not)-345.8(treatment)]TJ
0 -1.0559 TD
[(with)-325.7(an)-326.4(inhaled)-325.5(steroid)-321.6(can)-325.6(pr)15.3(event)-331.7(changes)-323.1(in)-328.8(F)]TJ
7.173 0 0 7.173 247.068 577.814 Tm
(E,NO)Tj
8.966 0 0 8.966 267.25 577.814 Tm
[(after)-327.7(the)-326.6(exposur)12(e)-328.1(t)0(o)-328.8(r)13.4(elevant)]TJ
-23.3062 -1.0622 TD
[(allergens,)-337.3(following)-334.2(avoidance,)-332.5(in)-335.1(asthmatic)-334.8(children)-330.9(allergic)-331.2(to)-335.1(house)-337(dust)-332.4(mite.)]TJ
0.999 -1.0496 TD
[(Thirty-two)-303.7(house)-299.1(dust)-294.5(mite-allergy)-306.2(asthmatic)-296.9(children)-292.9(wer)11.3(e)-296.5(randomly)-299.2(allocated)-302.8(to)]TJ
-0.999 -1.0623 TD
[(treatment)-249.6(with)-262.4(inhaled)-256(flunisolide)-267.2(\(500)]TJ
/F7 1 Tf
16.6419 0 TD
(m)Tj
/F6 1 Tf
0.5691 0 TD
(g)Tj
/F8 1 Tf
0.7587 0 TD
(b.i.d.)Tj
/F6 1 Tf
2.017 0 TD
[(\))-259.7(o)0(r)-258(placebo)-261.1(and)-254.9(evaluated)-261(before)-248.7(and)]TJ
-19.9867 -1.0559 TD
[(2)-258.7(weeks)-253(after)-264.5(a)-252.4(period)-261.6(of)-252.9(natural)-262.3(exposur)12(e)-258.5(t)0(o)-252.9(mite)-260.8(antigens.)-259.5(Lung)-259.1(function)-255(and)-261.2(F)]TJ
7.173 0 0 7.173 363.798 539.886 Tm
-0.0001 Tc
(E,NO)Tj
8.966 0 0 8.966 58.28 530.362 Tm
0 Tc
[(wer)11.3(e)-334.4(evaluated.)]TJ
0.999 -1.0559 TD
(F)Tj
7.173 0 0 7.173 72.68 520.894 Tm
-0.0001 Tc
(E,NO)Tj
8.966 0 0 8.966 93.373 520.894 Tm
0 Tc
[(was)-382.3(increased)-374.6(in)-385.7(the)-383.5(placebo-treated)-377.9(gr)13.9(oup)-387.7(after)-384.6(antigen)-382.4(exposure.)-375.9(T)71.6(r)13.4(eat-)]TJ
-3.9139 -1.0559 TD
[(ment)-282.3(with)-281.4(inhaled)-287.6(flunisolide)-286.1(pr)15.3(evented)-284.7(such)-280.6(increase)-275.4(in)-278.2(F)]TJ
7.173 0 0 7.173 280.516 511.427 Tm
-0.0001 Tc
(E,NO)Tj
8.966 0 0 8.966 300.302 511.427 Tm
0 Tc
(\(p)Tj
/F7 1 Tf
0.8726 0 TD
(<)Tj
/F6 1 Tf
0.5564 0 TD
[(0.001\).)-276.1(No)-286.8(change)]TJ
-28.4215 -1.0559 TD
[(was)-331.8(observed)-335(in)-335.1(lung)-332.6(function)-337.2(parameters.)]TJ
0.999 -1.0559 TD
[(Inhaled)-362.3(flunisolide)-368.3(is)-369.3(effective)-366.5(in)-360.4(preventing)-360(the)-364.5(incr)14.2(ease)-365.4(in)-366.7(airway)-362.8(inflammation)]TJ
-0.999 -1.0622 TD
[(observed)-335(in)-335.1(allergic)-331.2(asthmatic)-341.2(children)-324.5(r)13.4(e-exposed)-335.5(to)-335.1(allergens.)]TJ
/F4 1 Tf
0 -1.0559 TD
[(Eur)-331.9(Respir)-333.8(J)-334.4(2000;)-333.5(15:)-334.6(730\261734.)]TJ
/F3 1 Tf
7.97 0 0 7.97 401.499 635.641 Tm
[(*Clinica)-277.5(Pediatrica,)-284.8(Universita)]TJ
/F9 1 Tf
12.199 0 TD
(')Tj
/F3 1 Tf
0.505 0 TD
[(di)-282.7(V)106.3(erona,)]TJ
-12.7041 -1.0599 TD
[(V)106.3(erona,)-242.6(Italy)63.5(.)-255(**Istituto)-238.9(Pio)-250(XII,)-251.6(Misurina)12.6(,)]TJ
T*
[(Belluno,)-327(Italy)63.5(.)]TJ
0 -2.1268 TD
[(Corresponde)11.8(nce:)-248(A.L.)-247.8(Boner)35.1(,)-247.9(Clinica)-244.1(Ped-)]TJ
0 -1.0599 TD
[(iatrica,)-564.7(Policlinico)-560.7(Bor)15.6(go)-564.9(Roma,)-563.6(37134)]TJ
0 -1.067 TD
[(V)106.3(erona,)-328(Italy)63.5(.)-333.3(Fax:)-325.1(39)-330.1(0458200993)]TJ
0 -2.1268 TD
[(Keywords)11.5(:)-334.6(Airway)-328.3(inflammatio)7.7(n)]TJ
0 -1.0599 TD
[(aller)14.7(gen)-334.1(avoidance)]TJ
T*
(asthma)Tj
0 -1.067 TD
(corticosteroid)Tj
0 -1.0599 TD
[(nitric)-328(oxide)]TJ
0 -2.1268 TD
[(Received:)-327.9(April)-324.1(27)-330.1(1999)]TJ
0 -1.0599 TD
[(Accepted)-325.4(after)-331.6(revision)-329.8(January)-326.1(20)-330.1(2000)]TJ
0 -2.1268 TD
[(This)-609.6(study)-604.8(was)-608.1(supported,)-601.6(in)-617.1(part,)-603.8(by)]TJ
0 -1.0599 TD
[(V)106.3(aleas,)-330.4(Milan,)-325.6(Italy)63.5(.)]TJ
9.963 0 0 9.963 68.258 447.59 Tm
[(It)-438(is)-443.3(w)12.4(e)0(l)12.8(l)-447(re)19.2(co)15.1(gn)21.2(iz)18.4(ed)-440.1(th)18.9(at)-442.5(as)19.6(th)18.9(ma)-443.2(is)-437.6(an)-440.1(i)13.9(n)0(f)13.9(l)0(a)18.4(m)0(m)14.9(a)0(t)18.4(o)0(r)13.9(y)]TJ
-1.0015 -1.0527 TD
[(di)18.9(se)13.9(as)19.6(e)-314.1(a)0(n)20.8(d)-313.8(th)18.9(at)-305.9(in)18.9(do)15.5(or)-304.7(al)18.4(le)18.4(r)20.4(g)0(e)15.1(n)0(s)20(,)-313.4(in)-305.5(pa)20.8(rt)17.3(ic)12.8(ul)18.9(ar)-305.1(ho)21.2(us)14.4(e)-308.5(d)0(u)15.5(s)0(t)]TJ
0 -1.0471 TD
[(mi)15.7(te)18.4(,)-438.6(r)0(e)19.2(p)0(r)13.9(e)0(s)19.6(e)0(n)20.8(t)-441.3(a)-433.7(r)0(e)13.5(l)0(e)18.4(v)0(a)15.1(n)0(t)-425(f)0(a)19.2(c)0(t)12.8(o)0(r)-424.2(i)0(n)-430.7(t)0(h)18.9(e)-439.3(ae)20.4(ti)16.5(ol)18.9(og)15.5(y)-438.9(o)0(f)-424.2(t)0(h)13.2(e)]TJ
0 -1.0528 TD
[(di)18.9(se)13.9(as)19.6(e)-405.2([)0(1)13.9(])0(.)-412.5(I)0(t)-420.9(has)-419.3(been)-419.3(demon)-7.4(strated)-423.4(that)-417.9(the)-420.5(develo)-7.8(p-)]TJ
0 -1.0471 TD
[(ment)-304.9(or)-304.7(worseni)-9.1(ng)-297.4(of)-304.7(asthma)-308(symp)-7.4(toms)-305.7(in)-299.8(children)-309.2(may)]TJ
0 -1.0528 TD
[(be)-303.5(alle)-8.6(viated)-311.7(by)-303.1(allergen)-303.9(avoida)-7.8(nce)-304.7([2,)-305.1(3])-310.4(or)-304.7(by)-303.1(suppre)-7.8(s-)]TJ
T*
[(sing)-336.7(the)-335.1(bronchi)-9.7(al)-334.4(respon)-7.8(se)-338.9(to)-334(allergen)-332.3(challenge)-343.3([4\2619].)]TJ
1.0015 -1.0471 TD
[(In)-367.3(re)13.5(ce)20.4(nt)-368.1(ye)15.1(ar)19.2(s,)-366.5(di)18.9(f)14.7(f)0(e)19.2(r)0(e)19.2(n)0(t)-368.1(m)0(a)12(r)0(k)19.6(e)0(r)19.2(s)-377.5(ha)15.1(ve)-366.1(be)15.1(en)-366.1(pr)19.6(op)15.5(os)20(ed)]TJ
-1.0015 -1.0528 TD
[(fo)19.6(r)-400.7(t)0(h)13.2(e)-399.5(ev)20.8(al)12.8(ua)20.8(ti)16.5(on)-388.5(of)-395.8(le)18.4(ve)20.8(l)-401.5(o)0(f)-395.8(a)0(i)18.4(r)0(w)15.7(a)0(y)-388.9(i)0(n)18.9(f)0(l)17.3(a)0(m)12(m)0(a)17.7(t)0(i)16.5(o)0(n)-388.5([)0(1)13.9(0].)]TJ
0 -1.0471 TD
[(Among)-409.2(these)-8.2(,)-404.4(the)-403.4(meas)-8.2(urem)-8.2(ent)-403.4(of)-407.2(exhale)-8.2(d)-404.8(nitric)-412.1(oxide)]TJ
0 -1.0528 TD
[(levels)-267.4(\(expirator)-12.3(y)-256.8(nitr)-9.4(ic)-260.4(oxide)-262.7(fraction)-270.9(\(F)]TJ
7.97 0 0 7.97 219.968 342.935 Tm
0.0001 Tc
(E,NO)Tj
9.963 0 0 9.963 238.167 342.935 Tm
0 Tc
[(\)\))-260.8(is)-261.2(consi)-7.8(d-)]TJ
-18.0561 -1.0471 TD
[(ered)-312.7(a)-308.5(noninv)-7(asive)-315.5(means)-316.2(of)-310.4(assessing)-316.4(the)-312.4(degree)-314.7(of)-310.4(air-)]TJ
0 -1.0527 TD
[(way)-336.7(inflamm)-12.7(ation)-339(in)-334(asthmati)-12.7(cs)-333.2([1)25.3(1\26113].)]TJ
1.0015 -1.0471 TD
[(Re)16.1(ce)14.7(nt)-322.6(st)17.7(ud)21.2(ie)18.4(s)-332(h)0(a)15.1(v)0(e)-320.6(s)0(h)20(o)0(w)11.6(n)-330.8(th)18.9(at)-323(in)18.9(ha)15.1(l)13.9(e)0(d)-326.3(c)0(o)20.8(r)0(t)17.3(i)0(c)12.8(o)0(s)20(t)0(e)18.4(r)0(o)14(i)0(d)18.9(s)]TJ
-1.0015 -1.0528 TD
[(ar)19.2(e)-217.4(c)0(a)20.4(p)0(a)15.1(b)0(l)18.9(e)-211.7(of)-208(de)20.8(cr)13.5(ea)20.4(si)17.7(ng)-206.4(th)18.9(e)-211.7(F)]TJ
7.97 0 0 7.97 176.882 301.096 Tm
0.0001 Tc
[(E,)21.9(N)13.9(O)]TJ
9.963 0 0 9.963 196.951 301.096 Tm
0 Tc
[(in)-208.8(as)19.6(th)18.9(ma)12(t)13.9(i)0(c)-209.2(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)-204.3(i)0(n)]TJ
-13.9191 -1.0471 TD
[(a)-325.5(d)0(o)21.2(s)0(e)13.9(-)0(d)19.6(e)0(p)15.1(e)0(n)20.8(d)0(e)15.1(n)0(t)-316.9(f)0(a)19.2(s)0(h)20(i)0(o)18.9(n)-325.1([1)13.9(4,)-319.8(1)-6.5(5].)]TJ
1.0015 -1.0527 TD
[(In)-287.7(th)18.9(is)-283.9(st)17.7(ud)15.5(y)73.2(,)-296.3(wh)17.3(et)18.5(he)15.1(r)-292.6(t)0(r)17.3(e)0(a)14.7(t)0(m)15.7(e)0(n)20.8(t)-293.4(wi)14.9(th)-288.4(an)-280.8(in)13.2(ha)20.8(le)18.4(d)-296.7(s)0(t)17.7(e)0(r)19.2(o)0(i)13.2(d)]TJ
-1.0015 -1.0471 TD
[(ca)14.7(n)-273.9(p)0(r)19.6(e)0(v)15.1(e)0(n)20.8(t)-276.3(ch)20.8(an)15.1(ge)15.1(s)-269.4(i)0(n)-271.4(F)]TJ
7.97 0 0 7.97 156.076 269.745 Tm
