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BT
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0.0207 Tc
[(Treatment)-333(of)-333(chronic)-334(sarcoidosis)-334(with)-332.7(an)-332.7(azathioprine/)]TJ
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[(prednisolone)-334.1(regimen)]TJ
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0 Tc
[(J.)-331.2(Mu)]TJ
2.0486 0 TD
[(\310)-111.9(ller-Quernheim)]TJ
/F3 1 Tf
7.02 0 TD
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(*)Tj
/F2 1 Tf
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[(,)-334.6(K)0(.)-330.8(Kienast)]TJ
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(#)Tj
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[(,)-334.6(M)0(.)-329.3(Held)]TJ
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(#)Tj
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/F5 1 Tf
23.4833 0 TD
(#)Tj
/F4 1 Tf
0.999 0 TD
[(ERS)-334.2(Journals)-335.6(Ltd)-334.6(1999.)]TJ
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T*
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T*
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T*
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0 -1.0496 TD
[(pred)11.6(nisolone-sparing)-337.6(treatment.)]TJ
0.999 -1.0559 TD
[(In)-314.9(an)-313.7(open)-311.1(study)47.5(,)-312.7(the)-313.9(course)-318.5(of)-309.8(1)51.1(1)-315.7(patients)-314.5(with)-319.3(chron)12.2(ic)-317.3(sar)13.2(coidosis)-317.6(was)-312.8(analysed.)]TJ
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[(In)-226.4(an)-225.2(induction)-222.9(phase,)-226.1(2)-227.1(m)0(g)-220.8(azathioprine)]TJ
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(.)Tj
/F6 1 Tf
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[(kg)-225.2(body)-222.8(weight)-229.6(\(BW\))]TJ
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(-1)Tj
/F7 1 Tf
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(.)Tj
/F6 1 Tf
0.2719 -0.2213 TD
(day)Tj
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(-1)Tj
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[(in)-227.6(combination)]TJ
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[(kg)-433.9(BW)]TJ
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(-1)Tj
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(-1)Tj
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[(were)-430.5(administere)8.1(d)-440.7(with)-439.5(pred)11.6(nisolone)]TJ
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[(being)-211.8(reduced)-206.3(to)-214.9(0.1)-210.6(mg)]TJ
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9.9586 0.2213 TD
(.)Tj
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[(kg)-212.6(BW)]TJ
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[(22-month)-444.4(maintenance)-448.5(phase)-450.8(with)-445.8(2)-442.1(m)0(g)-448.4(azathioprine)]TJ
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23.5718 0.2213 TD
(.)Tj
/F6 1 Tf
0.2719 -0.2213 TD
[(kg)-446.5(BW)]TJ
6.725 0 0 5.977 300.246 536.031 Tm
(-1)Tj
/F7 1 Tf
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(.)Tj
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(day)Tj
6.725 0 0 5.977 326.098 536.031 Tm
(-1)Tj
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[(and)-444.6(0.1)-444.5(mg)]TJ
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[(pred)11.6(nisolone)]TJ
/F7 1 Tf
5.4377 0.2213 TD
(.)Tj
/F6 1 Tf
0.2719 -0.2213 TD
[(kg)-503.4(BW)]TJ
6.725 0 0 5.977 138.161 526.564 Tm
(-1)Tj
/F7 1 Tf
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(.)Tj
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0.7777 -0.2213 TD
(day)Tj
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(-1)Tj
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[(bronc)12.2(hoalveolar)-339.2(lavage)-334.2(\(BAL\))-334.6(wer)11.3(e)-334.4(analysed.)]TJ
0.999 -1.0559 TD
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[(physiological,)-395.9(serological)-394.1(and)-394(radiographic)-398.4(findings)-396.9(without)-393.2(suffering)-402.3(from)-384.9(serious)]TJ
T*
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T*
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T*
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T*
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T*
[(of)-335.1(cytokine)-331.1(release)-327.9(was)-331.8(suppressed.)]TJ
0.999 -1.0559 TD
[(This)-396.9(preliminary)-390.5(study)-401.4(suggests)-397.2(that)-396.8(azathioprine)-399.3(may)-397.3(be)-395.7(effective)-404.5(as)-392.2(a)-397.9(cortico-)]TJ
-0.999 -1.0559 TD
[(steroid-spa)8.5(ring)-289.6(agent)-287.6(in)-290.8(long-term)-289.2(therapy)-291.3(of)-290.8(sar)13.2(coidosis,)-288.9(but)-293.8(a)-284(much)-292.5(larger)-289.5(study)-287.6(is)]TJ
T*
[(necessary)-336.9(to)-335.1(give)-328.9(the)-339.2(definitive)-335.8(answer)82.6(.)]TJ
/F4 1 Tf
T*
[(Eur)-331.9(Respir)-333.8(J)-334.4(1999;)-333.5(14:)-334.6(1)70(1)76.4(17\2611)71.6(122.)]TJ
/F3 1 Tf
7.97 0 0 7.97 401.499 637.171 Tm
[(*Research)-445.4(Centre)-455(Borstel,)-449.3(Medical)-448.5(Hos-)]TJ
0 -1.067 TD
[(pital,)-506.7(Borstel,)-506.2(Germany)70.7(.)]TJ
5.977 0 0 5.313 485.064 632.239 Tm
(#)Tj
7.97 0 0 7.97 488.012 628.668 Tm
[(Third)-506.9(Dept)-507.6(of)]TJ
-10.8546 -1.0599 TD
[(Medicine,)-388.4(Pulmonary)-393.3(Division,)-391.3(Johannes)]TJ
T*
[(Gutenber)20.9(g-University)64.8(,)-660.5(Mainz,)-663.6(Germany)70.7(.)]TJ
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(+)Tj
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[(Ruhrlandklinik,)-786.7(Dept)-792.1(of)-792.7(Pneumolog)12.4(y)]TJ
-0.4197 -1.0599 TD
[(and)-327(Aller)11.2(gy)68.2(,)-333.3(Essen,)-326.8(Germany)63.6(.)]TJ
0 -2.1268 TD
[(Corresponde)11.8(nce:)-333.4(J.)-325.3(Mu)]TJ
8.9768 -0.0213 TD
(\310)Tj
0.4054 0.0213 TD
[(ller)11.6(-Quernheim)]TJ
-9.3822 -1.0599 TD
[(Medical)-327.5(Hospital)]TJ
0 -1.067 TD
[(Research)-326.6(Centre)-327(Borstel)]TJ
0 -1.0599 TD
[(Parkallee)-328.3(35)]TJ
T*
[(23845)-323.8(Borstel)]TJ
0 -1.067 TD
(Germany)Tj
0 -1.0599 TD
[(Fax:)-325.1(49)-330.1(4537188313)]TJ
0 -2.1268 TD
[(Keywords)11.5(:)-334.6(Azathioprine)]TJ
0 -1.0599 TD
[(bronchoalv)13.4(eolar)-331.5(lavage)]TJ
0 -1.067 TD
(prednisolone)Tj
0 -1.0599 TD
(sarcoidosis)Tj
T*
[(tumour)-324.6(necrosis)-327.5(factor)11.9(-)]TJ
/F8 1 Tf
9.3467 0 TD
(a)Tj
/F3 1 Tf
-9.3467 -2.1268 TD
[(Received:)-327.9(Februar)11.5(y)-332.2(2)0(4)-330.1(1999)]TJ
0 -1.0599 TD
[(Accepted)-325.4(after)-331.6(revision)-329.8(June)-326.1(30)-330.1(1999)]TJ
0 -2.1268 TD
[(This)-211.3(study)-206.5(was)-209.8(supported)-204.3(in)-211.6(part)-213.7(by)-209.2(a)-217.4(grant)]TJ
0 -1.0599 TD
[(from)-604(the)-599.7("Deutsche)-597.4(Forschung)13.7(sgemein-)]TJ
0 -1.067 TD
[(schaft",)-328.9(No.)-324.4(MU)-331.7(692/3-3.)]TJ
9.963 0 0 9.963 68.258 382.79 Tm
[(Co)16.5(rt)17.3(ic)18.4(os)14.4(te)18.4(ro)19.6(id)18.9(s)-468.6(s)0(t)17.7(i)0(l)16.5(l)-469.8(pr)14(ov)21.2(id)18.9(e)-467.8(t)0(h)13.2(e)-467.8(pr)19.6(in)18.9(ci)12.8(pa)20.8(l)-469.8(t)0(h)18.9(e)0(r)13.5(a)0(p)20.8(y)-467.4(fo)13.9(r)]TJ
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0 -1.0471 TD
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0 -1.0528 TD
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T*
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T*
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T*
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T*
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T*
[(14)15.5(%)-441.3(o)0(f)-429.9(t)0(h)18.8(e)-439.3(pa)15.1(ti)16.5(en)20.8(ts)-431.9(su)20(f)14.7(f)0(e)19.2(r)0(e)19.2(d)-444.6(fr)18(om)-431.5(re)19.2(la)18.4(ps)14.4(es)-429.9([1)19.6(].)-452.3(Studi)-7.8(es)]TJ
T*
[(analys)-9(ing)-385.9(the)-386.3(course)-389.4(of)-384.4(the)-386.3(disease)-392.6(after)-385.8(corti)-10.6(costeroids)]TJ
T*
[(have)-265.6(been)-259.9(taper)-8.6(ed)-263.7(off)-250.2(report)-266.6(relap)-8.6(ses)-261.2(requi)-8.2(ring)-263.1(therapy)-266.2(in)]TJ
T*
[(14%)-448.5([1],)]TJ
/F8 1 Tf
4.1143 0 TD
(>)Tj
/F3 1 Tf
0.552 0 TD
[(25%)-448.5([2])-443.7(a)-6.9(n)0(d)-445.4(u)0(p)-445.4(t)0(o)-442.1(74%)-448.5([3])-449.3(of)-447(patients.)-453.8(In)]TJ
-4.6662 -1.0527 TD
[(treating)-271.7(relapses)-269.7(after)-266.3(predni)-9(solone)-264.6(thera)-8.6(py)-263.3(cytotoxic)-270.9(and)]TJ
0 -1.0471 TD
[(non-cyt)-9.7(otoxic)-447.9(agents)-452.8(such)-442.8(as)-447(chlor)-8.2(ambuc)-7.8(il)-444.5([4],)-444(met)-8.2(ho-)]TJ
0 -1.0527 TD
[(trexa)-8.6(te)-277.5([5],)-284.7(cyclospori)-10.3(ne)-280.8(A)-277.8([6,)-282.3(7],)-276.6(azathi)-10.6(oprine)-282.1([7\2619],)-286.2(cy-)]TJ
T*
[(clopho)-7.4(spham)-8.6(ide)-431.9([10],)-439.1(melatoni)-11.5(n)-427.6([)0(1)25.3(1],)-430.3(thal)-8.2(idomide)-440.4([12])]TJ
T*
