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[(piratory)-242.1(volum)-9.3(e)-234.5(i)0(n)-231.5(one)-236(second)-239.9(\(FE)-7.2(V)]TJ
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25.1977 24.697 TD
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[(studi)-9.8(es)-242.1(and)]TJ
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[(labor)-8.2(atory)-315.5(experi)-9.4(ments)-312.5(sugges)-7.4(t)-310.4(that)-315.5(particles)-319.6(from)-316.7(diesel)]TJ
T*
[(exh)-8.4(aust,)-189.5(one)-190.5(of)-185.2(the)-192.9(major)-193.4(contribut)-10.3(ors)-187.2(to)-191.7(particula)-11.1(te)-186.4(matter)]TJ
T*
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T*
[(acti)-8.6(ons)-333.5(and)-338.4(BHR)-340([16].)]TJ
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[(fo)19.6(r)-292.6(9)0(\261)21.2(1)39.1(1)-285.3(y)0(r)-282(o)0(l)18.9(d)0(s)14.4(.)-284.9(A)-289.2(c)0(o)15.1(m)0(p)18.1(l)0(e)18.4(t)0(e)18.4(d)-291(qu)21.2(es)13.9(ti)22.2(on)15.5(na)15.1(ir)17.3(e)-285.7(w)0(a)16.9(s)-286.5(re)13.5(tu)18.9(rn)19.6(ed)]TJ
0 -1.0471 TD
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0 -1.0528 TD
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0 -1.0471 TD
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0 -1.0527 TD
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0 -1.0471 TD
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0 -1.0527 TD
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0 -1.0471 TD
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0 -1.0528 TD
[(iting")-356.1(wheezing)-355.1(in)-345.3(the)-352.2(last)-350.8(12)-348.7(months.)-353.1(Sympt)-8.6(oms)-348.1(of)-350.2(al-)]TJ
0 -1.0471 TD
[(lergic)-256.4(rhino)-7.8(conjunctiv)-9.9(itis)-261.8(\("sne)-10(ezing)-263.1(or)-259.2(runny)57.2(,)-256.5(o)-6.5(r)-258.4(blocke)-7.8(d)]TJ
0 -1.0527 TD
[(nose)-277.8(without)-278.2(a)-274.3(cold")-277(and)-275.8("itchy-)-9.4(watery)-280.7(eyes")-8.8(\))-269.8(and)-275.8(atopi)-9(c)]TJ
0 -1.0471 TD
[(eczem)-8.6(a)-575.9(\("itchy)-9.4(-rash"\))-583.7(during)-583.3(the)-574.1(last)-584.2(year)-580.2(were)-578.4(also)]TJ
0 -1.0528 TD
[(asses)-8.2(sed)]TJ
/F6 1 Tf
3.6932 0 TD
(via)Tj
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1.5421 0 TD
[(ISAA)-11.7(C)-329.8(core)-341.2(quest)-7.8(ions.)]TJ
-4.2338 -1.0471 TD
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-1.0015 -1.0528 TD
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0 -1.0471 TD
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0 -1.0528 TD
[(th)18.9(e)-342.6(l)0(a)18.4(s)0(t)-329.5(1)0(2)-331.6(m)0(o)18.1(n)0(t)18.9(h)0(s)20(?)0(")12.2(\))0(.)-327.1(T)0(h)17.1(i)0(s)-329.5(q)0(u)15.5(e)0(s)19.6(t)0(i)16.5(o)0(n)-331.6(h)0(a)20.8(d)-336.5(be)15.1(en)-332(de)20.8(ve)15.1(lo)18.9(pe)15.1(d)]TJ
0 -1.0471 TD
[(fo)19.6(r)-230(q)0(u)15.5(e)0(s)19.6(t)0(i)16.5(o)0(n)15.5(n)0(a)20.8(i)0(r)17.3(e)0(s)-219.4(o)0(f)-225.1(t)13.9(he)-223.9(B)11.6(r)0(i)17.3(t)0(i)16.5(s)0(h)-219(M)0(e)13.2(d)0(i)18.9(c)0(a)14.7(l)-225.1(Re)16.1(se)13.9(ar)19.2(ch)-218.2(Co)16.5(un)15.5(ci)18.5(l)]TJ
0 -1.0527 TD
[([2)19.6(0].)-276.6(Pa)-6.8(rents)-288.2(were)-288.2(furt)-8.6(hermore)-291.3(asked:)-293.5("Did)-285.5(a)-285.7(doctor)-293.5(ever)]TJ
0 -1.0471 TD
[(diagno)-7.4(se)-321.8(any)-327.1(of)-321.8(the)-329.4(follow)-9.2(ing)-323.3(disea)-8.2(ses)-323.7(in)-322.6(your)-329(child?)-328.8(a\))]TJ
0 -1.0528 TD
[(asthma;)-288.4(b\))-276.3(asthm)-10.9(atic,)-282.1(spastic)-280.7(or)-282(obstructi)-11.5(ve)-280.8(bronchiti)-10.3(s;)-278.2(c\))]TJ
0 -1.0471 TD
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0 -1.0527 TD
[(doctor)-458.5(had)-457.9(diagno)-7.4(sed)-453.4("asthm)-9(a")-454.4(at)-453.9(least)-460.1(once)-453.4(or)-458.4("asth-)]TJ
0 -1.0471 TD
[(matic,)-320.2(spast)-9(ic)-311.6(or)-316.1(obstru)-9.7(ctive)-316.7(bronchi)-9.7(tis")-313.6(more)-321.2(than)-318.8(once.)]TJ
0 -1.0528 TD
[(Childr)-10(en)-292.2(wer)-8.2(e)-297.1(classified)-304.5(as)-299(having)-297.6(bronchi)-9.7(tis,)-298.8(if)-295.7(a)-297.1(doctor)]TJ
T*
[(had)-327.1(diagno)-7.4(sed)-328.2("bronchit)-10.9(is")-327.5(more)-326.9(than)-330.2(once,)-328.6(and)-332.7(if)-324.2(these)]TJ
0 -1.0471 TD
[(children)-388.8(did)-385.9(not)-380.2(meet)-390.6(the)-380.7(defin)-8.2(ition)-386.5(criteria)-393.2(for)-381.1(asthm)-10.9(a.)]TJ
0 -1.0527 TD
[(The)-627.1(quest)-7.8(ions)-626.9(on)-621.8(doctor)]TJ
/F11 1 Tf
10.7096 0 TD
(')Tj
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0.2162 0 TD
[(s)-622.2(diagno)-7.4(ses)-625.3(o)-6.5(f)-622.6(asthma)-632.4(and)]TJ
-10.9259 -1.0471 TD
[(bronchi)-9.7(tis)-383.8(incl)-8.2(uded)-384.7(in)-390.9(this)-384.6(study)-394.3(were)-390.7(validated)-390.8(agains)-9(t)]TJ
0 -1.0527 TD
[(BHR)-271.7(to)-271.4(cold)-273.3(air)-268.4(in)-271.4(Bavarian)-277.8(schoolchil)-11.1(dren)-272.5([21].)-268.4(Final)-8.2(ly)58.7(,)]TJ
0 -1.0471 TD
[(quest)-7.8(ions)-439.1(on)-434(living)-438.5(cond)-9.1(itions,)-440.1(family)-441.3(backgro)-7.7(und)-440.5(and)]TJ
0 -1.0528 TD
[(traffic)-334.4(density)-341.7(on)-331.6(the)-335.1(stre)-8.6(et)-334.4(of)-333.2(resi)-8.6(dence)-340.8(were)-339.4(evaluated.)]TJ
1.0015 -1.0471 TD
[(Al)14.9(l)-225.1(9)0(\261)21.2(1)39.1(1)-228.4(y)0(r)-213.7(o)0(l)18.9(d)0(s)-219(a)0(n)20.8(d)-228.4(a)-223.1(r)0(a)13.5(n)0(d)21.2(o)0(m)-220.9(s)0(u)20(b)0(s)20(a)0(m)12(p)0(l)18.9(e)-223.1(of)-219.4(5\261)21.2(7)-228.4(y)0(r)-213.7(o)0(l)13.2(d)0(s)]TJ
-1.0015 -1.0528 TD
(\(n)Tj
/F9 1 Tf
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(=)Tj
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[(2,)21.6(32)15.5(8\))-498.2(we)16.9(re)-498.6(in)18.9(vi)13.2(te)18.4(d)-507.2(t)0(o)-499(t)0(a)18.4(k)0(e)-497(p)0(a)15.1(r)0(t)-494.9(i)0(n)-499(s)0(k)14.4(i)0(n)18.9(-)0(p)19.6(r)0(i)17.3(c)0(k)-502.7(t)13.9(es)13.9(ts)]TJ
-1.3487 -1.0471 TD
[(\(S)14.7(P)11.4(T)0(\))-206.4(a)0(n)20.8(d)-211.3(bl)13.2(oo)21.2(d)-211.3(s)0(a)13.9(m)0(p)18.1(l)0(i)16.5(n)0(g)-200.7(\()0(I)18(S)0(A)12.4(A)12.4(C)-216(P)11.4(h)0(a)15.1(s)0(e)-202.3(I)0(I)-203.9(m)0(o)12.4(d)0(u)21.2(l)0(e)18.4(s)0(\))12.8(.)-210.9(T)12.2(h)0(e)]TJ
0 -1.0528 TD
[(S)11.4(P)0(T)74.8(s)-525.5(w)12.4(e)0(r)13.5(e)-524.7(pe)15.1(rf)18(or)19.6(me)17.7(d)-530(o)0(n)-513.7(t)0(h)18.9(e)-530.4(le)18.4(ft)-517.7(fo)19.6(re)13.5(ar)19.2(m)-527.4(u)0(s)20(i)0(n)18.9(g)-530(A)12.4(L)0(K)]TJ
0 -1.0471 TD
[(la)18.4(nc)15.1(et)18.4(s)-349.1(a)0(n)15.1(d)-347.9(st)17.7(an)15.1(da)20.8(rd)19.6(iz)12.8(ed)-337.7(al)18.5(le)12.8(r)20.4(g)0(e)20.8(n)-353.6(ex)20.8(tr)17.3(ac)14.7(ts)-340.8(of)-338.9(mi)15.7(xe)15.1(d)-347.9(g)0(r)19.6(a)0(s)13.9(s)]TJ
25.1977 66.1583 TD
[(po)15.5(ll)16.5(en)20.8(,)-284.9(m)0(i)15.7(x)0(e)15.1(d)-279.6(tr)17.3(ee)-275.5(po)15.5(ll)16.5(en)20.8(,)]TJ
/F6 1 Tf
10.3682 0 TD
[(Al)14.7(te)18.4(rn)20(ar)14.4(ia)-271.4(te)12.8(nu)21.2(is)]TJ
/F3 1 Tf
6.6352 0 TD
(,)Tj
/F6 1 Tf
0.5349 0 TD
[(De)16.9(rm)16.1(at)18.8(op)15.5(ha)21.2(-)]TJ
-17.5383 -1.0471 TD
[(go)15.5(id)18.9(es)-651.8(pt)18.9(er)48.1(on)15.5(ys)19.6(si)17.7(nu)15.5(s)]TJ
/F3 1 Tf
9.1845 0 TD
[(an)15.1(d)]TJ
/F6 1 Tf
2.0827 0 TD
[(D.)-653.8(f)13.9(a)0(r)14.4(i)0(n)18.8(a)0(e)]TJ
/F3 1 Tf
4.4216 0 TD
[(,)-654.8(a)0(n)15.1(d)-660.9(ca)20.4(t)-663.2(\()0(A)15.7(L)12.2(K)]TJ
-15.6888 -1.0528 TD
[(la)12.8(bo)21.2(ra)13.5(t)13.9(o)0(r)14(i)0(e)18.4(s)0(,)-457.6(H)0(o)]TJ
6.0661 0 TD
[(\310)-76.3(r)0(s)18.4(h)0(o)15.5(l)0(m)15.7(,)-461.3(De)16.9(nm)18.1(ar)13.5(k\))19.6(.)-467(T)12.2(he)-457.2(wh)17.3(ea)14.7(l)-464.1(s)0(i)17.7(z)0(e)-457.6(w)0(a)16.9(s)]TJ
-6.0661 -1.0471 TD
[(ca)14.7(lc)18.4(ul)18.9(at)12.8(ed)-548.2(as)-549.4(th)18.9(e)-558.8(m)0(e)17.7(a)0(n)-548.2(o)0(f)-549.4(t)0(h)18.9(e)-558.8(lo)18.9(ng)-547.8(ax)15.1(is)-545.7(an)15.1(d)-558.4(i)0(t)16.5(s)-553.9(pe)15.1(r)20.4(-)]TJ
0 -1.0528 TD
[(pe)15.1(nd)15.5(i)13.9(c)0(u)15.1(l)0(a)18.4(r)60.2(.)-273.5(A)0(t)14.9(o)0(p)15.5(i)0(c)-266.1(s)0(e)19.6(n)0(s)14.3(i)0(t)16.5(i)0(z)18.4(a)0(t)18.5(i)0(o)18.9(n)-279.6(w)12.4(a)0(s)-270.6(d)0(e)15.1(f)0(i)17.3(n)0(e)20.8(d)-273.9(as)-270.6(a)-274.3(w)0(h)17.3(e)0(a)14.7(l)-276.3(of)]TJ
/F12 1 Tf
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($)Tj
/F3 1 Tf
0.8251 0 TD
[(3)-416.2(m)0(m)-406.2(t)0(o)-402.2(a)0(t)-408.3(l)0(e)18.4(a)0(s)19.6(t)-418.6(on)21.2(e)-416.6(a)0(l)18.5(l)0(e)18.4(r)20.4(ge)15.1(n)-410.5(a)0(f)13.5(t)0(e)18.4(r)-412.1(su)14.4(bt)18.8(ra)19.2(ct)18.4(io)13.2(n)-410.5(o)0(f)-407.2(t)0(h)18.9(e)]TJ
-0.8251 -1.0528 TD
[(re)13.5(ac)20.4(ti)16.5(on)-405.6(to)-402.3(th)18.9(e)-410.9(n)0(e)15.1(g)0(a)20.8(t)0(i)16.5(v)0(e)-406(c)0(o)20.8(n)0(t)18.9(r)0(o)13.9(l)0(.)-401.9(S)11.4(PT)-374.7(re)19.2(su)14.4(lt)16.5(s)-411.7(o)0(f)-401.5(c)0(h)20.8(i)0(l)16.5(d)0(r)13.9(e)0(n)]TJ
0 -1.0471 TD
[(re)13.5(ac)20.4(ti)16.5(ng)-263.3(ne)15.1(ga)20.8(ti)16.5(ve)-263.7(to)-265.7(hi)18.9(st)17.7(am)17.7(in)18.9(e)-274.3(\()0(w)15.7(h)0(e)15.1(a)0(l)]TJ
/F9 1 Tf
14.9377 0 TD
(<)Tj
/F3 1 Tf
0.5463 0 TD
0.2682 Tc
[(2m)268.2(m)283.1(,)-5.3(n)]TJ
/F9 1 Tf
3.3062 0 TD
0 Tc
(=)Tj
/F3 1 Tf
0.5463 0 TD
[(72)21.2(\))-275.5(w)0(e)16.9(r)0(e)]TJ
-19.3365 -1.0527 TD