0.0001 Tc
[(E,)21.9(N)13.9(O)]TJ
9.963 0 0 9.963 176.768 269.745 Tm
0 Tc
[(af)13.5(te)18.4(r)-275.5(a)-274.3(br)19.6(ie)12.8(f)-275.5(p)0(e)20.8(r)0(i)17.3(o)0(d)-263.3(o)0(f)-270.6(e)0(x)20.8(p)0(o)15.5(-)]TJ
-11.8932 -1.0528 TD
[(su)20(re)-236.8(to)-231.5(re)19.2(le)18.4(va)15.1(nt)-231.5(al)18.4(le)12.8(r)20.4(g)0(e)20.8(n)0(s)-236(w)12.4(as)-236.4(ev)20.8(al)12.8(ua)20.8(te)18.4(d)-239.8(i)0(n)-237.2(a)-240.2(gr)19.6(ou)15.5(p)-239.8(o)0(f)-230.7(a)0(s)13.9(t)0(h)18.9(-)]TJ
0 -1.0471 TD
[(ma)17.7(ti)16.5(c)-325.5(c)0(h)20.8(i)0(l)16.5(d)0(r)13.9(e)0(n)-314.9(a)0(l)18.4(l)0(e)18.4(r)20.4(gi)13.2(c)-319.8(t)0(o)-316.9(h)0(o)15.5(u)0(s)20(e)-325.5(du)21.2(st)-318.1(mi)15.7(te)18.4(.)]TJ
/F6 1 Tf
6.6295 -2.134 TD
[(Materi)-10.5(al)-334(an)-6.4(d)-330(methods)]TJ
/F4 1 Tf
-6.6295 -2.4469 TD
[(Subjec)-7.8(ts)]TJ
/F3 1 Tf
1.0015 -1.7527 TD
[(Th)17.1(ir)17.3(ty)18.9(-t)17.3(wo)-244.5(ch)15.1(il)22.2(dr)13.9(en)-240.9(\(2)13.9(6)-251.2(m)0(a)17.7(l)0(e)18.4(s)-252.3(an)20.8(d)-251.2(s)0(i)17.7(x)-251.2(fe)13.5(ma)17.7(le)18.4(s\))18.4(,)-250.8(r)0(a)13.5(n)0(g)21.2(i)0(n)13.2(g)]TJ
-1.0015 -1.0471 TD
[(in)-225.8(ag)15.1(e)-234.5(6)0(\261)21.2(1)0(5)-229.2(y)0(r)19.6(s)-235.3(an)20.8(d)-234.1(w)0(i)14.9(t)0(h)-225.8(a)-234.5(hi)18.9(st)17.7(or)13.9(y)-234.1(o)0(f)-225.1(b)0(r)19.6(o)0(n)15.5(c)0(h)15.1(i)13.9(al)-226.2(as)13.9(th)18.8(ma)-227(an)15.1(d)]TJ
0 -1.0528 TD
[(a)-399.5(p)0(o)21.2(s)0(i)17.7(t)0(i)16.5(v)0(e)-388.9(s)0(k)20(i)0(n)18.9(-)0(p)13.9(r)0(i)17.3(c)0(k)-388.9(t)13.9(es)13.9(t)-395.8(t)0(o)-385.2(h)0(o)15.5(u)0(s)20(e)-399.5(du)21.2(st)-392.1(mi)15.7(te)18.4(,)-393(w)0(e)16.9(r)0(e)-390.5(e)0(v)15.1(a)0(l)18.4(-)]TJ
0 -1.0471 TD
[(ua)15.1(te)18.4(d)-234.1(a)0(t)-226.2(t)0(h)18.9(e)-240.2(")13.4(I)0(s)12.8(t)0(i)22.2(t)0(u)13.2(t)0(o)-225.8(P)11.4(io)-225.8(XI)15.7(I")-228(lo)18.9(ng)15.5(-s)18.4(ta)18.4(y)-239.8(h)0(o)21.2(s)0(p)20(i)0(t)16.5(a)0(l)-231.9(\()0(M)17.7(i)0(s)17.7(u)0(r)19.6(i)0(n)18.9(a)0(,)]TJ
0 -1.0528 TD
[(Be)16.1(ll)16.5(un)21.2(o,)-376.7(It)11.6(al)18.5(y\))19.6(,)-387.3(s)0(i)17.7(t)0(u)18.9(a)0(t)18.4(e)0(d)-383.2(a)0(t)-374.2(a)0(n)-383.2(a)0(l)18.4(t)0(i)16.5(t)0(u)18.9(d)0(e)-377.5(o)0(f)-378.7(1)0(,)15.9(7)0(5)21.2(6)-387.7(m)-390.9(i)0(n)-373.8(t)0(h)13.2(e)]TJ
0 -1.0471 TD
[(It)17.3(al)18.5(ia)18.4(n)-512.9(A)0(l)14.9(p)0(s)20(.)-512.5(No)17.3(ne)-508.4(of)-503.9(th)18.9(e)-513.3(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)-500.2(h)0(a)15.1(d)-512.9(ha)20.8(d)-512.9(r)0(e)13.5(s)0(p)20(i)0(r)17.3(a)0(t)18.4(o)0(r)13.9(y)]TJ
0 -1.0528 TD
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[(1)-399.1(m)13.2(on)15.5(th)]TJ
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1.0015 -1.0471 TD
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T*
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[(Study)-342.3(design)]TJ
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0 -1.0471 TD
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0 -1.0527 TD
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T*
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0 -1.0527 TD
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0 -1.0471 TD
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1.0015 -1.0527 TD
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(0)Tj
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[(an)15.1(d)]TJ
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(1)Tj
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-6.9083 -1.0528 TD
[(\(M)17.7(ef)13.5(ar)47.7(,)-449.9(B)0(o)16.5(v)0(e)15.1(z)0(z)20.4(o)0(,)-445(I)0(t)17.3(a)0(l)18.5(y)0(\))13.9(,)-449.9(wh)17.3(ic)18.4(h)-456(w)0(a)16.9(s)-451.5(pr)14(ov)21.2(id)13.2(ed)-440.1(to)-447.8(al)18.4(l)-452.7(t)0(h)13.2(e)]TJ
0 -1.0471 TD
[(pa)15.1(ti)22.2(en)15.1(ts)17.7(.)]TJ
1.0015 -1.0528 TD
[(In)19.6(ha)15.1(le)18.4(d)]TJ
/F7 1 Tf
3.3802 0 TD
(b)Tj
/F3 1 Tf
7.472 0 0 6.641 107.32 728.164 Tm
(2)Tj
9.963 0 0 9.963 110.948 729.808 Tm
[(-a)13.5(go)21.2(ni)18.9(st)17.7(s)-468.6(w)12.4(er)13.5(e)-462.1(a)0(l)18.4(l)0(o)18.9(w)0(e)11.2(d)-461.7(as)-452.7(ne)15.1(ed)20.8(ed)15.1(.)-461.3(N)0(e)16.9(i)0(t)16.5(h)0(e)15.1(r)]TJ
-5.2865 -1.0471 TD
[(cr)19.2(om)12.4(on)21.2(s)-206.8(n)0(o)15.5(r)-207.2(in)18.9(ha)15.1(le)18.4(d)-205.6(s)0(t)12(e)0(r)19.2(o)0(i)18.9(d)0(s)14.4(,)-205.2(ot)18.9(he)15.1(r)-207.2(t)0(h)18.9(e)0(n)-201.1(f)0(l)17.3(u)0(n)21.2(i)0(s)17.7(o)0(l)13.2(i)13.9(de)-201.1(ad)15.1(mi)15.7(n-)]TJ
0 -1.0528 TD
[(is)17.7(te)18.4(re)13.5(d)-444.6(i)0(n)-436.4(d)0(o)21.2(u)0(b)15.5(l)0(e)18.4(-)0(b)19.6(l)0(i)16.5(n)0(d)-439.7(f)0(a)19.2(s)0(h)20(i)0(o)13.2(n)-444.6(ac)20.4(co)15.1(rd)19.6(in)18.9(g)-444.6(t)0(o)-436.4(t)0(h)13.2(e)-445(ex)20.8(pe)15.1(ri)17.3(-)]TJ
0 -1.0471 TD
[(me)17.7(nt)18.9(al)-277.5(de)20.8(si)12(gn)21.2(,)-284.9(w)12.4(er)13.5(e)-280(a)0(l)12.8(l)13.9(ow)11.6(ed)-269.4(fo)13.9(r)-281.2(t)0(h)18.9(e)-285.7(du)21.2(ra)13.5(ti)16.5(on)-269(of)-276.3(th)18.9(e)-285.7(s)0(t)17.7(u)0(d)21.2(y)67.5(.)]TJ
/F4 1 Tf
0 -2.1738 TD
[(Lung)-338(function)-343.7(and)-332.3(nitric)-343.4(oxide)-337.1(meas)-8.6(ur)31.4(emen)-7.8(t)]TJ
/F3 1 Tf
1.0015 -1.6503 TD
[(Lu)17.1(ng)-257.6(fu)19.6(nc)15.1(ti)22.2(on)-257.6(wa)16.9(s)-263.7(m)0(e)12(a)0(s)19.6(u)0(r)19.6(e)0(d)-258(u)0(s)14.4(i)0(n)18.9(g)-262.5(a)-268.6(V)63.6(it)16.5(al)18.5(og)15.5(ra)19.2(ph)-257.6(Co)16.5(m-)]TJ
-1.0015 -1.0471 TD
[(pa)15.1(ct)-618.9(sp)14.4(ir)17.3(om)18.1(et)18.5(er)-623.8(\(V)66.9(it)16.5(al)18.4(og)21.2(ra)13.5(ph)21.2(,)-632(B)0(u)16.5(c)0(k)20.8(i)0(n)13.2(g)0(h)21.2(a)0(m)12(,)-626.3(UK)13.4(\).)-623(T)12.2(h)0(e)]TJ
0 -1.0527 TD
[(fo)19.6(rc)13.5(ed)-206.8(ex)15.1(pi)18.9(ra)19.2(to)13.2(ry)-208(vo)21.2(lu)13.2(me)-209.9(in)-208.8(on)15.5(e)-217.4(s)0(e)19.6(c)0(o)15.1(n)0(d)-206.4(\()0(F)14.7(E)12.2(V)]TJ
7.97 0 0 7.97 235.162 639.439 Tm
(1)Tj
9.963 0 0 9.963 239.074 639.439 Tm
[(\))-218.6(a)0(n)20.8(d)-222.7(fo)19.6(rc)19.2(ed)]TJ
-18.1472 -1.0471 TD
[(mi)15.7(d-)19.6(ex)15.1(pi)18.9(ra)19.2(to)13.2(ry)-469.8(fl)17.3(ow)-472.1(\(F)14.7(E)12.2(F)]TJ
7.97 0 0 7.97 163.389 629.008 Tm
[(25)25.5(\2617)18.4(5)]TJ
9.963 0 0 9.963 182.835 629.008 Tm
0.4804 Tc
[(\)w)480.4(e)491.6(r)480.4(e)10.2(c)480.4(o)495.5(n)480.4(s)500.4(i)480.4(d)499.3(e)480.4(r)493.9(e)480.4(d)11.8(i)480.4(n)9.9(t)480.4(h)493.6(e)]TJ
-12.5021 -1.0527 TD
0 Tc
[(an)15.1(al)18.5(ys)20(is)-301(of)-293.3(re)13.5(su)20(lt)16.5(s.)-298.2(T)12.2(h)0(e)-297.8(F)]TJ
7.97 0 0 7.97 157.776 618.52 Tm
0.0001 Tc
[(E,)21.9(N)13.9(O)]TJ
9.963 0 0 9.963 178.809 618.52 Tm
-0.0137 Tc
[(wa)-13.7(s)-312.7(m)-13.7(e)4(a)-13.7(su)-13.7(r)5.9(e)-13.7(d)-311.5(u)-13.7(s)6.3(i)-13.7(ng)-316.1(a)-322.2(c)-13.7(he)-13.7(-)]TJ
-12.0981 -1.0471 TD
0 Tc
[(mi)15.7(lu)18.9(mi)15.7(ne)15.1(sc)19.6(en)15.1(ce)-292.6(an)20.8(al)18.5(ys)14.4(er)-293.7(\(L)15.5(og)21.2(an)-292.2(LR)-294.9(21)15.5(49)21.2(;)-304.7(L)12.2(og)15.5(an)20.8(,)-302(R)0(o)16.5(c)0(h)15.1(-)]TJ
0 -1.0527 TD
[(es)19.6(te)12.8(r)43.2(,)-324.7(UK)13.4(\))-321(b)0(e)15.1(f)0(o)19.6(r)0(e)-316.5(p)0(e)15.1(r)0(f)18(o)0(r)19.6(m)0(i)15.7(n)0(g)-314.5(s)0(p)14.4(i)13.9(ro)13.9(me)17.7(tr)17.3(y)-325.1([)0(1)19.6(4)0(,)-325.5(15].)]TJ
1.0015 -1.0471 TD
[(Br)14.9(ie)18.4(fl)17.3(y)73.2(,)-222.3(th)18.9(e)-217.4(s)0(u)14.4(b)0(j)18.9(e)0(c)20.4(t)0(s)-210(w)0(e)16.9(r)0(e)-214.1(a)0(s)19.6(k)0(e)15.1(d)-217(to)-208.8(pe)15.1(rf)18(or)13.9(m)-220.2(a)-217.4(si)17.7(ng)15.5(l)13.9(e)-223.1(sl)17.7(ow)]TJ