[(and)-355.5(pentoxifyl)-11.1(line)-355.3([13])-353.4(have)-351(bee)-8.8(n)-347.9(emplo)-9.7(yed.)-350.2(The)-353.9(effect)]TJ
T*
[(of)-424.2(these)-435(drugs)-427.7(on)-422.6(the)-431.9(prognos)-8.1(is)-426.2(of)-424.2(sarcoid)-11.3(osis)-423.2(ha)-7.6(s)-423.1(not)]TJ
T*
[(been)-351(adequat)-8.9(ely)-346.5(evalua)-8.2(ted)-346.5(and)-349.8(at)-351.4(present)-352.7(such)-346.1(thera)-8.6(pies)]TJ
T*
[(shoul)-7.4(d)-330.8(b)0(e)-337.7(conside)-9.7(red)-334.3(experi)-9.4(mental.)]TJ
1.0015 -1.0471 TD
[(Pa)15.9(ti)16.5(en)20.8(ts)-295.3(wi)14.9(t)13.9(h)-302.4(re)13.5(la)18.4(ps)20(es)-293.3(fr)18(eq)15.1(ue)15.1(nt)18.9(ly)-288.4(re)13.5(qu)21.2(ir)17.3(e)-302.8(l)0(o)18.9(n)0(g)15.5(-)0(t)17.3(e)0(r)19.2(m)-305.5(co)15.1(r)20.4(-)]TJ
-1.0015 -1.0528 TD
[(ti)16.5(co)20.8(st)17.7(er)13.5(oi)18.9(d)-507.2(t)0(h)13.2(e)0(r)19.2(a)0(p)20.8(y)-512.9([1)19.6(4])-509.6(and)-520.5(to)-521.7(enable)-526(the)-522.9(dose)-522.5(to)-521.7(be)]TJ
T*
[(lowered)-327(when)-326.1(unaccept)-10.1(ably)-324.5(high)-324.1(doses)-325.3(have)-322.5(to)-322.6(be)-320.6(used,)]TJ
T*
[(corticost)-11.9(eroid)-8.2(-sparing)-462.8(co)-7.6(mbinations)-469.1(have)-459.1(be)-7.6(en)-457.2(appli)-9(ed.)]TJ
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[(mo)18.1(nt)18.9(h)-387.7(i)0(n)18.9(t)0(e)18.4(r)0(v)13.9(a)0(l)18.5(s)-383.2(af)13.5(te)18.4(r)-383.6(d)0(i)18.9(s)0(c)13.9(o)0(n)21.2(t)0(i)16.5(n)0(u)15.5(a)0(t)18.4(i)0(o)18.9(n)-387.7(of)-373(th)18.9(er)13.5(ap)20.8(y)67.5(.)-381.7(Ev)17.1(al)18.4(ua)15.1(-)]TJ
0 -1.0528 TD
[(ti)16.5(on)-513.7(in)18.9(cl)18.4(ud)15.5(ed)20.8(:)-526.7(p)0(o)21.2(s)0(t)17.7(e)0(r)13.5(i)0(o)18.9(r)0(a)19.2(n)0(t)18.9(e)0(r)13.5(i)0(o)18.9(r)-520.2(an)15.1(d)-524.3(l)0(a)18.4(t)0(e)18.4(r)0(a)19.2(l)-526.7(ch)20.8(es)13.9(t)-521(r)0(a)19.2(d)0(i)13.2(o)0(-)]TJ
0 -1.0471 TD
[(gr)19.6(ap)15.1(hs)20(,)-142.6(p)0(u)15.5(l)0(m)15.7(o)0(n)21.2(a)0(r)13.5(y)-143(fu)19.6(nc)15.1(ti)16.5(on)-132.4(te)18.4(st)17.7(s,)-138.9(ar)19.2(te)18.4(ri)17.3(al)-135.2(bl)18.9(oo)15.5(d)-143(g)0(a)15.1(s)-144.2(an)20.8(al)18.5(ys)14.4(es)]TJ
0 -1.0528 TD
[(at)-368.5(re)13.5(st)-369.3(an)20.8(d)-376.3(e)0(x)15.1(e)0(r)19.2(c)0(i)12.8(s)0(e)19.6(,)-376(bl)18.9(oo)15.5(d)-376.3(c)0(h)15.1(e)0(m)17.7(i)0(s)17.7(t)0(r)17.3(y)-376.3(pr)14(of)19.6(il)16.5(es)19.6(,)-381.6(s)0(e)19.6(r)0(u)19.6(m)-379.5(an)15.1(-)]TJ
0 -1.0471 TD
[(gi)18.9(ot)18.9(en)15.1(si)17.7(n)-467.4(c)0(o)20.8(n)0(v)15.5(e)0(r)19.2(t)0(i)16.5(n)0(g)-456.8(e)0(n)15.1(z)0(y)20.8(m)0(e)-460.3(\()0(A)15.7(C)0(E)18.1(\))-469(te)18.4(st)17.7(s,)-457.6(an)20.8(d)-467.4(i)0(n)-459.2(c)0(a)20.4(s)0(e)13.9(s)]TJ
0 -1.0527 TD
[(tr)17.3(ea)14.7(te)18.4(d)-239.8(a)0(t)-231.9(t)0(h)18.8(e)-245.9(cl)18.4(in)18.9(ic)-231.9(of)-230.7(th)13.2(e)-240.2(U)0(n)17.3(i)0(v)18.9(e)0(r)19.2(s)0(i)17.7(t)0(y)-237.2(o)0(f)-230.7(M)0(a)18.9(i)0(n)18.9(z)0(,)-234.9(s)0(e)19.6(r)0(u)13.9(m)-242.9(te)18.4(st)17.7(s)]TJ
T*
[(fo)19.6(r)-338.1(s)0(o)20(l)0(u)18.9(b)0(l)18.9(e)-336.9(in)18.9(te)18.4(rl)17.3(eu)15.1(ki)18.9(n-)19.6(2)-336.5(r)0(e)19.2(c)0(e)20.4(p)0(t)13.2(o)0(r)-321.8(\()0(s)18.4(I)0(L)15.5(-)0(2)19.6(R)0(\))-326.5(a)0(n)15.1(d)-330.8(ne)15.1(op)21.2(te)18.4(ri)17.3(n.)]TJ
0 -1.0471 TD
[(In)-384.4(ad)20.8(di)18.9(ti)16.5(on)15.5(,)-387.3(B)0(A)18.3(L)-391.8(wa)16.9(s)-394.6(p)0(e)20.8(r)0(f)18(o)0(r)14(m)0(e)17.7(d)-387.7(in)-385.2(co)20.8(op)15.5(er)19.2(at)18.4(iv)18.8(e)-393.8(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)]TJ
0 -1.0528 TD
[(be)15.1(fo)19.6(re)-282.4(st)17.7(ar)19.2(ti)16.5(ng)-280.4(th)18.9(er)19.2(ap)15.1(y)-285.3(a)0(n)15.1(d)-285.3(af)13.5(te)18.4(r)-286.9(t)0(e)12.8(r)0(m)16.5(i)0(n)18.9(a)0(t)18.4(i)0(n)18.9(g)-291(th)18.9(e)-285.7(i)0(n)13.2(d)0(u)21.2(c)0(t)18.4(i)0(o)13.2(n)]TJ
0 -1.0471 TD
[(ph)15.5(as)19.6(e.)-331.6(B)11.6(A)0(L)-333.9(c)0(e)20.4(l)0(l)16.5(s)-337.7(we)11.2(re)-327.9(us)20(ed)-332(to)-328.3(pe)15.1(rf)18(or)13.9(m)-339.7(s)0(e)19.6(v)0(e)15.1(r)0(a)19.2(l)-338.9(im)15.7(mu)18.1(no)15.5(-)]TJ
0 -1.0527 TD
[(lo)18.9(gi)18.9(ca)14.7(l)-321.8(t)0(e)12.8(s)0(t)17.7(s)-320.6(\(s)18.4(ee)-321(be)20.8(lo)18.9(w\))15.7(.)]TJ
1.0015 -1.0471 TD
[(Th)17.1(e)-524.7(i)0(n)13.2(d)0(u)21.2(c)0(t)18.4(i)0(o)13.2(n)-524.3(ph)21.2(as)14(e)-524.7(w)0(a)16.9(s)-525.5(co)15.1(ns)20(id)13.2(er)19.2(ed)-519.8(ef)30.6(fe)19.2(ct)12.8(iv)18.8(e)-524.7(w)0(h)17.3(e)0(n)]TJ
-1.0015 -1.0527 TD
[(sy)20(mp)12.4(to)18.9(ms)-409.9(va)20.8(ni)13.2(sh)20(ed)-406(or)-412.8(im)21.4(pr)14(ov)21.2(ed)-411.7(an)20.8(d/)13.2(or)-407.2(VC)-408.5(or)-407.2(ex)15.1(er)19.2(ci)12.8(se)]TJ
0 -1.0471 TD
[(te)18.4(st)17.7(s)-229.6(i)13.9(mp)12.4(ro)19.6(ve)15.1(d.)-211.7(Af)15.7(te)18.4(r)-230(a)-223.1(st)17.7(ab)15.1(le)-214.9(re)19.2(mi)15.7(ss)18.9(io)13.2(n)-222.7(w)0(a)16.9(s)-223.9(re)13.5(ac)20.4(he)15.1(d)-222.7(m)0(a)12(i)0(n)18.9(-)]TJ
0 -1.0528 TD
[(te)18.4(na)15.1(nc)20.8(e)-649.9(t)0(h)18.9(e)0(r)19.2(a)0(p)15.1(y)-643.8(la)12.8(st)17.7(in)18.9(g)-643.8(2)0(1)15.5(\261)0(2)21.2(2)-649.5(mo)18.1(nt)18.9(hs)-640.1(wa)16.9(s)-645(i)0(n)18.9(t)0(e)12.8(n)0(d)21.2(e)0(d)15.1(,)]TJ
0 -1.0471 TD
[(al)18.4(th)18.9(ou)15.5(gh)-200.7(tw)14.9(o)-211.3(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)-198.6(t)0(e)12.8(r)0(m)16.5(i)0(n)18.9(a)0(t)18.4(e)0(d)-201.1(t)0(h)18.9(i)0(s)-204.3(p)0(h)15.5(a)0(s)19.6(e)-211.7(pr)19.6(em)12(at)18.4(ur)19.6(el)18.4(y)67.5(,)-210.9(as)]TJ
0 -1.0527 TD
[(st)17.7(at)18.4(ed)-314.9(pr)13.9(ev)20.8(io)18.9(us)14.4(ly)81.4(.)]TJ
/F4 1 Tf
0 -3.3517 TD
[(Br)27.3(onchoal)-8.1(veolar)-339(lavage)-337.8(and)-338(immun)-8.4(obiologic)-8.7(al)-334(tests)]TJ
0 -2.0998 TD
[(Reage)-8.7(nts.)]TJ
/F3 1 Tf
4.4272 0 TD
[(Ad)17.3(he)15.1(si)17.7(on)-519.4(sl)17.7(id)18.9(es)-515.3(we)16.9(re)-521.4(ob)15.5(t)13.9(a)0(i)12.8(n)0(e)20.8(d)-530(fr)18(om)-516.8(Bi)14.1(or)19.6(ad)]TJ
-4.4272 -1.0528 TD
[(\(M)17.7(un)15.5(ic)18.4(h,)-445(Ge)16.9(rm)16.5(an)20.8(y\))-447(an)15.1(d)-450.3(t)0(h)18.9(e)-456.4(an)20.8(ti)16.5(bo)15.5(di)18.9(es)-441.3(fo)13.9(r)-451.9(i)0(m)15.7(m)0(u)18.1(n)0(o)15.5(p)0(e)20.8(r)14.7(-)]TJ
0 -1.0471 TD
[(ox)15.5(id)18.8(as)19.6(e-)13.5(st)17.7(ai)18.5(ni)18.9(ng)-439.7(w)12.4(e)0(r)13.5(e)-445(pu)15.5(rc)19.2(ha)15.1(se)19.6(d)-450.3(f)0(r)18(o)0(m)-437.2(O)0(r)15.7(t)0(h)18.9(o)-450.3(D)12.4(i)0(a)12.8(g)0(n)21.2(o)0(s)14.4(t)0(i)16.5(c)]TJ
0 -1.0528 TD
[(S)11.4(y)0(s)14.4(t)0(e)18.4(m)0(s)-148.1(\()0(N)15.7(e)0(c)14.7(k)0(a)20.8(r)14.7(ge)20.8(mu)]TJ
8.2854 -0.0171 TD
0 Tw
(\310)Tj
0.3983 0.0171 TD
[(nd)21.2(,)-159.7(G)0(e)16.9(r)0(m)16.5(a)0(n)20.8(y)0(\))14(.)-444.2(Br)14.9(om)18.1(od)21.2(eo)15.1(xy)15.5(ur)19.6(id)18.9(in)18.9(e,)]TJ
-8.6838 -1.0471 TD
[(de)15.1(ox)21.2(yc)15.1(yt)18.9(id)18.9(in)18.9(e,)-360.1(ph)15.5(yt)18.9(oh)15.5(ae)20.4(ma)17.7(gg)15.5(lu)18.9(ti)16.5(ni)18.9(ne)-360.4(\(P)14.7(HA)19.1(\),)-150.7(ph)15.5(or)19.6(bo)15.5(l)13.9(m)0(y)12.4(-)]TJ
0 -1.0528 TD
[(ri)17.3(st)17.7(at)18.4(e)-348.3(a)0(c)20.4(e)0(t)12.8(a)0(t)18.5(e)-342.6(\(P)14.7(MA)15.4(\))-343.8(a)0(n)15.1(d)-342.2(li)16.5(po)21.2(po)15.5(ly)18.9(sa)13.9(cc)20.4(ha)15.1(ri)17.3(de)-337.7(\(L)21.2(PS)17.1(\))-343.8(w)0(e)16.9(r)0(e)]TJ
0 -1.0471 TD
[(pu)15.5(rc)19.2(ha)15.1(se)19.6(d)-552.8(f)0(r)18(o)0(m)-545.3(S)11.4(ig)18.9(ma)-153(\(S)14.7(t)13.9(.)-159.7(Lo)17.1(ui)18.9(s,)-542.9(MO)15.3(,)-552.4(U)0(S)18.1(A)0(\))15.7(.)-552.4(R)11.6(o)0(s)14.4(w)0(e)16.9(l)0(l)]TJ
0 -1.0527 TD
[(P)11.4(a)0(r)13.5(k)-376.3(Me)18.9(mo)12.4(ri)17.3(al)-368.5(In)19.6(st)17.7(it)16.5(ut)18.9(e)-376.7(m)0(e)17.7(d)0(i)13.2(u)0(m)-368.9(\()0(R)20.6(P)0(M)14.4(I)0(\))-368.9(1)0(6)21.2(4)0(0)-371.4(f)0(r)18(o)0(m)-368.9(S)11.4(e-)]TJ
0 -1.0471 TD
[(ro)19.6(me)12(d)-638.1(\()0(B)14.9(e)0(r)19.2(l)0(i)16.5(n)0(,)-627.1(G)0(e)16.9(r)0(m)16.5(a)0(n)15.1(y)0(\))19.6(;)]TJ
6.974 0 0 6.974 173.82 434.891 Tm
(L)Tj
9.963 0 0 9.963 177.959 434.891 Tm
[(-g)13.9(lu)18.9(ta)18.4(mi)15.7(ne)15.1(,)-637.7(p)0(e)20.8(n)0(i)13.2(c)0(i)18.4(l)0(l)16.5(i)0(n)-629.9(a)0(n)20.8(d)]TJ
-12.0127 -1.0527 TD
[(st)17.7(re)19.2(pt)13.2(om)18.1(yc)20.8(in)-658.3(fr)18(om)-659.1(Gi)14.9(bc)20.8(o)-666.6(\()0(G)15.7(r)0(a)19.2(n)0(d)-661.6(I)0(s)18.4(l)0(a)18.4(n)0(d)15.5(,)-660.5(NY)138.6(,)-666.2(U)12.4(SA)12.4(\);)]TJ
0 -1.0471 TD
[(fo)19.6(et)12.8(al)-379.9(ca)14.7(lf)-381.1(se)19.6(ru)13.9(m)-390.9(\()0(F)14.7(C)11.6(S\))-383.6(fr)18(om)-385.9(V)57.9(i)0(t)16.5(r)0(o)19.6(m)0(e)17.7(x)-393.4(\(V)66.9(i)13.9(l)0(s)12(h)0(o)21.2(f)0(e)19.2(n)0(,)-382.4(G)0(e)16.9(r)14.7(-)]TJ
0 -1.0528 TD
[(ma)17.7(ny)15.5(\))-605.6(a)0(n)15.1(d)-604(hu)15.5(ma)17.7(n)-604(b)0(l)13.2(o)0(o)21.2(d)-609.7(gr)19.6(ou)15.5(p)-604(A)0(B)-602(s)0(e)19.6(r)0(u)13.9(m)-607.1(fr)18(om)-596.5(th)13.2(e)]TJ
0 -1.0471 TD