[(ex)15.1(cl)18.4(ud)15.5(ed)-400.3(fr)18(om)-403(th)13.2(e)-410.9(a)0(n)20.8(a)0(l)12.8(y)0(s)20(i)0(s)17.7(.)-410.1(Sp)16.3(ec)20.4(if)17.3(ic)-402.6(se)14(ru)19.6(m)-413.6(i)0(m)15.7(m)0(u)18.1(n)0(o)15.5(g)0(l)18.9(o)0(-)]TJ
T*
[(bu)15.5(li)16.5(n)-199.9(\()0(I)12.4(g)0(\))19.6(E)-204.1(ag)20.8(ai)12.8(ns)20(t)-202.3(a)-206(pa)20.8(ne)15.1(l)-202.3(o)0(f)-196.6(a)0(e)20.4(r)0(o)19.6(a)0(l)12.8(l)0(e)18.5(r)20.4(ge)15.1(ns)-190.5(wa)16.9(s)-206.8(d)0(e)20.8(t)0(e)18.4(r)0(m)10.8(i)13.9(ne)15.1(d)]TJ
0 -1.0471 TD
[(by)-582(F)11.4(l)0(u)18.8(o)0(r)14(e)0(s)19.6(c)0(e)14.7(n)0(c)20.8(e)-587.3(En)17.1(zy)15.1(me)-579.8(Im)16.5(mu)18.1(no)-582(A)12.4(s)0(s)13.2(a)0(y)-576.7(\()0(S)14.7(X)12.4(1)-586.9(C)0(A)12.6(P)11.4(;)]TJ
0 -1.0528 TD
[(Ph)16.3(ar)13.5(m)13.2(a)0(c)14.7(i)0(a)18.4(,)-228(L)12.2(u)0(n)15.5(d)0(,)-217.4(S)11.4(we)16.9(de)15.1(n\))19.6(.)-228(S)11.4(PT)80.5(s)-229.6(w)0(e)16.9(r)0(e)-214.1(p)0(e)15.1(r)0(f)18(o)0(r)14(m)0(e)17.7(d)-222.7(in)-220.2(1,)21.6(36)15.5(0)]TJ
0 -1.0471 TD
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0 -1.0527 TD
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[(bu)15.5(t)-259.2(w)12.4(as)-253.5(al)18.5(so)-247.4(as)13.9(pi)18.9(re)19.2(d)-262.5(f)0(o)19.6(r)-258.4(th)18.9(e)-262.9(2)0(6)-246.2(m)0(e)12(a)0(s)19.6(u)0(r)19.6(e)0(m)12(e)0(n)20.8(t)0(s)-249.8(a)0(t)-254.7(t)0(h)18.8(e)-257.2(si)17.7(ng)15.5(le)]TJ
0 -1.0528 TD
[(po)15.5(in)18.8(ts)17.7(.)-632(M)0(e)13.2(a)0(s)19.6(u)0(r)19.6(e)0(m)12(e)0(n)20.8(t)-634.8(qu)15.5(al)18.4(it)16.5(y)-632.4(w)0(a)16.9(s)-633.6(co)15.1(nt)18.9(ro)19.6(ll)16.5(ed)-627.9(by)-621.8(da)15.1(il)16.5(y)]TJ
0 -1.0471 TD
[(ca)14.7(l)13.9(i)0(b)13.2(r)0(a)19.2(t)0(i)16.5(o)0(n)-343(w)0(i)14.9(t)0(h)-345.3(i)0(n)18.9(t)0(e)18.4(r)0(n)13.9(a)0(l)-345.7(s)0(t)17.7(a)0(n)20.8(d)0(a)15.1(r)0(d)19.6(s)-354.8(\(a)19.2(cc)14.7(ep)20.8(te)12.8(d)-353.6(r)0(a)19.2(n)0(g)15.5(e)-354(\213)11.8(1)0(0)15.5(%)]TJ
0 -1.0527 TD
[(ab)15.1(ou)21.2(t)-395.8(t)0(h)18.9(e)-393.8(re)19.2(fe)13.5(re)19.2(nc)15.1(e\))19.2(,)-393(a)0(n)15.1(d)-393.4(un)21.2(an)15.1(no)21.2(un)15.5(ce)14.7(d)-393.4(c)0(o)20.8(n)0(t)18.9(r)0(o)13.9(l)-395.8(m)13.2(e)0(a)14.7(s)0(u)20(r)0(e)13.5(-)]TJ
T*
[(me)17.7(nt)18.9(s)-400.3(w)0(i)14.9(t)0(h)-390.9(e)0(x)15.1(t)0(e)18.4(r)0(n)19.6(a)0(l)-391.3(s)0(t)17.7(a)0(n)15.1(d)0(a)20.8(r)0(d)13.9(s)-400.3([2)19.6(6].)-401.8(In)-412.8(addition,)-418.1(at)-414(each)]TJ
0 -1.0471 TD
[(meas)-8.2(urement)-292.1(50)-286.1(L)-283.7(o)0(f)-287.7(air)-285.5(wer)-8.2(e)-285.7(vacuum)-8.5(ed)-286.5(separately)-295.6(over)]TJ
0 -1.0528 TD
[(activa)-10.6(ted)-420.5(carbon,)-428.5(and)-423.8(analys)-9(ed)-423(by)-416.9(ga)-7.6(s)-417.4(chrom)-9(atogr)-8.2(aphy)]TJ
0 -1.0471 TD
[(for)-381.1(benzene)-382.5(\(Siem)-10.6(ens)-379.5(GC)-380.1(1/4;)-383.4(Siemens)-382(AG,)-385.3(Mu)]TJ
19.6893 -0.0228 TD
(\310)Tj
0.4097 0.0228 TD
(nchen-)Tj
-20.099 -1.0527 TD
[(Berli)-9.6(n,)-410.9(Germany\))-421.2(according)-416.1(to)-413.6(guidel)-9.7(ine)-409.1(3482/4)-416.7(of)-412.8(the)]TJ
0 -1.0471 TD
[("V)99.7(erein)-338.7(Deut)-9.8(scher)-337.5(Ingeni)-9(eure".)-339.6(Annu)-7(al)-340.1(mean)-337.1(immis)-10.4(sion)]TJ
0 -1.0527 TD
[(at)-488(a)-490.6(given)-490.3(grid-point)-496(was)-491.5(calcul)-10.5(ated)-489.9(as)-486.8(the)-488.8(arithmet)-13.1(ic)]TJ
0 -1.0471 TD
[(mean)-337.1(of)-338.9(the)-335.1(26)-337.3(values)-339(determin)-10.7(ed)-332(at)-340.1(this)-333.4(po)-7.2(int.)]TJ
/F6 1 Tf
0 -2.299 TD
[(Estimat)-10.3(ion)-334.7(of)-334(indi)-7.8(vidual)-339.8(exposur)25.6(e)]TJ
/F3 1 Tf
1.0015 -1.7527 TD
[(Ho)17.3(me)-272.5(ad)15.1(dr)19.6(es)19.6(se)13.9(s)-275.1(o)0(f)-270.6(a)0(l)12.8(l)-276.3(ch)15.1(il)22.2(dr)14(en)-269.4(an)15.1(d)-273.9(s)0(c)13.9(h)0(o)21.2(o)0(l)-271.4(a)0(d)15.1(d)0(r)19.6(e)0(s)19.6(s)0(e)13.9(s)-280.8(of)]TJ
-1.0015 -1.0471 TD
[(th)18.9(e)-507.6(9)0(\261)21.2(1)39.1(1)-501.5(y)0(r)-498.2(o)0(l)18.9(d)0(s)-492.1(w)0(e)16.9(r)0(e)-498.6(a)0(s)19.6(s)0(i)17.7(g)0(n)15.5(e)0(d)-491.3(t)0(o)-499(G)12.4(K-)15.7(co)15.1(or)19.6(di)18.9(na)15.1(te)18.5(s)-502.7(b)0(y)]TJ
0 -1.0527 TD
[(me)17.7(an)15.1(s)-536.9(o)0(f)-532.3(a)-541.8(ge)15.1(og)21.2(ra)13.5(ph)21.2(ic)18.4(al)-533.5(in)18.9(fo)13.9(rm)16.5(at)18.4(io)18.9(n)-541.4(s)0(y)20(s)0(t)17.7(e)0(m)-534.3(\()0(S)14.7(I)0(C)20.6(A)0(D)13.4(;)]TJ
0 -1.0471 TD
-0.0136 Tc
[(Si)-13.6(em)-13.6(e)4.1(n)-13.6(s)6.4(/)-13.6(Ni)-13.6(x)5.3(d)-13.6(or)-13.6(f)-786.5(A)-13.6(G.)-793.6(M)-13.6(u)]TJ
10.8405 -0.0228 TD
0 Tc
(\310)Tj
0.3983 0.0228 TD
[(nc)20.8(he)15.1(n-)19.6(Pa)15.9(de)20.8(rb)13.9(or)19.6(n,)-775.1(Ge)16.9(rm)16.5(an)15.1(y;)]TJ
-11.2388 -1.0527 TD
[(th)18.9(eo)15.1(re)19.2(ti)16.5(ca)14.7(l)-259.2(e)0(x)20.8(a)0(c)14.7(t)0(n)18.9(e)0(s)13.9(s)-258(0.)15.9(1)-256.8(m)0(\))16.5(.)-262.1(On)17.3(e)-262.9(h)0(u)21.2(n)0(d)15.5(r)0(e)19.2(d)-262.5(an)20.8(d)-262.5(t)0(h)18.9(r)0(e)19.2(e)-262.9(ho)15.5(me)]TJ
0 -1.0471 TD
[(ad)15.1(dr)19.6(es)19.6(se)13.9(s)-411.7(n)0(o)21.2(t)-412.9(in)18.9(cl)12.8(ud)21.2(ed)-406(in)-402.2(th)18.9(is)-403.4(da)15.1(ta)18.4(ba)20.8(se)-407.2(we)16.9(re)-401.9(lo)18.9(ca)14.7(te)18.4(d)-410.5(o)0(n)]TJ
0 -1.0527 TD
[(to)18.9(po)15.5(gr)19.6(ap)15.1(hi)18.9(c)-365.4(m)0(a)17.7(p)0(s)-355.5(w)0(i)14.9(t)0(h)-351(a)0(n)-360.4(a)0(c)20.4(c)0(u)15.1(r)0(a)19.2(c)0(y)-354.7(o)0(f)-355.9(a)0(b)15.1(o)0(u)21.2(t)-367.3(\213)11.8(5)0(0)-360(m)-362.4(an)15.1(d)]TJ
0 -1.0471 TD
[(th)18.9(en)-286.5(as)19.6(si)12(gn)21.2(ed)-286.5(to)-282.7(GK)-288.2(co)15.1(or)19.6(di)13.2(na)20.8(te)18.4(s.)-286.9(Th)17.1(e)-297.1(c)0(h)20.8(i)0(l)16.5(d)0(r)19.6(e)0(n)]TJ
/F11 1 Tf
18.3919 0 TD
(')Tj
/F3 1 Tf
0.2105 0 TD
0.2922 Tc
[(se)292.2(x)307.3(p)292.2(o)313.4(s)292.2(u)306.6(r)292.2(e)]TJ
-18.6024 -1.0527 TD
0 Tc
[(at)-340.1(th)18.9(e)-348.3(h)0(o)21.2(m)0(e)-340.8(a)0(d)15.1(d)0(r)19.6(e)0(s)19.6(s)-349.1(or)-338.9(th)18.9(e)-348.3(s)0(c)19.6(h)0(o)15.5(o)0(l)-334(a)0(d)15.1(d)0(r)19.6(e)0(s)13.9(s)-343.4(wa)16.9(s)-349.1(e)0(s)19.6(t)0(i)16.5(m)0(a)17.7(t)0(e)12.8(d)]TJ
0 -1.0471 TD
[(us)20(in)13.2(g)-302.4(t)0(h)18.9(e)-302.8(an)20.8(nu)15.5(al)-294.5(me)17.7(an)-292.2(im)15.7(mi)15.7(ss)18.9(io)13.2(n)-302.4(v)0(a)20.8(l)0(u)18.9(e)0(s)-293.3(f)0(r)12.4(o)0(m)-294.9(t)13.9(he)-297.8(ne)20.8(ar)13.5(es)19.6(t)]TJ
0 -1.0527 TD
[(mo)18.1(ni)18.9(to)13.2(ri)17.3(ng)-405.6(st)17.7(at)12.8(io)18.8(n)-416.2(i)0(n)-407.9(e)0(a)14.7(c)0(h)-411.7(o)0(f)-407.2(t)0(h)18.9(e)-422.3(fo)19.6(ur)-401.5(ge)20.8(og)15.5(ra)19.2(ph)15.5(ic)18.4(al)-408.3(di)13.2(r)20.4(-)]TJ
0 -1.0471 TD
[(ec)14.7(t)13.9(i)0(o)13.2(n)0(s)-219(\()0(i)17.3(n)-234.1(mo)18.1(st)-221.3(ca)14.7(se)19.6(s)-229.6(a)0(t)-226.2(t)13.9(he)-223.9(co)15.1(rn)19.6(er)19.2(s)-235.3(o)0(f)-219.4(t)0(h)18.9(e)-234.5(1)]TJ
/F11 1 Tf
17.0773 0 TD
(6)Tj
/F3 1 Tf
0.9617 0 TD
0.2275 Tc
[(1k)227.5(ms)227.5(q)247.5(u)227.5(a)242.6(r)227.5(e)]TJ
-18.039 -1.0528 TD
0 Tc
[(in)-493.3(w)12.4(h)0(i)13.2(c)0(h)-485.6(t)0(h)13.2(e)-496.3(ad)15.1(dr)19.6(es)13.9(s)-497(w)0(a)16.9(s)-502.7(l)13.9(o)0(c)15.1(a)0(t)18.4(e)0(d)15.1(\))0(.)-486.4(T)0(h)17.1(e)0(s)13.9(e)-496.3(fo)13.9(ur)-486.8(va)15.1(lu)18.9(es)13.9(,)]TJ
T*
[(we)16.9(ig)18.8(ht)13.2(ed)-309.2(by)-308.8(th)18.8(e)-319.8(i)0(n)18.9(v)0(e)15.1(r)0(s)18.4(e)-319.8(of)-310.4(th)18.9(e)-319.8(s)0(q)14.4(u)0(a)20.8(r)0(e)-310.8(o)0(f)-310.4(t)0(h)13.2(e)0(i)18.4(r)-321(di)18.9(st)17.7(an)20.8(ce)-315.3(to)]TJ
0 -1.0471 TD
-0.0166 Tc
[(t)-16.6(h)2.3(e)-279.5(r)-16.6(es)-16.6(pe)-16.6(ct)-16.6(iv)-16.6(e)-268.9(a)-16.6(d)4.2(d)-16.6(re)-16.6(ss)-16.6(,)-263.6(w)-16.6(er)-16.6(e)-264.8(a)-16.6(ve)-16.6(ra)-16.6(ge)-16.6(d)-263.2(\()-16.6(St)-16.6(ut)-16.6(tg)-16.6(ar)-16.6(te)-16.6(r)-264.8(C)-16.6(on)-16.6(to)-16.6(ur)]TJ
0 -1.0528 TD
0 Tc
[(P)11.4(r)0(o)13.9(g)0(r)19.6(a)0(m)17.7(m)0(e)-295.3(\()0(S)14.7(C)11.6(OP)12.4(\)\))-289.2(to)-294.1(cr)19.2(ea)14.7(te)18.4(,)-296.3(m)0(a)12(i)0(n)18.9(t)0(a)18.4(i)0(n)-294.1(a)0(n)20.8(d)-302.4(ap)20.8(pl)13.2(y)-296.7(d)0(i)13.2(g)0(i)18.9(t)0(a)18.4(l)]TJ
0 -1.0471 TD
[(te)18.4(rr)18(ai)12.8(n)-376.3(m)0(o)18.1(d)0(e)15.1(l)0(s)17.7(.)-376(In)19.6(st)17.7(it)16.5(ut)13.2(e)-376.7(o)0(f)-367.3(P)0(h)16.3(o)0(t)18.9(o)0(g)15.5(r)0(a)19.2(m)0(m)14.9(e)0(t)18.4(r)0(y)-373(a)0(n)20.8(d)-382(R)11.6(e)0(m)17.7(o)0(t)13.2(e)]TJ
0 -1.0528 TD
[(S)11.4(e)0(n)15.1(s)0(i)17.7(n)0(g)15.5(,)-734.5(U)12.4(n)0(i)13.2(v)0(e)20.8(r)0(s)18.4(i)0(t)16.5(y)-734.8(of)-731.5(T)74.8(e)0(c)14.7(h)0(n)21.2(o)0(l)13.2(o)0(g)21.2(y)73.2(,)-734.5(V)57.9(ie)18.4(nn)15.5(a,)-724.2(Au)17.3(st)17.7(ri)17.3(a,)]TJ
0 -1.0471 TD
[(19)15.5(94)21.2(\).)-429.5(Th)17.1(e)-439.3(9)0(5)21.2(t)0(h)-430.7(p)0(e)15.1(r)0(c)19.2(e)0(n)15.1(t)0(i)22.2(l)0(e)-431.1(o)0(f)-429.9(t)0(h)18.9(e)-439.3(10)15.5(4)-438.9(v)0(a)20.8(l)0(u)18.9(e)0(s)-429.9(m)0(e)12(a)0(s)19.6(u)0(r)19.6(e)0(d)]TJ
0 -1.0528 TD
[(at)-197.8(th)18.9(es)19.6(e)-206(f)0(o)13.9(u)0(r)-190.9(s)0(t)17.7(a)0(t)12.8(i)0(o)18.9(n)0(s)-196.2(d)0(u)21.2(r)0(i)17.3(n)0(g)-195(t)0(h)13.2(e)-200.3(ye)15.1(ar)-197(wa)16.9(s)-206.8(u)0(s)20(e)0(d)-195.4(a)0(s)-196.6(a)-206(pr)19.6(ox)15.5(y)-205.6(o)0(f)]TJ
0 -1.0471 TD