-1.0015 -1.0527 TD
[(ex)15.1(ha)20.8(la)18.4(ti)16.5(on)-536.4(st)17.7(ar)13.5(t)13.9(i)0(n)13.2(g)-541.4(fr)12.4(om)-533.9(to)18.9(ta)12.8(l)-543.7(l)0(u)18.9(n)0(g)-536.4(c)0(a)20.4(p)0(a)15.1(c)0(i)18.5(t)0(y)-538.8(t)0(h)18.9(r)0(o)19.6(u)0(g)15.5(h)-547.1(a)]TJ
0 -1.0471 TD
[(mo)18.1(ut)18.9(hp)15.5(ie)18.4(ce)14.7(,)-347.5(a)0(g)20.8(a)0(i)18.5(n)0(s)14.4(t)-344.6(a)-348.3(r)0(e)19.2(s)0(i)17.7(s)0(t)17.7(a)0(n)15.1(c)0(e)-338.1(\()0(m)16.5(o)0(u)15.5(t)0(h)-334(p)0(r)13.9(e)0(s)19.6(s)0(u)20(r)0(e)]TJ
/F7 1 Tf
19.8942 0 TD
(>)Tj
/F3 1 Tf
0.5463 0 TD
0.3479 Tc
[(5c)347.9(m)365.6(-)]TJ
-20.4404 -1.0527 TD
0 Tc
(H)Tj
7.472 0 0 6.641 65.367 554.116 Tm
(2)Tj
9.963 0 0 9.963 68.995 555.76 Tm
[(O\))-229(an)15.1(d)-234.1(w)0(i)14.9(t)0(h)-225.8(b)0(i)18.9(o)0(f)13.9(e)0(e)20.4(d)0(b)15.5(a)0(c)20.4(k)-239.8(us)20(ed)-229.6(to)-225.8(ma)17.7(in)13.2(ta)18.4(in)-225.8(a)-240.2(s)0(t)17.7(e)0(a)20.4(d)0(y)-229.2(f)0(l)17.3(o)0(w)]TJ
-1.0755 -1.0471 TD
[(of)-424.2(5)-427.6(L)]TJ
/F11 1 Tf
2.7713 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
[(mi)15.7(n)]TJ
7.472 0 0 6.641 103.691 549.751 Tm
(-1)Tj
9.963 0 0 9.963 109.644 545.329 Tm
[(.)-427.2(T)0(h)17.1(i)0(s)-426.2(m)0(e)17.7(t)0(h)18.9(o)0(d)-422.6(a)0(l)18.4(l)0(o)13.2(w)12.4(s)-434.4(t)0(h)18.9(e)-433.7(se)19.6(pa)15.1(ra)19.2(ti)16.5(on)-422.6(of)-418.5(th)13.2(e)]TJ
-5.1556 -1.0528 TD
[(na)15.1(so)20(ph)15.5(ar)19.2(yn)21.2(x)-222.7(f)0(r)18(o)0(m)-215.2(t)0(h)18.9(e)-223.1(or)19.6(op)15.5(ha)15.1(ry)19.6(nx)-212.1(by)-212.1(th)18.9(e)-223.1(s)0(o)20(f)0(t)-216.1(p)0(a)20.8(l)0(a)12.8(t)0(e)18.4(,)-222.3(he)20.8(nc)15.1(e)]TJ
T*
[(pr)19.6(ev)15.1(en)15.1(t)13.9(i)0(n)13.2(g)-268.2(th)18.8(e)-268.6(c)0(o)20.8(n)0(t)13.2(a)0(m)17.7(i)0(n)18.9(a)0(t)18.4(i)0(o)13.2(n)-268.2(of)-259.2(th)18.9(e)-268.6(F)]TJ
7.97 0 0 7.97 205.625 524.353 Tm
0.0001 Tc
[(E,)21.9(NO)]TJ
9.963 0 0 9.963 226.318 524.353 Tm
0 Tc
[(wi)20.6(th)-260(na)15.1(sa)19.6(l)-270.6(N)0(O)13.4(.)]TJ
-16.8668 -1.0471 TD
[(Th)17.1(is)-244.1(me)17.7(th)18.9(od)-240.5(ha)15.1(s)-252.3(b)0(e)20.8(e)0(n)-246.6(s)0(h)20(o)0(w)17.3(n)-251.2(to)-242.9(be)-240.9(su)14.4(cc)20.4(es)13.9(sf)18.4(ul)18.9(ly)-242.9(ap)15.1(pl)18.9(ic)18.4(ab)15.1(le)]TJ
0 -1.0528 TD
[(in)-203.1(bo)15.5(th)-203.1(ad)15.1(ul)18.9(ts)-204.3(an)20.8(d)-217(c)0(h)20.8(i)0(l)16.5(d)0(r)19.6(e)0(n)15.1(.)-210.9(Th)17.1(e)-211.7(F)]TJ
7.97 0 0 7.97 187.824 503.433 Tm
0.0001 Tc
[(E,)21.9(N)13.9(O)]TJ
9.963 0 0 9.963 207.893 503.433 Tm
0 Tc
[(wa)11.2(s)-212.5(m)0(e)17.7(a)0(s)19.6(u)0(r)13.9(e)0(d)-201.1(a)0(t)-203.5(t)0(h)13.2(e)]TJ
-15.0174 -1.0471 TD
[(pl)18.9(at)18.4(ea)14.7(u)-478.8(o)0(f)-475.4(t)0(h)18.8(e)-479.2(en)15.1(d-)19.6(ex)15.1(pi)18.9(ra)19.2(to)13.2(ry)-469.8(re)13.5(ad)20.8(in)18.9(g)-484.5(a)0(n)20.8(d)-484.5(ex)20.8(pr)13.9(es)19.6(se)19.6(d)-484.5(i)0(n)]TJ
0 -1.0527 TD
[(pa)15.1(rt)17.3(s)-377.5(p)0(e)15.1(r)-377.9(bi)18.9(ll)16.5(io)18.9(n)-382(\()0(p)19.6(p)0(b)15.5(\))-377.9(ac)20.4(co)15.1(rd)19.6(in)13.2(g)-376.3(t)0(o)-373.8(g)0(u)21.2(i)0(d)18.9(e)0(l)12.8(i)0(n)18.9(e)0(s)-367.3([)0(1)13.9(6].)-379.1(The)]TJ
0 -1.0471 TD
(F)Tj
7.97 0 0 7.97 63.78 472.082 Tm
0.0001 Tc
(E,NO)Tj
9.963 0 0 9.963 85.323 472.082 Tm
0 Tc
[(considered)-338.4(in)-334(the)-335.1(data)-336.3(analys)-9(is)-329.5(wer)-8.2(e)-331.2(always)-337.2(mea-)]TJ
-2.7144 -1.0527 TD
[(sured)-297.2(at)-288.8(the)-289.6(plat)-8.2(eau)-293.3(F)]TJ
7.97 0 0 7.97 144.34 461.594 Tm
0.0001 Tc
(E,NO)Tj
9.963 0 0 9.963 162.539 461.594 Tm
0 Tc
[(,)-290.6(taking)-294.3(the)-289.6(plat)-8.2(eau)-293.3(of)-287.6(the)-295.3(end-)]TJ
-10.4649 -1.0471 TD
[(expir)-8.2(atory)-281.3(carbon)-285.8(dioxide)-283.7(reading)-283.3(as)-282(representat)-13.5(ive)-278.2(of)-282(an)]TJ
0 -1.0528 TD
[(alveol)-10.1(ar)-333.6(samp)-7.8(le)-334.4([13,)-334.3(17].)]TJ
/F4 1 Tf
0 -2.3673 TD
[(Measu)-7.8(r)32.2(emen)-7.8(t)-333.2(o)0(f)-334(m)0(i)-7.8(t)0(e)-334.4(aller)24(gen)-332.7(level)-9.8(s)]TJ
/F3 1 Tf
1.0015 -1.7527 TD
[(Pa)15.9(re)19.2(nt)18.9(s)-218.2(w)0(e)16.9(r)0(e)-214.1(a)0(s)19.6(k)0(e)15.1(d)-217(to)-208.8(co)20.8(ll)16.5(ec)14.7(t)-219.4(d)0(u)21.2(s)0(t)-210(f)0(r)18(o)0(m)-209.5(t)0(h)13.2(e)-217.4(ma)17.7(tt)16.5(re)19.2(ss)18.9(es)-213.7(of)]TJ
-1.0015 -1.0471 TD
[(th)18.9(e)-433.7(s)0(u)20(b)0(j)18.9(e)0(c)14.7(t)0(s)-420.5(p)0(a)15.1(r)0(t)17.3(i)13.9(ci)12.8(pa)20.8(ti)16.5(ng)-422.6(in)-419.3(th)18.9(e)-433.7(s)0(t)17.7(u)0(d)21.2(y)-433.2(in)-419.3(a)-433.7(s)0(t)17.7(a)0(n)20.8(d)0(a)15.1(r)0(d)19.6(i)0(z)18.4(e)0(d)]TJ
0 -1.0527 TD
[(fa)19.2(sh)14.4(io)18.8(n,)-223.1(by)-223.5(va)20.8(cu)15.1(um)18.1(in)18.9(g)-234.1(t)0(h)18.9(e)-234.5(ma)17.7(tt)16.5(re)19.2(ss)-225.8(su)20(rf)18(ac)14.7(e)-228.8(o)0(v)15.5(e)0(r)-219.8(a)0(n)-223.9(a)0(r)13.5(e)0(a)-224.3(o)0(f)]TJ
0 -1.0471 TD
[(~2)-226.6(m)]TJ
7.472 0 0 6.641 78.406 372.699 Tm
(2)Tj
9.963 0 0 9.963 84.472 368.277 Tm
[(fo)19.6(r)-235.7(5)-234.1(mi)15.7(n)-234.1([)0(1)13.9(8)0(])-236.4(using)-246.4(a)-245.9(vacuum)-253.2(cleane)-8.6(r)-247.1(containing)-254.6(a)]TJ
-2.629 -1.0527 TD
[(new)-302.5(bag.)-299(Bags)-299.6(containing)-305.8(samp)-7.8(les)-296.5(were)-299.6(stor)-8.2(ed)-297.8(in)-294.1(a)-297.1(seal-)]TJ
0 -1.0471 TD
[(ed)-428.7(plast)-10.2(ic)-431.1(bag)-429.5(at)-431.1(4)]TJ
/F9 1 Tf
7.8814 0 TD
(8)Tj
/F3 1 Tf
0.387 0 TD
[(C)-432.3(until)-432.1(the)-431.9(dust)-433.4(was)-434.6(proces)-8.2(sed)-430.7(for)]TJ
-8.2684 -1.0528 TD
[(meas)-8.2(urement)-331.9(of)-321.8(mit)-10.2(e)-319.8(group)-329.8(I)-326.7(allergen)-321(levels,)-330.4(which)-329.2(was)]TJ
0 -1.0471 TD
[(perfor)-9.8(med)-284.7(using)-286.2(monoc)-7.4(lonal)-287.8(an)-7.6(tibodies)-288(in)-288.4(a)-280(t)0(w)-7.8(o-site)-285.7(im-)]TJ
0 -1.0528 TD
[(munom)-10.1(etric)-392.2(enzyme-li)-11.9(nked)-384.7(imm)-11(unosorbent)-394.5(assay)-388.3(\(E)-7.2(LI-)]TJ
0 -1.0471 TD
[(SA\))-337.1([19,)-340(20].)]TJ
1.0015 -1.0527 TD
[(Th)17.1(e)-228.8(r)0(e)19.2(s)0(u)20(l)0(t)16.5(s)-229.6(we)16.9(re)-219.8(ex)20.8(pr)13.9(es)19.6(se)19.6(d)-228.4(i)0(n)-220.2(m)0(i)15.7(c)0(r)19.2(o)0(g)15.5(r)0(a)19.2(m)0(s)-216.4(o)0(f)-219.4(m)0(i)15.7(t)0(e)-220.6(g)0(r)19.6(o)0(u)15.5(p)]TJ
-1.0015 -1.0471 TD
[(I)-326.7(a)0(l)18.4(l)0(e)18.4(r)20.4(ge)15.1(ns)-315.7(pe)20.8(r)-315.3(g)0(r)19.6(a)0(m)-318.1(o)0(f)-316.1(d)0(u)15.5(s)0(t)-312.4([)0(2)13.9(1].)]TJ
/F4 1 Tf
0 -2.0714 TD
[(Statist)-10.4(ical)-338.3(analysis)]TJ
/F3 1 Tf
1.0015 -1.5478 TD
[(Th)17.1(e)-206(F)]TJ
7.97 0 0 7.97 90.935 248.542 Tm
0.0001 Tc
[(E,)21.9(N)13.9(O)]TJ
9.963 0 0 9.963 110.948 248.542 Tm
0.2023 Tc
[(a)202.3(n)217.4(dl)202.3(u)221.2(n)202.3(gf)202.3(u)221.9(n)202.3(c)223.1(t)202.3(i)218.8(o)202.3(n\()202.3(F)222.7(E)202.3(V)]TJ
7.97 0 0 7.97 202.45 248.542 Tm
0 Tc
(1)Tj
9.963 0 0 9.963 208.46 248.542 Tm
[(an)15.1(d)-205.6(F)0(E)17.9(F)]TJ
7.97 0 0 7.97 241.455 248.542 Tm
-0.0168 Tc
[(25)-16.8(\26175)]TJ
9.963 0 0 9.963 260.901 248.542 Tm
0.2072 Tc
[(\)e)207.2(v)222.3(a)207.2(l)225.6(-)]TJ
-20.338 -1.0528 TD
0 Tc
[(ua)15.1(te)18.4(d)-524.3(a)0(t)]TJ
/F4 1 Tf
3.8582 0 TD
(t)Tj
/F3 1 Tf
7.97 0 0 7.97 99.326 238.053 Tm
(0)Tj
9.963 0 0 9.963 108.51 238.053 Tm
[(an)15.1(d)-524.3(a)]TJ
/F4 1 Tf
2.9079 0 TD
(t)Tj
/F3 1 Tf
7.97 0 0 7.97 140.031 238.053 Tm
(1)Tj
9.963 0 0 9.963 149.272 238.053 Tm
[(we)16.9(re)-515.7(st)17.7(at)18.4(is)17.7(ti)16.5(ca)14.7(ll)16.5(y)-524.3(e)0(v)20.8(a)0(l)18.4(u)0(a)15.1(t)0(e)18.4(d)-524.3(us)20(in)13.2(g)]TJ
-9.1333 -1.0527 TD