[(Bl)14.1(oo)21.2(d)-683.6(B)0(a)16.1(n)0(k)-673(L)0(u)17.1(e)0(t)18.4(j)0(e)18.4(n)0(s)14.4(e)0(e)20.4(,)-683.3(Ge)16.9(rm)16.5(an)15.1(y)73.2(.)-683.2(Th)17.1(e)-684(c)0(y)20.8(t)0(o)18.9(t)0(o)13.2(x)0(i)18.9(c)-684(T)91.9(-)]TJ
0 -1.0527 TD
[(ly)18.9(mp)18.1(ho)15.5(cy)15.1(te)-419.7(li)16.5(ne)-417.3(\(C)14.9(TL)18.7(L\))-422.7(ce)14.7(ll)-421.7(li)16.5(ne)-417.3(as)-424.2(bi)18.9(oi)18.9(nd)15.5(ic)18.4(at)18.4(or)-424.2(of)-418.5(in)13.2(-)]TJ
0 -1.0471 TD
[(te)18.4(rl)17.3(eu)15.1(ki)18.9(n)-404.8(\()0(I)18(L)12.2(\)-)12.4(2)-399.1(w)0(a)16.9(s)-400.3(a)-405.2(k)0(i)18.9(n)0(d)-394.2(g)0(i)18.9(f)0(t)-392.5(o)0(f)-395.8(R)0(.)-392.8(B)0(a)16.1(r)0(t)17.3(l)0(e)18.4(t)0(t)-393.2(\()0(H)15.7(o)0(e)15.1(c)0(h)20.8(s)0(t)17.7(,)]TJ
0 -1.0528 TD
[(W)37.9(i)0(e)18.4(s)0(b)20(a)0(d)15.1(e)0(n)15.1(,)-376(Ge)16.9(rm)16.5(an)15.1(y\))19.6(.)-381.7(A)0(n)17.3(t)0(i)16.5(b)0(o)21.2(d)0(i)18.9(e)0(s)-373(\()0(c)13.5(l)13.9(on)15.5(e)-382.4(1)0(9)21.2(5)0(\))-373(a)0(n)20.8(d)-382(st)17.7(an)15.1(-)]TJ
0 -1.0471 TD
[(da)15.1(rd)19.6(s)-354.8(\()0(r)18(e)0(c)14.7(o)0(m)18.1(b)0(i)18.9(n)0(a)15.1(n)0(t)-345.3(h)0(u)21.2(m)0(a)17.7(n)-353.6(tu)13.2(mo)18.1(ur)-344.6(ne)15.1(cr)19.2(os)20(is)-346.5(fa)19.2(ct)12.8(or)-344.6(\(T)15.5(N)12.4(F)0(\))]TJ
0 -1.0528 TD
(-)Tj
/F8 1 Tf
0.313 0 TD
(a)Tj
/F3 1 Tf
0.626 0 TD
[(\))-525.9(f)0(o)13.9(r)-525.9(en)15.1(zy)20.8(me)17.7(-l)17.3(in)13.2(ke)20.8(d)-530(i)0(m)15.7(m)0(u)18.1(n)0(o)21.2(s)0(o)14.4(r)0(b)19.6(e)0(n)15.1(t)-526.7(as)19.6(sa)19.6(ys)-520.6(\(E)15.5(L)12.2(I)0(S)14.7(A)0(\))]TJ
-0.9389 -1.0471 TD
[(of)-321.8(TN)18.9(F-)]TJ
/F8 1 Tf
3.3062 0 TD
(a)Tj
/F3 1 Tf
0.9674 0 TD
[(w)12.4(e)0(r)13.5(e)-331.2(ki)18.9(nd)21.2(ly)-322.6(pr)19.6(ov)15.5(id)18.9(ed)-320.6(by)-320.2(Kn)11.6(ol)18.9(l)-327.5(A)0(G)-322.4(\()0(L)15.5(u)0(d)15.5(w)12.4(ig)13.2(s-)]TJ
-4.2736 -1.0528 TD
[(ha)15.1(fe)19.2(n,)-325.5(Ge)16.9(rm)16.5(an)15.1(y\))19.6(.)-336.1(T)12.2(he)-326.3(ti)16.5(ss)18.9(ue)-326.3(cu)15.1(lt)22.2(ur)14(e)-331.2(p)0(l)13.2(a)0(t)18.4(e)0(s)-327.5(a)0(n)20.8(d)-336.5(cr)19.2(yo)15.5(tu)18.8(be)15.1(s)]TJ
0 -1.0471 TD
[(we)16.9(re)-316.5(ob)15.5(t)13.9(a)0(i)12.8(n)0(e)20.8(d)-325.1(fr)18(om)-317.7(Nu)17.3(nc)-314.9(\(W)46.9(ie)18.4(sb)14.4(ad)20.8(en)15.1(,)-324.7(G)12.4(er)13.5(ma)17.7(ny)21.2(\).)]TJ
/F4 1 Tf
0 -2.0031 TD
[(Br)27.3(onchoal)-8.1(veolar)-549.6(lavage)-7.8(,)-546.7(cell)-549.2(differ)20.8(entials,)-555.1(and)-548.6(immu-)]TJ
0 -1.0528 TD
[(nophenot)-8.9(yping.)]TJ
/F3 1 Tf
6.7718 0 TD
[(B)11.6(A)0(L)-578.6(w)0(i)14.9(t)0(h)-573(2)0(0)21.2(0)0(\261)15.5(3)0(0)15.5(0)-581.2(mL)-572.2(st)12(er)19.2(il)16.5(e)-581.6(s)0(a)19.6(l)0(i)16.5(n)0(e)]TJ
-6.7718 -1.0471 TD
[(\(0)19.6(.9)15.9(%)-600.6(N)0(a)16.9(C)0(l)14.1(\))0(,)-588.9(c)0(e)20.4(l)0(l)-592.4(p)0(r)19.6(e)0(p)15.1(a)0(r)19.2(a)0(t)18.5(i)0(o)13.2(n)0(,)-587.3(d)0(i)18.9(f)20.4(fe)13.5(re)19.2(nt)18.9(ia)12.8(l)-595(c)0(e)14.7(l)0(l)-592.4(c)0(o)20.8(u)0(n)15.5(t)0(s)]TJ
0 -1.0528 TD
[(an)15.1(d)-473.1(i)0(m)15.7(m)0(u)18.1(n)0(o)15.5(p)0(h)21.2(e)0(n)15.1(o)0(t)18.9(y)0(p)15.5(i)0(n)18.9(g)-478.8(w)12.4(e)0(r)13.5(e)-473.5(pe)15.1(rf)18(or)19.6(me)12(d)-473.1(a)0(s)-469.7(p)0(r)19.6(e)0(v)15.1(i)0(o)18.9(u)0(s)14.4(l)13.9(y)]TJ
0 -1.0471 TD
[(re)19.2(po)15.5(rt)17.3(ed)-314.9([2)19.6(0,)-325.5(21)]TJ
/F11 1 Tf
11.955 0 0 11.955 122.343 247.578 Tm
(].)Tj
/F4 1 Tf
9.963 0 0 9.963 58.28 227.565 Tm
[(Cell)-348.7(cult)-8.2(ur)31.4(es.)]TJ
/F3 1 Tf
5.7475 0 TD
[(W)77.7(a)0(s)19.6(h)0(e)15.1(d)-330.8(BA)12.6(L)-334.9(c)0(e)20.4(l)0(l)16.5(s)-332(we)11.2(re)-322.2(cu)15.1(lt)16.5(ur)19.6(ed)-326.3(in)-322.6(RP)11.6(MI)]TJ
-5.7475 -1.0471 TD
[(16)15.5(40)-371.4(su)20(pp)15.5(le)18.4(me)17.7(nt)18.9(ed)-377.5(w)12.4(i)0(t)16.5(h)-382(2%)-373.8(he)15.1(at)-368.5(in)13.2(ac)20.4(ti)16.5(va)15.1(te)18.4(d)-382(e)0(n)20.8(d)0(o)15.5(t)0(o)18.9(x)0(i)18.9(n)0(-)]TJ
0 -1.0527 TD
[(fr)18(ee)-395(hu)21.2(ma)12(n)-399.1(A)0(B)-391.4(s)0(e)19.6(r)0(u)13.9(m)0(,)-391.2(2)-399.1(mM)]TJ
6.974 0 0 6.974 184.932 206.646 Tm
(L)Tj
9.963 0 0 9.963 189.071 206.646 Tm
[(-g)13.9(lu)18.9(ta)18.4(mi)15.7(ne)15.1(,)-398.7(1)0(0)21.2(0)-404.8(U)]TJ
/F7 1 Tf
7.4319 0.2049 TD
(.)Tj
/F3 1 Tf
0.2731 -0.2049 TD
(mL)Tj
7.472 0 0 6.641 279.383 211.124 Tm
(-1)Tj
9.963 0 0 9.963 58.28 196.214 Tm
[(pe)15.1(ni)18.9(ci)18.4(ll)16.5(in)-396.6(an)15.1(d)-410.5(1)0(0)21.2(0)-410.5(mg)-397.3(st)17.7(re)13.5(pt)18.9(om)18.1(yc)15.1(in)-396.6(at)-402.7(a)-405.2(d)0(e)15.1(n)0(s)20(i)0(t)16.5(y)-410.5(of)-395.8(1)]TJ
/F12 1 Tf
21.8005 0 TD
(6)Tj
/F3 1 Tf
-21.8005 -1.0527 TD
(10)Tj
7.472 0 0 6.641 68.088 190.205 Tm
(6)Tj
9.963 0 0 9.963 75.402 185.726 Tm
[(ce)14.7(l)13.9(l)0(s)]TJ
/F7 1 Tf
1.7527 0.2049 TD
(.)Tj
/F3 1 Tf
0.2731 -0.2049 TD
(mL)Tj
7.472 0 0 6.641 109.134 190.205 Tm
(-1)Tj
9.963 0 0 9.963 118.772 185.726 Tm
[(ov)15.5(er)-350.7(a)-365.4(p)0(e)20.8(r)0(i)17.3(o)0(d)-354.3(o)0(f)-355.9(2)0(4)-348.7(h)-365(wi)20.6(th)13.2(ou)21.2(t)-361.7(a)0(n)15.1(y)-359.3(st)17.7(im)15.7(u-)]TJ
-6.0718 -1.0471 TD
[(la)18.4(ti)16.5(on)-439.7(to)-436.4(me)17.7(as)13.9(ur)19.6(e)-445(t)0(h)18.9(e)-450.7(sp)20(on)15.5(ta)18.4(ne)20.8(ou)15.5(s)-445.8(r)0(e)13.5(l)13.9(ea)14.7(se)-435.6(of)-441.3(cy)20.8(to)13.2(ki)18.9(ne)20.8(s.)]TJ
0 -1.0528 TD
[(Co)16.5(nt)18.9(ro)13.9(l)-452.7(c)0(u)15.1(l)0(t)16.5(u)0(r)19.6(e)0(s)-447(r)0(e)13.5(c)0(e)20.4(i)0(v)18.9(e)0(d)]TJ
/F4 1 Tf
10.6868 0 TD
[(Sa)21.2(lm)14.9(on)15.5(el)18.5(la)-447.8(ab)21.2(or)14.4(tu)18.9(s)-457.2(e)0(q)20.8(u)0(i)]TJ
/F3 1 Tf
10.4194 0 TD
[(LP)17.9(S)]TJ
-21.1062 -1.0471 TD
(1)Tj
/F8 1 Tf
0.882 0 TD
(m)Tj
/F3 1 Tf
0.5691 0 TD
(g)Tj
/F7 1 Tf
0.4894 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 93.827 158.797 Tm
(-1)Tj
9.963 0 0 9.963 103.691 154.375 Tm
[(or)-378.7(P)11.4(H)0(A)-379.3(\()0(5)-378.7(m)0(g)]TJ
/F7 1 Tf
6.0092 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 179.773 158.797 Tm
(-1)Tj
9.963 0 0 9.963 185.726 154.375 Tm
[(\))-383.6(a)0(n)15.1(d)-382(PM)14.4(A)-386(\()0(2)-378.7(n)0(g)]TJ
/F7 1 Tf
7.2156 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 273.827 158.797 Tm
(-1)Tj
9.963 0 0 9.963 279.779 154.375 Tm
(\).)Tj
-22.233 -1.0528 TD
[(Af)15.7(te)18.4(r)-349.5(2)0(4)-343(h)-347.9(th)18.8(e)-348.3(s)0(u)20(p)0(e)15.1(r)0(n)19.6(a)0(t)12.8(a)0(n)20.8(t)0(s)-340.8(w)0(e)16.9(r)0(e)-339.3(h)0(a)15.1(r)0(v)19.6(e)0(s)13.9(t)0(e)18.4(d)-347.9(an)15.1(d)-347.9(s)0(t)17.7(o)0(r)19.6(e)0(d)-343.4(a)0(t)]TJ
0 -1.0471 TD
[(-7)19.6(0)]TJ
/F12 1 Tf
1.2974 0 TD
(8)Tj
/F3 1 Tf
0.3756 0 TD
[(C)-500.6(u)0(n)21.2(t)0(i)16.5(l)-498.2(as)13.9(sa)19.6(ye)15.1(d)-495.8(f)0(o)13.9(r)-497.4(TN)13.2(F)11.4(-)]TJ
/F8 1 Tf
10.7551 0 TD
(a)Tj
/F3 1 Tf
1.1381 0 TD
[(an)20.8(d)-501.5(I)0(L)21.2(-)0(2)-492.5(a)0(c)14.7(t)0(i)16.5(v)0(i)18.9(t)0(y)81.4(.)-501.2(T)12.2(h)0(e)]TJ
-13.5663 -1.0528 TD
[(vi)18.9(ab)15.1(il)16.5(it)16.5(y)-404.8(o)0(f)-395.8(t)0(h)18.9(e)-405.2(ce)14.7(l)13.9(l)0(s)-397.7(a)0(f)13.5(t)0(e)18.4(r)-406.4(cu)20.8(lt)16.5(ur)13.9(e)-405.2(a)0(l)18.4(w)0(a)16.9(y)0(s)-395.4(e)0(x)15.1(c)0(e)20.4(e)0(d)15.1(e)0(d)-394.6(9)0(5)15.5(%)]TJ
0 -1.0471 TD
[(as)-316.1(de)20.8(te)12.8(rm)16.5(in)18.9(ed)-314.9(by)-314.5(tr)17.3(yp)15.5(an)-314.9(bl)18.9(ue)-314.9(ex)15.1(cl)18.4(us)20(io)18.9(n.)]TJ
/F4 1 Tf
25.1977 66.1583 TD
[(Cyt)-9.8(okine)-416.7(assays)-8.6(.)]TJ
/F3 1 Tf
7.2099 0 TD
-0.0123 Tc
[(TN)-12.3(F-)]TJ
/F8 1 Tf
2.1624 0 TD
0 Tc
(a)Tj
/F3 1 Tf
1.0414 0 TD
[(co)20.8(nc)15.1(en)20.8(tr)11.6(at)18.4(io)18.9(ns)-395.4(in)-396.6(th)13.2(e)-405.2(B)11.6(AL)-402.2(su)20(-)]TJ
-10.4137 -1.0471 TD
[(pe)15.1(rn)19.6(at)12.8(an)20.8(ts)-551.4(we)16.9(re)-555.5(me)17.7(as)19.6(ur)13.9(ed)-548.2(by)-553.5(an)-548.2(EL)13(IS)20.4(A)-562.4(t)0(e)18.5(c)0(h)15.1(n)0(i)18.9(q)0(u)15.5(e)-558.8(as)]TJ
0 -1.0528 TD
[(pu)15.5(bl)18.9(is)17.7(he)15.1(d)-530(p)0(r)19.6(e)0(v)15.1(i)0(o)18.9(u)0(s)14.4(l)13.9(y)-535.7([)0(2)19.6(0].)-532.7(The)-547.4(backgro)-7.7(und)-542.9(release)-547(of)]TJ
0 -1.0471 TD
[(TNF)-9.6(-)]TJ
/F8 1 Tf
2.2022 0 TD
(a)Tj
/F3 1 Tf
1.0584 0 TD
[(in)-419.3(the)-426.2(system)-428.3(employed)-427.8(was)-423.2(219\213)-7.6(149)-417.7(pg)]TJ
/F7 1 Tf
17.2708 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 530.305 744.718 Tm
(-1)Tj
9.963 0 0 9.963 309.316 729.808 Tm
[(as)-407.2(meas)-8.2(ured)-409.1(in)-407.9(20)-405.6(contr)-8.2(ol)-402.2(subje)-7.8(cts)-410.3(for)-403.8(BAL)-413.4(and)-406.7(in)-407.9(18)]TJ
0 -1.0471 TD
[(for)-381.1(peripheral)-381(blood.)-382.1(The)-376.7(upper)-375.7(limit)-380.7(of)-373(norm)-7.8(al)-374.2(TNF-)]TJ
/F8 1 Tf
22.1647 0 TD
(a)Tj
/F3 1 Tf
-22.1647 -1.0528 TD
[(relea)-9(se)-344.6(was)-343.6(set)-342(at)-345.7(650)-343.7(pg)]TJ
/F7 1 Tf
10.2942 0.1992 TD
(.)Tj
/F3 1 Tf
0.2675 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 428.315 713.31 Tm
(-1)Tj