[(th)18.9(e)-297.1(p)0(e)15.1(a)0(k)-286.5(e)0(x)20.8(p)0(o)15.5(s)0(u)20(r)0(e)-288.1(o)0(f)-293.3(e)0(a)20.4(c)0(h)-286.5(c)0(h)15.1(i)0(l)16.5(d)0(.)-285.7(I)0(n)-287.7(1)0(6)21.2(8)-296.7(ch)15.1(il)16.5(dr)19.6(en)-286.5(li)16.5(vi)13.2(ng)-286.1(in)]TJ
25.1977 41.8483 TD
[(th)13.2(e)-245.9(p)0(e)20.8(r)0(i)17.3(p)0(h)15.5(e)0(r)19.2(y)-251.1(of)-236.4(th)18.9(e)-245.9(m)0(o)12.4(n)0(i)18.9(t)0(o)18.8(r)0(e)19.2(d)-251.2(ar)19.2(ea)14.7(,)-245.1(o)0(n)21.2(e)-251.6(or)-236.4(tw)14.9(o)-245.5(o)0(f)-236.4(t)0(h)18.9(e)-251.6(fo)19.6(ur)]TJ
0 -1.0471 TD
[(mo)12.4(ni)18.9(to)18.8(ri)17.3(ng)-348.7(st)17.7(at)18.4(io)18.9(ns)-344.2(we)16.9(re)-350.7(l)13.9(o)0(c)15.1(a)0(t)18.4(e)0(d)]TJ
/F9 1 Tf
13.3899 0 TD
(>)Tj
/F3 1 Tf
0.5406 0 TD
[(1)-353.6(k)0(m)-346.1(f)0(r)12.4(o)0(m)-346.1(t)0(h)18.9(e)-354(ot)18.9(he)15.1(rs)18.5(.)]TJ
-13.9305 -1.0528 TD
[(V)109.1(a)0(l)18.4(u)0(e)15.1(s)-195.4(fr)12.4(om)-186.8(th)13.2(es)19.6(e)-200.3(s)0(t)17.7(a)0(t)18.4(i)0(o)18.8(n)0(s)-190.5(w)0(e)16.9(r)0(e)-191.3(n)0(o)15.5(t)-196.6(us)14.4(ed)-189.7(fo)19.6(r)-201.5(t)0(h)18.9(e)-200.3(as)19.6(se)14(ss)18.9(me)17.7(nt)]TJ
0 -1.0471 TD
[(of)-361.6(pe)15.1(ak)-354.7(ex)15.1(po)21.2(su)14.4(re)19.2(.)-370.3(F)11.4(or)-361.6(9\261)21.2(1)39.1(1)-365(yr)-361.6(ol)18.9(d)-365(c)0(h)15.1(i)0(l)16.5(d)0(r)19.6(e)0(n)15.1(,)-364.6(a)-371.1(c)0(o)20.8(m)0(b)18.1(i)0(n)13.2(e)0(d)]TJ
0 -1.0528 TD
[(es)13.9(ti)16.5(ma)17.7(te)-197.8(w)12.4(a)0(s)-196.6(a)0(l)18.5(s)0(o)-196.2(c)0(a)14.7(l)0(c)18.4(u)0(l)18.9(a)0(t)12.8(e)0(d)-195.4(a)0(s)-190.9(t)0(h)13.2(e)-200.3(me)12(an)-195.4(of)-196.6(th)18.8(e)-206(e)0(s)19.6(t)0(i)16.5(m)0(a)17.7(t)0(e)18.4(s)-206.8(of)]TJ
0 -1.0471 TD
[(ex)15.1(po)15.5(su)20(re)-316.5(at)-317.3(ho)21.2(me)-318.1(an)20.8(d)-325.1(a)0(t)-317.3(s)0(c)19.6(h)0(o)15.5(o)0(l)18.9(.)]TJ
1.0015 -1.0528 TD
[(Th)17.1(e)-479.2(e)0(x)20.8(p)0(o)15.5(s)0(u)20(r)0(e)-470.2(e)0(s)19.6(t)0(i)16.5(m)0(a)17.7(t)0(e)18.4(s)-480(co)20.8(ul)18.9(d)-478.8(b)0(e)-462.9(v)0(a)15.1(l)0(i)16.5(d)0(a)20.8(t)0(e)18.4(d)-478.8(ag)20.8(ai)12.8(ns)20(t)-475.5(a)]TJ
-1.0015 -1.0471 TD
[(co)15.1(nt)18.9(in)18.8(uo)15.5(us)-395.4(mo)18.1(ni)18.9(to)18.8(ri)11.6(ng)-394.2(st)17.7(at)18.5(io)18.8(n)-404.8(i)0(n)-390.9(t)0(h)13.2(e)-399.5(ci)12.8(ty)-390.9(10)15.5(0)-404.8(m)-402.3(fr)18(om)-397.3(a)]TJ
0 -1.0527 TD
[(st)17.7(re)13.5(et)-391.3(wi)14.9(th)-390.9(de)15.1(ns)20(e)-399.5(t)0(r)17.3(a)0(f)24.9(f)0(i)17.3(c)-399.5(\()]TJ
/F9 1 Tf
10.2714 0 TD
(>)Tj
/F3 1 Tf
0.5463 0 TD
[(50)21.2(00)-394.2(ca)14.7(rs)]TJ
/F10 1 Tf
3.9208 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
[(24)-388.5(h)]TJ
7.472 0 0 6.641 477.581 692.39 Tm
(-1)Tj
9.963 0 0 9.963 483.534 687.968 Tm
[(\).)-395.4(Th)17.1(e)-399.5(y)0(e)15.1(a)0(r)19.2(l)0(y)]TJ
-17.4871 -1.0527 TD
[(me)12(an)-605.1(co)15.1(nc)20.8(en)15.1(tr)17.3(at)18.5(io)18.8(ns)-611.6(of)-606.3(SO)]TJ
7.472 0 0 6.641 425.764 675.836 Tm
(2)Tj
9.963 0 0 9.963 429.449 677.48 Tm
0.615 Tc
[(,N)615(O)]TJ
7.472 0 0 6.641 452.239 675.836 Tm
0 Tc
(2)Tj
9.963 0 0 9.963 462.104 677.48 Tm
[(an)20.8(d)-621(O)]TJ
7.472 0 0 6.641 489.43 675.836 Tm
(3)Tj
9.963 0 0 9.963 499.351 677.48 Tm
[(me)17.7(as)19.6(ur)13.9(ed)]TJ
-19.0747 -1.0471 TD
[(co)15.1(nt)18.9(in)18.8(uo)15.5(us)20(ly)-282.7(at)-283.2(th)18.9(is)-283.9(st)17.7(at)18.4(io)18.8(n)-291(w)0(e)16.9(r)0(e)-282.4(c)0(o)20.8(m)0(p)12.4(a)0(r)19.2(e)0(d)-280.8(w)0(i)14.9(t)0(h)-282.7(e)0(s)19.6(t)0(i)16.5(m)0(a)17.7(t)0(e)18.4(s)]TJ
0 -1.0528 TD
[(ba)15.1(se)19.6(d)-512.9(o)0(n)-502.3(t)0(h)18.9(e)-513.3(no)21.2(nc)15.1(on)21.2(ti)16.5(nu)15.5(ou)21.2(s)-514.1(m)0(e)17.7(a)0(s)13.9(u)0(r)19.6(e)0(m)17.7(e)0(n)15.1(t)0(s)-500.2(a)0(t)-505.1(t)0(h)18.8(e)-513.3(fo)19.6(ur)]TJ
0 -1.0471 TD
[(ne)15.1(ar)19.2(es)14(t)-441.3(g)0(r)19.6(i)0(d)13.2(p)0(o)21.2(i)0(n)18.9(t)0(s)17.7(:)-447(S)11.4(O)]TJ
7.472 0 0 6.641 399.742 644.485 Tm
(2)Tj
9.963 0 0 9.963 407.905 646.129 Tm
[(42)21.2(.3)]TJ
/F9 1 Tf
2.1624 0 TD
(m)Tj
/F3 1 Tf
0.5634 0 TD
(g)Tj
/F10 1 Tf
0.4894 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(m)Tj
7.472 0 0 6.641 450.255 650.551 Tm
(3)Tj
9.963 0 0 9.963 458.419 646.129 Tm
[(\(c)19.2(on)15.5(ti)22.2(nu)15.5(ou)15.5(s\))]TJ
/F6 1 Tf
5.3491 0 TD
[(ve)14.7(rs)18.8(us)]TJ
/F3 1 Tf
-20.3153 -1.0527 TD
[(46)15.5(.1)]TJ
/F9 1 Tf
1.9803 0 TD
(m)Tj
/F3 1 Tf
0.5634 0 TD
(g)Tj
/F10 1 Tf
0.4894 0.2049 TD
(.)Tj
/F3 1 Tf
0.2731 -0.2049 TD
(m)Tj
7.472 0 0 6.641 349.852 640.12 Tm
(3)Tj
9.963 0 0 9.963 356.088 635.641 Tm
[(\(n)13.9(on)21.2(co)15.1(nt)18.9(in)18.9(uo)15.5(us)20(\);)-250.2(N)12.4(O)]TJ
7.472 0 0 6.641 438.973 633.997 Tm
(2)Tj
9.963 0 0 9.963 445.266 635.641 Tm
[(25)21.2(.5)]TJ
/F9 1 Tf
1.9746 0 TD
(m)Tj
/F3 1 Tf
0.5634 0 TD
(g)Tj
/F10 1 Tf
0.4951 0.2049 TD
(.)Tj
/F3 1 Tf
0.2675 -0.2049 TD
(m)Tj
7.472 0 0 6.641 485.745 640.12 Tm
(3)Tj
/F6 1 Tf
9.963 0 0 9.963 492.038 635.641 Tm
[(ve)20.4(rs)13.2(us)]TJ
/F3 1 Tf
2.7371 0 TD
[(32)15.5(.1)]TJ
/F9 1 Tf
-21.0778 -1.0471 TD
(m)Tj
/F3 1 Tf
0.5691 0 TD
(g)Tj
/F10 1 Tf
0.4894 0.1992 TD
(.)Tj
/F3 1 Tf
0.2675 -0.1992 TD
(m)Tj
7.472 0 0 6.641 330.123 629.631 Tm
(3)Tj
9.963 0 0 9.963 333.808 625.209 Tm
0.3275 Tc
(;O)Tj
7.472 0 0 6.641 346.847 623.565 Tm
0 Tc
(3)Tj
9.963 0 0 9.963 353.877 625.209 Tm
[(44)21.2(.1)]TJ
/F6 1 Tf
2.0486 0 TD
[(ve)14.7(rs)18.9(us)]TJ
/F3 1 Tf
2.8168 0 TD
[(48)15.5(.9)]TJ
/F9 1 Tf
2.0543 0 TD
(m)Tj
/F3 1 Tf
0.5634 0 TD
(g)Tj
/F10 1 Tf
0.4894 0.1992 TD
(.)Tj
/F3 1 Tf
0.2732 -0.1992 TD
(m)Tj
7.472 0 0 6.641 443.622 629.631 Tm
(3)Tj
9.963 0 0 9.963 447.25 625.209 Tm
[(.)-330.4(T)12.2(he)-326.3(va)20.8(lu)18.8(es)-321.8(es)13.9(ti)16.5(ma)17.7(te)18.4(d)]TJ
-13.8451 -1.0527 TD
[(by)-365.7(di)13.2(sc)19.6(on)15.5(t)13.9(i)0(n)13.2(u)0(o)21.2(u)0(s)-366.9(m)0(e)17.7(a)0(s)14(u)0(r)19.6(e)0(m)17.7(e)0(n)15.1(t)0(s)-363.6(m)0(i)15.7(g)0(h)15.5(t)-373(be)-366.1(sl)17.7(ig)18.9(ht)13.2(l)13.9(y)-376.3(hi)18.9(gh)15.5(er)]TJ
0 -1.0471 TD
[(be)15.1(ca)14.7(us)20(e)-405.2(n)0(o)-399.9(g)0(r)19.6(i)0(d)18.9(p)0(o)15.5(i)0(n)18.9(t)-407.2(me)17.7(as)19.6(ur)14(em)17.7(en)15.1(ts)-397.7(w)12.4(e)0(r)13.5(e)-405.2(pe)15.1(rf)18(or)19.6(me)17.7(d)-410.5(b)0(e)20.8(-)]TJ
0 -1.0528 TD
[(tw)14.9(ee)14.7(n)-319.4(2)0(3)15.5(:)0(0)18.9(0)0(h)-314.5(a)0(n)15.1(d)-325.1(06)21.2(:0)18.9(0h)-320.2(at)-311.6(ni)18.9(gh)15.5(t.)]TJ
/F6 1 Tf
0 -2.299 TD
[(Dat)-8.6(a)-330.8(analys)-8.6(is)]TJ
/F3 1 Tf
1.0015 -1.747 TD
-0.0155 Tc
[(T)-15.5(h)1.6(e)-346.7(a)-15.5(n)5.3(a)-15.5(ly)-15.5(s)4.5(e)-15.5(s)-331.6(w)-15.5(er)-15.5(e)-337.7(r)-15.5(e)3.7(s)-15.5(tr)-15.5(ic)-15.5(te)-15.5(d)-330.4(t)-15.5(o)-338.1(c)-15.5(h)5.3(i)-15.5(ld)-15.5(r)4.1(e)-15.5(n)-336.1(w)-15.5(it)-15.5(h)-332.4(c)-15.5(om)-15.5(p)2.6(l)-15.5(e)2.9(t)-15.5(e)]TJ
-1.0015 -1.0527 TD
0 Tc
[(ad)15.1(dr)19.6(es)13.9(se)19.6(s)-258(w)12.4(ho)-246.2(ha)15.1(d)-251.2(l)0(i)16.5(v)0(e)15.1(d)-251.2(in)-248.6(Dr)15.7(es)19.6(de)15.1(n)-251.2(f)0(o)13.9(r)-252.8(at)-249(le)18.4(as)19.6(t)-259.2(1)0(2)-240.5(m)0(o)12.4(n)0(t)18.8(h)0(s)]TJ
0 -1.0471 TD
[(an)15.1(d,)-365.3(be)15.1(ca)20.4(us)14.4(e)-371.1(o)0(f)-367.3(c)0(o)15.1(n)0(c)20.8(e)0(r)13.5(n)0(s)-366.9(r)0(e)19.2(g)0(a)15.1(r)0(d)19.6(i)0(n)18.9(g)-376.3(th)18.9(e)-376.7(v)0(a)15.1(l)13.9(id)13.2(it)16.5(y)-370.7(o)0(f)-367.3(q)0(u)15.5(e)0(s)19.6(-)]TJ
0 -1.0527 TD
[(ti)16.5(on)15.5(na)20.8(ir)17.3(e)-507.6(r)0(e)19.2(s)0(p)14.4(o)0(n)21.2(s)0(e)13.9(s)0(,)-491.7(w)0(h)11.6(o)-501.5(ha)15.1(d)-501.5(G)0(e)16.9(r)0(m)10.8(a)0(n)-491.3(n)0(a)15.1(t)0(i)16.5(o)0(n)21.2(a)0(l)12.8(i)0(t)22.2(y)67.5(.)-501.2(T)0(h)17.1(i)0(s)]TJ
0 -1.0471 TD
[(re)13.5(du)21.2(ce)14.7(d)-359.3(t)13.9(he)-349.1(nu)15.5(mb)18.1(er)-350.7(of)-350.3(ch)20.8(il)16.5(dr)19.6(en)-349.1(to)-351(2,)21.6(79)15.5(6)-353.6(a)0(n)15.1(d)-359.3(2,)21.6(62)15.5(5)-353.6(w)0(i)14.9(t)0(h)]TJ
0 -1.0527 TD
[(co)15.1(mp)18.1(le)18.4(te)12.8(d)-376.3(q)0(u)15.5(e)0(s)19.6(t)0(i)16.5(o)0(n)15.5(n)0(a)20.8(i)0(r)17.3(e)0(s)19.6(,)-381.7(1,)15.9(13)21.2(8)-382(a)0(n)20.8(d)-382(2,)21.6(05)15.5(0)-376.3(w)0(i)14.9(t)0(h)-373.8(S)11.4(PT)91.9(,)-381.6(a)0(s)]TJ
0 -1.0471 TD
[(we)16.9(ll)-211.1(as)-208(87)15.5(0)-217(a)0(n)20.8(d)-217(1,)15.9(88)21.2(7)-217(w)0(i)14.9(t)0(h)-208.8(s)0(e)13.9(r)0(u)19.6(m)-220.2(Ig)19.6(E)-215.4(m)0(e)12(a)0(s)19.6(u)0(r)19.6(e)0(m)12(e)0(n)20.8(t)0(s)-210(i)0(n)-208.8(t)0(h)18.9(e)]TJ
0 -1.0527 TD
[(yo)15.5(un)15.5(ge)20.8(r)-235.7(a)0(n)20.8(d)-234.1(ol)18.9(de)15.1(r)-235.7(a)0(g)20.8(e)-234.5(gr)13.9(ou)21.2(ps)14.4(,)-228(r)0(e)13.5(s)0(p)20(e)0(c)14.7(t)0(i)16.5(v)0(e)20.8(l)0(y)81.4(.)-233.7(Me)13.2(as)19.6(ur)19.6(em)12(en)20.8(ts)]TJ
0 -1.0471 TD
[(of)-253.5(lu)13.2(ng)-251.9(fu)19.6(nc)15.1(ti)16.5(on)-251.9(w)12.4(e)0(r)13.5(e)-262.9(an)20.8(al)18.5(ys)14.4(ed)-252.3(fo)19.6(r)-264.1(1)0(,)15.9(1)0(3)21.2(7)-262.5(ch)15.1(il)16.5(dr)19.6(en)-252.3(ag)15.1(ed)-252.3(9\261)]TJ
0 -1.0527 TD
[(1)39.1(1)-404.8(ye)20.8(ar)13.5(s.)-389.3(Wh)14.4(en)-394.6(co)20.8(mp)12.4(ar)19.2(in)18.8(g)-404.8(t)0(h)18.8(e)-405.2(qu)21.2(es)13.9(ti)22.2(on)15.5(na)15.1(ir)17.3(e)-399.5(r)0(e)13.5(s)0(p)20(o)0(n)15.5(d)0(e)20.8(r)0(s)]TJ
0 -1.0471 TD
[(se)13.9(le)18.4(ct)18.4(ed)-201.1(fo)19.6(r)-207.2(t)0(h)18.9(e)-206(an)15.1(al)18.4(ys)20(es)-202.3(\(n)]TJ
/F9 1 Tf
10.5673 0 TD
(=)Tj
/F3 1 Tf