[(mu)18.1(lt)16.5(ip)18.9(le)-453.9(re)19.2(gr)13.9(es)19.6(si)17.7(on)-451.1(an)15.1(al)18.5(ys)20(is)-454.7([2)19.6(2])-458.4(of)-475.4(the)-471.7(two)-469.5(regres)-9.8(sion)]TJ
0 -1.0471 TD
[(lines)-368.7(for)-364(flunisol)-10.3(ide)-363.6(and)-361.2(placeb)-8.2(o)-365(\()]TJ
/F4 1 Tf
13.9134 0 TD
(t)Tj
/F3 1 Tf
7.97 0 0 7.97 199.559 217.134 Tm
(0)Tj
/F4 1 Tf
9.963 0 0 9.963 207.156 217.134 Tm
[(versus)-367.5(t)]TJ
/F3 1 Tf
7.97 0 0 7.97 238.677 217.134 Tm
(1)Tj
9.963 0 0 9.963 242.702 217.134 Tm
[(\):)-364(the)-363.6(dep-)]TJ
-18.5114 -1.0527 TD
[(endent)-372(\(y\))-369.7(varia)-8.6(ble)-369.3(is)-369.3(the)-369.3(value)-371.2(measured)-371.7(a)-6.9(t)]TJ
/F4 1 Tf
18.4317 0 TD
(t)Tj
/F3 1 Tf
7.97 0 0 7.97 244.63 206.646 Tm
(1)Tj
9.963 0 0 9.963 252.227 206.646 Tm
[(for)-369.7(e)-6.9(ach)]TJ
-19.4674 -1.0471 TD
[(param)-9.4(eter)-315.1(and)-315.7(each)-317.2(pati)-8.2(ent,)-312.7(wher)-9(eas)-317.3(the)-312.4(indepe)-7.8(ndent)-319.6(\(x\))]TJ
0 -1.0527 TD
[(varia)-8.6(ble)-215.6(is)-215.6(the)-215.6(value)-217.6(meas)-8.2(ured)-215.6(at)]TJ
/F4 1 Tf
12.9858 0 TD
(t)Tj
/F3 1 Tf
7.97 0 0 7.97 190.375 185.726 Tm
(0)Tj
9.963 0 0 9.963 194.343 185.726 Tm
[(.)-210.9(Maxi)-7.8(mal)-218.8(protectio)-10.7(n)-211.3(i)0(s)]TJ
-13.6573 -1.0471 TD
[(repres)-9.8(ented)-257.4(by)-251.9(a)-251.6(slope)-258.2(which)-255.2(is)-255.5(not)-255.1(signifi)-9.6(cantly)-254.8(different)]TJ
0 -1.0528 TD
[(from)-436.2(the)-431.9(line)-435(of)-435.6(identity)57.9(,)]TJ
/F4 1 Tf
10.8007 0 TD
(i.e.)Tj
/F3 1 Tf
1.6389 0 TD
[(there)-435.4(wer)-8.2(e)-428(n)0(o)-434(signifi)-9.6(cant)]TJ
-12.4395 -1.0471 TD
[(changes)-445.9(in)-442.1(the)-443.2(inves)-7.8(tigated)-445.8(param)-9.4(eters)-442.3(between)]TJ
/F4 1 Tf
20.2527 0 TD
(t)Tj
/F3 1 Tf
7.97 0 0 7.97 262.715 154.375 Tm
(0)Tj
9.963 0 0 9.963 271.105 154.375 Tm
(and)Tj
/F4 1 Tf
-21.3623 -1.0528 TD
(t)Tj
/F3 1 Tf
7.97 0 0 7.97 61.002 143.887 Tm
(1)Tj
9.963 0 0 9.963 64.97 143.887 Tm
[(.)-353.2(This)-357.9(was)-360.6(tested)-358.5(by)-360(evalua)-8.2(ting)-354.9(the)-357.9(follo)-10.2(wing)-356.5(null)-360.6(hy-)]TJ
-0.6715 -1.0471 TD
[(pothes)-8.6(is:)-383.8(1\))-384.4(The)-382.4(p)-6.5(arallelism)-394.2(of)-384.4(the)-386.3(two)-384.2(regres)-9.8(sion)-382.2(line)-8.2(s)]TJ
0 -1.0528 TD
[(\(flunisol)-12.7(ide:)-213.1(y)]TJ
/F7 1 Tf
5.5426 0 TD
(=)Tj
/F3 1 Tf
0.552 0 TD
(a)Tj
7.97 0 0 7.97 123.364 122.967 Tm
(Fl)Tj
9.963 0 0 9.963 129.883 122.967 Tm
0.0071 Tc
(+b)Tj
7.97 0 0 7.97 140.542 122.967 Tm
0 Tc
(Fl)Tj
9.963 0 0 9.963 147.061 122.967 Tm
[(x;)-208.8(placeb)-8.2(o:)-214.5(y)]TJ
/F7 1 Tf
5.0532 0 TD
(=)Tj
/F3 1 Tf
0.552 0 TD
(a)Tj
7.97 0 0 7.97 207.269 122.967 Tm
(Pl)Tj
9.963 0 0 9.963 213.789 122.967 Tm
(+b)Tj
7.97 0 0 7.97 224.391 122.967 Tm
(Pl)Tj
9.963 0 0 9.963 230.967 122.967 Tm
[(x\))-208(to)-214.5(the)-209.9(theo-)]TJ
-17.3334 -1.0471 TD
[(retical)-419.3(line)-412.2(\(y)]TJ
/F7 1 Tf
5.5767 0 TD
(=)Tj
/F3 1 Tf
0.552 0 TD
[(a+bx\))-410.4(wi)-7.8(th)-407.9(slope)-411.8(\(b\))-415.2(equal)-411(to)-413.6(1)-404.8(and)-412.4(the)]TJ
19.069 66.1583 TD
[(inte)-8.2(rcept)-378.5(of)-373(the)-375(y-axi)-8.2(s)-371.8(\(a\))-375.8(equal)-382.6(to)-373.8(0)-370.7(\(line)-380.5(of)-373(maxi)-9(mum)]TJ
0 -1.0471 TD
[(prote)-8.2(ction)-418.7(to)-419.3(alle)-8.6(rgen)-409.1(exposure)-419.4(\(L)-7.2(MP)82.7(AE\):)-419.1(y)]TJ
/F7 1 Tf
18.3349 0 TD
(=)Tj
/F3 1 Tf
0.5577 0 TD
[(x\),)-418.9(where)]TJ
-18.8926 -1.0528 TD
(a)Tj
7.97 0 0 7.97 313.682 750.727 Tm
(Fl)Tj
9.963 0 0 9.963 323.15 750.727 Tm
[(and)-298.6(b)]TJ
7.97 0 0 7.97 345.43 750.727 Tm
0.0001 Tc
(Fl)Tj
9.963 0 0 9.963 354.841 750.727 Tm
0 Tc
[(are)-300.6(the)-295.3(a)-291.4(and)-298.6(b)-291(for)-295.7(flunisol)-10.3(ide)-295.3(and)-292.9(a)]TJ
7.97 0 0 7.97 498.274 750.727 Tm
(Pl)Tj
9.963 0 0 9.963 507.685 750.727 Tm
[(and)-298.6(b)]TJ
7.97 0 0 7.97 529.965 750.727 Tm
(Pl)Tj
9.963 0 0 9.963 309.316 740.296 Tm
[(are)-300.6(the)-301(a)-297.1(and)-298.6(b)-296.7(for)-301.4(placebo,)-299.5(givi)-7.8(ng)-297.4(b)]TJ
7.97 0 0 7.97 455.698 740.296 Tm
0.0001 Tc
(Fl)Tj
9.963 0 0 9.963 465.165 740.296 Tm
0 Tc
[(and)-298.6(b)]TJ
7.97 0 0 7.97 487.446 740.296 Tm
(Pl)Tj
/F7 1 Tf
9.963 0 0 9.963 494.022 740.296 Tm
(=)Tj
/F3 1 Tf
0.552 0 TD
[(1.)-297.1(2\))-299(The)]TJ
-19.0918 -1.0528 TD
[(coinci)-10.1(dence)-278.2(of)-276.3(each)-277.4(regres)-9.8(sion)-279.8(line)-275.7(with)-279.2(the)-278.2(LMP)77.8(AE)-277(\(a)]TJ
7.97 0 0 7.97 529.965 729.808 Tm
(Fl)Tj
9.963 0 0 9.963 309.316 719.376 Tm
[(or)-276.3(a)]TJ
7.97 0 0 7.97 324.624 719.376 Tm
(Pl)Tj
/F7 1 Tf
9.963 0 0 9.963 331.2 719.376 Tm
(=)Tj
/F3 1 Tf
0.552 0 TD
[(0\),)-276.6(if)-273(the)-278.2(paral)-8.6(lelism)-283.9(hypothesis)-282.6(is)-272.6(ve)-7.6(rified.)-280.8(3\))-276.3(The)]TJ
-2.7485 -1.0528 TD
[(coinci)-10.1(dence)-272.5(betwe)-10.9(en)-269.4(the)-272.5(two)-270.4(regres)-9.8(sion)-268.4(line)-8.2(s)-269.4(\()0(a)]TJ
7.97 0 0 7.97 499.238 708.888 Tm
(Pl)Tj
/F7 1 Tf
9.963 0 0 9.963 505.757 708.888 Tm
(=)Tj
/F3 1 Tf
0.552 0 TD
(a)Tj
7.97 0 0 7.97 515.622 708.888 Tm
0.0001 Tc
(Fl)Tj
9.963 0 0 9.963 522.198 708.888 Tm
0 Tc
[(\),)-270.2(if)]TJ
-21.368 -1.0471 TD
(a)Tj
7.97 0 0 7.97 313.682 698.456 Tm
(Fl)Tj
9.963 0 0 9.963 322.979 698.456 Tm
[(an)-7.6(d)-273.9(a)]TJ
7.97 0 0 7.97 344.466 698.456 Tm
(Pl)Tj
/F12 1 Tf
9.963 0 0 9.963 351.042 698.456 Tm
(?)Tj
/F3 1 Tf
0.8308 0 TD
[(0.)-280(The)-280(compa)-7.8(risons)-284.1(were)-282.5(carri)-10.2(ed)-275.1(out)-283.5(using)-280.5(a)]TJ
-5.0191 -1.0527 TD
[(t-t)-8.6(est)-336.3(utilizing)-343.5(the)-335.1(regres)-9.8(sion)-336.7(coefficients)-341(of)-333.2(the)-335.1(mul)-7.8(tiple)]TJ
T*
[(regres)-9.8(sion)-336.7(model)-339.8(adopte)-7.8(d.)]TJ
1.0015 -1.0471 TD
[(Br)14.9(on)15.5(ch)20.8(ia)12.8(l)-378.7(s)0(y)14.4(m)0(p)18.1(t)0(o)18.8(m)0(s)-375.7(w)0(e)16.9(r)0(e)-379.1(a)0(n)20.8(a)0(l)12.8(y)0(s)20(e)0(d)-377.5(b)0(y)-371.4(c)0(o)15.1(m)0(p)18.1(a)0(r)19.2(i)0(n)13.2(g)-382(th)18.9(e)]TJ
-1.0015 -1.0528 TD
[(su)14.4(m)-277.1(o)0(f)-264.9(a)-274.3(sc)19.6(or)14(e)-274.3(r)0(a)19.2(n)0(g)15.5(i)0(n)18.9(g)-273.9(0\261)15.5(3)-273.9(f)0(o)19.6(r)-275.5(da)15.1(yt)18.9(im)15.7(e)-274.3(c)0(o)20.8(u)0(g)15.5(h)0(,)-262.9(n)0(i)13.2(g)0(h)21.2(t)0(-)17.3(t)0(i)16.5(m)0(e)]TJ
0 -1.0471 TD
[(co)15.1(ug)15.5(h)-319.4(a)0(n)15.1(d)-325.1(w)12.4(h)0(e)15.1(e)0(z)14.7(i)13.9(ng)-320.2(us)20(in)18.9(g)-325.1(t)0(h)18.9(e)-325.5(Ma)18.9(nn)15.5(-W)18.5(hi)13.2(t)13.9(n)0(e)15.1(y)-325.1(U-)15.7(te)18.4(st)17.7(.)]TJ
/F6 1 Tf
9.8617 -2.6746 TD
[(Res)-7.8(ults)]TJ
/F3 1 Tf
-8.8602 -1.5478 TD
[(Of)-206.2(th)18.9(e)-211.7(3)0(2)-206.4(c)0(h)20.8(i)0(l)16.5(d)0(r)19.6(e)0(n)-206.8(w)12.4(ho)-206.4(w)12.4(e)0(r)13.5(e)-211.7(ad)20.8(mi)15.7(tt)16.5(ed)-201.1(\(t)17.3(ab)15.1(le)-203.5(1\),)-214.1(28)-217.8(co)-7.6(m-)]TJ
-1.0015 -1.0527 TD
[(plet)-8.2(ed)-223.9(the)-221.3(study)55.2(.)-216.6(One)-222.9(c)-6.9(hild)-224.1(in)-220.2(the)-221.3(placeb)-8.2(o)-222.7(group)-221.7(p)-6.5(resented)]TJ
0 -1.0471 TD
[(wi)-7.8(th)-322.6(an)-326.3(upper)-324.5(respi)-9.4(ratory)-329.2(tract)-329.7(infection)-329.4(and)-327.1(three)-327.3(in)-322.6(the)]TJ
0 -1.0527 TD
[(fluni)-10.2(solide-t)-10.7(reated)-521.9(group)-523.3(were)-521.5(not)-516.8(compl)-9.7(iant)-520.4(with)-518.2(the)]TJ
0 -1.0471 TD
[(schedul)-9.7(ed)-326.3(regim)-11.3(en,)-326.7(as)-327.5(verified)-333.5(by)-325.9(checki)-8.2(ng)-325.9(the)-323.7(p)-6.5(ersonal)]TJ
0 -1.0528 TD