9.963 0 0 9.963 434.438 708.888 Tm
[(.)-341.8(I)0(t)-341.2(was)-343.6(demon)-7.4(stra)-8.6(ted)-340.8(for)]TJ
-12.559 -1.0471 TD
[(a)-655.6(wide)-652.8(range)-654.9(of)-651.9(TNF-)]TJ
/F8 1 Tf
10.1975 0 TD
(a)Tj
/F3 1 Tf
1.2861 0 TD
[(concent)-8.9(rations)-656.3(relea)-9(sed)-652.6(by)]TJ
-11.4835 -1.0527 TD
[(alveol)-10.1(ar)-510(macr)-8.6(ophages)-513.8(either)-512.5(spont)-7.4(aneously)-516.9(or)-509.6(after)]TJ
/F4 1 Tf
22.0281 0 TD
(in)Tj
-22.0281 -1.0527 TD
[(vitr)24.7(o)]TJ
/F3 1 Tf
2.4412 0 TD
[(stimulati)-12.1(on)-599(that)-611.4(the)-602.6(TNF-)]TJ
/F8 1 Tf
11.1535 0 TD
(a)Tj
/F3 1 Tf
1.2349 0 TD
[(conten)-7.8(t)-600.7(o)0(f)-606.3(the)-602.6(su-)]TJ
-14.8296 -1.0471 TD
[(pernat)-9.4(ants)-376.9(meas)-8.2(ured)-374.9(by)-377.1(ELISA)-375.3(correl)-11(ated)-376.1(with)-375.9(the)-375(bio-)]TJ
0 -1.0528 TD
[(acti)-8.6(vity)-394.8(meas)-8.2(ured)-397.7(by)-394.2(the)-397.7(L-cell)-402.8(\(lytic)-400.7(fibroblas)-10.7(ts\))-394.4(assay)]TJ
0 -1.0471 TD
(\(r)Tj
7.472 0 0 6.641 315.779 644.485 Tm
(s)Tj
/F8 1 Tf
9.963 0 0 9.963 318.671 646.129 Tm
(=)Tj
/F3 1 Tf
0.552 0 TD
[(0.85,)-390(p)]TJ
/F8 1 Tf
2.8908 0 TD
(<)Tj
/F3 1 Tf
0.552 0 TD
[(0.001,)-390.8(n)]TJ
/F8 1 Tf
3.3916 0 TD
(=)Tj
/F3 1 Tf
0.552 0 TD
[(23)-7.2(,)-381.6(range)-393.2(20\2615,000)-392.7(pg)]TJ
/F7 1 Tf
9.3723 0.1992 TD
(.)Tj
/F3 1 Tf
0.2732 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 507.572 650.551 Tm
(-1)Tj
9.963 0 0 9.963 513.694 646.129 Tm
[(,)-387.3(data)]TJ
-20.5144 -1.0527 TD
[(not)-340.4(shown\).)]TJ
0 -1.0471 TD
[(IL)15.5(-2)-225.1(bi)18.9(ol)18.9(og)15.5(ic)18.4(al)-226.2(ac)20.4(ti)16.5(vi)18.9(ty)-225.8(w)12.4(a)0(s)-225.1(d)0(e)15.1(t)0(e)18.4(r)0(m)16.5(i)0(n)18.8(e)0(d)-223.9(b)0(y)-223.5(C)0(T)18.1(L)0(L)-226(b)0(i)18.9(o)0(a)15.1(s)0(s)18.8(a)0(y)]TJ
0 -1.0527 TD
[(as)-264.9(pr)19.6(ev)15.1(io)18.8(us)14.4(l)13.9(y)-273.9(de)20.8(sc)13.9(ri)17.3(be)20.8(d)-273.9([)0(2)19.6(2].)-276.6(In)-282(the)-283.9(test)-282.6(syst)-7.8(em)-278.2(e)-6.9(mployed)]TJ
0 -1.0471 TD
[(in)-220.2(the)-221.3(presen)-8.2(t)-213.7(study)55.2(,)-216.6(a)-217.4(backgro)-7.7(und)-218.5(release)-222.7(of)-219.4(IL-2)-220.9(by)-217.8(BAL)]TJ
0 -1.0528 TD
[(cell)-8.6(s)-366.2(o)0(f)]TJ
/F8 1 Tf
3.3688 0 TD
(<)Tj
/F3 1 Tf
0.552 0 TD
[(1.0)-371.8(IU)]TJ
/F7 1 Tf
2.6632 0.2049 TD
(.)Tj
/F3 1 Tf
0.2731 -0.2049 TD
(mL)Tj
7.472 0 0 6.641 391.351 598.223 Tm
(-1)Tj
9.963 0 0 9.963 400.875 593.801 Tm
(10)Tj
7.472 0 0 6.641 410.853 598.223 Tm
(6)Tj
9.963 0 0 9.963 418.224 593.801 Tm
[(ce)-8(lls)]TJ
7.472 0 0 6.641 436.252 598.223 Tm
(-1)Tj
/F7 1 Tf
9.963 0 0 9.963 442.375 595.842 Tm
(.)Tj
/F3 1 Tf
0.2732 -0.2049 TD
[(24)-371.4(h)]TJ
7.472 0 0 6.641 463.748 598.223 Tm
(-1)Tj
9.963 0 0 9.963 473.556 593.801 Tm
[(was)-372(estab)-8.2(lished)]TJ
-16.4855 -1.0471 TD
[(using)-388.7(the)-386.3(BAL)-390.6(cells)-386.2(of)-384.4(eight)-390.2(normal)-387.7(volunt)-9.3(eers)-387.9(and)-384(20)]TJ
0 -1.0527 TD
[(pati)-8.2(ents)-411.1(be)-7.6(ing)-408.7(retr)-9(ospectivel)-11.5(y)-410.5(free)-416.8(of)-412.8(any)-412.4(inflammato)-12.1(ry)]TJ
0 -1.0471 TD
[(lung)-375.3(disease,)-370.2(and)-372.6(periphe)-10.1(ral)-365.2(blood)-376.1(cells)-369.1(of)-367.3(nine)-375.7(healthy)]TJ
0 -1.0528 TD
[(don)-8(ors.)]TJ
/F4 1 Tf
0 -2.299 TD
[(Serum)-339.4(pa)-7.2(rameter)-9.1(s)]TJ
/F3 1 Tf
1.0015 -1.7527 TD
[(Th)17.1(e)-684(c)0(o)20.8(n)0(c)15.1(e)0(n)20.8(t)0(r)17.3(a)0(t)12.8(i)13.9(on)15.5(s)-679.1(o)0(f)-674.6(s)0(I)18.4(L)12.2(-2)14(R)-677(a)0(n)15.1(d)-677.9(ne)15.1(op)21.2(te)12.8(ri)17.3(n)-677.9(w)0(e)16.9(r)0(e)]TJ
-1.0015 -1.0471 TD
[(me)12(as)19.6(ur)19.6(ed)-627.9(by)-621.8(co)15.1(mm)14.9(er)19.2(ci)18.4(al)12.8(l)13.9(y)-638.1(av)20.8(ai)18.5(la)12.8(bl)18.9(e)-632.8(E)0(L)18.7(I)0(S)14.7(A)-630.7(\(s)12.8(IL)21.2(-2)13.9(R)11.6(:)]TJ
0 -1.0528 TD
[(Im)16.5(mu)12.4(li)16.5(te)-220.6(IL)15.5(-2)19.6(R;)-224.9(D)12.4(P)0(C)-227.4(B)11.6(ie)18.4(rm)16.5(an)15.1(n,)-223.1(B)11.6(a)0(d)-223.9(N)0(a)16.9(u)0(h)15.5(e)0(i)18.4(m)0(,)-220.5(G)0(e)16.9(r)0(m)16.5(a)0(n)15.1(y)73.2(,)]TJ
0 -1.0471 TD
[(Ne)16.9(op)15.5(te)18.4(ri)17.3(n:)-573(Ne)16.9(op)15.5(te)18.4(ri)17.3(n)-581.2(E)0(L)18.7(I)0(S)14.7(A)0(;)-571.2(M)0(e)13.2(r)0(c)19.2(k)0(,)-570.2(D)0(a)16.9(r)0(m)16.5(s)0(t)17.7(a)0(d)15.1(t)0(,)-572.6(G)0(e)16.9(r)20.4(-)]TJ
0 -1.0528 TD
[(ma)12(ny)21.2(\).)-236.1(AC)12.6(E)-243.9(w)0(a)16.9(s)-241(me)12(as)19.6(ur)19.6(ed)-240.9(by)-234.8(a)-245.9(k)0(i)18.8(n)0(e)20.8(t)0(i)16.5(c)-245.9(te)18.4(st)-238.4(ob)21.2(ta)12.8(i)13.9(n)0(e)15.1(d)-245.5(fr)18(om)]TJ
0 -1.0471 TD
(Bu)Tj
0.7568 -0.0228 TD
(\310)Tj
0.3926 0.0228 TD
[(hl)13.2(m)13.2(a)0(n)15.1(n)-325.1(L)12.2(a)0(b)15.1(o)0(r)19.6(a)0(t)12.8(o)0(r)19.6(i)0(e)18.4(s)-326.3(\(A)15.7(ll)16.5(sc)19.6(hw)17.3(il)16.5(,)-324.7(S)11.4(wi)14.9(tz)18.4(er)19.2(la)12.8(nd)21.2(\).)]TJ
/F4 1 Tf
-1.1495 -2.3047 TD
[(Stat)-7.8(istical)-340.8(methods)]TJ
/F3 1 Tf
1.0015 -1.7527 TD
[(St)14(ud)21.2(en)15.1(t)]TJ
/F12 1 Tf
2.9705 0 TD
(')Tj
/F3 1 Tf
0.2106 0 TD
[(s)-707.6(t)0(-)17.3(t)0(e)18.4(s)0(t)17.7(s)-713.3(w)12.4(e)0(r)13.5(e)-706.8(us)14.4(ed)-696.2(to)-703.8(te)18.4(st)-699.3(fo)13.9(r)-708(s)0(i)17.7(g)0(n)21.2(i)0(f)11.6(i)13.9(ca)14.7(nt)]TJ
-4.1826 -1.0471 TD
[(di)13.2(f)20.4(f)0(e)19.2(r)0(e)13.5(n)0(c)20.8(e)0(s)13.9(.)-319.1(Al)14.9(l)-327.5(d)0(a)20.8(t)0(a)-317.3(a)0(r)19.2(e)-325.5(pr)19.6(es)13.9(en)20.8(te)18.4(d)-325.1(a)0(s)-316.1(m)0(e)17.7(a)0(n)15.1(\213)]TJ
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(SD)Tj
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[(Se)15.9(ru)19.6(m)-254.3(A)0(C)12.6(E)-249.6(co)15.1(nc)20.8(en)15.1(tr)17.3(at)18.4(io)18.9(n)-256.8(w)12.4(as)-247.8(el)18.5(ev)15.1(at)18.4(ed)-240.9(in)-248.6(9/)18.9(1)39.1(1)-251.2(pa)20.8(ti)16.5(en)15.1(ts)]TJ
-1.0015 -1.0527 TD
[(at)-214.9(th)13.2(e)-223.1(s)0(t)17.7(a)0(r)19.2(t)-230.8(of)-213.7(th)18.8(er)13.5(ap)20.8(y)-228.4(w)12.4(hi)13.2(ch)-212.5(re)13.5(so)20(lv)18.9(ed)-218.2(du)15.5(ri)17.3(ng)-212.1(th)13.2(er)19.2(ap)15.1(y)-222.7(i)0(n)-214.5(s)0(i)17.7(x)0(,)]TJ
0 -1.0471 TD
[(de)15.1(cr)19.2(ea)20.4(se)13.9(d)-518.6(i)0(n)-510.4(t)0(w)14.9(o)0(,)-513.3(a)0(n)20.8(d)-518.6(re)13.5(ma)17.7(in)18.9(ed)-514.1(st)17.7(ab)20.8(le)-516.5(in)-510.4(on)21.2(e)-524.7(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(.)]TJ
0 -1.0528 TD
[(Ne)16.9(op)15.5(te)18.4(ri)17.3(ti)16.5(n)-501.5(a)0(n)15.1(d)-501.5(sI)18.4(L-)15.5(2R)-495.6(se)19.6(ru)13.9(m)-504.7(l)0(e)18.4(v)0(e)20.8(l)0(s)-494.5(w)0(e)11.2(r)0(e)-492.9(a)0(n)20.8(a)0(l)12.8(y)0(s)20(e)0(d)-497(i)0(n)]TJ
0 -1.0471 TD
[(se)19.6(ve)15.1(n)-268.2(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)17.7(.)-267.8(A)12.4(l)0(l)-262.4(e)0(x)20.8(h)0(i)13.2(b)0(i)18.9(t)0(e)18.4(d)-268.2(el)18.4(ev)15.1(at)18.4(ed)-258(ne)15.1(op)21.2(te)18.4(ri)17.3(n)-268.2(l)0(e)18.4(v)0(e)15.1(l)0(s)-261.2(t)13.9(ha)15.1(t)]TJ
0 -1.0528 TD
[(no)15.5(rm)16.5(al)18.5(iz)18.4(ed)-240.9(un)21.2(de)15.1(r)-247.1(t)0(h)18.9(e)0(r)19.2(a)0(p)15.1(y)73.2(.)-245.1(S)0(i)13.9(x)-245.5(ha)20.8(d)-251.2(i)0(n)18.9(c)0(r)19.2(e)0(a)14.7(s)0(e)19.6(d)-245.5(sI)12.8(L)12.2(-)0(2)13.9(R)-244.5(le)18.4(ve)15.1(ls)]TJ
0 -1.0471 TD
[(wh)17.3(ic)18.4(h)-325.1(r)0(e)19.2(s)0(o)14.3(l)0(v)18.9(e)0(d)-314.9(i)0(n)-316.9(6)-325.1(an)20.8(d)-325.1(i)0(m)15.7(p)0(r)19.6(o)0(v)15.5(e)0(d)-314.9(i)0(n)-316.9(o)0(n)21.2(e)-325.5(pa)15.1(t)13.9(i)0(e)12.8(n)0(t)18.9(.)]TJ
1.0015 -1.0527 TD
[(Af)15.7(te)18.4(r)-520.2(a)0(n)-514.1(a)0(v)20.8(e)0(r)13.5(a)0(g)20.8(e)-519(of)-515.3(20)21.2(.2)15.9(\2136)16.7(.3)-507.6(mo)12.4(nt)18.9(hs)-509.2(\(r)18(an)15.1(ge)-508.4(8\261)15.5(26)15.5(\),)]TJ
-1.0015 -1.0471 TD
[(tr)17.3(ea)14.7(tm)21.4(en)15.1(t)-361.6(w)0(a)16.9(s)-360.5(di)18.9(sc)19.6(on)15.5(ti)16.5(nu)21.2(ed)15.1(.)-358.9(A)0(t)-349.3(t)0(h)13.2(a)0(t)-351.4(t)13.9(im)15.7(e)-359.7(a)0(l)12.8(l)-356(pa)15.1(ti)16.5(en)20.8(ts)-352.2(ha)15.1(d)]TJ
0 -1.0527 TD
[(re)19.2(so)14.4(lv)18.8(in)18.9(g)-154.4(o)0(r)-151.1(i)0(m)15.7(p)0(r)19.6(o)0(v)21.2(i)0(n)13.2(g)-154.4(sy)20(mp)12.4(t)13.9(o)0(m)12.4(s)0(,)-144.6(n)0(o)15.5(r)0(m)16.5(a)0(l)18.4(i)0(z)18.4(a)0(t)18.4(i)0(o)18.9(n)-160.1(of)-145.4(ph)21.2(ys)14.4(io)18.9(-)]TJ
0 -1.0471 TD
[(lo)18.9(gi)18.9(ca)14.7(l)-623.4(f)0(i)17.3(n)0(d)21.2(i)0(n)13.2(g)0(s)-611.6(a)0(n)20.8(d)-626.7(an)-610.8(im)15.7(pr)19.6(ov)15.5(em)17.7(en)15.1(t)-617.7(o)0(f)-617.7(r)0(a)19.2(d)0(i)18.9(o)0(g)15.5(r)0(a)19.2(p)0(h)15.5(i)0(c)]TJ
0 -1.0528 TD
[(fi)17.3(nd)15.5(in)18.9(gs)-395.4(\(t)17.3(ab)15.1(le)-397(2\).)-407.5(After)-423.4(8,)-416.6(18)-416.9(and)-418.1(22)-416.9(months,)-421.4(relap)-8.6(ses)]TJ
0 -1.0471 TD
[(were)-532.9(observed)-533.2(in)-521.7(three)-532.1(pati)-8.2(ents.)-525.2(The)-530.3(rema)-8.6(ining)-526.4(eight)]TJ