0.7568 0 TD
[(5,)15.9(42)21.2(1\))-202.3(w)12.4(i)0(t)16.5(h)-205.6(th)13.2(os)20(e)-206(e)0(x)15.1(c)0(l)18.5(u)0(d)15.5(e)0(d)-195.4(\()0(n)]TJ
/F9 1 Tf
-11.3242 -1.0528 TD
(=)Tj
/F3 1 Tf
0.8308 0 TD
[(93)15.5(6\))19.6(,)-279.2(n)0(o)-269(s)0(i)17.7(g)0(n)15.5(i)0(f)17.3(i)0(c)18.4(a)0(n)15.1(t)-276.3(di)18.9(f)14.7(f)0(e)19.2(r)0(e)19.2(n)0(c)15.1(e)0(s)-270.6(w)0(e)16.9(r)0(e)-271(f)0(o)19.6(u)0(n)15.5(d)-279.6(w)12.4(i)0(t)16.5(h)-279.6(re)19.2(sp)14.4(ec)20.4(t)]TJ
-0.8308 -1.0527 TD
[(to)-305.5(al)18.5(l)-316.1(h)0(e)20.8(a)0(l)12.8(t)0(h)-299.8(o)0(u)15.5(t)0(c)18.4(o)0(m)18.1(e)0(s)-304.7(a)0(s)-304.7(l)0(i)16.5(s)0(t)17.7(e)0(d)-303.5(i)0(n)-305.5(t)0(a)18.4(b)0(l)18.9(e)-314.2(1.)-314.1(In)-321.8(the)-329.4(selected)]TJ
0 -1.0471 TD
[(group,)-216.3(exposur)-8.5(e)-206(t)0(o)-214.5(maternal)-216(smok)-7.4(ing)-209.5(\(26.6)]TJ
/F6 1 Tf
17.157 0 TD
(versus)Tj
/F3 1 Tf
2.7428 0 TD
(21.4%\))Tj
-19.8999 -1.0528 TD
[(and)-378.3(low)-8.6(er)-373.4(p)-6.5(arental)-382.8(educat)-8.2(ion)-374.6(\(72.8)]TJ
/F6 1 Tf
14.693 0 TD
(versus)Tj
/F3 1 Tf
2.9136 0 TD
[(67.1%\))-383.7(were)]TJ
-17.6066 -1.0471 TD
[(more)-452.1(prevalent)-452.6(as)-441.3(c)-6.9(ompared)-449.1(to)-442.1(the)-448.9(nonsel)-8.5(ected)-445.6(group.)]TJ
0 -1.0528 TD
[(Fu)-6.4(rthermor)-11.1(e,)-485.2(slightl)-10.4(y)-484.5(more)-491.9(children)-497(of)-486.8(the)-488.8(higher)-492.6(age)]TJ
0 -1.0471 TD
[(group)-324.1(were)-322.4(selected)-326.7(\(48.5)]TJ
/F6 1 Tf
10.7722 0 TD
(versus)Tj
/F3 1 Tf
2.851 0 TD
[(44.9%\))-8.1(.)-313.4(N)0(o)-318.4(signi)-9.8(ficant)]TJ
-13.6232 -1.0528 TD
[(differences)-393.9(wer)-8.2(e)-388.1(found)-398.1(for)-392.4(the)-397.7(other)-395.2(potential)-398.5(confoun)-7.3(-)]TJ
0 -1.0471 TD
[(ders)-507(incl)-8.2(uded)-504.2(in)-504.7(the)-505.8(multiv)-9.2(ariate)-507.2(model)-9.7(s)-502.7(\(see)-507.4(below\).)]TJ
ET
1 i 
58.28 328.932 478.205 -0.51 re
f
58.28 312.491 478.205 -0.51 re
f
58.28 163.559 478.205 -0.51 re
f
BT
/F2 1 Tf
8.966 0 0 8.966 58.28 333.298 Tm
[(Table)-331.9(1.)-336.7(\261)-333.2(Respiratory)-333.8(health)-334.2(and)-335.7(atopy)-332.3(in)-330.2(the)-334.8(study)-333.8(population)]TJ
/F3 1 Tf
30.9001 -1.7072 TD
[(5\2617)-333.6(yr)-335.1(olds)-11414.4(9\2611)26.8(1)-328.3(y)0(r)-335.1(olds)]TJ
-30.9001 -1.998 TD
[(Symptoms)-336.9(in)-330.2(the)-335.8(past)-336.4(12)-327.8(months)]TJ
0.3351 -1.0559 TD
[(Wheeze)-26949.9(188/2730)-333.4(\(6.9\))-10049.9(210/2595)-333.4(\(8.1\))]TJ
T*
[(Morning)-329.3(cough)-23392(279/2737)-333.4(\(10.2\))-9549.9(310/2592)-333.4(\(12.0\)*)]TJ
T*
[(Symptoms)-330.6(of)-335.1(allergi)8.6(c)-334.4(rhinoconjunctivitis)-13659.8(153/2727)-333.4(\(5.6\))-9550.4(325/2567)-333.4(\(12.7\)*)]TJ
T*
[(Symptoms)-330.6(of)-335.1(atopic)-336.4(eczema)-18226.6(317/2737)-333.4(\(1)31.7(1.6\))-9549.9(409/2588)-333.4(\(15.8\)*)]TJ
-0.3351 -1.0559 TD
(Doctor)Tj
/F11 1 Tf
2.7505 0 TD
(')Tj
/F3 1 Tf
0.215 0 TD
[(s)-335.8(diagnosis)]TJ
-2.6303 -1.0559 TD
[(Asthma)-27054.9(158/2700)-333.4(\(5.9\))-10049.9(203/2582)-333.4(\(7.9\)*)]TJ
T*
[(Bronchitis)-25515.3(826/2512)-333.4(\(32.9\))-9549.9(920/2478)-333.4(\(37.1\)*)]TJ
-0.3351 -1.0559 TD
[(Pulmonary)-334.1(function)]TJ
0.3351 -1.0559 TD
[(Bronchial)-334.2(hyperresponsiveness)]TJ
6.276 0 0 6.276 351.666 214.866 Tm
0.0001 Tc
(ND)Tj
8.966 0 0 8.966 475.37 214.866 Tm
0 Tc
[(156/956)-333.9(\(16.3\))]TJ
-46.1825 -1.0559 TD
(FEV)Tj
7.173 0 0 7.173 78.066 205.398 Tm
(1)Tj
/F9 1 Tf
8.966 0 0 8.966 84.643 205.398 Tm
(<)Tj
/F3 1 Tf
0.5501 0 TD
[(85%)-334.1(pred.)]TJ
6.276 0 0 6.276 351.666 205.398 Tm
0.0001 Tc
(ND)Tj
8.966 0 0 8.966 480.132 205.398 Tm
0 Tc
[(72/1)31.3(137)-333.6(\(6.3\))]TJ
-46.7137 -1.0559 TD
(FEF)Tj
7.173 0 0 7.173 76.592 195.931 Tm
(25\26175%)Tj
/F9 1 Tf
8.966 0 0 8.966 103.408 195.931 Tm
(<)Tj
/F3 1 Tf
0.5501 0 TD
[(70%)-334.1(pred.)]TJ
6.276 0 0 6.276 351.666 195.931 Tm
0.0001 Tc
(ND)Tj
8.966 0 0 8.966 471.175 195.931 Tm
0 Tc
[(150/1)31.8(123)-333.6(\(13.4\))]TJ
-46.0498 -1.0559 TD
(Atopy)Tj
0.3351 -1.0559 TD
[(Specific)-334.7(IgE)-331.7(to)-336.5(aeroallergen)6.9(s)]TJ
/F9 1 Tf
12.0072 0 TD
(>)Tj
/F3 1 Tf
0.5501 0 TD
[(0.7)-330.7(kU)]TJ
/F10 1 Tf
2.801 0.2213 TD
(.)Tj
/F3 1 Tf
0.2719 -0.2213 TD
(L)Tj
6.725 0 0 5.977 206.816 181.02 Tm
(-1)Tj
8.966 0 0 8.966 331.483 176.995 Tm
[(190/870)-333.9(\(21.8\))-9549.9(605/1887)-333.4(\(32.1\)*)]TJ
-30.135 -1.0559 TD
[(SPT)-302.6(reaction)]TJ
/F12 1 Tf
5.5199 0 TD
($)Tj
/F3 1 Tf
0.8283 0 TD
[(3)-334.6(m)0(m)-337.9(t)0(o)-330.2(a)0(t)-336.3(least)-331.7(one)-333.4(allergen***)-9888.5(146/1)31.8(138)-333.6(\(12.8\))-9549.9(534/2050)-333.4(\(26.0\)*)]TJ
-6.6833 -1.9411 TD
[(Data)-249.8(are)-258.2(presented)-252.2(as)-246.5(absolute)-254.3(numbers,)-256.1(with)-252.6(percentages)-250.7(in)-254.3(parentheses.)-255(*:)-248(p)]TJ
/F9 1 Tf
30.7293 0 TD
(<)Tj
/F3 1 Tf
0.5501 0 TD
[(0.05)-254.3(for)-253.3(Chi-squared)-250.7(test)-250.3(for)-253.3(comparison)-253.8(of)-252.9(age)-250.9(groups;)]TJ
-31.2794 -1.0559 TD
[(**:)-373.9(Fluorescence)-375.2(Enzyme)-374.9(Immuno)-374.7(Assay)-376(\(SX1)-373.9(panel;)-380.6(Pharmacia,)-374.3(Lund,)-371.1(Sweden\):)-380.1(timothy)-378.5(grass,)-370.2(rye,)-375.2(birch,)-376.5(hazel,)]TJ
/F6 1 Tf
47.6368 0 TD
(Cladosporium)Tj
-47.6368 -1.0559 TD
(herbarum)Tj
/F3 1 Tf
3.9265 0 TD
(,)Tj
/F6 1 Tf
0.5564 0 TD
[(Dermatophagoides)-308.6(pter)30.3(onyssinus)]TJ
/F3 1 Tf
13.354 0 TD
[(,)-306.4(cat)-310.2(dog;)-303.8(***:)-303.8(Skin-prick)-309.8(test)-307.2(solution)-307.8(\(ALK,)-309.1(Ho)]TJ
19.5504 0 TD
[(\310)-82.7(rsholm,)-309.8(Denmark\):)-307.9(Grass)-307.4(mixture,)-310.2(tree)]TJ
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[(Af)15.7(te)12.8(r)-286.9(a)0(d)15.1(j)0(u)18.8(s)0(t)17.7(i)0(n)18.9(g)-291(fo)13.9(r)-292.6(p)0(o)21.2(t)0(e)18.4(n)0(t)13.2(i)0(a)18.4(l)-287.7(co)15.1(nf)19.6(ou)15.5(nd)15.5(i)13.9(n)0(g)-286.1(f)0(a)19.2(c)0(t)18.5(o)0(r)13.9(s)-292.2(mo)18.1(rn)19.6(-)]TJ
-1.0015 -1.0527 TD
[(in)13.2(g)-393.4(c)0(o)20.8(u)0(g)15.5(h)-393.4(in)-385.2(th)18.8(e)-393.8(p)0(a)15.1(s)0(t)-380.7(1)0(2)-388.5(m)0(o)18.1(n)0(t)18.9(h)0(s)-384(s)0(h)14.4(o)0(w)17.3(e)0(d)-383.2(t)0(h)18.8(e)-393.8(mo)12.4(st)-380.7(co)15.1(n-)]TJ
0 -1.0471 TD
[(si)17.7(st)17.7(en)15.1(t)-259.2(p)0(o)21.2(s)0(i)17.7(t)0(i)16.5(v)0(e)-246.6(a)0(s)13.9(s)0(o)20(c)0(i)18.4(a)0(t)12.8(i)0(o)18.8(n)-256.8(wi)14.9(th)-248.6(th)18.9(e)-257.2(a)0(n)20.8(n)0(u)15.5(a)0(l)-249(m)0(e)17.7(a)0(n)-246.6(e)0(x)15.1(p)0(o)15.5(s)0(u)20(r)0(e)]TJ
0 -1.0528 TD
[(to)-231.5(se)19.6(ve)20.8(ra)13.5(l)-236.5(a)0(i)18.4(r)-235.7(po)21.2(ll)16.5(ut)13.2(an)20.8(ts)17.7(:)-236.5(S)11.4(O)]TJ
7.472 0 0 6.641 416.806 654.916 Tm
(2)Tj
9.963 0 0 9.963 420.435 656.56 Tm
0.2394 Tc
[(,N)251.8(O)]TJ
7.472 0 0 6.641 439.427 654.916 Tm
0 Tc
(2)Tj
9.963 0 0 9.963 443.055 656.56 Tm
[(,)-239.4(C)11.6(O)-238(a)0(n)20.8(d)-239.8(be)20.8(nz)15.1(en)20.8(e)-240.2(\()0(t)17.3(a)0(b)20.8(l)0(e)]TJ
-13.424 -1.0471 TD
[(4\).)-379.1(For)-384.4(examp)-7.8(le,)-386(the)-386.3(preval)-9.4(ence)-385.5(of)-384.4(morn)-7.8(ing)-385.9(cough)-391.2(was)]TJ
0 -1.0527 TD
[(esti)-9.4(mated)-340.2(to)-334(incre)-8.6(ase)-334.3(by)-337.3(~20%)-338.6(per)-340(increase)-342.9(of)-333.2(1)-336.5(m)0(g)]TJ
/F10 1 Tf
21.2599 0.1992 TD
(.)Tj
/F3 1 Tf
0.2675 -0.1992 TD
(m3)Tj
-21.5274 -1.0471 TD
[(ben)-8.4(zene.)-346.1(Likew)-9(ise,)-348.1(the)-346.5(lifetime)-356.9(prevalence)-355.1(of)-344.6(bronchi)-9.7(tis)]TJ
0 -1.0527 TD
[(was)-292.3(signifi)-9.6(cantly)-289(and)-287.2(positive)-9.2(ly)-288.4(associated)-295.2(with)-290.6(levels)-290.2(of)]TJ
T*
(NO)Tj
7.472 0 0 6.641 323.716 602.589 Tm
(2)Tj
9.963 0 0 9.963 327.401 604.233 Tm
[(,)-324.7(C)0(O)-323.2(and)-321.4(benzene)-325.6(\(but)-325.7(not)-323.3(SO)]TJ
7.472 0 0 6.641 450.935 602.589 Tm
(2)Tj
9.963 0 0 9.963 454.677 604.233 Tm
[(\).)-321.4(In)-321.8(contr)-8.2(ast,)-319.6(yea)-8.8(rly)]TJ
-14.5906 -1.0471 TD
[(mean)-308.6(ozone)-311.9(exposure)-311.3(tended)-303.7(to)-305.5(be)-303.5(neg)-8.4(atively)-309.2(associated)]TJ
0 -1.0527 TD
[(wi)-7.8(th)-334(morn)-7.8(ing)-334.7(cough)-334.3(a)-6.9(n)0(d)-331.6(bronchi)-9.7(tis.)]TJ
1.0015 -1.0471 TD
[(In)-264.9(an)-269.4(at)18.4(te)18.4(mp)18.1(t)-276.3(t)0(o)-265.7(d)0(i)18.9(s)0(e)19.6(n)0(t)13.2(a)0(n)20.8(g)0(l)18.9(e)-274.3(th)18.9(e)-274.3(s)0(p)14.4(e)0(c)20.4(i)0(f)17.3(i)0(c)-266.1(e)0(f)24.9(f)0(e)19.2(c)0(t)-266.1(o)0(f)-264.9(o)0(z)20.8(o)0(n)15.5(e)]TJ
-1.0015 -1.0527 TD
[(fr)12.4(om)-442.8(th)18.9(at)-448.2(of)-447(th)18.9(e)-456.4(o)0(t)18.9(h)0(e)15.1(r)-451.9(tr)17.3(af)24.9(fi)17.3(c)-450.7(r)0(e)13.5(l)0(a)18.4(t)0(e)18.4(d)-456(po)15.5(l)13.9(l)0(u)13.2(t)0(a)18.4(n)0(t)18.9(s)-457.2(O)]TJ
7.472 0 0 6.641 513.014 560.749 Tm
(3)Tj
9.963 0 0 9.963 521.291 562.394 Tm
[(wa)16.9(s)]TJ
-21.277 -1.0471 TD
[(in)13.2(tr)17.3(od)21.2(uc)15.1(ed)-201.1(in)18.9(to)-203.1(th)18.9(e)-211.7(m)0(u)18.1(l)0(t)16.5(i)0(v)18.9(a)0(r)13.5(i)0(a)18.4(t)0(e)-203.5(m)0(o)18.1(d)0(e)15.1(l)-208(in)-203.1(co)15.1(mb)18.1(in)18.9(at)18.4(io)18.9(n)-211.3(w)0(i)14.9(t)0(h)]TJ
0 -1.0527 TD