[(diary)-321.2(card)-324.1(and)-315.7(evalua)-8.2(ting)-320.8(the)-318.1(quantity)-320.9(of)-321.8(unused)-319.1(drug)-317.6(at)]TJ
0 -1.0471 TD
[(the)-238.4(end)-236(of)-236.4(the)-232.7(study)-240.7(perio)-8.2(d.)-228.8(The)-6.8(se)-236.4(subjects)-241.7(were)-237(exclud)-7.8(ed)]TJ
0 -1.0527 TD
[(from)-254.1(the)-249.8(study)-246.4(and)-247.4(there)-8.6(fore)-251.3(the)-249.8(final)-249.6(analys)-9(is)-244.1(for)-250.2(the)-249.8(two)]TJ
0 -1.0471 TD
[(groups)-343.1(included)-341.7(15)-331.6(placeb)-8.2(o)-336.5(and)-332.7(13)-337.3(flunisol)-10.3(ide)-335.1(subje)-7.8(cts.)]TJ
1.0015 -1.0527 TD
[(It)-238.8(wa)16.9(s)-241(p)0(o)15.5(s)0(s)18.8(i)0(b)18.9(l)0(e)-237.6(t)0(o)-231.5(o)0(b)15.5(t)0(a)18.4(i)0(n)-237.2(d)0(u)21.2(s)0(t)-232.7(s)0(a)14(m)0(p)18.1(l)0(e)18.4(s)-246.7(fr)18(om)-232.3(25)-234.8(of)-236.4(th)18.9(e)-245.9(2)0(8)]TJ
-1.0015 -1.0471 TD
[(ch)15.1(il)16.5(dr)19.6(en)-189.7(wh)17.3(o)-199.9(c)0(o)15.1(m)0(p)18.1(l)0(e)18.4(t)0(e)18.4(d)-199.9(th)13.2(e)-194.6(s)0(t)17.7(u)0(d)15.5(y)73.2(.)-199.6(F)0(o)16.3(u)0(r)-190.9(s)0(a)19.6(m)0(p)18.1(l)0(e)12.8(s)0(,)-190.1(o)0(n)21.2(e)-200.3(in)-191.7(th)18.9(e)]TJ
0 -1.0528 TD
[(pl)13.2(ac)20.4(eb)15.1(o)-325.1(a)0(n)15.1(d)-325.1(th)18.9(re)13.5(e)-325.5(i)0(n)-322.6(t)0(h)18.9(e)-325.5(fl)17.3(un)15.5(is)17.7(ol)18.9(id)18.8(e)-331.2(g)0(r)19.6(o)0(u)15.5(p)0(,)-319.8(w)12.4(er)13.5(e)-325.5(n)0(o)15.5(t)-327.5(su)20(it)16.5(-)]TJ
0 -1.0471 TD
[(ab)15.1(le)-214.9(fo)13.9(r)-224.3(a)0(n)20.8(a)0(l)12.8(y)0(s)20(i)0(s)-215.7(b)0(e)15.1(c)0(a)20.4(u)0(s)20(e)-228.8(th)18.9(e)-223.1(q)0(u)15.5(a)0(n)20.8(t)0(i)16.5(t)0(y)-220.2(o)0(f)-213.7(d)0(u)15.5(s)0(t)-215.6(c)0(o)20.8(l)0(l)16.5(e)0(c)14.7(t)0(e)18.4(d)-222.7(wa)16.9(s)]TJ
0 -1.0528 TD
[(no)15.5(t)-247.8(s)0(u)14.4(f)20.4(fi)17.3(ci)18.4(en)15.1(t)-247.8(t)0(o)-242.9(p)0(e)15.1(r)0(f)18(o)0(r)19.6(m)-254.3(t)13.9(h)0(e)-246.6(a)0(l)18.5(l)0(e)18.5(r)20.4(ge)15.1(n)-251.1(e)0(x)20.8(t)0(r)17.3(a)0(c)14.7(t)0(i)16.5(o)0(n)21.2(.)-250.8(T)12.2(h)0(e)-246.6(m)13.2(ea)14.7(n)]TJ
0 -1.0471 TD
[(le)12.8(ve)20.8(l)-316.1(o)0(f)-304.7(m)0(i)15.7(t)0(e)-305.9(a)0(l)12.8(l)0(e)18.4(r)20.4(ge)15.1(n)-313.7(i)0(n)-305.5(s)0(a)19.6(m)0(p)12.4(l)0(e)18.4(s)-314.9(co)15.1(l)13.9(l)0(e)12.8(c)0(t)18.5(e)0(d)-303.5(i)0(n)-311.2(t)13.9(he)-309.2(re)19.2(si)17.7(de)15.1(n-)]TJ
0 -1.0527 TD
[(ti)16.5(al)-317.3(ho)15.5(us)20(e)-325.5(w)0(a)16.9(s)-326.3(0.)21.6(04)]TJ
/F7 1 Tf
8.0521 0 TD
(m)Tj
/F3 1 Tf
0.5634 0 TD
(g)Tj
/F11 1 Tf
0.4951 0.1992 TD
(.)Tj
/F3 1 Tf
0.2675 -0.1992 TD
0.3251 Tc
[(gd)325.1(u)340.6(s)325.1(t)]TJ
7.472 0 0 6.641 427.124 451.559 Tm
0 Tc
(-1)Tj
9.963 0 0 9.963 433.077 447.137 Tm
[(.)-324.7(T)12.2(he)-320.6(l)13.9(e)0(v)15.1(e)0(l)18.5(s)-326.3(of)-316.1(ho)21.2(us)14.4(e)-325.5(d)0(u)21.2(s)0(t)]TJ
-12.4225 -1.0471 TD
[(mi)15.7(te)-226.2(gr)13.9(ou)21.2(p)-234.1(I)-235.7(al)18.4(le)18.4(r)20.4(g)0(e)15.1(n)0(s)-224.7(\()]TJ
/F4 1 Tf
9.0594 0 TD
[(De)16.9(r)-235.3(p)]TJ
/F3 1 Tf
2.2478 0 TD
0.2357 Tc
[(Ia)235.7(n)256.5(d)]TJ
/F4 1 Tf
2.2079 0 TD
0 Tc
[(De)16.9(r)-235.3(f)]TJ
/F3 1 Tf
2.0201 0 TD
[(I\))-226.7(we)16.9(re)-225.5(16)21.2(.4)15.9(6)]TJ
/F7 1 Tf
5.4402 0 TD
(m)Tj
/F3 1 Tf
0.5634 0 TD
(g)Tj
/F11 1 Tf
0.4894 0.1992 TD
(.)Tj
/F3 1 Tf
0.2732 -0.1992 TD
(g)Tj
-22.3013 -1.0527 TD
[(du)15.5(st)]TJ
7.472 0 0 6.641 325.474 430.639 Tm
(-1)Tj
9.963 0 0 9.963 335.168 426.217 Tm
[(in)-356.7(th)13.2(e)-365.4(p)0(l)18.9(a)0(c)14.7(e)0(b)20.8(o)-370.7(gr)19.6(ou)15.5(p)-365(a)0(n)20.8(d)-370.7(12)21.2(.8)15.9(4)]TJ
/F7 1 Tf
13.0996 0 TD
(m)Tj
/F3 1 Tf
0.5634 0 TD
(g)Tj
/F11 1 Tf
0.4951 0.1992 TD
(.)Tj
/F3 1 Tf
0.2675 -0.1992 TD
0.3707 Tc
[(gd)370.7(u)391.9(s)370.7(t)]TJ
7.472 0 0 6.641 503.66 430.639 Tm
0 Tc
(-1)Tj
9.963 0 0 9.963 513.354 426.217 Tm
[(in)-362.4(th)18.9(e)]TJ
-20.4803 -1.0471 TD
[(fl)17.3(un)15.5(is)17.7(ol)18.9(id)18.8(e-)13.5(tr)17.3(ea)20.4(te)12.8(d)-416.2(g)0(r)14(o)0(u)21.2(p)-421.9(\()]TJ
6.974 0 0 6.974 413.972 415.786 Tm
0.0001 Tc
(NS)Tj
9.963 0 0 9.963 426.954 415.786 Tm
0 Tc
[(be)15.1(tw)14.9(ee)20.4(n)-421.9(t)0(r)17.3(e)0(a)20.4(t)0(m)15.7(e)0(n)15.1(t)0(s)-409.1(a)0(n)15.1(d)-421.9(p)]TJ
/F7 1 Tf
10.4422 0 TD
(<)Tj
/F3 1 Tf
-22.2501 -1.0528 TD
[(0.)15.9(01)]TJ
/F4 1 Tf
2.0486 0 TD
[(ve)14.7(rs)18.8(us)]TJ
/F3 1 Tf
2.8111 0 TD
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[(I)-17.5(t)-421.3(h)-17.5(a)3.3(s)-429.2(p)-17.5(re)-17.5(vi)-17.5(ou)-17.5(sl)-17.5(y)-419.7(b)-17.5(ee)-17.5(n)-417.8(d)-17.5(e)3.3(m)-17.5(on)-17.5(st)-17.5(ra)-17.5(te)-17.5(d)-417.8(t)-17.5(ha)-17.5(t)-420.2(i)-17.5(nh)-17.5(al)-17.5(ed)-428(c)-17.5(o)-2.4(r)2.9(-)]TJ
-1.0015 -1.0471 TD
0 Tc
[(ti)16.5(co)20.8(st)17.7(er)13.5(oi)18.9(ds)-201.9(ar)19.2(e)-211.7(e)0(f)30.6(f)0(e)13.5(c)0(t)18.5(i)0(v)18.9(e)-211.7(in)-197.4(pr)14(ev)20.8(en)15.1(ti)16.5(ng)-200.7(th)18.9(e)-206(i)0(n)13.2(c)0(r)19.2(e)0(a)14.7(s)0(e)-196.6(i)0(n)-203.1(b)0(r)19.6(o)0(n)15.5(-)]TJ
0 -1.0528 TD
[(ch)15.1(ia)18.4(l)-247.8(r)0(e)19.2(a)0(c)14.7(t)0(i)16.5(v)0(i)18.9(t)0(y)-242.9(i)0(n)-237.2(a)0(l)12.8(l)13.9(er)24.9(gi)18.9(c)-251.6(a)0(s)19.6(t)0(h)13.2(m)13.2(a)0(t)12.8(i)0(c)-237.6(c)0(h)15.1(i)0(l)16.5(d)0(r)19.6(e)0(n)-240.9(r)0(e)19.2(-)0(e)13.5(x)0(p)21.2(o)0(s)14.4(e)0(d)-240.9(t)0(o)]TJ
0 -1.0471 TD
[(al)18.4(le)18.4(r)14.7(g)0(e)20.8(n)0(s)-315.7(f)0(o)13.9(r)-321(3)-325.1(m)0(o)18.1(n)0(t)18.9(h)0(s)-315.7([)0(9)13.9(])0(.)]TJ
1.0015 -1.0528 TD
(F)Tj
7.97 0 0 7.97 73.701 341.518 Tm
0.0001 Tc
[(E,)29(NO)]TJ
9.963 0 0 9.963 94.45 341.518 Tm
-0.0178 Tc
[(h)-17.8(a)3(s)-298.6(b)-17.8(ee)-17.8(n)-287.2(d)-17.8(em)-17.8(on)-17.8(st)-17.8(ra)-17.8(t)-5(e)-17.8(d)-287.2(t)-3.9(o)-297.4(b)-17.8(e)-287.2(m)-17.8(or)-17.8(e)-288.8(p)-17.8(ro)-17.8(mp)-17.8(tl)-17.8(y)-289.2(m)-17.8(o-)]TJ
-3.6306 -1.0471 TD
0 Tc
[(di)18.9(fi)17.3(ed)-252.3(by)-251.9(ex)15.1(po)21.2(su)14.4(re)-248.2(to)-254.3(or)-253.5(av)20.8(oi)18.9(da)15.1(nc)15.1(e)-257.2(o)0(f)-253.5(r)0(e)19.2(l)0(e)12.8(v)0(a)20.8(n)0(t)-254.3(a)0(l)18.5(l)0(e)18.4(r)20.4(ge)15.1(ns)-253.1(in)]TJ
0 -1.0527 TD
[(al)18.4(le)18.4(r)14.7(g)0(i)18.9(c)-439.3(as)13.9(th)18.9(ma)17.7(ti)16.5(c)-445(c)0(h)20.8(i)0(l)16.5(d)0(r)19.6(e)0(n)-434.4([)0(2)13.9(3)0(,)-439.3(24])-453.4(than)-455.4(lung)-455(funct)-8.2(ion.)]TJ
25.1977 3.8127 TD
(B)Tj
6.974 0 0 6.974 316.006 358.583 Tm
0.0001 Tc
(ARALDI)Tj
/F4 1 Tf
9.963 0 0 9.963 345.6 358.583 Tm
0 Tc
[(et)-345.7(al.)]TJ
/F3 1 Tf
2.4242 0 TD
[([23])-347.7(demon)-7.4(strated)-349.4(that)-8.2(,)-341.8(durin)-7.8(g)-342.2(the)-352.2(pollen)]TJ
-6.0661 -1.0755 TD
[(season)-7.8(,)-273.5(F)]TJ
7.97 0 0 7.97 346.45 347.868 Tm
0.0001 Tc
(E,NO)Tj
9.963 0 0 9.963 367.427 347.868 Tm
0 Tc
[(increased)-281.1(signi)-9.8(ficantly)-283.1(in)-271.4(spit)-9(e)-274.3(o)0(f)-270.6(a)-274.3(lack)-279.4(of)]TJ
-5.8328 -1.0755 TD
[(signi)-9.8(ficant)-239.4(changes)-241.1(in)-237.2(FEV)]TJ
7.97 0 0 7.97 416.239 337.153 Tm
(1)Tj
9.963 0 0 9.963 420.208 337.153 Tm
[(,)-239.4(and)-236(also)-240.3(showed)-237.7(a)-234.5(relat)-11(ively)]TJ
-11.1307 -1.0755 TD
[(high)-250.1(F)]TJ
7.97 0 0 7.97 334.942 326.438 Tm
0.0001 Tc
(E,NO)Tj
9.963 0 0 9.963 355.578 326.438 Tm
0 Tc
[(in)-242.9(these)-252.9(patients)-248.6(ou)-7.2(tside)-243.5(the)-249.8(grass)-247.2(poll)-7.8(en)-240.9(seas-)]TJ
-4.6435 -1.0755 TD
[(on,)-434.4(in)-430.7(agreem)-10.5(ent)-431.9(with)-432.8(the)-431.9(hypoth)-7(esis)-435(that)-429.3(mild)-437.7(airway)]TJ
T*
[(infl)-9.4(ammati)-10.7(on)-360(may)-358.7(persi)-9.4(st)-357.9(even)-362.4(in)-362.4(the)-363.6(absence)-366.7(of)-361.6(symp-)]TJ