0 -1.0528 TD
[(patien)-10.1(ts)-255.5(hav)-8.4(e)-257.2(stable)-267.4(remissions)-271.5(persisting)-269.5(for)-261.6(4,)-257.2(6,)-262.9(1)33.4(1)0(,)-262.9(30,)]TJ
0 -1.0471 TD
[(40,)-337.7(49,)-332(52,)-337.7(and)-332.7(73)-337.3(mont)-8.6(hs)-332.8(at)-334.4(the)-335.1(tim)-10.2(e)-331.2(o)0(f)-333.2(wri)-10.2(ting.)]TJ
1.0015 -1.0527 TD
[(In)-304.7(on)15.5(e)-314.2(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(,)-310.8(c)0(o)20.8(u)0(g)15.5(h)-313.7(an)20.8(d)-319.4(c)0(o)20.8(n)0(s)14.4(t)0(i)16.5(t)0(u)18.9(t)0(i)16.5(o)0(n)21.2(a)0(l)-305.9(s)0(y)14.4(m)0(p)18.1(t)0(o)18.9(m)0(s)-307.5(\()0(f)12.4(a)0(-)]TJ
-1.0015 -1.0528 TD
[(ti)16.5(gu)21.2(e)-245.9(a)0(n)15.1(d)-239.8(ni)18.9(gh)15.5(t)-242.2(s)0(w)16.1(e)0(a)14.7(t)0(\))-233.1(d)0(i)18.9(d)-245.5(no)21.2(t)-247.8(r)0(e)19.2(s)0(o)20(l)0(v)13.2(e)-240.2(du)15.5(ri)17.3(ng)-234.8(th)18.9(e)-240.2(i)0(n)13.2(d)0(u)21.2(c)0(t)18.4(i)0(o)13.2(n)]TJ
0 -1.0471 TD
[(ph)15.5(as)19.6(e)-393.8(a)0(n)15.1(d)-393.4(th)18.9(e)-393.8(c)0(h)20.8(e)0(s)13.9(t)-390.1(ra)13.5(di)18.9(og)15.5(ra)19.2(ph)-382.8(sh)14.4(ow)17.3(ed)-383.2(on)15.5(ly)-385.2(a)-393.8(m)0(a)17.7(r)20.4(gi)18.9(na)15.1(l)]TJ
0 -1.0527 TD
[(im)15.7(pr)19.6(ov)15.5(em)17.7(en)15.1(t,)-276.7(al)18.5(th)18.9(ou)15.5(gh)-274.7(a)-291.4(s)0(e)19.6(c)0(o)15.1(n)0(d)-274.7(B)0(A)12.6(L)-283.7(do)15.5(cu)15.1(me)17.7(nt)18.9(ed)-280.8(a)-285.7(n)0(o)15.5(r)20.4(-)]TJ
0 -1.0471 TD
[(ma)17.7(li)16.5(za)14.7(ti)16.5(on)-303.1(of)-304.7(th)18.9(e)-314.2(p)0(e)15.1(r)0(c)19.2(e)0(n)15.1(t)0(a)18.4(g)0(e)-303.5(o)0(f)-304.7(l)0(y)18.9(m)0(p)12.4(h)0(o)21.2(c)0(y)15.1(t)0(e)18.4(s)-314.9(\(5)19.6(2.)15.9(2)]TJ
/F4 1 Tf
20.3153 0 TD
[(ve)20.4(rs)13.2(us)]TJ
/F3 1 Tf
-20.3153 -1.0527 TD
[(16)15.5(.2)21.6(%\))-329.8(an)15.1(d)-336.5(a)-331.2(de)15.1(cr)19.2(ea)14.7(se)-327.5(in)-328.3(th)18.9(e)-336.9(C)0(D)18.3(4)0(/)13.2(C)11.6(D8)-329.8(ra)19.2(ti)16.5(o)-336.5(\()0(4)13.9(.)0(4)]TJ
/F4 1 Tf
20.3153 0 TD
[(ve)20.4(rs)18.9(us)]TJ
/F3 1 Tf
-20.3153 -1.0471 TD
[(3.)15.9(7\))-447(at)-448.2(th)18.9(at)-448.2(ti)16.5(me)-448.9(\(f)18(ig)18.9(.)-455.6(1\).)-458.7(As)-467.6(a)-467.8(consequ)-7.3(ence,)-471.3(a)-467.8(second)]TJ
0 -1.0527 TD
[(induct)-9.7(ion)-266.4(phase)-273.3(was)-269.6(initiated)-275.7(and)-270.2(all)-269.2(symptom)-9.5(s)-263.7(a)0(n)-7.6(d)-262.5(find-)]TJ
0 -1.0471 TD
[(ings)-222.9(norm)-7.8(alized.)-227.2(Unfortu)-9.1(nately)-226.4(this)-219.6(pati)-8.2(ent)-221.3(terminated)-231.3(the)]TJ
0 -1.0528 TD
[(maintenan)-10.3(ce)-372.2(thera)-8.6(py)-371.4(prem)-8.2(ature)-8.6(ly)-368.1(after)-380.1(8)-370.7(mont)-8.6(hs)-372.6(due)-372.6(to)]TJ
0 -1.0471 TD
[(menta)-10.1(l)-208(illness)-220.1(and)-213.2(suf)12(fered)-218.4(from)-214.3(a)-211.7(relap)-8.6(se)-208(2)-6.5(2)-205.6(mont)-8.6(hs)-213.3(later)45.9(.)]TJ
/F4 1 Tf
0 -3.1639 TD
[(Immuno)-8.3(logi)-7.8(cal)-335.1(findings)-338.8(of)-339.7(br)31.4(onchoal)-8.1(veolar)-339(lavage)]TJ
/F3 1 Tf
1.0015 -2.0998 TD
[(At)-281(st)17.7(ar)19.2(t)-287.7(o)0(f)-276.3(t)0(h)18.9(e)0(r)19.2(a)0(p)15.1(y)-285.3(th)18.9(e)-285.7(p)0(e)15.1(r)0(c)19.2(e)0(n)15.1(t)0(a)18.4(g)0(e)-275.1(o)0(f)-276.3(B)0(A)12.6(L)-283.7(ly)18.9(mp)18.1(ho)15.5(cy)15.1(te)18.4(s)]TJ
-1.0015 -1.0471 TD
[(in)-225.8(se)19.6(ve)15.1(n)-234.1(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-227(w)0(a)16.9(s)-235.3(19)15.5(.9)21.6(\2131)16.7(7.)15.9(2%)-225.8(ra)19.2(ng)15.5(in)18.9(g)-234.1(1)0(.)15.9(6)0(\261)21.2(5)0(2)15.5(.)0(5)21.6(%)-236.4(\(f)18(ig)13.2(.)]TJ
0 -1.0528 TD
[(1\).)-367.7(After)-377.9(the)-375(induct)-9.7(ion)-374.6(phase,)-381.8(BAL)-379.3(was)-377.7(repeated)-381.6(in)-373.8(six)]TJ
0 -1.0471 TD
[(patien)-10.1(ts)-261.2(with)-267.8(a)-262.9(decreas)-9.7(e)-262.9(o)0(f)-264.9(BAL)-265.4(lympho)-10.1(cytes)-264.3(in)-265.7(four)-268(and)]TJ
0 -1.0528 TD
[(a)-274.3(consi)-7.8(derabl)-9.4(e)-274.3(incre)-8.6(ase)-277.4(in)-277.1(two)-276.1(pati)-8.2(ents.)-280.6(Thus,)-276.2(on)-280.4(average)]TJ
0 -1.0471 TD
[(the)-238.4(percentage)-241.2(of)-236.4(BAL)-237(lym)-7.8(phocytes)-238.1(rema)-8.6(ined)-233.5(unch)-9.1(anged)]TJ
0 -1.0528 TD
[(at)-374.2(20.5\21313.5%)-377.9(\(range)-378.5(7.0\26144.0%)-8.5(,)-370.3(p)]TJ
/F8 1 Tf
14.6702 0 TD
(>)Tj
/F3 1 Tf
0.552 0 TD
[(0.2\).)-374.5(Howev)-12.1(er)30.6(,)-370.3(for)]TJ
-15.2222 -1.0471 TD
[(the)-557.1(CD4/CD8)-559.9(ratio)-556.9(of)-555.1(BAL)-555.7(lymph)-9.3(ocytes)-555.3(which)-556.8(was)]TJ
25.1977 41.2565 TD
[(5.5\213)-7.2(3.1)-303.5(\(range)-304.5(2.2)-7.6(\26110.0,)-305.4(p)]TJ
/F8 1 Tf
10.7381 0 TD
(>)Tj
/F3 1 Tf
0.552 0 TD
[(0.2\))-305.9(before)-304.5(thera)-8.6(py)-303.1(and)-304.3(3.7\213)]TJ
-11.2901 -1.0755 TD
[(1.2)-280.7(\(range)-281.7(2.2\2614.5,)-278.1(p)]TJ
/F8 1 Tf
8.3594 0 TD
(>)Tj
/F3 1 Tf
0.5577 0 TD
[(0.2\))-277.4(when)-280.5(the)-278.2(induction)-281.9(phase)-284.6(was)]TJ
-8.9171 -1.0755 TD
[(compl)-9.7(eted,)-467.6(a)-462.1(n)-6.5(otable)-465.4(decreas)-9.7(e)-467.8(was)-463.1(o)-6.5(bserved.)-470.2(This)-466(de-)]TJ
T*
[(crease,)-390.6(howe)-7.4(ver)29.9(,)-381.6(did)-380.3(not)-385.9(reach)-382.2(a)-382.4(statist)-12(ically)-382.4(signi)-9.8(ficant)]TJ
T*
[(level)-9.4(.)]TJ
1.0015 -1.0528 TD
[(Sp)16.3(on)15.5(ta)18.4(ne)15.1(ou)21.2(s)-343.4(r)0(e)19.2(l)0(e)18.4(a)0(s)13.9(e)-336.9(of)-333.2(cy)15.1(to)18.8(ki)18.9(ne)15.1(s)-337.7(w)0(a)16.9(s)-343.4(me)17.7(as)14(ur)19.6(ed)-332(in)-334(th)18.9(e)]TJ
-1.0015 -1.0698 TD
[(BA)12.6(L)-209.8(c)0(e)20.4(l)0(l)-205.5(c)0(u)20.8(l)0(t)16.5(u)0(r)19.6(e)-211.7(su)14.4(pe)20.8(rn)19.6(at)12.8(an)20.8(ts)-204.3(of)-190.9(fi)17.3(ve)-201.1(pa)20.8(ti)16.5(en)15.1(t)13.9(s)-212.5(be)15.1(fo)19.6(re)-202.7(an)20.8(d)-211.3(o)0(f)]TJ
0 -1.0755 TD
[(fo)13.9(ur)-208(pa)20.8(ti)16.5(en)15.1(ts)-204.3(af)13.5(te)18.4(r)-212.9(c)0(o)15.1(m)0(p)18.1(l)0(e)18.4(t)0(i)16.5(o)0(n)-206.4(o)0(f)-208(t)0(h)13.2(e)-211.7(in)13.2(du)21.2(ct)18.5(io)13.2(n)-211.3(p)0(h)15.5(a)0(s)19.6(e)0(.)-206.4(T)0(N)13.2(F)11.4(-)]TJ
/F8 1 Tf
T*
(a)Tj
/F3 1 Tf
1.1153 0 TD
[(w)12.4(a)0(s)-469.8(e)0(l)18.5(e)0(v)20.8(a)0(t)12.8(e)0(d)-462.9(i)0(n)-464.8(4)0(/)13.2(5)-473.1(an)20.8(d)-478.8(I)0(L)21.2(-)0(2)-469.8(i)0(n)-464.8(3)0(/)18.9(4)-478.8(pa)20.8(ti)16.5(en)20.8(ts)12(.)-472.7(I)0(n)-464.1(a)0(l)18.5(l)]TJ
-1.1153 -1.0755 TD
[(pa)15.1(ti)16.5(en)20.8(ts)17.7(,)-393(I)0(L)21.2(-)0(2)-378.7(r)0(e)13.5(l)0(e)18.4(a)0(s)19.6(e)-393.8(no)21.2(rm)16.5(al)18.4(iz)12.8(ed)-377.5(un)15.5(de)20.8(r)-389.3(t)0(h)18.9(e)0(r)13.5(a)0(p)20.8(y)-387.7(sh)14.3(ow)17.3(in)18.8(g)]TJ
T*
[(th)13.2(at)-249(th)18.9(e)-262.9(t)0(h)18.8(e)0(r)19.2(a)0(p)15.1(e)0(u)20.8(t)0(i)16.5(c)-262.9(ap)20.8(pr)14(oa)20.8(ch)-252.3(su)20(pp)15.5(re)19.2(ss)13.2(ed)-246.6(th)13.2(e)-257.2(i)0(n)18.8(f)0(l)17.3(a)0(m)17.7(m)0(a)12(t)0(o)18.9(r)0(y)]TJ
T*
[(ac)14.7(ti)16.5(vi)18.9(ty)-396.6(of)-395.8(BA)18.3(L)-323.6(T)91.9(-c)19.2(el)18.4(ls)-397.8(\(f)18(ig)13.2(.)-398.7(2\).)-407.5(Thre)-9.2(e)-410.9(pati)-8.2(ents)-416.7(with)-415.8(in-)]TJ
T*
[(itiall)-11.2(y)-228.4(elevated)-234.4(spontaneous)-235.9(TNF-)]TJ
/F8 1 Tf
13.4012 0 TD
(a)Tj
/F3 1 Tf
0.8593 0 TD
[(relea)-9(se)-230.7(had)-224.6(foll)-9.4(ow-up)]TJ
-14.2605 -1.0755 TD
[(BAL)-618.3(and)-611.6(demon)-7.4(strated)-616.9(a)-610.1(TNF-)]TJ
/F8 1 Tf
13.8565 0 TD
(a)Tj
/F3 1 Tf
1.2462 0 TD
[(relea)-9(se)-612(within)-613.2(the)]TJ
-15.1027 -1.0755 TD
[(norm)-7.8(al)-311.6(range)-313.5(indica)-10.1(ting)-309.4(a)-308.5(dampe)-7.8(ning)-312.7(of)-310.4(alveol)-10.1(ar)-310.8(macro-)]TJ
T*
[(pha)-8.4(ge)-417.3(activity)51.9(.)-415.8(The)-422.2(observ)-7.8(ed)-417.3(trend)-8.2(s)-417.4(did)-420.1(not)-420.1(reach)-422(stat-)]TJ
T*
[(ist)-8.2(ical)-338.7(significan)-12.7(ce)-332.4(\(p)]TJ
/F8 1 Tf
8.6212 0 TD
(>)Tj
/F3 1 Tf
0.552 0 TD
[(0.1)-337.7(in)-334(both)-335.5(compa)-7.8(riso)-8.2(ns\).)]TJ
ET
0 0 0 1 K
0 J 0 j 0.49 w 3.864 M []0 d
/GS3 gs
1 i 
495.516 650.751 m
521.976 679.171 l
487.513 651.895 m
521.976 650.261 l
490.976 677.603 m
522.14 669.535 l
490.976 747.51 m
522.63 694.525 l
368.312 694.59 m
401.926 735.521 l
370.926 755.349 m
403.429 673.03 l
374.846 696.55 m
402.906 678.681 l
372.526 659.081 m
402.906 658.101 l
371.579 670.417 m
402.906 651.731 l
371.579 649.183 m
403.07 696.321 l
S
BT
/F16 1 Tf
0 9.8 -9.8 0 319.609 674.761 Tm
0 0 0 1 k
/GS4 gs
[(L)30(ymphocytes  %)]TJ
ET
/GS3 gs
341.656 635.071 m
341.656 773.25 l
S
BT
9.8 0 0 9.8 325.489 770.634 Tm
/GS4 gs
(60)Tj
ET
/GS3 gs
337.736 773.25 m
341.656 773.25 l
S
BT
9.8 0 0 9.8 325.489 745.699 Tm
/GS4 gs
(50)Tj
ET
/GS3 gs
337.736 748.316 m
341.656 748.316 l
S
BT
9.8 0 0 9.8 325.489 723.536 Tm
/GS4 gs
(40)Tj
ET
/GS3 gs
337.736 726.153 m
341.656 726.153 l
S
BT
9.8 0 0 9.8 325.489 699.983 Tm
/GS4 gs
(30)Tj
ET
/GS3 gs
337.736 702.599 m
341.656 702.599 l