[(ot)13.2(he)20.8(r)-429.2(t)0(r)17.3(a)0(f)24.9(f)0(i)17.3(c)-428(re)13.5(la)18.5(te)18.4(d)-433.3(p)0(o)21.2(l)0(l)16.5(u)0(t)18.9(a)0(n)15.1(t)0(s)17.7(.)-427.2(Th)17.1(is)-420.5(pr)13.9(oc)20.8(ed)15.1(ur)19.6(e)-433.6(g)0(e)20.8(n)0(e)15.1(r)0(a)19.2(l)0(l)16.5(y)]TJ
0 -1.0471 TD
[(re)13.5(du)21.2(ce)14.7(d)-245.5(t)0(h)18.8(e)-245.9(po)21.2(in)18.8(t)-247.8(e)0(s)19.6(t)0(i)16.5(m)0(a)17.7(t)0(e)12.8(s)-241(of)-236.4(th)18.8(e)-245.9(o)0(d)15.5(d)0(s)-236(r)0(a)19.2(t)0(i)16.5(o)0(s)-236(a)0(n)20.8(d)-245.5(wi)14.9(de)20.8(ne)15.1(d)]TJ
0 -1.0527 TD
[(th)13.2(e)-490.6(c)0(o)20.8(n)0(f)13.9(i)0(d)18.9(e)0(n)15.1(c)0(e)-480.3(i)0(n)18.8(t)0(e)18.4(r)0(v)13.9(a)0(l)18.5(s)-491.3(pr)19.6(ob)15.5(ab)20.8(ly)-487.6(du)21.2(e)-490.6(t)0(o)-481.9(c)0(o)15.1(l)0(i)16.5(n)0(e)20.8(a)0(r)13.5(i)0(t)16.5(y)-490.2(of)]TJ
0 -1.0471 TD
[(th)13.2(es)19.6(e)-348.3(s)0(t)17.7(r)0(o)13.9(n)0(g)-343(i)13.9(nv)15.5(er)19.2(se)13.9(ly)-339.7(co)15.1(rr)18(el)18.4(at)18.4(ed)-343.4(ga)20.8(se)13.9(s)-349.1(\()0(O)]TJ
7.472 0 0 6.641 475.88 508.422 Tm
(3)Tj
9.963 0 0 9.963 479.509 510.123 Tm
[(\261N)17.3(O)]TJ
7.472 0 0 6.641 498.557 508.422 Tm
(2)Tj
9.963 0 0 9.963 502.186 510.123 Tm
0.3503 Tc
(:r)Tj
/F9 1 Tf
0.9332 0 TD
0 Tc
(=)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(66)15.5(,)]TJ
-20.8388 -1.0528 TD
(O)Tj
7.472 0 0 6.641 316.403 497.99 Tm
(3)Tj
9.963 0 0 9.963 320.031 499.634 Tm
[(\261C)16.5(O:)-298.1(r)]TJ
/F9 1 Tf
2.7485 0 TD
(=)Tj
/F3 1 Tf
0.5349 0 TD
[(-0)19.6(.5)15.9(5,)-291.4(an)15.1(d)-302.4(O)]TJ
7.472 0 0 6.641 402.69 497.99 Tm
(3)Tj
9.963 0 0 9.963 406.318 499.634 Tm
[(\261b)21.2(en)15.1(ze)20.4(ne)15.1(:)-304.7(r)]TJ
/F9 1 Tf
4.5638 0 TD
(=)Tj
/F3 1 Tf
0.5349 0 TD
[(-0)19.6(.5)15.9(9\))19.6(.)-302(H)0(o)17.3(w)0(e)16.9(v)0(e)15.1(r)-304(th)18.9(e)]TJ
-14.8353 -1.0527 TD
[(ge)15.1(ne)15.1(ra)19.2(l)-572.2(p)0(a)15.1(t)0(t)16.5(e)0(r)19.2(n)-575.5(of)-566.5(th)18.9(e)-575.9(o)0(b)15.5(s)0(e)19.6(r)0(v)19.6(e)0(d)-571(a)0(s)19.6(s)0(o)20(c)0(i)12.8(a)0(t)18.4(i)0(o)18.8(n)0(s)-566.1(r)0(e)19.2(m)0(a)12(i)13.9(ne)15.1(d)]TJ
0 -1.0471 TD
[(un)15.5(ch)15.1(an)20.8(ge)15.1(d)-319.4(\()0(d)13.9(a)0(t)18.4(a)-325.5(no)21.2(t)-327.5(s)0(h)20(o)0(w)17.3(n)0(\))14(.)]TJ
1.0015 -1.0528 TD
[(No)-346.9(cl)18.4(ea)20.4(r)-355.2(p)0(a)20.8(t)0(t)16.5(e)0(r)19.2(n)-353.6(em)17.7(er)30.6(ge)15.1(d)-347.9(f)0(o)13.9(r)-349.5(th)18.9(e)-348.3(a)0(s)13.9(s)0(o)20(c)0(i)18.5(a)0(t)12.8(i)13.9(on)15.5(s)-349.1(b)0(e)15.1(t)0(w)20.6(e)0(e)14.7(n)]TJ
-1.0015 -1.0471 TD
[(ai)12.8(r)-230(p)0(o)21.2(l)0(l)16.5(u)0(t)18.9(a)0(n)15.1(t)-230.8(ex)20.8(po)15.5(su)20(re)-225.5(an)20.8(d)-234.1(a)0(s)19.6(t)0(h)18.9(m)0(a)12(t)13.9(ic)-226.2(co)20.8(nd)15.5(it)16.5(io)18.9(ns)20(.)-233.7(T)12.2(he)15.1(re)-219.8(wa)16.9(s)]TJ
0 -1.0528 TD
[(a)-245.9(t)0(r)17.3(e)0(n)15.1(d)-239.8(to)18.9(wa)11.2(rd)19.6(s)-241(a)-245.9(po)15.5(si)17.7(ti)22.2(ve)-235.2(as)13.9(so)20(ci)18.4(at)12.8(i)13.9(o)0(n)-234.8(b)0(e)15.1(t)0(w)14.9(e)0(e)20.4(n)-245.5(ex)20.8(po)15.5(su)20(re)-236.8(to)]TJ
0 -1.0471 TD
[(se)13.9(ve)20.8(ra)13.5(l)-447(p)0(o)15.5(l)0(l)16.5(u)0(t)18.9(a)0(n)20.8(t)0(s)-443.3(a)0(n)15.1(d)-444.6(th)13.2(e)-445(l)0(i)16.5(f)0(e)13.5(t)0(i)16.5(m)0(e)-437.6(p)0(r)13.9(e)0(v)20.8(a)0(l)12.8(e)0(n)20.8(c)0(e)-440.5(o)0(f)-441.3(d)0(o)15.5(c)0(t)18.5(o)0(r)]TJ
0 -1.0527 TD
[(di)13.2(ag)20.8(no)15.5(se)19.6(d)-376.3(a)0(s)19.6(t)0(h)13.2(m)0(a)17.7(,)-376(bu)21.2(t)-378.7(t)0(h)18.8(i)0(s)-369.3(a)0(s)19.6(s)0(o)14.4(c)0(i)18.4(a)0(t)18.5(i)0(o)18.9(n)-376.3(re)13.5(ac)20.4(he)15.1(d)-376.3(s)0(t)17.7(a)0(t)18.4(i)0(s)17.7(t)0(i)16.5(c)0(a)20.4(l)]TJ
0 -1.0471 TD
[(si)17.7(gn)15.5(if)17.3(ic)18.4(an)15.1(ce)-230(on)21.2(ly)-231.5(fo)19.6(r)-241.4(t)0(h)18.9(e)-240.2(co)20.8(mb)12.4(in)18.9(ed)-229.6(es)19.6(ti)16.5(ma)17.7(te)-231.9(of)-230.7(ex)20.8(po)15.5(su)20(re)-231.2(to)]TJ
0 -1.0527 TD
[(be)15.1(nz)15.1(en)20.8(e)-450.7(a)0(t)-448.2(h)0(o)21.2(m)0(e)-448.9(a)0(n)20.8(d)-456(at)-442.5(sc)19.6(ho)15.5(ol)-442.1(ad)15.1(dr)19.6(es)19.6(s.)-446.2(No)-443.6(si)17.7(gn)15.5(i)13.9(f)0(i)17.3(c)0(a)14.7(n)0(t)]TJ
0 -1.0471 TD
[(as)13.9(so)20(ci)18.4(at)12.8(io)18.9(n)-552.8(w)0(a)16.9(s)-553.9(fo)19.6(un)15.5(d)-552.7(b)0(e)20.8(t)0(w)14.9(e)0(e)14.7(n)-552.7(th)18.8(e)-553.2(m)0(e)17.7(a)0(n)-542.5(l)0(e)12.8(v)0(e)20.8(l)-555.1(of)-543.7(ai)18.4(r)]TJ
0 -1.0528 TD
[(po)15.5(ll)16.5(ut)18.9(io)18.8(n)-478.8(a)0(n)15.1(d)-473.1(wh)11.6(ee)20.4(ze)-469(in)-470.5(th)18.9(e)-479.2(p)0(a)20.8(s)0(t)-471.7(1)0(2)-468.2(m)0(o)18.1(n)0(t)13.2(h)0(s)-469.3(\()0(t)17.3(a)0(b)20.8(l)0(e)-470.9(4\).)]TJ
T*
[(Moreo)-7.8(ver)24.2(,)-444.2(neit)-8.2(her)-453.8(the)-448.9(freque)-8.6(ncy)-452.3(of)-447(whee)-7.8(zing)-449.7(e)-6.9(pisodes)]TJ
0 -1.0471 TD
[(nor)-311.2(the)-306.7(prevalence)-315.2(of)-304.7(speech)-308.6(lim)-10.2(iting)-306.9(or)-304.7(sleep)-309.8(disturbi)-10.3(ng)]TJ
0 -1.0527 TD
[(asthm)-10.9(a)-405.2(attacks)-416.5(in)-402.2(the)-409.1(past)-411.1(12)-405.6(mont)-8.6(hs)-406.7(was)-411.8(signifi)-9.6(cantly)]TJ
0 -1.0471 TD
[(associ)-10.1(ated)-222.5(with)-228(exposure)-225.9(to)-220.2(any)-224.6(of)-219.4(the)-221.3(pollu)-8.6(tants)-220.7(\(data)-224.8(not)]TJ
0 -1.0527 TD
[(show)-8.2(n\).)]TJ
1.0015 -1.0471 TD
[(BH)12.6(R)-278.6(w)0(a)16.9(s)-280.8(ne)15.1(ga)20.8(ti)16.5(ve)20.8(ly)-271.4(as)13.9(so)20(ci)18.5(at)18.5(ed)-275.1(w)12.4(i)0(t)16.5(h)-279.6(NO)]TJ
7.472 0 0 6.641 480.019 320.145 Tm
(2)Tj
9.963 0 0 9.963 486.538 321.789 Tm
[(an)20.8(d)-279.6(C)0(O)12.6(,)-273.5(an)15.1(d)]TJ
-17.7887 -1.0528 TD
[(po)15.5(si)17.7(ti)16.5(ve)20.8(ly)-299.8(as)19.6(so)14.4(ci)18.4(at)18.5(ed)-297.8(w)12.4(i)0(t)16.5(h)-308.1(O)]TJ
7.472 0 0 6.641 420.548 309.657 Tm
(3)Tj
9.963 0 0 9.963 424.176 311.301 Tm
[(.)-302(N)0(o)-295.7(i)0(n)13.2(c)0(r)19.2(e)0(a)20.4(s)0(e)14(d)-302.4(ri)17.3(sk)-298.6(of)-293.4(at)12.8(op)21.2(ic)]TJ
-11.5291 -1.0471 TD
[(se)13.9(ns)20(it)16.5(iz)18.4(at)18.5(io)13.2(n)-285.3(w)12.4(as)-282(se)19.6(en)-275.1(fo)13.9(r)-281.2(a)0(n)15.1(y)-285.3(po)15.5(l)13.9(l)0(u)13.2(t)0(a)18.4(n)0(t)18.9(.)-284.9(Li)14.7(ke)20.8(wi)14.9(se)19.6(,)-284.9(n)0(e)15.1(i)0(t)16.5(h)0(e)20.8(r)]TJ
0 -1.0528 TD
0.3711 Tc
[(ad)371.1(o)386.6(c)371.1(t)389.5(o)371.1(r)]TJ
/F11 1 Tf
3.2834 0 TD
0 Tc
(')Tj
/F3 1 Tf
0.2106 0 TD
[(s)-366.2(d)0(i)13.2(a)0(g)20.8(n)0(o)15.5(s)0(i)17.7(s)-366.2(of)-361.6(ha)15.1(y)-365(f)0(e)13.5(v)0(e)20.8(r)-372.2(an)20.8(d)-370.7(e)0(c)20.4(z)0(e)14.7(m)0(a)-357.9(n)0(o)15.5(r)-372.2(sy)20(mp)18.1(-)]TJ
-3.494 -1.0471 TD
[(to)13.2(ms)-335.9(of)-344.6(al)18.5(le)18.4(r)20.4(g)0(i)18.9(c)-348.3(rh)13.9(in)18.8(oc)15.1(on)21.2(ju)18.9(nc)15.1(ti)16.5(vi)18.9(ti)16.5(s)-349.1(a)0(n)20.8(d)-347.9(at)18.5(op)15.5(ic)-340.1(ec)14.7(ze)20.4(ma)-340.8(in)]TJ
0 -1.0528 TD
[(th)13.2(e)-325.5(p)0(a)15.1(s)0(t)-318.1(1)0(2)-320.2(m)0(o)18.1(n)0(t)18.9(h)0(s)-321.4(w)0(e)16.9(r)0(e)-316.5(a)0(s)14(s)0(o)20(c)0(i)18.4(a)0(t)12.8(e)0(d)-314.9(w)0(i)14.9(t)0(h)-316.9(o)0(u)15.5(t)0(d)18.9(o)0(o)15.5(r)-326.7(ai)18.5(r)-332.4(p)0(o)21.2(l)0(-)]TJ
0 -1.0471 TD
[(lu)13.2(ti)22.2(on)-320.2(ex)20.8(po)15.5(su)20(re)-316.5(\(d)19.6(at)12.8(a)-319.8(n)0(o)15.5(t)-321.8(sh)14.4(ow)17.3(n\))19.6(.)]TJ
1.0015 -1.0528 TD
[(Wh)14.4(en)-223.9(st)17.7(ra)19.2(ti)16.5(fy)19.6(in)13.2(g)-228.4(c)0(h)20.8(i)0(l)16.5(d)0(r)14(e)0(n)-218.2(w)0(i)14.9(t)0(h)-220.2(d)0(o)15.5(c)0(t)18.5(o)0(r)-219.4(d)0(i)13.2(a)0(g)20.8(n)0(o)15.5(s)0(e)19.6(d)-228.4(as)14(th)18.9(ma)]TJ
-1.0015 -1.0528 TD
[(in)13.2(to)-578.7(at)18.5(op)15.5(ic)-579.1(\(S)14.7(X1)-580.2(CA)12.6(P)11.4(;)-589.3(Ph)16.3(ar)19.2(ma)12(ci)18.5(a;)]TJ
/F9 1 Tf
15.4385 0 TD
(>)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(7)-592.6(k)0(U)]TJ
/F10 1 Tf
3.0217 0.2049 TD
(.)Tj
/F3 1 Tf
0.2675 -0.2049 TD
(L)Tj
7.472 0 0 6.641 507.288 242.532 Tm
(-1)Tj
9.963 0 0 9.963 513.241 238.053 Tm
0.5885 Tc
[(\)a)588.5(n)603.6(d)]TJ
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[(Th)17.1(e)-484.9(r)0(e)19.2(s)0(u)14.4(l)0(t)16.5(s)-485.7(of)-475.4(th)18.9(is)-477.4(su)20(rv)13.9(ey)-474.2(su)20(gg)15.5(es)19.6(t)-486.8(t)0(h)18.9(a)0(t)-476.6(m)0(o)12.4(d)0(e)20.8(r)0(a)13.5(t)13.9(e)-490.6(i)0(n)18.9(-)]TJ
-1.0015 -1.0471 TD
[(cr)19.2(ea)14.7(se)19.6(s)-326.3(i)0(n)-311.2(i)0(n)13.2(n)0(e)20.8(r)-326.7(ci)18.4(ty)-311.2(ai)12.8(r)-321(p)0(o)15.5(l)0(l)16.5(u)0(t)18.9(i)0(o)18.9(n)-325.1(w)12.4(e)0(l)12.8(l)-321.8(be)20.8(lo)13.2(w)-323.4(t)0(h)18.9(e)-325.5(na)20.8(ti)16.5(on)15.5(al)]TJ
0 -1.0527 TD
[(am)17.7(bi)18.9(en)15.1(t)-293.4(a)0(i)18.4(r)-298.3(qu)21.2(al)12.8(i)13.9(t)0(y)-288.4(s)0(t)17.7(a)0(n)15.1(d)0(a)20.8(r)0(d)19.6(s)-297.9([2)19.6(9,)-297.1(30])-305.5(are)-306.3(associ)-10.1(ated)-307.8(with)]TJ
0 -1.0471 TD
[(an)-462.9(incre)-8.6(ased)-460.3(preval)-9.4(ence)-465.2(of)-464.1(morning)-467.7(cough)-465.2(and)-463.6(doctor)]TJ
0 -1.0527 TD
[(diagno)-7.4(sed)-277(bronchi)-9.7(tis,)-276.1(but)-277.8(not)-277.8(of)-276.3(airway)-280.7(hyperr)-8.2(espons)-7.4(ive-)]TJ
0 -1.0471 TD
[(ness,)-262.3(atopi)-9(c)-257.2(sensi)-9(tization)-10.7(,)-256.5(o)0(r)-259.2(symp)-7.4(tom)-7.8(s)-258(o)0(f)-259.2(atopi)-9(c)-257.2(disea)-8.2(ses)]TJ
0 -1.0527 TD
[(in)-334(chil)-8.2(dren.)]TJ
1.0015 -1.0471 TD