T*
[(tom)-7.8(s)-423.1([14].)-433.4(A)-425.8(signi)-9.8(ficant)-432.8(time-dep)-10.7(endent)-428.9(modul)-9.3(ation)-430.1(of)]TJ
T*
(F)Tj
7.97 0 0 7.97 314.872 283.578 Tm
0.0001 Tc
(E,NO)Tj
9.963 0 0 9.963 336.642 283.578 Tm
0 Tc
[(durin)-7.8(g)-365(house)-363.9(dust)-365.1(mite)-369.9(avoida)-7.8(nce)-361.6(has)-368.1(previously)]TJ
-2.7428 -1.0755 TD
[(bee)-8.8(n)-370.7(observ)-7.8(ed)-377.5(in)-373.8(a)-376.8(group)-381(of)-373(alle)-8.6(rgi)10.8(c)-376.7(asthm)-10.9(atic)-378.5(children)]TJ
T*
[(durin)-7.8(g)-313.7(a)-308.5(stay)-314.3(in)-311.2(the)-318.1(Alpine)-315.3(envir)-8.2(onmen)-7.4(t,)-310.8(despite)-319.4(discon-)]TJ
0 -1.0698 TD
[(tinu)-7.8(ation)-339(of)-333.2(ster)-8.6(oid)-334.7(thera)-8.6(py)-331.6([24].)]TJ
1.0015 -1.0527 TD
[(In)-259.2(th)18.9(e)-268.6(p)0(r)19.6(e)0(s)13.9(e)0(n)20.8(t)-264.9(st)17.7(ud)15.5(y)73.2(,)-267.8(a)-262.9(s)0(i)17.7(g)0(n)15.5(i)0(f)17.3(i)0(c)18.5(a)0(n)15.1(t)-264.9(in)18.9(cr)19.2(ea)14.7(se)-253.5(in)-260(F)]TJ
7.97 0 0 7.97 500.655 241.002 Tm
0.0001 Tc
[(E,)21.9(NO)]TJ
9.963 0 0 9.963 521.291 241.002 Tm
0 Tc
[(wa)16.9(s)]TJ
-21.277 -1.0755 TD
[(ob)15.5(se)19.6(rv)13.9(ed)-252.3(in)-248.6(th)18.9(e)-262.9(g)0(r)19.6(o)0(u)15.5(p)-262.5(of)-247.8(pa)15.1(ti)16.5(en)20.8(ts)-255.5(tr)17.3(ea)20.4(te)12.8(d)-256.8(w)0(i)14.9(t)0(h)-254.3(p)0(l)18.9(a)0(c)20.4(e)0(b)15.1(o)0(,)-251.5(b)0(u)21.2(t)]TJ
T*
[(no)15.5(t)-208(i)0(n)-203.1(t)0(h)18.9(o)0(s)14.4(e)-206(tr)17.3(ea)14.7(te)18.4(d)-211.3(w)12.4(it)16.5(h)-211.3(i)0(n)18.9(h)0(a)15.1(l)0(e)18.5(d)-211.3(fl)17.3(un)21.2(is)17.7(ol)18.9(id)13.2(e)-206(d)0(u)15.5(r)0(i)17.3(n)0(g)-200.7(2)-211.3(w)12.4(e)0(e)14.7(k)0(s)]TJ
T*
[(of)-282(ex)20.8(po)15.5(su)20(re)-276.7(to)-277.1(si)17.7(gn)15.5(if)17.3(ic)18.4(an)15.1(t)-287.7(l)0(e)18.4(v)0(e)20.8(l)0(s)-278.2(o)0(f)-276.3(m)0(i)15.7(t)0(e)-277.5(a)0(l)12.8(l)0(e)18.4(r)20.4(ge)15.1(ns)20(.)-284.9(I)0(n)-276.3(c)0(o)15.1(n)0(-)]TJ
T*
[(tr)17.3(as)13.9(t,)-418.9(no)-422.6(di)18.9(f)20.4(f)0(e)13.5(r)0(e)19.2(n)0(c)15.1(e)-428(ha)15.1(s)-428.7(b)0(e)15.1(e)0(n)-417.3(o)0(b)15.5(s)0(e)19.6(r)0(v)13.9(e)0(d)-417.3(b)0(e)15.1(t)0(w)14.9(e)0(e)20.4(n)-433.2(th)18.9(e)-428(t)0(w)14.9(o)]TJ
T*
[(tr)17.3(ea)14.7(tm)15.7(en)20.8(ts)-318.1(in)-316.9(te)18.4(rm)16.5(s)-326.3(o)0(f)-310.4(l)0(u)13.2(n)0(g)-314.5(f)0(u)19.6(n)0(c)15.1(t)0(i)16.5(o)0(n)21.2(.)]TJ
1.0015 -1.0471 TD
[(Th)17.1(is)-204.3(ob)21.2(se)14(rv)19.6(at)18.5(io)13.2(n)-205.6(i)0(s)-204.3(n)0(o)21.2(t)-213.7(un)21.2(ex)15.1(pe)20.8(ct)12.8(ed)-201.1(si)17.7(nc)20.8(e)-211.7(i)0(t)-199.8(i)0(s)-204.3(k)0(n)21.2(o)0(w)17.3(n)-211.3(th)18.9(at)]TJ
-1.0015 -1.0755 TD
[(ai)12.8(rw)15.7(ay)-354.8(in)18.9(fl)17.3(am)17.7(ma)17.7(ti)16.5(on)-360(m)13.2(a)0(y)-360.4(b)0(e)-354.7(f)0(o)19.6(u)0(n)15.5(d)-365(in)-356.7(as)19.6(th)18.9(ma)17.7(ti)16.5(c)-365.4(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)]TJ
T*
[(wh)17.3(os)14.4(e)-274.3(l)0(u)13.2(n)0(g)-269(f)0(u)19.6(n)0(c)20.8(t)0(i)16.5(o)0(n)-269(v)0(a)15.1(l)0(u)18.9(e)0(s)-270.6(a)0(r)19.2(e)-280(no)21.2(rm)16.5(al)-271.8(an)20.8(d)-279.6(c)0(l)18.5(i)0(n)18.8(i)0(c)12.8(a)0(l)18.4(l)0(y)-265.7(w)0(e)16.9(l)0(l)]TJ
T*
[(co)15.1(nt)18.9(ro)13.9(l)13.9(l)0(e)12.8(d)-262.5([2)19.6(5].)-265.3(For)-276.2(this)-276.5(reason,)-276(it)-273.7(was)-275.3(recent)-9.8(ly)-271.4(sugges)-7.4(ted)]TJ
T*
[(that)-389.5(the)-386.3(monitor)-9.1(ing)-385.9(of)-384.4(lung)-381(funct)-8.2(ion)-385.9(and)-384(symp)-7.4(toms)-385.3(are)]TJ
T*
[(not)-403(sensi)-9(tive)-406.6(enough)-403.3(to)-402.2(reflect)-407.2(the)-403.4(extent)-408.5(of)-401.5(airway)-405.9(in-)]TJ
T*
[(flam)-10.6(mation)-337.2([25].)]TJ
ET
0 0 0 1 K
0 J 0 j 0.5 w 3.864 M []0 d
/GS3 gs
1 i 
96.245 171.3 m
96.245 299.925 l
96.12 273.909 m
93.745 273.909 l
96.245 299.675 m
93.745 299.675 l
96.12 248.302 m
93.745 248.302 l
96.245 222.695 m
93.745 222.695 l
96.245 171.55 m
93.745 171.55 l
116.87 171.55 m
170.62 171.55 l
119.495 171.425 m
119.495 169.175 l
166.495 171.55 m
166.495 169.175 l
S
BT
/F16 1 Tf
10 0 0 10 89.287 168.425 Tm
0 0 0 1 k
/GS4 gs
(1)Tj
0 10 -10 0 68.777 207.905 Tm
(FEF)Tj
0 8 -8 0 68.777 223.395 Tm
(25\32075)Tj
0 10 -10 0 68.777 241.635 Tm
(  L\341s)Tj
0 8 -8 0 65.943 257.135 Tm
(-1)Tj
10 0 0 10 62.278 296.05 Tm
(a\))Tj
/F18 1 Tf
5.4093 -13.55 TD
(t)Tj
/F16 1 Tf
8 0 0 8 118.65 160.551 Tm
(0)Tj
/F18 1 Tf
10 0 0 10 163.444 160.545 Tm
(t)Tj
/F16 1 Tf
8 0 0 8 165.724 160.545 Tm
(1)Tj
10 0 0 10 133.403 152.051 Tm
(Time)Tj
ET
/GS3 gs
112.464 203.059 m
112.464 204.025 113.247 204.808 114.214 204.808 c
115.18 204.808 115.964 204.025 115.964 203.059 c
115.964 202.092 115.18 201.308 114.214 201.308 c
113.247 201.308 112.464 202.092 112.464 203.059 c
b
114.186 208.814 m
114.186 196.939 l
112.561 208.939 m
115.811 208.939 l
112.572 197.059 m
115.822 197.059 l
S
170.582 209.816 m
170.582 210.782 171.366 211.566 172.332 211.566 c
173.299 211.566 174.082 210.782 174.082 209.816 c
174.082 208.849 173.299 208.066 172.332 208.066 c
171.366 208.066 170.582 208.849 170.582 209.816 c
b
172.304 218.189 m
172.304 200.689 l
170.679 218.314 m
173.929 218.314 l
170.691 200.809 m
173.941 200.809 l
96.155 196.939 m
93.78 196.939 l
S
BT
10 0 0 10 87.905 296.347 Tm
/GS4 gs
(6)Tj
0 -2.575 TD
(5)Tj
-0.0125 -2.5625 TD
(4)Tj
0.0125 -2.5466 TD
(3)Tj
0.0125 -2.5775 TD
(2)Tj
ET
/GS3 gs
119.405 261.813 m
166.28 294.313 l
166.28 244.313 m
119.405 223.314 l
166.28 241.064 m
119.405 211.939 l
119.405 206.939 m
166.28 221.314 l
166.28 217.439 m
119.405 209.814 l
119.405 207.689 m
166.28 188.814 l
166.28 195.314 m
119.405 186.689 l
119.405 179.564 m
166.28 177.564 l
166.28 175.314 m
119.405 181.814 l
119.405 184.814 m
166.28 182.689 l
119.405 185.314 m
166.28 201.439 l
119.405 189.939 m
166.28 183.564 l
166.28 179.564 m
119.405 193.939 l
205.221 171.408 m
205.221 300.032 l
205.096 274.017 m
202.721 274.017 l
205.221 299.782 m
202.721 299.782 l
205.096 248.41 m
202.721 248.41 l
205.221 222.803 m
202.721 222.803 l
205.221 171.658 m
202.721 171.658 l
225.846 171.658 m
279.595 171.658 l
228.471 171.533 m
228.471 169.283 l
277.171 171.658 m
277.171 169.283 l
S
BT
10 0 0 10 191.534 296.05 Tm
/GS4 gs
(b\))Tj
/F18 1 Tf
3.3882 -13.5401 TD
(t)Tj
/F16 1 Tf
8 0 0 8 227.697 160.65 Tm
(0)Tj
/F18 1 Tf
10 0 0 10 274.049 160.645 Tm
(t)Tj
/F16 1 Tf
8 0 0 8 276.329 160.645 Tm
(1)Tj
10 0 0 10 244.009 152.15 Tm
(Time)Tj
ET
/GS3 gs
220.578 208.248 m
220.578 209.214 221.361 209.998 222.328 209.998 c
223.294 209.998 224.078 209.214 224.078 208.248 c
224.078 207.281 223.294 206.498 222.328 206.498 c
221.361 206.498 220.578 207.281 220.578 208.248 c
b
222.3 211.814 m
222.3 204.814 l
220.675 211.939 m
223.925 211.939 l
220.686 204.934 m
223.936 204.934 l
S
281.605 208.707 m
281.605 209.674 282.388 210.457 283.355 210.457 c
284.321 210.457 285.105 209.674 285.105 208.707 c
285.105 207.741 284.321 206.957 283.355 206.957 c
282.388 206.957 281.605 207.741 281.605 208.707 c
b
283.327 215.189 m
283.327 202.189 l
281.702 215.314 m
284.951 215.314 l
281.713 202.309 m
284.963 202.309 l
205.296 196.814 m
202.796 196.814 l
276.536 170.439 m
228.411 217.314 l
228.286 185.314 m
277.286 196.939 l
277.161 173.314 m
228.411 199.189 l
228.411 204.189 m
277.286 175.939 l
228.411 189.064 m
277.286 190.564 l
277.286 191.939 m
228.411 193.814 l
228.411 202.814 m
277.286 207.564 l
277.286 207.564 m
228.411 212.064 l
228.411 209.189 m