S
BT
9.8 0 0 9.8 325.489 677.819 Tm
/GS4 gs
(20)Tj
ET
/GS3 gs
337.736 680.436 m
341.656 680.436 l
S
BT
9.8 0 0 9.8 325.489 655.655 Tm
/GS4 gs
(10)Tj
ET
/GS3 gs
337.736 658.272 m
341.656 658.272 l
S
BT
9.8 0 0 9.8 325.489 632.657 Tm
/GS4 gs
(  0)Tj
ET
/GS3 gs
337.736 635.274 m
341.656 635.274 l
S
BT
9.8 0 0 9.8 312.256 771.291 Tm
/GS4 gs
(a\))Tj
ET
/GS3 gs
345.576 635.071 m
416.626 635.071 l
372.526 631.151 m
372.526 635.071 l
403.886 631.151 m
403.886 635.071 l
S
BT
9.8 0 0 9.8 370.566 621.352 Tm
/GS4 gs
2.644 Tc
(04)Tj
0.7 -1 TD
0 Tc
(Month)Tj
ET
0 0 0 0 k
/GS3 gs
370.076 638.665 m
370.076 639.747 370.954 640.625 372.036 640.625 c
373.119 640.625 373.996 639.747 373.996 638.665 c
373.996 637.582 373.119 636.705 372.036 636.705 c
370.954 636.705 370.076 637.582 370.076 638.665 c
b
369.619 649.183 m
369.619 650.266 370.497 651.143 371.579 651.143 c
372.662 651.143 373.539 650.266 373.539 649.183 c
373.539 648.101 372.662 647.224 371.579 647.224 c
370.497 647.224 369.619 648.101 369.619 649.183 c
b
369.619 659.31 m
369.619 660.393 370.496 661.27 371.579 661.27 c
372.662 661.27 373.539 660.393 373.539 659.31 c
373.539 658.228 372.662 657.35 371.579 657.35 c
370.496 657.35 369.619 658.228 369.619 659.31 c
b
369.619 670.417 m
369.619 671.499 370.496 672.377 371.579 672.377 c
372.662 672.377 373.539 671.499 373.539 670.417 c
373.539 669.334 372.662 668.456 371.579 668.456 c
370.496 668.456 369.619 669.334 369.619 670.417 c
b
366.352 694.59 m
366.352 695.672 367.23 696.55 368.312 696.55 c
369.395 696.55 370.272 695.672 370.272 694.59 c
370.272 693.507 369.395 692.63 368.312 692.63 c
367.23 692.63 366.352 693.507 366.352 694.59 c
b
372.886 696.55 m
372.886 697.632 373.763 698.51 374.846 698.51 c
375.928 698.51 376.806 697.632 376.806 696.55 c
376.806 695.467 375.928 694.59 374.846 694.59 c
373.763 694.59 372.886 695.467 372.886 696.55 c
b
401.632 651.797 m
401.632 652.879 402.51 653.757 403.592 653.757 c
404.675 653.757 405.552 652.879 405.552 651.797 c
405.552 650.714 404.675 649.837 403.592 649.837 c
402.51 649.837 401.632 650.714 401.632 651.797 c
b
401.632 658.003 m
401.632 659.086 402.51 659.963 403.592 659.963 c
404.675 659.963 405.552 659.086 405.552 658.003 c
405.552 656.921 404.675 656.043 403.592 656.043 c
402.51 656.043 401.632 656.921 401.632 658.003 c
b
401.436 672.311 m
401.436 673.394 402.314 674.271 403.396 674.271 c
404.479 674.271 405.356 673.394 405.356 672.311 c
405.356 671.229 404.479 670.351 403.396 670.351 c
402.314 670.351 401.436 671.229 401.436 672.311 c
b
401.632 678.91 m
401.632 679.992 402.51 680.87 403.592 680.87 c
404.675 680.87 405.552 679.992 405.552 678.91 c
405.552 677.828 404.675 676.95 403.592 676.95 c
402.51 676.95 401.632 677.828 401.632 678.91 c
b
401.436 696.484 m
401.436 697.567 402.314 698.445 403.396 698.445 c
404.479 698.445 405.356 697.567 405.356 696.484 c
405.356 695.402 404.479 694.525 403.396 694.525 c
402.314 694.525 401.436 695.402 401.436 696.484 c
b
400.652 735.75 m
400.652 736.832 401.53 737.71 402.612 737.71 c
403.695 737.71 404.572 736.832 404.572 735.75 c
404.572 734.667 403.695 733.79 402.612 733.79 c
401.53 733.79 400.652 734.667 400.652 735.75 c
b
368.966 755.349 m
368.966 756.432 369.843 757.309 370.926 757.309 c
372.008 757.309 372.886 756.432 372.886 755.349 c
372.886 754.267 372.008 753.39 370.926 753.39 c
369.843 753.39 368.966 754.267 368.966 755.349 c
b
461.216 635.071 m
461.216 773.25 l
S
BT
9.8 0 0 9.8 445.049 770.634 Tm
0 0 0 1 k
/GS4 gs
(12)Tj
ET
/GS3 gs
457.296 773.25 m
461.216 773.25 l
S
BT
9.8 0 0 9.8 445.049 744.589 Tm
/GS4 gs
(10)Tj
ET
/GS3 gs
457.296 747.205 m
461.216 747.205 l
S
BT
9.8 0 0 9.8 445.049 720.758 Tm
/GS4 gs
(  8)Tj
ET
/GS3 gs
457.296 723.375 m
461.216 723.375 l
S
BT
9.8 0 0 9.8 445.049 695.538 Tm
/GS4 gs
(  6)Tj
ET
/GS3 gs
457.296 698.155 m
461.216 698.155 l
S
BT
9.8 0 0 9.8 445.049 670.597 Tm
/GS4 gs
(  4)Tj
ET
/GS3 gs
457.296 673.214 m
461.216 673.214 l
S
BT
9.8 0 0 9.8 445.049 646.766 Tm
/GS4 gs
(  2)Tj
ET
/GS3 gs
457.296 649.383 m
461.216 649.383 l
S
BT
9.8 0 0 9.8 431.816 771.291 Tm
/GS4 gs
(b\))Tj
ET
/GS3 gs
465.136 635.071 m
536.186 635.071 l
492.086 631.151 m
492.086 635.071 l
523.446 631.151 m
523.446 635.071 l
S
BT
9.8 0 0 9.8 490.126 621.352 Tm
/GS4 gs
2.644 Tc
(04)Tj
0.7 -1 TD
0 Tc
(Month)Tj
0 9.8 -9.8 0 439.166 681.621 Tm
(CD4/CD8 ratio)Tj
ET
/GS3 gs
490.976 700.143 m
525.929 660.943 l
518.546 662.511 m
491.106 722.291 l
S
0 0 0 0 k
486.402 651.143 m
486.402 652.226 487.28 653.103 488.362 653.103 c
489.445 653.103 490.322 652.226 490.322 651.143 c
490.322 650.061 489.445 649.183 488.362 649.183 c
487.28 649.183 486.402 650.061 486.402 651.143 c
b
492.936 650.817 m
492.936 651.899 493.813 652.777 494.896 652.777 c
495.978 652.777 496.856 651.899 496.856 650.817 c
496.856 649.734 495.978 648.857 494.896 648.857 c
493.813 648.857 492.936 649.734 492.936 650.817 c
b
520.702 650.49 m
520.702 651.573 521.58 652.45 522.662 652.45 c
523.745 652.45 524.622 651.573 524.622 650.49 c
524.622 649.408 523.745 648.53 522.662 648.53 c
521.58 648.53 520.702 649.408 520.702 650.49 c
b
523.969 660.943 m
523.969 662.026 524.846 662.903 525.929 662.903 c
527.011 662.903 527.889 662.026 527.889 660.943 c
527.889 659.861 527.011 658.983 525.929 658.983 c
524.846 658.983 523.969 659.861 523.969 660.943 c
b
517.109 662.577 m
517.109 663.659 517.986 664.537 519.069 664.537 c
520.151 664.537 521.029 663.659 521.029 662.577 c
521.029 661.494 520.151 660.617 519.069 660.617 c
517.986 660.617 517.109 661.494 517.109 662.577 c
b
520.376 670.09 m
520.376 671.172 521.253 672.05 522.336 672.05 c
523.418 672.05 524.296 671.172 524.296 670.09 c
524.296 669.007 523.418 668.13 522.336 668.13 c
521.253 668.13 520.376 669.007 520.376 670.09 c
b
489.016 677.603 m
489.016 678.686 489.893 679.563 490.976 679.563 c
492.058 679.563 492.936 678.686 492.936 677.603 c
492.936 676.521 492.058 675.643 490.976 675.643 c
489.893 675.643 489.016 676.521 489.016 677.603 c
b
520.376 679.89 m
520.376 680.972 521.253 681.85 522.336 681.85 c
523.418 681.85 524.296 680.972 524.296 679.89 c
524.296 678.807 523.418 677.93 522.336 677.93 c
521.253 677.93 520.376 678.807 520.376 679.89 c
b
520.506 694.524 m
520.506 695.607 521.384 696.484 522.466 696.484 c
523.549 696.484 524.426 695.607 524.426 694.524 c
524.426 693.442 523.549 692.565 522.466 692.565 c
521.384 692.565 520.506 693.442 520.506 694.524 c
b
489.016 700.143 m
489.016 701.226 489.893 702.103 490.976 702.103 c
492.058 702.103 492.936 701.226 492.936 700.143 c
492.936 699.06 492.058 698.183 490.976 698.183 c
489.893 698.183 489.016 699.06 489.016 700.143 c
b
489.342 723.01 m
489.342 724.092 490.22 724.97 491.302 724.97 c
492.385 724.97 493.262 724.092 493.262 723.01 c
493.262 721.927 492.385 721.05 491.302 721.05 c
490.22 721.05 489.342 721.927 489.342 723.01 c
b
489.016 747.51 m
489.016 748.592 489.893 749.469 490.976 749.469 c
492.058 749.469 492.936 748.592 492.936 747.51 c
492.936 746.427 492.058 745.549 490.976 745.549 c
489.893 745.549 489.016 746.427 489.016 747.51 c
b
BT
/F3 1 Tf
7.97 0 0 7.97 309.316 597.033 Tm
0 g
/GS2 gs
[(Fig.)-334.3(1.)-324.1(\261)-332.2(Bronchoalve)11.8(olar)-235(lavage)-228.6(\(BAL\))-234.5(cytology)-228.8(at)-231.9(the)-236.9(start)-229.4(and)-234.5(after)-232.1(4)]TJ
0 -1.0599 TD
[(months)-410.9(of)-415.7(therapy)-412.6(when)-412.8(the)-414.8(induction)-406.9(phase)-408.3(was)-416.1(completed)-409.9(and)-412.4(the)]TJ
T*
[(maintenance)-232.9(phase)-237.6(began.)-228.2(a\))-243.9(Percentage)-230.3(of)-237.8(BAL)-238.3(lymphoc)13.1(ytes.)-235(This)-239.7(was)]TJ
0 -1.067 TD
[(determined)-265.7(in)-268.5(seven)-266.1(patients)-266.9(at)-267.5(the)-272.5(start)-264.9(of)-273.4(the)-265.4(induction,)-263.6(and)-270.1(then)-263.3(BAL)]TJ
0 -1.0599 TD
[(was)-273.8(repeated)-266.2(in)-275.6(six)-274.7(patients)-266.9(after)-274.7(the)-272.5(induction)-264.6(phase.)-272.1(b\))-273.4(The)-272.8(CD4/CD8)]TJ
T*
[(ratio)-306.4(of)-301.8(BAL)-302.4(lymphocytes)11.8(.)-304.8(Data)-300.3(points)-306.3(of)-301.9(patients)-295.4(who)-302.1(underwent)-297.1(two)]TJ
0 -1.067 TD
[(BALs)-329.9(are)-333.3(connected)-320.8(by)-330.1(a)-331.2(line.)]TJ
ET
0.495 w 3.864 M 
/GS3 gs
530.322 188.919 m
493.115 312.008 l
492.702 264.159 m
525.785 189.249 l
493.115 203.109 m
522.32 188.754 l
494.352 189.744 m
517.865 189.53 l
S
3.864 M 
380.751 290.229 m
409.461 188.754 l
380.916 247.494 m
411.441 213.009 l
381.741 217.959 m
411.936 240.234 l
415.071 188.919 m
380.751 243.699 l
473.81 185.742 m
537.665 185.742 l
493.115 181.782 m
493.115 185.742 l
524.795 181.782 m
524.795 185.742 l
S
BT
/F16 1 Tf
9.9 0 0 9.9 491.135 171.882 Tm
0 0 0 1 k
/GS4 gs
2.644 Tc
(04)Tj
0.7 -1 TD