[(In)19.6(ne)15.1(r)-332.4(c)0(i)18.4(t)0(y)-328.3(a)0(i)18.4(r)-332.4(po)15.5(l)13.9(l)0(u)13.2(t)0(i)16.5(o)0(n)-320.2(h)0(a)15.1(s)-332(ma)17.7(ny)-325.9(so)20(ur)19.6(ce)14.7(s)-332(o)0(f)-327.5(w)12.4(hi)13.2(ch)-320.6(ca)14.7(r)]TJ
-1.0015 -1.0528 TD
[(tr)17.3(af)24.9(fi)17.3(c)-416.6(i)0(s)-409.1(o)0(n)21.2(e)-416.6(im)15.7(po)15.5(rt)17.3(an)20.8(t)-418.6(c)0(o)15.1(n)0(t)18.9(r)0(i)17.3(b)0(u)15.5(t)13.9(or)65.2(.)-415.8(I)0(n)-407.2(D)0(r)15.7(e)0(s)19.6(d)0(e)15.1(n)-416.2(th)18.8(e)-416.6(p)0(o)15.5(l)0(-)]TJ
T*
[(lu)18.9(ta)18.4(nt)-248.6(me)17.7(as)19.6(ur)13.9(em)17.7(en)20.8(ts)-244.1(pr)14(es)19.6(en)15.1(te)18.4(d)-251.2(h)0(e)15.1(r)0(e)-242.5(h)0(a)15.1(v)0(e)-240.9(a)0(l)18.4(s)0(o)-247.4(b)0(e)20.8(e)0(n)-246.6(r)0(e)19.2(l)0(a)18.4(t)0(e)12.8(d)]TJ
0 -1.0471 TD
[(to)-260(ac)14.7(tu)18.9(al)-260.4(tr)17.3(af)24.9(fi)17.3(c)-268.6(c)0(o)15.1(u)0(n)21.2(t)0(s)17.7(.)-273.5(In)-259.2(th)18.9(es)13.9(e)-268.6(e)0(s)19.6(t)0(i)16.5(m)0(a)12(t)13.9(es)-264.9(87)21.2(%)-276.3(o)0(f)-259.2(t)0(h)18.8(e)-274.3(to)18.8(ta)18.4(l)]TJ
0 -1.0528 TD
[(be)15.1(nz)20.8(en)15.1(e)-268.6(e)0(m)17.7(i)0(s)17.7(s)0(i)17.7(o)0(n)-263.3(w)0(a)16.9(s)-275.1(at)18.4(tr)17.3(ib)18.9(ut)18.9(ab)15.1(le)-260.4(to)-265.7(ro)19.6(ad)-263.7(tr)17.3(af)30.6(fi)17.3(c)-274.3([)0(3)19.6(1].)-276.6(For)]TJ
0 -1.0471 TD
[(other)-440.7(pollutants)-439.8(the)-437.6(associati)-11.9(on)-434(with)-432.8(traffic)-431.1(was)-440.3(lower:)]TJ
0 -1.0528 TD
[(46%)-294.9(of)-287.7(the)-289.6(NO)]TJ
7.472 0 0 6.641 119.679 384.435 Tm
(2)Tj
9.963 0 0 9.963 126.312 386.079 Tm
[(emissi)-9.6(on,)-286.4(48%)-294.9(of)-287.6(the)-295.3(CO)-289(emi)-8.2(ssion,)-293.5(and)]TJ
-6.8287 -1.0471 TD
[(only)-221.7(1.7%)-215.6(of)-219.4(the)-215.6(SO)]TJ
7.472 0 0 6.641 138.161 374.003 Tm
(2)Tj
9.963 0 0 9.963 144.057 375.647 Tm
[(emissi)-9.6(on)-212.1(could)-222.8(be)-218.2(ascribed)-223(to)-214.5(mot)-7.8(or)]TJ
16.5879 39.7485 TD
[(veh)-8.4(icle)-315.9(exhaust)-9.7(s)-309.2([32].)-319.6(Anthropo)-8.3(genic)-320(O)]TJ
7.472 0 0 6.641 469.984 770.003 Tm
(3)Tj
9.963 0 0 9.963 476.844 771.647 Tm
[(is)-312.4(produce)-7.7(d)-313.7(b)0(y)]TJ
-16.8156 -1.0755 TD
[(pho)-8(tochemica)-10.7(l)-333.2(react)-9(ions)-336.7(involving)-344.1(NO)]TJ
7.472 0 0 6.641 465.505 759.288 Tm
(2)Tj
9.963 0 0 9.963 469.247 760.932 Tm
[(.)-330.4(I)0(t)-341.2(i)0(s)-335.2(reduced)-338.2(in)]TJ
-16.053 -1.0755 TD
[(the)-369.3(presen)-8.2(ce)-360.8(of)-367.3(high)-363.9(NO)-367.9(concent)-8.9(rations)-371.8(which)-369(occur)-364.7(in)]TJ
T*
[(areas)-559.8(wi)-7.8(th)-550.2(dense)-557.8(traffic.)-556.7(Therefor)-10.1(e,)-553.5(the)-557.1(measured)-565.2(O)]TJ
7.472 0 0 6.641 532.743 737.858 Tm
(3)Tj
9.963 0 0 9.963 309.316 728.787 Tm
[(level)-9.4(s)-440.1(were)-441.9(inver)-8.2(sely)-439.5(correl)-11(ated)-438.7(wi)-7.8(th)-436.4(concent)-8.9(rations)-445.8(of)]TJ
0 -1.0698 TD
(NO)Tj
7.472 0 0 6.641 323.716 716.428 Tm
(2)Tj
9.963 0 0 9.963 327.401 718.129 Tm
[(,)-336.1(CO,)-334.9(a)-6.9(n)0(d)-331.6(benzene.)]TJ
-0.8138 -1.0527 TD
[(Th)17.1(e)-359.7(a)0(d)20.8(v)0(e)15.1(r)0(s)18.4(e)-354(he)15.1(al)18.4(th)-345.3(ef)30.6(fe)13.5(ct)18.5(s)-354.8(w)0(e)16.9(r)0(e)-345(r)0(e)13.5(l)0(a)18.4(t)0(e)18.5(d)-353.6(to)-345.3(ex)15.1(po)21.2(su)14.4(re)-345(to)]TJ
-1.0015 -1.0755 TD
[(se)13.9(ve)20.8(ra)13.5(l)-333.2(p)0(o)21.2(l)0(l)16.5(u)0(t)18.9(a)0(n)15.1(t)0(s)17.7(.)-330.4(Th)17.1(e)-336.9(p)0(r)19.6(e)0(v)15.1(a)0(l)18.4(e)0(n)20.8(c)0(e)-326.7(o)0(f)-327.5(m)0(o)18.1(r)0(n)19.6(i)0(n)18.9(g)-336.5(co)20.8(ug)15.5(h)-330.8(a)0(n)15.1(d)]TJ
T*
[(br)13.9(on)21.2(ch)15.1(it)16.5(is)-585.5(wa)16.9(s)-599.5(p)0(o)15.5(s)0(i)17.7(t)0(i)16.5(v)0(e)20.8(l)0(y)-590(a)0(s)19.6(s)0(o)14.3(c)0(i)18.5(a)0(t)18.5(e)0(d)-588.1(w)0(i)14.9(t)0(h)-590(e)0(x)20.8(p)0(o)15.5(s)0(u)20(r)0(e)-589.7(t)0(o)]TJ
T*
[(be)15.1(nz)15.1(en)20.8(e,)-320.2(NO)]TJ
7.472 0 0 6.641 360.964 673.852 Tm
(2)Tj
9.963 0 0 9.963 367.994 675.496 Tm
[(an)20.8(d)-330.8(C)0(O)18.3(,)-330.4(an)20.8(d)-330.8(i)0(n)18.9(v)0(e)15.1(r)0(s)18.4(e)0(l)18.4(y)-330.8(re)19.2(la)18.4(te)18.4(d)-330.8(t)0(o)-316.9(O)]TJ
7.472 0 0 6.641 508.138 673.852 Tm
(3)Tj
9.963 0 0 9.963 511.767 675.496 Tm
0.3304 Tc
[(.B)330.4(e)346.5(n)330.4(-)]TJ
-20.3209 -1.0755 TD
0 Tc
[(ze)14.7(ne)-326.3(co)15.1(nc)15.1(en)20.8(tr)17.3(at)18.4(io)13.2(ns)-327.1(ar)19.2(e)-336.9(a)0(l)12.8(m)0(o)18.1(s)0(t)-329.5(e)0(x)20.8(c)0(l)12.8(u)0(s)20(i)0(v)18.9(e)0(l)18.5(y)-342.2(at)18.5(tr)17.3(ib)18.9(ut)18.9(ab)15.1(le)-328.7(to)]TJ
T*
[(mo)12.4(to)18.8(r)-332.4(v)0(e)20.8(h)0(i)18.9(c)0(l)12.8(e)-331.2(em)17.7(is)17.7(si)17.7(on)21.2(s.)-321(Co)16.5(nc)15.1(en)20.8(tr)17.3(at)12.8(io)18.9(ns)-321.4(of)-321.8(NO)]TJ
7.472 0 0 6.641 498.331 652.422 Tm
(2)Tj
9.963 0 0 9.963 505.304 654.066 Tm
[(an)15.1(d)-330.8(C)11.6(O)]TJ
-19.6722 -1.0698 TD
[(ar)13.5(e)-354(a)0(l)18.4(s)0(o)-349.8(d)0(e)20.8(t)0(e)12.8(r)0(m)16.5(i)0(n)18.8(e)0(d)-349.1(t)13.9(o)-359.3(a)-354(su)14.4(bs)20(ta)18.4(nt)18.9(ia)12.8(l)-356(d)0(e)20.8(g)0(r)14(e)0(e)-343.8(b)0(y)-348.7(t)0(r)17.3(a)0(f)30.6(f)0(i)17.3(c)-359.7(bu)21.2(t)]TJ
0 -1.0755 TD
[(al)12.8(so)-378.3(by)-388.5(ot)18.9(he)20.8(r)-395(s)0(o)20(u)0(r)14(c)0(e)20.4(s)-394.6(\()]TJ
/F6 1 Tf
9.3496 0 TD
[(e.)21.2(g.)]TJ
/F3 1 Tf
1.8039 0 TD
[(i)13.9(n)0(d)15.5(o)0(o)15.5(r)-389.3(he)15.1(at)18.4(in)18.9(g)-393.4(a)0(n)20.8(d)-393.4(in)18.9(du)15.5(st)17.7(ri)17.3(al)]TJ
-11.1535 -1.0755 TD
[(co)15.1(mb)18.1(us)14.4(ti)22.2(on)15.5(\).)-258.8(T)12.2(h)0(u)15.5(s)0(,)-252.7(t)0(r)17.3(a)0(f)24.9(f)0(i)17.3(c)-262.9(is)-261.2(an)-252.3(im)15.7(po)15.5(rt)17.3(an)20.8(t)-270.6(b)0(u)21.2(t)-264.9(no)15.5(t)-264.9(t)0(h)18.9(e)-268.6(on)21.2(ly)]TJ
T*
[(so)14.4(ur)19.6(ce)-497.4(of)-492.5(ag)20.8(en)15.1(ts)-494.5(w)12.4(h)0(i)13.2(c)0(h)-491.3(m)0(a)17.7(y)-501.5(ac)14.7(co)15.1(un)21.2(t)-503.9(f)0(o)19.6(r)-503.1(th)18.8(e)-501.9(o)0(b)15.5(s)0(e)19.6(r)0(v)13.9(e)0(d)]TJ
T*
[(as)13.9(so)20(ci)18.4(at)12.8(io)18.9(ns)20(.)]TJ
1.0015 -1.0527 TD
(SO)Tj
7.472 0 0 6.641 331.824 588.416 Tm
(2)Tj
9.963 0 0 9.963 340.611 590.06 Tm
[(wa)16.9(s)-514.1(p)0(o)21.2(s)0(i)17.7(t)0(i)16.5(v)0(e)15.1(l)0(y)-499(a)0(s)14(s)0(o)20(c)0(i)18.5(a)0(t)18.5(e)0(d)-502.7(w)0(i)14.9(t)0(h)-504.7(c)0(u)20.8(r)0(r)18(e)0(n)15.1(t)-509.6(mo)18.1(rn)13.9(in)18.8(g)]TJ
-3.1412 -1.0698 TD
[(co)15.1(ug)15.5(h)-467.4(b)0(u)15.5(t)-469.8(no)15.5(t)-469.8(w)0(i)14.9(t)0(h)-464.8(b)0(r)19.6(o)0(n)15.5(c)0(h)20.8(i)0(t)16.5(i)0(s)17.7(.)-472.7(Th)17.1(is)-460.3(po)15.5(ll)16.5(ut)18.9(an)15.1(t)-469.8(p)0(r)19.6(e)0(d)15.1(o)0(m)18.1(i)0(-)]TJ
0 -1.0755 TD
[(na)15.1(nt)18.9(ly)-442.1(re)13.5(pr)19.6(es)19.6(en)15.1(ts)-443.3(ot)18.8(he)20.8(r)-451.9(s)0(o)14.4(u)0(r)19.6(c)0(e)14.7(s)-451.5(th)18.8(an)-440.1(tr)17.3(af)24.9(fi)17.3(c)-450.7(t)0(h)18.8(e)0(r)19.2(e)0(f)13.5(o)0(r)19.6(e)-450.7(it)16.5(s)]TJ
T*
[(lo)13.2(ng)21.2(te)18.4(rm)-376.2(ef)30.6(fe)13.5(ct)18.4(s)-377.5(m)0(a)12(y)-376.3(di)13.2(f)20.4(f)0(e)19.2(r)-383.6(fr)18(om)-374.6(t)13.9(h)0(o)15.5(s)0(e)-373(o)0(f)-373(t)13.9(he)-371.8(ot)13.2(he)20.8(r)-383.6(p)0(o)21.2(l)0(-)]TJ
T*
[(lu)13.2(ta)18.4(nt)18.8(s.)-377.9(Th)17.1(e)-393.8(i)0(n)18.9(v)0(e)20.8(r)0(s)12.8(e)-388.1(as)19.6(so)14.4(ci)18.5(at)18.4(io)18.8(ns)-384(of)-378.7(an)15.1(nu)21.2(al)-385.6(me)17.7(an)-383.2(O)]TJ
7.472 0 0 6.641 516.472 545.612 Tm
(3)Tj
9.963 0 0 9.963 524.126 547.257 Tm
[(ex)20.8(-)]TJ
-21.5615 -1.0755 TD
[(po)15.5(su)20(re)-316.5(wi)14.9(th)-311.2(mo)12.4(rn)19.6(in)18.9(g)-325.1(c)0(o)20.8(u)0(g)15.5(h)-325.1(an)20.8(d)-325.1(b)0(r)19.6(o)0(n)15.5(c)0(h)20.8(i)0(t)16.5(i)0(s)-318.1(w)12.4(er)13.5(e)-325.5(n)0(o)21.2(t)-321.8(se)13.9(en)]TJ
T*
-0.0155 Tc
[(f)-15.5(o)-1.6(r)-262.6(p)-15.5(ea)-15.5(k)-256.4(e)-15.5(xp)-15.5(o)5.7(s)-15.5(ur)-15.5(es)-267.8(to)-266.7(O)]TJ
7.472 0 0 6.641 402.406 524.182 Tm
0 Tc
(3)Tj
9.963 0 0 9.963 406.035 525.827 Tm
-0.0193 Tc
[(.)-270.1(E)-19.3(xp)-19.3(o)-3.8(s)-19.3(ur)-19.3(e)-261.8(t)-19.3(o)-262.2(h)-19.3(ig)-19.3(h)-259.8(c)-19.3(on)-19.3(c)-4.2(e)-19.3(nt)-19.3(r)-7.7(a)-19.3(ti)-19.3(on)-19.3(s)]TJ
-9.7081 -1.0755 TD
0 Tc
[(of)-503.9(O)]TJ
7.472 0 0 6.641 329.612 513.468 Tm
(3)Tj
9.963 0 0 9.963 338.457 515.112 Tm
[(ar)13.5(e)-507.6(k)0(n)15.5(o)0(w)17.3(n)-512.9(to)-504.7(in)18.9(du)15.5(ce)-503.1(ai)18.4(rw)15.7(ay)-502.7(ir)17.3(ri)17.3(ta)12.8(ti)22.2(on)-508([3)19.6(3])-515.3(and)]TJ
-2.9249 -1.0755 TD
[(imp)-7.8(airment)-317.2(of)-310.4(pulm)-8.6(onary)-313.1(function)-314.5([34].)-313.9(This)-312.3(may)-313.1(coun-)]TJ
T*
[(terac)-9(t)-310.4(the)-312.4(inver)-8.2(se)-310.4(effects)-309.2(of)-310.4(low)-315.9(traffic)-305.9(exposur)-8.5(e)-308.5(i)0(n)-311.2(some)]TJ
T*
[(dist)-9(ricts)-336.1(of)-338.9(the)-335.1(Dresden)-342.9(area.)]TJ
1.0015 -1.0471 TD
[(Th)17.1(er)13.5(e)-302.8(w)12.4(as)-299(no)-291.8(po)21.2(si)17.7(ti)16.5(ve)-292.2(as)13.9(so)20(ci)18.5(at)12.8(io)18.9(n)-302.4(b)0(e)20.8(t)0(w)14.9(e)0(e)14.7(n)-302.4(ex)20.8(po)15.5(su)20(re)-293.8(to)]TJ
-1.0015 -1.0755 TD
[(be)15.1(nz)15.1(en)20.8(e,)-246.2(NO)]TJ
7.472 0 0 6.641 360.283 460.176 Tm
(2)Tj
9.963 0 0 9.963 366.576 461.82 Tm
-0.0168 Tc