277.286 239.438 l
228.411 235.313 m
277.286 247.189 l
228.411 222.689 m
277.286 233.314 l
277.286 234.064 m
228.411 212.564 l
228.411 214.189 m
277.036 233.939 l
228.536 222.939 m
277.286 223.814 l
277.286 218.189 m
228.536 221.939 l
S
BT
/F3 1 Tf
7.97 0 0 7.97 58.28 138.104 Tm
0 g
/GS2 gs
[(Fig.)-327.1(3.)-331.2(\261)-332.2(Forced)-232.3(mid-expira)10.5(tory)-236(flow)-238.5(\(FEF)]TJ
6.376 0 0 6.376 193.833 138.104 Tm
(25\26175)Tj
7.97 0 0 7.97 209.82 138.104 Tm
[(%\))-235.9(at)-239(the)-229.8(time)-237.5(of)-237.8(admis-)]TJ
-19.0134 -1.0599 TD
[(sion)-400.6(\()]TJ
/F4 1 Tf
2.3758 0 TD
(t)Tj
/F3 1 Tf
6.376 0 0 6.376 79.37 129.657 Tm
(0)Tj
7.97 0 0 7.97 82.545 129.657 Tm
[(\))-403.5(and)-398.1(2)-396.3(weeks)-396.6(later)-405(following)-389.3(re-exposure)-395.2(to)-403.7(house)-395.1(dust)-393.5(mite)]TJ
-3.0444 -1.067 TD
[(aller)14.7(gens)-240.7(in:)-233.2(a\))-243.9(the)-236.9(flunisolid)10.1(e)-245.9(group;)-231.8(and)-234.5(b\))-237.8(the)-236.9(placebo)-233.6(group)-238.6(\()]TJ
/F4 1 Tf
25.1592 0 TD
(t)Tj
/F3 1 Tf
6.376 0 0 6.376 260.957 121.153 Tm
(1)Tj
7.97 0 0 7.97 264.132 121.153 Tm
[(\).)-238.9(Data)]TJ
-25.8278 -1.0599 TD
[(are)-333.3(presented)-323.2(as)-330.3(individual)-328.9(values)-323.3(and)-334.1(mean\213)]TJ
5.579 0 0 5.579 205.228 112.705 Tm
(SEM)Tj
7.97 0 0 7.97 216.624 112.705 Tm
(.)Tj
ET
/GS3 gs
95.687 644.559 m
95.687 773.184 l
95.687 772.934 m
93.187 772.934 l
95.562 708.384 m
93.187 708.384 l
95.687 666.199 m
93.187 666.199 l
95.687 644.809 m
93.187 644.809 l
114.612 644.809 m
168.361 644.809 l
118.229 644.684 m
118.229 642.434 l
163.67 644.809 m
163.67 642.434 l
S
BT
/F16 1 Tf
0 10 -10 0 68.219 694.33 Tm
0 0 0 1 k
/GS4 gs
(FEV)Tj
0 8 -8 0 68.219 710.28 Tm
(1)Tj
0 10 -10 0 68.219 713.928 Tm
(  L)Tj
10 0 0 10 61.719 769.309 Tm
(a\))Tj
/F18 1 Tf
5.3384 -13.55 TD
(t)Tj
/F16 1 Tf
8 0 0 8 117.384 633.81 Tm
(0)Tj
/F18 1 Tf
10 0 0 10 160.619 633.804 Tm
(t)Tj
/F16 1 Tf
8 0 0 8 162.899 633.804 Tm
(1)Tj
10 0 0 10 132.845 625.31 Tm
(Time)Tj
ET
/GS3 gs
111.906 688.626 m
111.906 689.592 112.689 690.376 113.656 690.376 c
114.622 690.376 115.406 689.592 115.406 688.626 c
115.406 687.659 114.622 686.876 113.656 686.876 c
112.689 686.876 111.906 687.659 111.906 688.626 c
b
113.628 696.256 m
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[(li)16.5(de)-235.2(an)15.1(d)-245.5(p)0(l)18.9(a)0(c)14.7(e)0(b)20.8(o)0(-)19.6(t)0(r)17.3(e)0(a)14.7(t)0(e)18.4(d)-245.5(ch)15.1(il)16.5(dr)19.6(en)15.1(.)-245.1(H)12.4(ow)17.3(ev)15.1(er)47.7(,)-245.1(p)0(r)19.6(e)0(v)15.1(i)0(o)18.9(u)0(s)-236(s)0(t)17.7(u)0(d)15.5(-)]TJ
0 -1.0528 TD
[(ie)18.4(s)-366.2(h)0(a)15.1(v)0(e)-360.4(s)0(h)20(o)0(w)17.3(n)-370.7(th)18.9(at)-357.1(in)18.9(ha)15.1(le)18.4(d)-370.7(s)0(t)17.7(e)0(r)19.2(o)0(i)18.9(d)0(s)-361.2(s)0(i)17.7(g)0(n)21.2(i)0(f)17.3(i)0(c)12.8(a)0(n)20.8(t)0(l)16.5(y)-365(re)13.5(du)21.2(ce)]TJ
0 -1.0471 TD
(F)Tj
7.97 0 0 7.97 63.666 583.37 Tm
0.0001 Tc
[(E,)21.9(NO)]TJ
9.963 0 0 9.963 84.529 583.37 Tm
0 Tc
[([1)19.6(4,)-285.7(15],)-300.2(and,)-299(there)-8.6(fore,)-297.2(it)-302.2(is)-295.3(tempti)-9.6(ng)-297.4(to)-294.1(specul)-9(ate)]TJ
-2.6347 -1.0527 TD
[(that)-270(the)-266.8(lack)-273.7(of)-264.9(changes)-275.2(in)-265.7(F)]TJ
7.97 0 0 7.97 170.702 572.882 Tm
(E,NO)Tj
9.963 0 0 9.963 191.565 572.882 Tm
[(occurr)-8.6(ed)-269.4(as)-264.9(a)-268.6(result)-274.3(and)]TJ
-13.3785 -1.0471 TD
[(not)-385.9(In)-384.4(spit)-9(e)-382.4(o)0(f)-384.4(stero)-9.4(id)-385.2(treatmen)-11.1(t.)-384.8(Therefor)-10.1(e,)-382.8(the)-386.3(author)-9(s)]TJ
0 -1.0528 TD
[(sugges)-7.4(t)-521(that)-520.4(treat)-11(ment)-521.1(with)-523.9(inhal)-9(ed)-519.8(steroid)-525.4(is)-522.9(able)-524.1(to)]TJ
0 -1.0471 TD
[(prevent)-436.9(the)-437.6(incre)-8.6(ase)-431.1(in)-436.4(F)]TJ
7.97 0 0 7.97 162.595 541.531 Tm
0.0001 Tc
(E,NO)Tj
9.963 0 0 9.963 185.102 541.531 Tm
0 Tc
[(occurr)-8.6(ing)-431.5(after)-437(a)-433.7(natur)-8.2(al)]TJ
-12.7298 -1.0527 TD
[(allergen)-332.3(chall)-9.4(enge.)]TJ
1.0015 -1.0471 TD
[(In)-310.4(co)20.8(nc)15.1(lu)18.9(si)17.7(on)15.5(,)-313.4(t)0(h)18.9(e)-319.8(ex)20.8(pi)13.2(ra)19.2(to)18.9(ry)-310.4(ni)18.9(tr)17.3(ic)-311.6(ox)21.2(id)18.9(e)-319.8(f)0(r)18(a)0(c)14.7(t)0(i)22.2(o)0(n)-308.8(m)0(e)12(a)0(-)]TJ
-1.0015 -1.0528 TD
[(su)20(re)13.5(me)17.7(nt)-345.3(wa)16.9(s)-354.8(w)12.4(el)12.8(l)-350.3(a)0(c)14.7(c)0(e)20.4(p)0(t)13.2(e)0(d)-343.4(b)0(y)-343(t)0(h)18.9(e)-354(ch)15.1(il)22.2(dr)14(en)-343.4(wh)17.3(o)-353.6(p)0(a)15.1(r)0(t)17.3(i)0(c)18.4(i)0(-)]TJ
0 -1.0471 TD
[(pa)15.1(te)18.4(d)-495.8(i)0(n)-487.6(t)0(h)18.9(e)-496.3(st)17.7(ud)15.5(y)73.2(,)-495.5(an)15.1(d,)-484.8(fr)12.4(om)-488.4(th)18.9(e)-496.3(p)0(r)19.6(e)0(s)13.9(e)0(n)20.8(t)-498.2(re)13.5(su)20(lt)16.5(s,)-486(it)-490(is)]TJ
0 -1.0527 TD
[(te)18.4(mp)18.1(ti)16.5(ng)-331.6(t)13.9(o)-336.5(sp)14.4(ec)20.4(ul)18.9(at)12.8(e)-336.9(t)0(h)18.9(a)0(t)-328.7(e)0(x)20.8(p)0(i)18.9(r)0(a)13.5(t)0(o)18.9(r)0(y)-327.5(n)0(i)18.9(t)0(r)17.3(i)0(c)-328.7(o)0(x)15.5(i)0(d)18.9(e)-336.9(fr)18(ac)20.4(ti)16.5(on)]TJ
0 -1.0471 TD
[(ma)17.7(y)-330.8(p)0(r)19.6(o)0(v)15.5(i)0(d)18.9(e)-331.2(cl)18.5(in)18.9(ic)12.8(al)-317.3(in)13.2(fo)19.6(rm)16.5(at)18.4(io)18.9(n)-330.8(w)0(h)17.3(i)0(c)18.4(h)-330.8(wo)17.3(ul)13.2(d)-325.1(n)0(o)15.5(t)-327.5(be)-320.6(re)13.5(-)]TJ
0 -1.0528 TD
[(ve)15.1(al)18.5(ed)-366.1(by)-371.4(ro)19.6(ut)18.9(in)13.2(e)-376.8(l)0(u)18.9(n)0(g)-371.4(f)0(u)19.6(n)0(c)15.1(t)0(i)22.2(o)0(n)-371.4(t)0(e)18.4(s)0(t)17.7(i)0(n)18.9(g)0(.)-371(F)11.4(ur)13.9(th)18.9(er)19.2(mo)12.4(re)19.2(,)-376(b)0(y)]TJ
0 -1.0471 TD
[(me)17.7(an)15.1(s)-462.9(o)0(f)-452.7(t)0(h)18.9(i)0(s)-454.7(t)0(e)18.4(c)0(h)15.1(n)0(i)18.9(q)0(u)15.5(e)0(,)-451.1(i)0(t)-455.8(h)0(a)15.1(s)-462.9(be)20.8(en)-457.2(de)20.8(mo)18.1(ns)14.4(tr)17.3(at)18.4(ed)-451.5(th)13.2(at)]TJ
0 -1.0528 TD
[(in)18.9(ha)15.1(le)18.4(d)-222.7(f)0(l)17.3(u)0(n)21.2(i)0(s)17.7(o)0(l)13.2(i)13.9(de)-212.5(is)-215.7(ef)30.6(fe)13.5(ct)18.5(iv)18.9(e)-223.1(i)0(n)-214.5(p)0(r)19.6(e)0(v)20.8(e)0(n)15.1(t)0(i)16.5(n)0(g)-212.1(t)0(h)18.9(e)-223.1(in)18.9(cr)19.2(ea)14.7(se)-213.7(in)]TJ
0 -1.0471 TD
[(ai)18.4(rw)15.7(ay)-548.2(in)13.2(fl)17.3(am)17.7(ma)17.7(ti)16.5(on)-547.8(in)-550.2(al)12.8(le)18.4(r)20.4(g)0(i)18.9(c)-558.8(as)13.9(th)18.9(ma)17.7(ti)16.5(c)-558.8(c)0(h)15.1(i)0(l)16.5(d)0(r)19.6(e)0(n)-548.2(r)0(e)13.5(-)]TJ
0 -1.0527 TD
[(ex)15.1(po)21.2(se)13.9(d)-245.5(t)0(o)-242.9(a)0(l)18.5(l)0(e)18.4(r)14.7(ge)20.8(ns)20(,)-250.8(e)0(v)15.1(e)0(n)-240.9(i)0(f)17.3(,)-245.1(fr)12.4(om)-238(th)18.9(is)-244.1(st)17.7(ud)15.5(y)73.2(,)-250.8(i)13.9(t)-253.5(is)-238.4(no)15.5(t)-247.8(p)0(o)15.5(s)0(-)]TJ
0 -1.0471 TD
[(si)17.7(bl)18.9(e)-587.3(t)0(o)-584.3(r)0(e)19.2(a)0(c)14.7(h)-586.9(fi)17.3(rm)-581(co)20.8(nc)15.1(lu)18.9(si)17.7(on)15.5(s)-588.1(r)0(e)19.2(g)0(a)15.1(r)0(d)19.6(i)0(n)18.9(g)-592.6(th)18.9(e)-587.3(c)0(l)18.4(i)0(n)18.9(i)0(c)12.8(a)0(l)]TJ
0 -1.0527 TD
[(si)17.7(gn)15.5(if)17.3(ic)18.4(an)20.8(ce)-303.9(of)-299(an)-303.5(in)18.9(cr)13.5(ea)20.4(se)-304.7(i)13.9(n)-313.7(ex)20.8(pi)13.2(ra)19.2(to)18.9(ry)-304.7(ni)18.9(tr)17.3(ic)-300.2(ox)15.5(i)13.9(d)0(e)-303.5(f)0(r)18(a)0(c)14.7(-)]TJ
0 -1.0471 TD
[(ti)16.5(on)-354.3(in)-356.7(th)18.9(e)-365.4(a)0(b)20.8(s)0(e)13.9(n)0(c)20.8(e)-365.4(of)-355.9(me)17.7(as)13.9(ur)19.6(em)17.7(en)15.1(ts)-352.2(of)-355.9(lu)13.2(ng)-354.3(fu)19.6(nc)15.1(t)13.9(i)0(o)13.2(n)-365(or)]TJ
0 -1.0528 TD