0 Tc
(Month)Tj
ET
0 0 0 0 k
/GS3 gs
491.003 203.628 m
491.003 204.722 491.89 205.608 492.983 205.608 c
494.077 205.608 494.963 204.722 494.963 203.628 c
494.963 202.535 494.077 201.648 492.983 201.648 c
491.89 201.648 491.003 202.535 491.003 203.628 c
b
491.003 189.108 m
491.003 190.202 491.89 191.088 492.983 191.088 c
494.077 191.088 494.963 190.202 494.963 189.108 c
494.963 188.015 494.077 187.128 492.983 187.128 c
491.89 187.128 491.003 188.015 491.003 189.108 c
b
490.673 265.008 m
490.673 266.101 491.56 266.988 492.653 266.988 c
493.747 266.988 494.633 266.101 494.633 265.008 c
494.633 263.914 493.747 263.028 492.653 263.028 c
491.56 263.028 490.673 263.914 490.673 265.008 c
b
491.003 312.528 m
491.003 313.621 491.89 314.508 492.983 314.508 c
494.077 314.508 494.963 313.621 494.963 312.528 c
494.963 311.434 494.077 310.548 492.983 310.548 c
491.89 310.548 491.003 311.434 491.003 312.528 c
b
516.083 189.108 m
516.083 190.202 516.97 191.088 518.063 191.088 c
519.157 191.088 520.043 190.202 520.043 189.108 c
520.043 188.015 519.157 187.128 518.063 187.128 c
516.97 187.128 516.083 188.015 516.083 189.108 c
b
520.092 189.084 m
520.092 190.178 520.979 191.064 522.072 191.064 c
523.166 191.064 524.052 190.178 524.052 189.084 c
524.052 187.991 523.166 187.104 522.072 187.104 c
520.979 187.104 520.092 187.991 520.092 189.084 c
b
524.003 189.108 m
524.003 190.202 524.89 191.088 525.983 191.088 c
527.077 191.088 527.963 190.202 527.963 189.108 c
527.963 188.015 527.077 187.128 525.983 187.128 c
524.89 187.128 524.003 188.015 524.003 189.108 c
b
527.963 189.108 m
527.963 190.202 528.849 191.088 529.943 191.088 c
531.037 191.088 531.923 190.202 531.923 189.108 c
531.923 188.015 531.037 187.128 529.943 187.128 c
528.849 187.128 527.963 188.015 527.963 189.108 c
b
468.86 185.742 m
468.86 325.331 l
S
BT
9.9 0 0 9.9 452.528 322.688 Tm
0 0 0 1 k
/GS4 gs
(50)Tj
ET
/GS3 gs
464.9 325.331 m
468.86 325.331 l
S
BT
9.9 0 0 9.9 452.528 295.816 Tm
/GS4 gs
(40)Tj
ET
/GS3 gs
464.9 298.459 m
468.86 298.459 l
S
BT
9.9 0 0 9.9 452.528 267.813 Tm
/GS4 gs
(30)Tj
ET
/GS3 gs
464.9 270.457 m
468.86 270.457 l
S
BT
9.9 0 0 9.9 452.528 240.653 Tm
/GS4 gs
(20)Tj
ET
/GS3 gs
464.9 243.296 m
468.86 243.296 l
S
BT
9.9 0 0 9.9 452.528 211.528 Tm
/GS4 gs
(10)Tj
ET
/GS3 gs
464.9 214.172 m
468.86 214.172 l
S
BT
9.9 0 0 9.9 452.528 182.964 Tm
/GS4 gs
(  0)Tj
ET
/GS3 gs
464.9 185.608 m
468.86 185.608 l
S
BT
9.9 0 0 9.9 439.161 323.351 Tm
/GS4 gs
(b\))Tj
0 9.9 -9.9 0 446.767 236.274 Tm
(IL-2  U\341mL)Tj
0 7.92 -7.92 0 444.522 274.171 Tm
(-1)Tj
ET
3.864 M 
/GS3 gs
459.635 192.714 m
447.095 192.714 l
S
459.346 192.714 m
459.346 194.447 l
463.678 192.714 l
459.346 190.982 l
459.346 192.714 l
f*
3.864 M 
363.921 185.742 m
425.714 185.742 l
381.164 181.782 m
381.164 185.742 l
412.844 181.782 m
412.844 185.742 l
S
BT
9.9 0 0 9.9 379.184 171.882 Tm
/GS4 gs
2.644 Tc
(04)Tj
0.7 -1 TD
0 Tc
(Month)Tj
ET
0 0 0 0 k
/GS3 gs
406.772 189.108 m
406.772 190.202 407.658 191.088 408.752 191.088 c
409.845 191.088 410.732 190.202 410.732 189.108 c
410.732 188.015 409.845 187.128 408.752 187.128 c
407.658 187.128 406.772 188.015 406.772 189.108 c
b
413.042 188.118 m
413.042 189.212 413.928 190.098 415.022 190.098 c
416.115 190.098 417.002 189.212 417.002 188.118 c
417.002 187.025 416.115 186.138 415.022 186.138 c
413.928 186.138 413.042 187.025 413.042 188.118 c
b
409.742 212.868 m
409.742 213.962 410.628 214.848 411.722 214.848 c
412.815 214.848 413.702 213.962 413.702 212.868 c
413.702 211.775 412.815 210.888 411.722 210.888 c
410.628 210.888 409.742 211.775 409.742 212.868 c
b
379.052 218.478 m
379.052 219.572 379.938 220.458 381.032 220.458 c
382.125 220.458 383.012 219.572 383.012 218.478 c
383.012 217.385 382.125 216.498 381.032 216.498 c
379.938 216.498 379.052 217.385 379.052 218.478 c
b
378.722 244.218 m
378.722 245.311 379.608 246.198 380.702 246.198 c
381.795 246.198 382.682 245.311 382.682 244.218 c
382.682 243.125 381.795 242.238 380.702 242.238 c
379.608 242.238 378.722 243.125 378.722 244.218 c
b
378.854 226.332 m
378.854 227.426 379.74 228.312 380.834 228.312 c
381.927 228.312 382.814 227.426 382.814 226.332 c
382.814 225.238 381.927 224.352 380.834 224.352 c
379.74 224.352 378.854 225.238 378.854 226.332 c
b
378.854 247.452 m
378.854 248.545 379.74 249.432 380.834 249.432 c
381.927 249.432 382.814 248.545 382.814 247.452 c
382.814 246.358 381.927 245.472 380.834 245.472 c
379.74 245.472 378.854 246.358 378.854 247.452 c
b
409.742 240.588 m
409.742 241.682 410.628 242.568 411.722 242.568 c
412.815 242.568 413.702 241.682 413.702 240.588 c
413.702 239.494 412.815 238.608 411.722 238.608 c
410.628 238.608 409.742 239.494 409.742 240.588 c
b
378.722 290.748 m
378.722 291.841 379.608 292.728 380.702 292.728 c
381.795 292.728 382.682 291.841 382.682 290.748 c
382.682 289.654 381.795 288.768 380.702 288.768 c
379.608 288.768 378.722 289.654 378.722 290.748 c
b
358.394 185.809 m
358.394 324.836 l
S
BT
9.9 0 0 9.9 312.359 322.856 Tm
0 0 0 1 k
/GS4 gs
(a\))Tj
0 9.9 -9.9 0 320.361 223.404 Tm
-0.014 Tw
(Log TNF-)Tj
/F18 1 Tf
3.449 0 TD
0 Tw
(a)Tj
/F16 1 Tf
0.631 0 TD
(  ng\341mL)Tj
0 7.92 -7.92 0 318.116 290.872 Tm
(-1)Tj
ET
/GS3 gs
354.434 324.836 m
358.394 324.836 l
354.434 279.067 m
358.394 279.067 l
354.434 231.613 m
358.394 231.613 l
354.434 185.282 m
358.394 185.282 l
S
BT
9.9 0 0 9.9 321.153 322.965 Tm
/GS4 gs
(100000)Tj
0 -4.6232 TD
(  10000)Tj
0 -4.7933 TD
(    1000)Tj
0 -4.6799 TD
(      100)Tj
ET
3.864 M 
/GS3 gs
349.566 221.424 m
337.686 221.424 l
S
349.277 221.424 m
349.277 223.156 l
353.608 221.424 l
349.277 219.691 l
349.277 221.424 l
f*
BT
/F3 1 Tf
7.97 0 0 7.97 308.976 146.494 Tm
0 g
/GS2 gs
[(Fig.)-327.1(2.)-331.2(\261)-332.2(Spontaneo)13.7(us)-174.8(cytokine)-170.9(release)-169.9(of)-173.8(bronchoalv)13.4(eolar)-175(lavage)-164.6(\(BAL\))]TJ
0 -1.0599 TD
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[(gi)18.9(ve)15.1(n)-535.7(i)0(n)-533.1(t)0(h)18.9(e)-536.1(in)13.2(du)21.2(ct)18.4(io)13.2(n)-535.7(p)0(h)15.5(a)0(s)19.6(e)-541.8(re)19.2(su)20(lt)16.5(ed)-531.2(in)-527.4(th)13.2(e)-536.1(e)0(x)15.1(p)0(e)20.8(c)0(t)18.4(e)0(d)]TJ
T*
[(im)15.7(pr)19.6(ov)15.5(em)17.7(en)15.1(ts)-340.8(wh)11.6(i)13.9(c)0(h)-349.1(s)0(t)17.7(a)0(b)20.8(i)0(l)16.5(i)0(z)18.4(e)0(d)-349.1(o)0(r)-344.6(e)0(v)20.8(e)0(n)-349.1(f)0(u)19.6(r)0(t)17.3(h)0(e)15.1(r)-355.2(i)13.9(m)0(p)12.4(r)0(o)19.6(v)0(e)15.1(d)]TJ
T*
[(in)-260(th)18.9(e)-268.6(m)0(a)12(i)0(n)18.9(t)0(e)18.4(n)0(a)15.1(n)0(c)20.8(e)-268.6(ph)15.5(as)19.6(e)-274.3(r)0(e)19.2(s)0(u)20(l)0(t)16.5(i)0(n)18.9(g)-273.9(i)13.9(n)-273.9(a)-268.6(h)0(i)18.9(g)0(h)-257.6(r)0(a)13.5(t)0(e)-260.4(o)0(f)-259.2(s)0(y)14.3(m)0(p)18.1(-)]TJ
T*
[(to)18.9(ma)17.7(ti)16.5(c)-319.8(r)0(e)13.5(l)13.9(ie)12.8(f)-315.3(a)0(n)15.1(d)-319.4(im)15.7(pr)19.6(ov)21.2(em)12(en)20.8(t)-321.8(o)0(f)-310.4(p)0(u)21.2(l)0(m)15.7(o)0(n)15.5(a)0(r)19.2(y)-319.4(fu)19.6(nc)15.1(ti)16.5(on)-308.8(in)]TJ
T*
[(an)-314.9(av)15.1(er)19.2(ag)15.1(e)-319.8(t)0(r)17.3(e)0(a)14.7(t)0(m)15.7(e)0(n)20.8(t)-327.5(ti)16.5(me)-312.4(of)-316.1(20)15.5(.2)21.6(\2136)16.7(.3)-314.1(mo)12.4(nt)18.9(hs)20(.)]TJ
1.0015 -1.0471 TD
[(An)-233.1(in)13.2(te)18.4(re)19.2(st)17.7(in)13.2(g)-239.8(a)0(s)13.9(p)0(e)20.8(c)0(t)-237.6(i)0(s)-232.7(t)0(h)18.9(e)-245.9(du)21.2(ra)13.5(ti)16.5(on)-229.2(of)-236.4(th)18.9(e)-245.9(r)0(e)19.2(m)0(i)15.7(s)0(s)18.9(i)0(o)13.2(n)0(.)-234.5(I)0(n)]TJ
-1.0015 -1.0584 TD
[(ei)18.4(gh)15.5(t)-304.7(o)0(f)-299(1)39.1(1)-302.4(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-301(w)12.4(ho)-297.4(co)15.1(mp)18.1(le)18.4(te)18.4(d)-308.1(t)0(h)18.9(e)0(r)13.5(a)0(p)20.8(y)73.2(,)-307.7(a)-308.5(re)19.2(la)18.4(ps)14.4(e)-302.8(h)0(a)15.1(s)]TJ
T*
[(no)15.5(t)-407.2(b)0(e)20.8(e)0(n)-400.3(o)0(b)15.5(s)0(e)19.6(r)0(v)13.9(e)0(d)-394.6(a)0(t)-402.7(t)0(h)18.9(e)-410.9(ti)16.5(m)13.2(e)-410.9(of)-401.5(wr)15.7(it)22.2(in)13.2(g.)-399.5(T)12.2(h)0(e)-400.3(o)0(b)15.5(s)0(e)19.6(r)0(v)19.6(e)0(d)]TJ
T*
[(re)19.2(mi)15.7(ss)18.9(io)13.2(ns)-327.1(ha)15.1(ve)-326.3(no)21.2(w)-340.4(l)0(a)18.4(s)0(t)17.7(e)0(d)-332(4)0(\261)21.2(7)0(3)-331.6(m)0(o)18.1(n)0(t)18.9(h)0(s)14.4(.)-336.1(In)-327.5(vi)18.9(ew)-330.2(of)-327.5(th)13.2(e)]TJ
T*
[(fa)19.2(ct)-305.9(th)18.9(at)-300.2(th)18.9(es)14(e)-308.5(p)0(a)15.1(t)13.9(ie)12.8(nt)18.9(s)-309.2(h)0(a)15.1(d)-308.1(ha)20.8(d)-313.7(u)0(p)-297.4(t)0(o)-305.5(f)0(o)19.6(u)0(r)-299(r)0(e)13.5(l)0(a)18.4(p)0(s)20(e)0(s)-304.7(w)0(i)14.9(t)13.9(hi)13.2(n)]TJ
T*
[(th)18.9(e)-206(p)0(r)14(e)0(v)20.8(i)0(o)13.2(u)0(s)-196.2(3)-205.6(yr)13.9(s,)-195.8(th)18.9(es)13.9(e)-206(r)0(e)19.2(s)0(u)14.4(l)0(t)22.2(s)-212.5(ar)19.2(e)-206(n)0(o)15.5(t)0(e)18.4(w)0(o)17.3(r)0(t)17.3(h)0(y)78.1(.)-205.2(T)12.2(h)0(e)-201.1(p)0(a)15.1(t)0(i)22.2(e)0(n)15.1(t)]TJ