[(a)-16.8(n)-1.7(d)-273.6(C)-5.2(O)-277.6(a)-16.8(nd)-273.6(t)-16.8(h)2.1(e)-274(p)-16.8(re)-16.8(va)-16.8(le)-16.8(nc)-16.8(e)-263.8(o)-16.8(f)-264.6(s)-16.8(ym)-16.8(pt)-16.8(om)-16.8(s)-267.4(o)-16.8(r)]TJ
-5.7475 -1.0755 TD
0 Tc
[(di)13.2(ag)20.8(no)15.5(se)19.6(s)-388.9(o)0(f)-384.4(h)0(a)20.8(y)-393.4(fe)19.2(ve)15.1(r)-389.3(a)0(n)20.8(d)-393.4(ec)20.4(ze)14.7(ma)17.7(,)-387.3(a)0(t)12.8(o)0(p)21.2(i)0(c)-385.6(s)0(e)19.6(n)0(s)20(i)0(t)16.5(i)0(z)18.5(a)0(t)12.8(i)13.9(on)15.5(,)]TJ
T*
[(an)15.1(d)-450.3(B)11.6(HR)12.6(.)-444.2(T)0(h)17.1(e)-450.7(as)19.6(so)20(ci)12.8(at)18.5(io)18.9(ns)-440.9(be)20.8(tw)14.9(ee)20.4(n)-450.3(p)0(o)15.5(l)13.9(lu)13.2(ta)18.4(nt)-436.4(ex)15.1(po)15.5(su)20(re)]TJ
T*
[(an)15.1(d)-569.8(r)0(e)19.2(s)0(p)20(i)0(r)17.3(a)0(t)12.8(o)0(r)19.6(y)-569.8(sy)20(mp)18.1(to)13.2(m)13.2(s)-571(an)15.1(d)-564.1(d)0(i)18.9(a)0(g)15.1(n)0(o)15.5(s)0(e)19.6(s)-565.3(we)16.9(re)-561.2(cl)18.4(ea)14.7(rl)17.3(y)]TJ
T*
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T*
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T*
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T*
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T*
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T*
[(assessed)-518.5(with)-511.9(4.5%)-514(NAC.)-518.5(FEV)]TJ
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(1)Tj
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T*
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T*
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T*
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T*
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[(12)-582(mo)12.4(nt)18.9(hs)-583.2(in)-584.3(Dr)15.7(es)13.9(de)20.8(n)-592.6(r)0(e)13.5(s)0(u)20(l)0(t)16.5(e)0(d)-582.4(i)0(n)-590(a)]TJ
-7.0961 -1.0698 TD
[(po)15.5(pu)21.2(la)18.4(ti)16.5(on)-195(w)12.4(i)0(t)16.5(h)-199.9(sl)17.7(ig)13.2(ht)18.9(ly)-191.7(hi)18.9(gh)15.5(er)-191.3(ex)20.8(po)15.5(su)20(re)-191.3(to)-191.7(ma)12(te)18.4(rn)19.6(al)-192.1(sm)16.9(ok)15.5(-)]TJ
25.1977 19.2966 TD
[(in)13.2(g)-239.8(a)0(n)15.1(d)-245.5(lo)18.8(we)16.9(r)-247.1(p)0(a)20.8(r)0(e)13.5(n)0(t)18.9(a)0(l)-237.6(e)0(d)20.8(u)0(c)15.1(a)0(t)18.5(i)0(o)18.9(n)0(.)-234.5(I)0(n)-236.4(s)0(u)14.4(c)0(h)-235.2(c)0(h)20.8(i)0(l)16.5(d)0(r)14(e)0(n)-235.2(o)0(u)21.2(t)0(d)13.2(o)0(o)21.2(r)]TJ
0 -1.0755 TD
[(po)15.5(ll)16.5(ut)18.9(io)18.8(n)-228.4(m)0(a)12(y)-228.4(co)20.8(nt)13.2(ri)17.3(bu)21.2(te)-220.6(to)-220.2(a)-228.8(s)0(m)11.2(a)0(l)18.5(l)0(e)18.4(r)-230(am)17.7(ou)15.5(nt)-220.1(to)-220.2(th)18.8(e)-228.8(o)0(v)15.5(e)0(r)19.2(a)0(l)18.5(l)]TJ
T*
[(ef)24.9(fe)19.2(ct)12.8(s)-417.4(o)0(f)-407.2(e)0(n)15.1(v)0(i)18.9(r)0(o)19.6(n)0(m)18.1(e)0(n)15.1(t)0(a)18.4(l)-418.6(ha)15.1(za)20.4(rd)13.9(s.)-406.4(Th)17.1(er)19.2(ef)13.5(or)19.6(e)-416.6(t)0(h)13.2(e)-416.6(as)19.6(so)14.4(ci)18.5(a-)]TJ
T*
[(ti)16.5(on)15.5(s)-332(b)0(e)15.1(t)0(w)20.6(e)0(e)14.7(n)-330.8(ou)15.5(td)18.9(oo)15.5(r)-332.4(p)0(o)21.2(l)0(l)16.5(u)0(t)18.9(i)0(o)13.2(n)-330.8(an)15.1(d)-330.8(r)0(e)19.2(s)0(p)14.4(i)0(r)17.3(a)0(t)18.5(o)0(r)19.6(y)-336.5(he)20.8(al)12.8(t)13.9(h)-336.5(or)]TJ
T*
[(at)12.8(op)21.2(y)-342.2(m)0(i)15.7(g)0(h)15.5(t)-344.6(ha)20.8(ve)-337.7(be)15.1(en)-332(un)15.5(de)20.8(re)13.5(st)17.7(im)15.7(at)18.4(ed)-332(in)-339.7(th)18.8(is)-335.2(st)17.7(ud)15.5(y)73.2(.)-341.8(Th)17.1(e)]TJ
0 -1.0698 TD
[(re)13.5(du)21.2(ct)12.8(i)13.9(o)0(n)-297.4(o)0(f)-293.3(t)0(h)18.8(e)-308.5(st)17.7(ud)21.2(y)-302.4(p)0(o)15.5(p)0(u)21.2(l)0(a)12.8(t)0(i)16.5(o)0(n)-291.8(b)0(y)-291.7(s)0(e)13.9(l)0(e)18.5(c)0(t)18.5(i)0(o)18.8(n)-308.1(of)-293.3(ch)20.8(il)16.5(dr)13.9(en)]TJ
0 -1.0755 TD
[(wi)14.9(th)-328.3(Ge)16.9(rm)16.5(an)-326.3(na)15.1(ti)16.5(on)21.2(al)12.8(i)13.9(t)0(y)-328.3(w)0(a)16.9(s)-337.7(qu)15.5(an)20.8(ti)16.5(ta)18.5(ti)16.5(ve)15.1(ly)-328.3(ne)20.8(gl)18.9(ig)13.2(i)13.9(b)0(l)13.2(e)0(.)-325.9(I)0(n)]TJ
T*
[(ad)15.1(di)18.9(ti)16.5(on)15.5(,)-284.9(e)0(t)18.5(h)0(n)21.2(i)0(c)18.4(i)0(t)16.5(y)-285.3(ha)15.1(s)-286.5(b)0(e)20.8(e)0(n)-275.1(s)0(h)14.3(o)0(w)17.3(n)-285.3(to)-277.1(be)-275.1(a)-285.7(s)0(i)17.7(g)0(n)21.2(i)0(f)17.3(i)0(c)12.8(a)0(n)20.8(t)-287.7(de)20.8(t-)]TJ
T*
[(er)13.5(mi)15.7(na)20.8(nt)-254.3(fo)19.6(r)-264.1(t)0(h)18.9(e)-257.3(pr)14(ev)20.8(al)12.8(en)20.8(ce)-252.7(of)-253.5(at)18.5(op)15.5(i)13.9(c)-262.9(di)18.8(se)13.9(as)19.6(es)-253.5(in)-248.6(Ge)16.9(rm)16.5(an)15.1(y)]TJ
T*
[([3)13.9(5].)]TJ
1.0015 -1.0528 TD
[(Wh)14.4(en)-292.2(in)18.9(te)18.4(rp)19.6(re)13.5(ti)16.5(ng)-286.1(th)18.9(es)13.9(e)-297.1(f)0(i)17.3(n)0(d)15.5(i)0(n)18.9(g)0(s)-287.3(i)0(t)-290.8(i)0(s)-289.6(i)0(m)15.7(p)0(o)15.5(r)0(t)17.3(a)0(n)20.8(t)-299(to)-288.4(be)15.1(ar)]TJ
-1.0015 -1.0755 TD
[(in)-407.9(mi)15.7(nd)-411.3(th)18.8(at)-408.3(in)-407.9(Dr)15.7(es)19.6(de)15.1(n,)-405.2(as)-407.2(in)-407.9(ma)12(ny)-405.6(ot)18.9(he)15.1(r)-417.8(a)0(r)19.2(e)0(a)14.7(s)-417.4(of)-407.2(th)18.9(e)]TJ
0 -1.0698 TD
[(fo)13.9(rm)16.5(er)-646.6(E)12.2(a)0(s)14(t)-651.9(Ge)16.9(rm)16.5(an)15.1(y)73.2(,)-654.8(ex)15.1(po)21.2(su)20(re)-646.6(to)-646.9(ai)18.5(r)-656.8(p)0(o)15.5(l)13.9(lu)13.2(ti)16.5(on)-644.6(ha)20.8(s)]TJ
0 -1.0755 TD
[(ch)15.1(an)15.1(ge)20.8(d)-547.1(t)0(r)17.3(e)0(m)17.7(e)0(n)15.1(d)0(o)21.2(u)0(s)14.4(l)13.9(y)-547.1(i)0(n)-538.8(t)0(h)18.9(e)-547.5(fi)17.3(rs)18.4(t)-543.7(y)0(e)15.1(a)0(r)19.2(s)-548.3(af)19.2(te)18.4(r)-548.6(G)12.4(er)13.5(ma)17.7(n)]TJ
T*
[(re)13.5(un)21.2(if)17.3(ic)12.8(at)18.4(io)18.8(n)-569.8(i)0(n)-555.9(1)0(9)15.5(8)0(9)21.2(.)-569.4(L)12.2(e)0(v)15.1(e)0(l)18.5(s)-571(O)12.4(f)-571.4(S)11.4(O)]TJ
7.472 0 0 6.641 464.938 158.513 Tm
(2)Tj
9.963 0 0 9.963 474.349 160.214 Tm
[(ha)20.8(ve)-559.6(de)15.1(cr)19.2(ea)14.7(se)19.6(d)]TJ
-16.5652 -1.0755 TD
[(su)14.4(bs)20(ta)18.4(nt)13.2(ia)18.4(ll)16.5(y)-325.1(b)0(e)15.1(t)0(w)20.6(e)0(e)14.7(n)-330.8(19)21.2(89)15.5(\2611)21.2(99)15.5(2)-325.1([)0(3)13.9(6)0(])-327.5(and)-344.1(car)-340.4(traffic)-334.4(ex-)]TJ
T*
[(posure)-377.7(has)-368.1(increa)-9.8(sed)-368.1(between)-377.1(1990\261199)-6.1(4)-365([37].)-370.8(The)-371(ad-)]TJ
T*
[(verse)-291.9(health)-289(effects)-280.8(seen)-289.6(in)-282.7(this)-287.8(study)-286.2(are)-289.2(therefore)-294.1(likely)]TJ
T*
[(to)-379.5(refl)-9(ect)-381.1(exposur)-8.5(e)-376.8(i)0(n)-379.5(the)-380.7(past)-382.6(few)-383.8(years.)-383.4(The)-382.4(exposur)-8.5(e)]TJ
ET
1 i 
58.28 758.834 478.205 -0.51 re
f
58.28 732.926 478.205 -0.51 re
f
58.28 404.164 478.205 -0.51 re
f
BT
/F2 1 Tf
8.966 0 0 8.966 58.28 772.667 Tm
[(Table)-331.9(4.)-336.7(\261)-333.2(Association)-283.3(of)-286.1(respiratory)-282.6(symptoms)-279.5(and)-285.1(diseases,)-282.1(pulmonary)-281.4(function,)-283.8(and)-285.1(atopy)-281.8(in)-285.9(children)-285(with)-279.6(exposure)-282.3(to)]TJ
0 -1.0559 TD
[(inner)-334.7(city)-334.6(air)-332.3(pollutants)-332.3(at)-336.7(home)-330.9(\(EHA\))-337.9(and)-329.3(at)-336.7(home)-330.9(and)-335.7(school)-331.6(sddress)-329.9(\(EHSA\))]TJ
/F3 1 Tf
11.944 -1.7072 TD
(Subjects)Tj
1.1761 -1.0559 TD
(n*)Tj
5.5325 1.0559 TD
(SO)Tj
6.725 0 0 5.977 236.92 746.362 Tm
(2)Tj
8.966 0 0 8.966 213.279 738.425 Tm
(+10)Tj
/F9 1 Tf
1.8905 0 TD
(m)Tj
/F3 1 Tf
0.5754 0 TD
(g)Tj
/F10 1 Tf
0.4995 0.2213 TD
(.)Tj
/F3 1 Tf
0.2719 -0.2213 TD
(m)Tj
6.725 0 0 5.977 249.222 742.393 Tm
(3)Tj
8.966 0 0 8.966 292.422 747.893 Tm
(NO)Tj
6.725 0 0 5.977 305.291 746.362 Tm
(2)Tj
8.966 0 0 8.966 280.913 738.425 Tm
(+10)Tj
/F9 1 Tf
1.8906 0 TD
(m)Tj
/F3 1 Tf
0.5754 0 TD
(g)Tj
/F10 1 Tf
0.4995 0.2213 TD
(.)Tj
/F3 1 Tf
0.2719 -0.2213 TD
(m)Tj
6.725 0 0 5.977 316.857 742.393 Tm
(3)Tj
8.966 0 0 8.966 361.984 747.893 Tm
(CO)Tj
-1.625 -1.0559 TD
(+0.2)Tj
/F9 1 Tf
2.1435 0 TD
(m)Tj
/F3 1 Tf
0.5754 0 TD
(g)Tj
/F10 1 Tf
0.4995 0.2213 TD
(.)Tj
/F3 1 Tf
0.2719 -0.2213 TD
(m)Tj
6.725 0 0 5.977 385.625 742.393 Tm
(3)Tj
8.966 0 0 8.966 420.548 747.893 Tm
(Benzene)Tj
-0.2339 -1.0559 TD
(+1)Tj
/F9 1 Tf
1.391 0 TD
(m)Tj
/F3 1 Tf
0.5754 0 TD
(g)Tj
/F10 1 Tf
0.4995 0.2213 TD
(.)Tj
/F3 1 Tf
0.2719 -0.2213 TD
(m)Tj
6.725 0 0 5.977 449.915 742.393 Tm
(3)Tj
8.966 0 0 8.966 498.557 747.893 Tm
(O)Tj
6.725 0 0 5.977 505.02 746.362 Tm
(3)Tj
8.966 0 0 8.966 483.817 738.425 Tm
(+10)Tj
/F9 1 Tf
1.8969 0 TD
(m)Tj
/F3 1 Tf
0.5754 0 TD
(g)Tj
/F10 1 Tf
0.4995 0.2213 TD
(.)Tj
/F3 1 Tf
0.2656 -0.2213 TD
(m)Tj
6.725 0 0 5.977 519.76 742.393 Tm
(3)Tj
8.966 0 0 8.966 58.28 720.453 Tm
[(Symptoms)-336.9(in)-330.2(the)]TJ
0.3351 -1.0559 TD
[(past)-330.1(12)-334.1(months)]TJ
T*
(Wheeze)Tj
0.3288 -1.0559 TD
[(EHA)-9916.6(4518)-1490.2(1.07)-336.5(\(0.92\2611.24\))-812.5(1.13)-336.5(\(0.93\2611.37\))-818.8(1.05)-330.2(\(0.93\2611.18\))-818.8(1.05)-330.2(\(0.93\2611.18\))-818.8(0.84)-330.2(\(0.66\2611.07\))]TJ
0 -1.0496 TD
[(EHSA)-9364.5(2218)-1490.2(1.09)-336.5(\(0.86\2611.38\))-812.5(0.95)-336.5(\(0.72\2611.26\))-818.8(1.02)-330.2(\(0.85\2611.22\))-818.8(1.08)-330.2(\(0.90\2611.29\))-818.8(0.79)-330.2(\(0.56\2611.13\))]TJ
-0.3288 -1.0559 TD
[(Morning)-329.3(cough)]TJ
0.3288 -1.0559 TD
[(EHA)-9916.6(4515)-1490.2(1.16)-336.5(\(1.02\2611.31\))-812.5(1.22)-336.5(\(1.04\2611.44\))-818.8(1.12)-330.2(\(1.01\2611.23\))-818.8(1.15)-330.2(\(1.04\2611.27\))-818.8(0.80)-330.2(\(0.65\2610.98\))]TJ