[(sy)20(mp)12.4(to)18.9(ms)16.9(.)]TJ
/F8 1 Tf
7.97 0 0 7.97 129.43 342.255 Tm
[(Acknowledgem)11.3(ents.)]TJ
/F3 1 Tf
8.55 0 TD
[(The)-429.3(authors)-429(wish)-431.6(to)-432.1(thank)]TJ
-9.5458 -1.1239 TD
[(M.)-501(Fano)-500.5(\(V)101.1(aleas,)-501.1(Milan,)-496.3(Italy\))-503.7(for)-499.1(the)-507.2(statistical)]TJ
T*
[(analysis)-450.7(and)-455(V)106.3(aleas)-452.4(for)-456.4(providin)11.9(g)-453.2(flunisolide)-449.1(and)]TJ
T*
[(the)-500.1(nitric)-498.8(oxide)-495.9(analyser)58.8(.)]TJ
/F6 1 Tf
8.966 0 0 8.966 151.257 272.409 Tm
[(Referenc)8.7(es)]TJ
/F3 1 Tf
-10.3696 -2.2762 TD
[(1.)-1766.5(Nathan)-349.9(RA,)-351.3(Kinsman)-359(RA,)-351.3(Spector)-352(SL,)-351.7(Horton)-351.4(DJ.)-354.1(Rel-)]TJ
2.5165 -1.1128 TD
[(ationship)-351.3(between)-355.5(airway)-357.2(response)-352.9(to)-355.5(aller)9.9(gens)-353(and)-352.3(non)]TJ
0 -1.1065 TD
[(specific)-596.5(bronchial)-595(reactivity)58.5(.)]TJ
/F4 1 Tf
12.4878 0 TD
[(J)-593.6(Aller)31.3(gy)-593.1(Clin)-595.5(Immunol)]TJ
/F3 1 Tf
-12.4878 -1.1128 TD
[(1979;)-328.6(64:)-336(491.)]TJ
-2.5165 -1.1128 TD
[(2.)-1766.5(Platts-Mills)-396.3(T)72.9(AE,)-394.4(T)60.2(ovey)-396.1(ER,)-395.8(Mitchell)-397.7(EB,)-395.8(Moszoro)-391.1(H,)]TJ
2.5165 -1.1128 TD
[(Nock)-481.6(P)103.1(,)-489.8(W)32.8(ilkins)-492.2(RS.)-485.7(Reduction)-485(of)-493.1(bronchial)-487.5(hyperre-)]TJ
0 -1.1065 TD
[(activity)-624.7(during)-619.9(prolonged)-624.5(aller)9.9(gen)-617.9(avoidance.)]TJ
/F4 1 Tf
20.1195 0 TD
(Lancet)Tj
/F3 1 Tf
-20.1195 -1.1128 TD
[(1982;)-328.6(ii:)-334.4(675\261678.)]TJ
-2.5165 -1.1128 TD
[(3.)-1766.5(Murray)-498.8(AB,)-496.8(Ferguson)-489.6(AC.)-503.1(Dust)-498(free)-505.3(bedroom)-498.6(in)-500.9(the)]TJ
2.5165 -1.1128 TD
[(treatment)-542.2(of)-537.4(asthmatic)-542.4(children)-545(with)-537.2(house)-542.2(dust)-539(mite)]TJ
0 -1.1065 TD
[(aller)9.9(gy:)-317(a)-309.1(controlled)-318.7(trial.)]TJ
/F4 1 Tf
10.5213 0 TD
(Pediatrics)Tj
/F3 1 Tf
4.3755 0 TD
[(1983;)-316(71:)-317(418\261422.)]TJ
-17.4133 -1.1128 TD
[(4.)-1766.5(Cockroft)-624.4(DW)87(,)-622.6(Murdock)-623.8(KY)127.2(.)-622.6(Comparative)-625.7(effects)-620.9(of)]TJ
2.5165 -1.1128 TD
[(inhaled)-323.2(salbutamol,)-336.3(sodium)-324.9(cromoglycate,)-332.3(and)-327(beclome-)]TJ
0 -1.1065 TD
[(thasone)-277.8(dipropionate)-286.1(on)-277.2(aller)9.9(gen-induced)-281.6(early)-284.9(asthmatic)]TJ
0 -1.1128 TD
[(responses,)-350.2(late)-350(asthmatic)-359(responses,)-350.2(and)-352.3(increased)-353.1(bron-)]TJ
27.9978 73.5671 TD
[(chial)-223.1(responsiveness)-221.6(to)-222.7(histamine.)]TJ
/F4 1 Tf
13.6069 0 TD
[(J)-220.6(Aller)24.9(gy)-220.1(Clin)-222.4(Immunol)]TJ
/F3 1 Tf
-13.6069 -1.1191 TD
[(1987;)-334.9(79:)-329.6(734\261740.)]TJ
-2.5165 -1.1065 TD
[(5.)-1766.5(Dutoit)-456.3(JI,)-453(Salome)-454.6(CM,)-449.9(W)70.8(oolcock)-453.6(AJ.)-455.3(Inhaled)-454.6(cortico-)]TJ
2.5165 -1.1192 TD
[(steroids)-503.3(reduce)-496.7(the)-500.2(severity)-501.9(of)-499.5(bronchial)-500.2(hyperrespon-)]TJ
0 -1.1128 TD
[(siveness)-229.1(in)-229(asthma)-229.6(but)-228.5(oral)-228.7(theophylline)-230.6(does)-226.6(not.)]TJ
/F4 1 Tf
19.7907 0 TD
[(Am)-227.1(Rev)]TJ
-19.7907 -1.1192 TD
[(Respir)-333.8(Dis)]TJ
/F3 1 Tf
4.622 0 TD
[(1987;)-334.9(136:)-335.5(1)32.1(174\2611)34.2(178.)]TJ
-7.1386 -1.1065 TD
[(6.)-1766.5(Jenkins)-557.4(CR,)-555.1(W)70.8(oolcock)-561.1(AJ.)-556.5(Effec)10.2(t)-558.3(o)0(f)-556.4(prednisone)-561.7(and)]TJ
2.5165 -1.1192 TD
[(beclomethasone)-448.5(dipropionate)-456.8(on)-447.9(airway)-452.1(responsiveness)]TJ
0 -1.1128 TD
[(in)-361.8(asthma:)-364.2(a)-366(comparative)-361.5(study)55.9(.)]TJ
/F4 1 Tf
13.3161 0 TD
(Thorax)Tj
/F3 1 Tf
3.2373 0 TD
[(1988;)-366.6(43:)-361.3(378\261)]TJ
-16.5534 -1.1191 TD
(384.)Tj
-2.5165 -1.1128 TD
[(7.)-1766.5(Juniper)-272.6(EF)74.8(,)-274.8(Kline)-270.9(P)84.1(A)0(,)-271.3(V)104.7(anzieleghem)-278.1(MA.)-271.4(Effec)10.2(t)-273.8(o)0(f)-271.8(long-)]TJ
2.5165 -1.1128 TD
[(term)-382.4(treatment)-390.4(with)-385.4(an)-378.1(inhaled)-386.5(corticosteroid)-384.2(\(budeson-)]TJ
0 -1.1192 TD
[(ide\))-216.1(on)-214(airway)-211.8(hyperresponsiveness)-219.8(and)-213.2(clinical)-213.4(asthma)-216.9(in)]TJ
0 -1.1128 TD
[(nonsteroid-dependent)-612.5(asthmatics.)]TJ
/F4 1 Tf
14.2266 0 TD
[(Am)-612.8(Rev)-614.8(Respir)-612(Dis)]TJ
/F3 1 Tf
-14.2266 -1.1192 TD
[(1990;)-334.9(142:)-329.1(832\261836.)]TJ
-2.5165 -1.1065 TD
[(8.)-1766.5(Boner)-217.9(AL,)-217.3(Piacentini)-223.6(GL,)-217.3(Bonizzato)-219.2(C,)-222.1(Dattoli)-217.7(V)123.6(,)-217.9(Sette)-221.7(L.)]TJ
2.5165 -1.1192 TD
[(Effec)10.2(t)-362.3(o)0(f)-360.4(inhaled)-361.2(beclomethasone)-366.3(dipropionate)-361.9(on)-359.4(bron-)]TJ
0 -1.1128 TD
[(chial)-374.8(hyperreactivity)-382.3(in)-374.4(asthmatic)-371.7(children)-380.6(during)-373.3(maxi-)]TJ
0 -1.1192 TD
[(mal)-331.3(allergen)-329.8(exposure.)]TJ
/F4 1 Tf
9.478 0 TD
[(Ped)-330.5(Pulmonol)]TJ
/F3 1 Tf
6.07 0 TD
[(1991;)-334.9(10:)-329.7(2\2615.)]TJ
-18.0646 -1.1065 TD
[(9.)-1766.5(Boner)-243.2(AL,)-242.6(Comis)-241.6(A,)-246(Schiassi)-241.5(M,)-243.4(V)104.7(enge)-244.1(P)103.1(,)-243.2(Piacentini)-242.6(GL.)]TJ
2.5165 -1.1192 TD
[(Bronchial)-252(reactivity)-257.6(in)-248(asthmatic)-257.9(children)-254.1(at)-247.7(high)-253.3(and)-251.2(low)]TJ
0 -1.1128 TD
[(altitude:)-240.8(ef)12.9(fect)-241.1(of)-233.9(budesonide.)]TJ
/F4 1 Tf
11.9882 0 TD
[(Am)-239.7(J)-233.2(Respir)-238.9(Crit)-236.3(Car)33.6(e)-239.5(Med)]TJ
/F3 1 Tf
-11.9882 -1.1192 TD
[(1995;)-334.9(151:)-329.1(1)32.1(194\2611200.)]TJ
-2.5165 -1.1128 TD
[(10.)-1266.5(Holgate)-446.6(ST)68.5(.)-445.5(Biomarkers)-449.1(of)-448.9(asthma.)]TJ
/F4 1 Tf
17.7042 0 TD
(Lancet)Tj
/F3 1 Tf
3.1425 0 TD
[(1998;)-448.8(351:)]TJ
-18.3301 -1.1128 TD
(1300\2611301.)Tj
-2.5165 -1.1128 TD
[(1)25.8(1)0(.)-1292.3(Alving)-295.9(K,)-296.5(W)70.8(eitzberg)-291.8(E,)-296.7(Lundber)12(g)-296.7(JM.)-294.6(Increased)-301.1(amount)]TJ
2.5165 -1.1128 TD
[(of)-309.8(nitric)-308.3(oxide)-309.4(in)-311.2(exhaled)-308(air)-311.4(of)-309.8(asthmatics.)]TJ
/F4 1 Tf
17.6915 0 TD
[(Eur)-313(Respir)-308.5(J)]TJ
/F3 1 Tf
-17.6915 -1.1192 TD
[(1993;)-334.9(6:)-330.2(1368\2611370.)]TJ
-2.5165 -1.1128 TD
[(12.)-1266.5(Kharitonov)-250.3(SA,)-244(Y)92(ates)-241.4(DH,)-248.7(Robins)-245.5(RA,)-243.8(Logan)-247.3(Sinclair)-248.8(R,)]TJ
2.5165 -1.1128 TD
[(Shinebourne)-495.4(EA,)-495.5(Barnes)-496.5(PJ.)-494.9(Increased)-497.1(nitric)-498(oxide)-492.8(in)]TJ
0 -1.1191 TD
[(exhaled)-257.4(air)-254.5(of)-259.2(asthmatic)-257.9(patients.)]TJ
/F4 1 Tf
13.3161 0 TD
(Lancet)Tj
/F3 1 Tf
2.9528 0 TD
[(1994;)-252.8(343:)-259.6(133\261)]TJ
-16.2688 -1.1128 TD
(135.)Tj
-2.5165 -1.1128 TD
[(13.)-1266.5(Kharitonov)-231.3(SA,)-225.1(Barnes)-231(PJ.)-223(Exhaled)-229.5(nitric)-232.5(oxide:)-229.1(a)-226.9(marker)]TJ
2.5165 -1.1128 TD
[(of)-290.8(airway)-287.7(inflammation?)]TJ
/F4 1 Tf
10.1356 0 TD
[(Curr)-289.6(Opin)-288.2(Anesthesiol)]TJ
/F3 1 Tf
9.3516 0 TD
[(1996;)-290.7(9:)]TJ
-19.4872 -1.1192 TD
(542\261548.)Tj
-2.5165 -1.1065 TD
[(14.)-1266.5(Kharitonov)-484.2(SA,)-484.3(Y)92(ates)-488(DH,)-489(Fan)-483.7(Chung)-482.7(K,)-486.2(Barnes)-483.9(PJ.)]TJ
2.5165 -1.1192 TD
[(Changes)-482.4(in)-488.2(the)-481.2(dose)-485.8(of)-480.5(inhaled)-487.6(steroid)-483.7(affect)-474.8(exhaled)]TJ
0 -1.1128 TD
[(nitric)-485.4(oxide)-480.2(levels)-489.3(in)-481.9(asthmatic)-485.5(patients.)]TJ
/F4 1 Tf
17.3437 0 TD
[(Eur)-483.7(Respir)-485.5(J)]TJ
/F3 1 Tf
-17.3437 -1.1192 TD
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