25.1977 66.1583 TD
[(wi)14.9(th)-191.7(th)18.9(e)-200.3(r)0(e)13.5(m)0(i)15.7(s)0(s)18.9(i)0(o)18.9(n)-199.9(of)-190.9(73)-195(mo)18.1(nt)18.9(hs)-190.5(ha)15.1(d)-199.9(s)0(u)20(f)14.7(fe)19.2(re)19.2(d)-199.9(t)0(h)13.2(r)0(e)19.2(e)-200.3(re)19.2(la)12.8(ps)20(es)]TJ
0 -1.0471 TD
[(wi)14.9(th)18.9(in)-254.3(th)18.8(e)-262.9(p)0(r)13.9(e)0(v)20.8(i)0(o)18.9(u)0(s)-253.1(4)-262.5(yr)13.9(s)-258(r)0(e)13.5(q)0(u)21.2(i)0(r)17.3(i)0(n)13.2(g)-256.8(a)-262.9(t)0(o)13.2(t)0(a)18.4(l)-259.2(of)-253.5(32)-251.9(mo)12.4(nt)18.9(hs)-253.1(of)]TJ
0 -1.0528 TD
[(pr)13.9(ed)20.8(ni)13.2(so)20(lo)18.8(ne)-514.1(th)13.2(er)19.2(ap)15.1(y)73.2(.)-523.9(Un)17.3(fo)19.6(rt)17.3(un)15.5(at)18.4(el)18.5(y)73.2(,)-523.9(th)13.2(re)19.2(e)-524.7(p)0(a)15.1(t)13.9(ie)12.8(nt)18.8(s)-525.5(s)0(u)20(f)0(-)]TJ
T*
[(fe)13.5(re)19.2(d)-473.1(f)0(r)18(o)0(m)-459.9(r)0(e)13.5(l)0(a)18.4(p)0(s)20(e)0(s)-464.1(a)0(n)15.1(d)-467.4(no)-462.5(cl)18.5(in)18.9(ic)12.8(al)-459.6(fi)17.3(nd)15.5(in)18.9(gs)-463.7(co)20.8(ul)18.8(d)-473.1(d)0(i)18.8(s)0(-)]TJ
0 -1.0471 TD
[(ti)16.5(ng)15.5(ui)18.9(sh)-281.6(t)13.9(w)0(o)-284.3(o)0(f)-276.3(t)0(h)18.8(e)0(m)-283.9(f)0(r)18(o)0(m)-277.8(t)0(h)18.9(e)-291.4(gr)19.6(ou)15.5(p)-285.3(w)0(i)14.9(t)0(h)18.9(o)0(u)15.5(t)-287.7(re)19.2(la)18.4(ps)14.4(e.)-274.7(Th)17.1(e)]TJ
0 -1.0527 TD
[(th)13.2(ir)17.3(d,)-217.4(ho)21.2(we)16.9(ve)15.1(r)37.5(,)-222.3(re)13.5(qu)21.2(ir)17.3(ed)-223.9(t)13.9(w)0(o)-221.7(i)0(n)18.9(d)0(u)15.5(c)0(t)18.4(i)0(o)18.9(n)-228.4(ph)15.5(as)19.6(es)-219.4(an)15.1(d)-228.4(a)0(f)19.2(t)0(e)18.4(r)-230(th)18.9(e)]TJ
0 -1.0471 TD
[(se)13.9(co)20.8(nd)-394.2(in)18.8(du)15.5(ct)18.5(io)18.9(n)-404.8(p)0(h)21.2(a)0(s)13.9(e)0(,)-388.5(w)0(h)11.6(i)13.9(ch)-394.6(wa)16.9(s)-406(s)0(u)20(c)0(c)20.4(e)0(s)13.9(s)0(f)18.4(u)0(l)18.8(,)-404.4(th)18.8(ey)-394.6(te)18.5(r)20.4(-)]TJ
0 -1.0527 TD
[(mi)15.7(na)15.1(te)18.4(d)-433.2(t)0(h)13.2(e)-433.7(tr)17.3(ea)20.4(tm)15.7(en)15.1(t)-435.6(p)0(r)19.6(e)0(m)17.7(a)0(t)12.8(u)0(r)19.6(e)0(l)18.5(y)-433.3(af)13.5(te)18.4(r)-434.8(8)-433.3(mo)12.4(nt)18.9(hs)20(.)-432.9(T)0(h)17.1(i)0(s)]TJ
0 -1.0471 TD
[(ra)13.5(is)17.7(es)-486.8(th)18.9(e)-490.6(p)0(o)15.5(s)0(s)18.8(i)0(b)18.9(i)0(l)16.5(i)0(t)16.5(i)0(e)18.4(s)-497(th)18.9(at)-488(ei)18.4(th)18.9(er)-487.2(th)18.9(e)-496.3(d)0(i)18.9(s)0(e)19.6(a)0(s)14(e)-490.6(pr)13.9(oc)20.8(es)13.9(se)19.6(s)]TJ
0 -1.0527 TD
[(we)16.9(re)-356.3(re)13.5(si)17.7(st)17.7(an)20.8(t)-361.6(t)0(o)-356.7(i)0(m)15.7(m)0(u)18.1(n)0(o)15.5(s)0(u)20(p)0(p)21.2(r)0(e)13.5(s)0(s)18.9(i)0(o)18.9(n)-365(or)-350.2(th)13.2(e)-359.7(m)0(a)17.7(i)0(n)13.2(t)0(e)18.4(n)0(a)20.8(n)0(c)15.1(e)]TJ
0 -1.0471 TD
[(th)13.2(er)19.2(ap)15.1(y)-319.4(w)0(a)16.9(s)-326.3(to)18.8(o)-325.1(s)0(h)20(o)0(r)14(t)0(.)]TJ
1.0015 -1.0528 TD
[(Th)17.1(e)-325.5(u)0(s)14.4(e)-325.5(of)-310.4(az)14.7(at)18.5(hi)18.9(op)15.5(ri)17.3(ne)-314.9(an)15.1(d)-325.1(p)0(r)19.6(e)0(d)15.1(n)0(i)18.9(s)0(o)20(l)0(o)18.9(n)0(e)-320.6(f)0(o)19.6(r)-326.7(th)18.8(e)-325.5(t)0(r)17.3(e)0(a)20.4(t)0(-)]TJ
-1.0015 -1.0471 TD
[(me)12(nt)-447.8(of)-452.7(ch)15.1(ro)19.6(ni)18.9(c)-462.1(i)0(n)18.8(f)0(l)17.3(a)0(m)17.7(m)0(a)12(t)0(o)18.9(r)0(y)-452.7(d)0(i)18.9(s)0(o)20(r)0(d)13.9(e)0(r)19.2(s)-462.9(w)12.4(a)0(s)-452.7(d)0(e)15.1(v)0(e)20.8(l)0(o)18.9(p)0(e)15.1(d)]TJ
0 -1.0527 TD
[(em)12(pi)18.9(ri)17.3(ca)20.4(ll)16.5(y)-347.9([)0(2)19.6(4)0(])-344.6(but)-357.5(there)-361.4(is)-357.9(now)-359(some)-354.9(eviden)-7.8(ce)-355.2(for)-358.3(the)]TJ
0 -1.0471 TD
[(requi)-8.2(reme)-8.6(nt)-538.8(of)-543.7(a)-541.8(2-yr)-546.8(maintenan)-10.3(ce)-542.9(thera)-8.6(py)61.1(.)-541(Immuno-)]TJ
0 -1.0527 TD
[(logi)-7.8(cal)-506.2(findi)-10.2(ngs)-504.2(in)-510.4(sarcoidosi)-11.5(s)-502.7(are)-511.2(consi)-7.8(stent)-510.9(with)-506.8(the)]TJ
T*
[(con)-8.4(cept)-433(of)-435.6(an)-428.7(overexu)-7.7(berant)-441.8(cellular)-437.2(imm)-11(une)-429.5(respon)-7.8(se)]TJ
0 -1.0471 TD
[(aga)-8.8(inst)-299.2(an)-297.8(unknown)-299.5(anti)-8.2(gen)-298.6(or)-299(antigens)-303.1(withi)-9.2(n)-296.7(the)-295.3(lungs)]TJ
0 -1.0527 TD
[(and)-560.4(other)-565.9(organs)-554.1([17,)-556.2(31].)-561.9(In)-560.8(acute)-559.4(sarcoi)-10.6(dosis)-560.6(with)]TJ
0 -1.0471 TD
[(spont)-7.4(aneous)-228.5(resoluti)-10.7(on)-217.8(of)-225.1(the)-221.3(disea)-8.2(se,)-225.4(the)-221.3(immune)-229.9(system)]TJ
0 -1.0527 TD
[(is)-517.3(capabl)-8.2(e)-507.6(o)0(f)-515.3(elimin)-9.6(ating)-515.4(the)-517.2(antigen)-517.4(and)-514.8(down-regu-)]TJ
0 -1.0471 TD
[(latin)-11.4(g)-353.6(the)-352.2(immu)-11.7(ne)-354.7(response)-358([23],)-359.4(but)-357.5(in)-356.7(chronic)-357.3(d)-6.5(isease)]TJ
0 -1.0527 TD
[(the)-545.7(causat)-9.4(ive)-540(ag)-7.6(ent)-540(withst)-11.1(ands)-545.3(the)-540(immune)-548.6(proces)-8.2(ses)]TJ
0 -1.0471 TD
[(induci)-9.7(ng)-269(a)-268.6(long)-267.2(lasting)-275.8(granul)-9(omatous)-274.2(reaction)-275.4(simil)-9.6(ar)-265.3(to)]TJ
0 -1.0527 TD
[(chroni)-9(c)-524.7(beryl)-8.2(liosis)-531.9(in)-521.7(whi)-8.6(ch)-525.5(the)-528.6(causative)-532.3(agent)-530.5(of)-526.7(a)]TJ
0 -1.0471 TD
[(granul)-9(omat)-9(ous)-242.5(inflamm)-12.7(ation)-248(persists)-255.4(in)-242.9(the)-244.1(alveol)-10.1(ar)-242.5(mac-)]TJ
0 -1.0528 TD
[(rophage)-7.7(s)-320.6([17].)-319.6(Althoug)-8.3(h)-313.8(corticost)-11.9(eroids)-317.4(suppre)-7.8(ss)-316.9(the)-318.1(ac-)]TJ
T*
[(tivity)-321.4(of)-310.4(pulmonary)-321.7(immune)-315.3(cell)-8.6(s)-309.2(within)-317.2(a)-308.5(few)-315.5(weeks,)-317.4(it)]TJ
0 -1.0471 TD
[(takes)-355.3(more)-355.3(than)-353(6)-347.9(months)-352.7(for)-352.6(lym)-7.8(phocyt)-7.4(es)-350.2(to)-345.3(disap)-7.8(pear)]TJ
0 -1.0528 TD
[(from)-311(the)-312.4(lower)-308(respi)-9.4(ratory)-312.2(tract)-312.6([32])-307.8(and)-310(the)-306.7(loweri)-9.6(ng)-303.1(of)]TJ
0 -1.0471 TD
[(imm)-11(unosupp)-6.5(ressive)-376.7(therapy)-374.3(too)-374.6(early)-378.5(might)-375.9(allow)-371.4(a)-371.1(re-)]TJ
0 -1.0528 TD
[(acti)-8.6(vation)-305.7(of)-304.7(these)-304.1(ce)-8(lls.)-304.5(Since)-302.1(a)-6.9(zathiopri)-10.7(ne)-303.5(is)-301(though)-7(t)-299.1(t)0(o)]TJ
0 -1.0471 TD
[(hav)-8.4(e)-428(a)-428(delaye)-8.2(d)-427.6(effect)-426.8([24])-433(a)-433.7(treatmen)-11.1(t)-429.9(period)-435.8(of)-429.9(2)-427.6(yrs)]TJ
0 -1.0527 TD
[(seem)-8.2(s)-332(app)-8.4(ropriate.)]TJ
1.0015 -1.0471 TD
[(Fo)16.3(rt)17.3(un)15.5(at)18.4(el)18.4(y)73.2(,)-387.3(ad)15.1(ve)20.8(rs)18.4(e)-388.1(e)0(f)30.6(f)0(e)13.5(c)0(t)18.4(s)-383.2(re)13.5(qu)21.2(ir)17.3(in)18.9(g)-387.7(t)0(r)17.3(e)0(a)20.4(t)0(m)15.7(e)0(n)15.1(t)-384.4(or)-378.7(te)18.5(r)20.4(-)]TJ
-1.0015 -1.0527 TD
[(mi)15.7(na)15.1(ti)16.5(on)-451.1(of)-447(th)18.8(er)13.5(ap)20.8(y)-461.7(w)0(e)16.9(r)0(e)-453.1(n)0(o)21.2(t)-458.4(ob)15.5(se)19.6(rv)13.9(ed)20.8(.)-461.3(I)0(n)-447(o)0(n)15.5(e)-462.1(ca)20.4(se)19.6(,)-461.3(a)]TJ
0 -1.0471 TD
[(ma)12(r)20.4(g)0(i)18.9(n)0(a)15.1(l)0(l)16.5(y)-399.1(el)18.5(ev)15.1(at)18.4(ed)-394.6(le)18.4(ve)15.1(l)-401.5(o)0(f)-395.8(l)0(i)16.5(p)0(a)20.8(s)0(e)-395.8(w)0(a)16.9(s)-400.3(ob)15.5(se)19.6(rv)13.9(ed)20.8(,)-404.4(a)-405.2(ra)19.2(re)]TJ
0 -1.0528 TD
[(si)17.7(de)15.1(-e)19.2(f)14.7(f)0(e)19.2(c)0(t)-345.7(o)0(f)-344.6(a)0(z)20.4(a)0(t)18.5(h)0(i)13.2(o)0(p)21.2(r)0(i)17.3(n)0(e)-343.4(k)0(n)15.5(o)0(w)17.3(n)-353.6(to)-345.3(re)19.2(so)20(lv)13.2(e)-348.3(b)0(y)-343(l)0(o)13.2(w)12.4(er)13.5(in)18.8(g)]TJ
T*
[(th)13.2(e)-382.4(d)0(o)21.2(s)0(e)-378.7(o)0(r)-373(c)0(e)14.7(s)0(s)18.9(a)0(t)18.4(i)0(o)18.8(n)-382(of)-378.7(th)18.9(er)19.2(ap)15.1(y)-382([)0(1)19.6(5].)-390.5(Thus,)-395.7(the)-392(a)-6.9(uthors)]TJ
0 -1.0471 TD
[(con)-8.4(sider)-407.7(azathi)-10.6(oprine/pre)-10.7(dnisolone)-411.6(thera)-8.6(py)-405.6(to)-407.9(be)-406(a)-405.2(safe)]TJ
0 -1.0527 TD
[(thera)-8.6(peuti)-9(cal)-335.5(option)-339.4(for)-335.5(resistant)-343.2(sarcoi)-10.5(dosis.)]TJ
1.0015 -1.0471 TD
[(An)11.6(al)18.5(ys)20(in)18.9(g)-273.9(B)11.6(AL)-260(cy)15.1(to)18.9(lo)18.8(gy)-263.3(be)20.8(fo)13.9(re)-259.6(an)15.1(d)-268.2(a)0(f)19.2(t)0(e)18.4(r)-269.8(th)13.2(e)-268.6(i)0(n)18.9(d)0(u)15.5(c)0(t)18.5(i)0(o)18.8(n)]TJ
-1.0015 -1.0527 TD
[(ph)15.5(as)19.6(e)-416.6(r)0(e)19.2(v)0(e)15.1(a)0(l)18.4(e)0(d)-400.3(t)0(h)18.8(a)0(t)-408.3(t)0(h)18.8(e)-410.9(ex)15.1(pe)20.8(ct)18.4(ed)-406(de)15.1(cr)19.2(ea)20.4(se)-407.2(in)-402.2(BA)18.3(L)-414.6(l)0(y)18.8(m)0(-)]TJ
0 -1.0471 TD
[(ph)15.5(oc)15.1(yt)18.9(es)-196.6(an)20.8(d)-205.6(t)0(h)18.9(e)0(i)18.4(r)-207.2(CD)18.3(4/)13.2(C)11.6(D)0(8)-198.9(r)0(a)19.2(t)0(i)16.5(o)-205.6(oc)20.8(cu)15.1(rr)18(ed)-195.4(in)-197.4(4/)18.9(6)-205.6(a)0(n)15.1(d)-199.9(in)-197.4(5/)]TJ
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