T*
[(EHSA)-9396.2(221)33.1(1)-1491.7(1.30)-336.5(\(1.06\2611.59\))-812.5(1.21)-336.5(\(0.96\2611.52\))-818.8(1.13)-330.2(\(0.98\2611.30\))-818.8(1.21)-330.2(\(1.04\2611.40\))-818.8(0.71)-330.2(\(0.53\2610.96\))]TJ
-0.6639 -1.0559 TD
(Doctor)Tj
/F11 1 Tf
2.7505 0 TD
(')Tj
/F3 1 Tf
0.215 0 TD
[(s)-335.8(diagnosis)]TJ
-2.6303 -1.0559 TD
(Asthma)Tj
0.3288 -1.0559 TD
[(EHA)-9916.6(4477)-1490.2(1.06)-336.5(\(0.90\2611.24\))-812.5(1.16)-336.5(\(0.94\2611.42\))-818.8(1.07)-330.2(\(0.94\2611.21\))-831.4(1.1)29.7(1)-334.6(\(0.97\2611.25\))-831.4(0.79)-330.2(\(0.61\2611.02\))]TJ
T*
[(EHSA)-9364.5(2203)-1490.2(1.05)-336.5(\(0.83\2611.34\))-812.5(1.14)-336.5(\(0.86\2611.51\))-818.8(1.16)-330.2(\(0.97\2611.38\))-818.8(1.21)-330.2(\(1.01\2611.45\))-818.8(0.62)-330.2(\(0.43\2610.89\))]TJ
-0.3288 -1.0559 TD
(Bronchitis)Tj
0.3288 -1.0559 TD
[(EHA)-9916.6(4228)-1490.2(0.92)-336.5(\(0.85\2611.00\))-831.4(1.23)-330.2(\(1.1)29.3(1\2611.38\))-848.1(1.19)-330.2(\(1.1)29.3(1\2611.27\))-848.1(1.1)29.7(1)-334.6(\(1.03\2611.19\))-831.4(0.83)-330.2(\(0.73\2610.96\))]TJ
T*
[(EHSA)-9396.2(21)32.6(14)-1491.2(0.91)-336.5(\(0.80\2611.04\))-812.5(1.27)-336.5(\(1.09\2611.49\))-818.8(1.24)-330.2(\(1.12\2611.38\))-818.8(1.16)-330.2(\(1.04\2611.29\))-818.8(0.83)-330.2(\(0.67\2611.02\))]TJ
-0.6639 -1.0559 TD
[(Pulmonary)-334.1(function)]TJ
0.3351 -1.0559 TD
(BHR)Tj
0.3288 -1.0559 TD
[(EHA)-10416.1(838)-1490.7(0.92)-336.5(\(0.68\2611.23\))-812.5(0.61)-336.5(\(0.45\2610.84\))-818.8(0.79)-330.2(\(0.63\2610.99\))-818.8(0.80)-330.2(\(0.62\2611.03\))-818.8(1.52)-330.2(\(1.00\2612.31\))]TJ
T*
[(EHSA)-9864.1(838)-1490.7(0.94)-336.5(\(0.66\2611.34\))-812.5(0.58)-336.5(\(0.41\2610.82\))-818.8(0.77)-330.2(\(0.60\2610.99\))-818.8(0.81)-330.2(\(0.62\2611.06\))-818.8(1.60)-330.2(\(1.02\2612.52\))]TJ
-0.3288 -1.0559 TD
(FEV)Tj
7.173 0 0 7.173 78.066 540.623 Tm
(1)Tj
/F9 1 Tf
8.966 0 0 8.966 84.643 540.623 Tm
(<)Tj
/F3 1 Tf
0.5501 0 TD
[(85%)-334.1(pred.)]TJ
-2.8263 -1.0559 TD
[(EHA)-10416.1(992)-1490.7(1.24)-336.5(\(0.83\2611.83\))-812.5(0.95)-336.5(\(0.62\2611.44\))-818.8(1.09)-330.2(\(0.81\2611.47\))-818.8(1.19)-330.2(\(0.86\2611.64\))-818.8(1.20)-330.2(\(0.70\2612.07\))]TJ
T*
[(EHSA)-9864.1(992)-1490.7(1.44)-336.5(\(0.89\2612.33\))-812.5(0.85)-336.5(\(0.54\2611.36\))-818.8(1.01)-330.2(\(0.73\2611.41\))-818.8(1.17)-330.2(\(0.81\2611.67\))-818.8(1.34)-330.2(\(0.76\2612.37\))]TJ
-0.3288 -1.0559 TD
(FEF)Tj
7.173 0 0 7.173 76.592 512.22 Tm
(25\26175)Tj
8.966 0 0 8.966 94.507 512.22 Tm
(%)Tj
/F9 1 Tf
1.1571 0 TD
(<)Tj
/F3 1 Tf
0.5501 0 TD
[(70%)-334.1(pred.)]TJ
-5.0836 -1.0496 TD
[(EHA)-10416.1(981)-1490.7(1.18)-336.5(\(0.90\2611.56\))-812.5(1.14)-336.5(\(0.86\2611.51\))-818.8(1.15)-330.2(\(0.94\2611.39\))-818.8(1.27)-330.2(\(1.03\2611.58\))-818.8(0.75)-330.2(\(0.51\2611.10\))]TJ
0 -1.0559 TD
[(EHSA)-9864.1(981)-1490.7(1.25)-336.5(\(0.90\2611.73\))-812.5(1.05)-336.5(\(0.78\2611.43\))-818.8(1.07)-330.2(\(0.86\2611.34\))-818.8(1.17)-330.2(\(0.92\2611.50\))-818.8(0.89)-330.2(\(0.59\2611.32\))]TJ
-0.6639 -1.0559 TD
(Atopy)Tj
0.3351 -1.0559 TD
[(Specific)-334.7(IgE)-331.7(against)-337(aero-)]TJ
T*
[(aller)9.9(gens)]TJ
/F9 1 Tf
3.8823 0 TD
(>)Tj
/F3 1 Tf
0.5501 0 TD
(0.7kU)Tj
/F10 1 Tf
2.4723 0.2213 TD
(.)Tj
/F3 1 Tf
0.2719 -0.2213 TD
(L)Tj
6.725 0 0 5.977 131.017 468.907 Tm
(-1)Tj
8.966 0 0 8.966 64.233 455.471 Tm
[(EHA)-9916.6(2361)-1490.2(1.02)-336.5(\(0.90\2611.16\))-812.5(0.96)-336.5(\(0.82\2611.12\))-818.8(0.95)-330.2(\(0.86\2611.06\))-818.8(0.98)-330.2(\(0.88\2611.09\))-818.8(0.93)-330.2(\(0.76\2611.13\))]TJ
0 -1.0559 TD
[(EHSA)-9364.5(1629)-1490.2(0.87)-336.5(\(0.74\2611.03\))-812.5(0.89)-336.5(\(0.73\2611.08\))-818.8(0.94)-330.2(\(0.83\2611.06\))-818.8(0.92)-330.2(\(0.81\2611.05\))-818.8(1.06)-330.2(\(0.82\2611.35\))]TJ
-0.3288 -1.0559 TD
[(SPT)-302.6(reaction)]TJ
/F12 1 Tf
5.5199 0 TD
($)Tj
/F3 1 Tf
0.8283 0 TD
0.3363 Tc
[(3m)336.3(mt)336.3(o)]TJ
-6.3482 -1.0559 TD
0 Tc
[(at)-329.9(least)-338.1(one)-333.4(aller)9.9(gen)]TJ
0.3288 -1.0559 TD
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1.0015 -1.0471 TD
[(Ot)14.9(he)20.8(r)-497.4(s)0(t)17.7(u)0(d)15.5(i)0(e)18.4(s)-497(ha)20.8(ve)-491.3(su)20(gg)15.5(es)19.6(te)18.4(d)-495.8(t)0(h)18.9(a)0(t)-488(e)0(x)15.1(p)0(o)15.5(s)0(u)20(r)0(e)-487.2(t)0(o)-487.6(t)0(r)17.3(u)0(c)15.1(k)]TJ
-1.0015 -1.0528 TD
[(tr)17.3(af)24.9(fi)17.3(c)-410.9(a)0(n)15.1(d)-410.5(bl)18.9(ac)14.7(k)-410.5(s)0(m)16.9(o)0(k)15.5(e)-410.9(ma)12(y)-410.5(b)0(e)-406(a)0(s)19.6(s)0(o)14.4(c)0(i)18.4(a)0(t)18.4(e)0(d)-406(w)0(i)14.9(t)0(h)-402.3(a)0(s)19.6(t)0(h)13.2(m)0(a)]TJ
0 -1.0584 TD
[(sy)20(mp)12.4(to)18.9(ms)-472.5(an)20.8(d)-478.8(r)0(e)13.5(d)0(u)21.2(c)0(e)14.7(d)-478.8(pu)21.2(lm)15.7(on)15.5(ar)19.2(y)-478.8(f)0(u)13.9(n)0(c)20.8(t)0(i)16.5(o)0(n)-473.8(i)13.9(n)-484.5(c)0(h)20.8(i)0(l)16.5(d)0(r)19.6(e)0(n)]TJ
0 -1.0528 TD
[([1)48.1(1\26115].)-256.2(This)-272.5(specific)-270.9(associ)-10.1(ation)-265.1(was)-269.6(not)-266.4(inves)-7.8(tigated)-269.4(in)]TJ
T*
[(the)-500.2(curren)-8.6(t)-492.5(study)55.2(,)-495.5(because)-503.2(black)-502.1(smok)-7.4(e)-496.3(had)-497.8(not)-499.7(been)]TJ
0 -1.0584 TD
[(meas)-8.2(ured)-357.9(in)-362.4(the)-357.9(1)-359.3(k)0(m)]TJ
7.472 0 0 6.641 147.798 127.446 Tm
(2)Tj
9.963 0 0 9.963 155.055 123.024 Tm
[(grid.)-365.9(In)-355.9(studies)-365.7(which)-363.3(meas)-8.2(ured)]TJ
-9.7138 -1.0528 TD
[(both,)-375.7(gases)-376.9(and)-372.6(pa)-7.6(rticles,)-380.6(a)-371.1(close)-378.1(correlati)-12.7(on)-371.4(was)-377.7(found)]TJ
25.1977 37.956 TD
[(betw)-9.8(een)-492.5(concent)-8.9(rations)-502.7(of)-492.5(NO)]TJ
7.472 0 0 6.641 437.159 488.976 Tm
(2)Tj
9.963 0 0 9.963 445.776 490.677 Tm
[(and)-497.8(particula)-11.1(te)-493.7(matter)]TJ
/F9 1 Tf
-13.6972 -1.0584 TD
(<)Tj
/F3 1 Tf
0.5577 0 TD
(10)Tj
/F9 1 Tf
1.3771 0 TD
(m)Tj
/F3 1 Tf
0.5747 0 TD
[(m)-379.5(i)0(n)-379.5(diam)-9(eter)-383.4(\(PM)]TJ
7.97 0 0 7.97 413.008 480.132 Tm
(10)Tj
9.963 0 0 9.963 420.945 480.132 Tm
0.3779 Tc
[(\)\()377.9(r)]TJ
/F9 1 Tf
1.3487 0 TD
0 Tc
(=)Tj
/F3 1 Tf
0.552 0 TD
[(0.94)-383.9(,)-376([8]\),)-383.8(or)-378.7(NO)]TJ
7.472 0 0 6.641 514.658 478.488 Tm
(2)Tj
9.963 0 0 9.963 522.142 480.132 Tm
(and)Tj
-21.3623 -1.0528 TD
[(black)-496.4(smok)-7.4(e)-490.6(\()0(r)]TJ
/F9 1 Tf
6.3791 0 TD
(>)Tj
/F3 1 Tf
0.552 0 TD
[(0.70,)-492.4([14]\))-8.6(.)-489.8(However)24.2(,)-489.8(P)0(M)]TJ
7.97 0 0 7.97 487.899 469.644 Tm
(10)Tj
9.963 0 0 9.963 500.712 469.644 Tm
[(does)-494(not)]TJ
-19.2113 -1.0528 TD
[(speci)-8.2(fically)-652.2(represent)-652.2(diesel)-648.7(exhausts,)-649.4(and)-645.7(the)-642.4(black)]TJ
0 -1.0584 TD
[(smok)-7.4(e)-268.6(concentrati)-13(ons)-265.3(wer)-8.2(e)-262.9(moni)-8.6(tored)-270(in)-265.7(school)-8.5(s)-263.7(close)-270(to)]TJ
0 -1.0528 TD
[(mot)-7.8(orways)-393(where)-391.4(large)-384.2(variation)-10.7(s)-383.2(i)0(n)-390.9(traffic)-385.6(density)-393(can)]TJ
T*
[(incre)-8.6(ase)-300.2(correlati)-12.7(ons)-293.7(be)-7.6(tween)-301.2(all)-297.7(traffic)-294.5(dependen)-7.3(t)-299.1(pollu-)]TJ
0 -1.0584 TD
[(tant)-8.2(s)-519.8(regard)-8.6(less)-520.4(of)-521(the)-522.9(speci)-8.2(fic)-518.8(source)-8.2(.)-518.2(The)-6.8(refore,)-522.7(the)]TJ
0 -1.0528 TD
[(curren)-8.6(t)-435.6(N)0(O)]TJ
7.472 0 0 6.641 355.861 404.957 Tm
(2)Tj
9.963 0 0 9.963 363.968 406.601 Tm
[(exposur)-8.5(e)-433.7(estimat)-11.9(es)-435.6(cannot)-440.2(be)-440.1(regard)-8.6(ed)-434.4(as)]TJ
-5.4857 -1.0527 TD
[(speci)-8.2(fic)-336.7(mark)-8.2(ers)-335.5(of)-333.2(truck)-343.9(traffic)-328.7(exposur)-8.5(e.)]TJ
1.0015 -1.0527 TD
[(Wh)14.4(en)-354.8(in)18.8(cl)18.5(ud)15.5(in)18.8(g)-365(p)0(a)20.8(r)0(e)13.5(n)0(t)18.9(a)0(l)-351.4(r)0(e)13.5(p)0(o)21.2(r)0(t)17.3(s)-360.5(of)-355.9(tr)17.3(uc)15.1(k)-359.3(t)0(r)17.3(a)0(f)24.9(f)0(i)17.3(c)-359.7(in)-356.7(th)18.9(e)]TJ
-1.0015 -1.0528 TD
[(st)17.7(re)13.5(et)-283.1(of)-287.7(re)19.2(si)17.7(de)20.8(nc)15.1(e)-291.4(i)0(n)13.2(s)0(t)17.7(e)0(a)20.4(d)-296.7(of)-282(th)18.8(e)-297.1(e)0(s)19.6(t)0(i)16.5(m)0(a)17.7(t)0(e)18.5(s)-292.2(of)-287.7(ai)18.5(r)-292.6(p)0(o)15.5(l)0(l)16.5(u)0(t)18.8(a)0(n)20.8(t)]TJ
T*
[(ex)15.1(po)15.5(su)20(re)-373.4(in)18.8(to)-373.8(th)18.8(e)-382.4(m)0(u)18.1(l)0(t)16.5(i)0(v)18.8(a)0(r)13.5(i)0(a)18.4(t)0(e)-374.2(m)0(o)18.1(d)0(e)20.8(l)-384.4(si)17.7(gn)15.5(if)17.3(ic)18.4(an)20.8(t)-384.4(a)0(s)19.6(s)0(o)14.4(c)0(i)18.5(a)0(-)]TJ
0 -1.0584 TD
[(ti)16.5(on)15.5(s)-127.1(w)0(i)14.9(t)0(h)-123.4(m)0(o)18.1(r)0(n)19.6(i)0(n)13.2(g)-126(co)15.1(ug)21.2(h)-131.7(\()0(a)19.2(P)0(O)12.4(R)-130.7(fo)19.6(r)-133.2(")13.4(co)15.1(ns)20(ta)12.8(nt)18.8(")-128.9(c)0(o)15.1(m)13.2(pa)15.1(re)19.2(d)-131.7(t)0(o)]TJ
0 -1.0528 TD
[("n)18.3(o)-370.7(t)0(r)17.3(u)0(c)15.1(k)-365(tr)17.3(af)24.9(fi)17.3(c")17.9(:)-367.3(1)0(.)15.9(6)0(0)-360(\()0(1)19.6(.)0(0)15.9(6)0(\261)21.2(2)0(.)15.9(4)0(2)15.5(\))0(\))-357.5(a)0(n)15.1(d)-365(wh)11.6(ee)20.4(ze)-360.8(\(a)19.2(PO)12.4(R)11.6(:)]TJ
T*
[(2.)15.9(09)-217.8(\(1)13.9(.2)21.6(4\261)15.5(3.)21.6(53)15.5(\)\))-221(w)12.4(e)0(r)13.5(e)-228.8(fo)19.6(un)15.5(d.)-217.4(On)17.3(ly)-220.2(no)15.5(ns)20(ig)18.9(ni)18.9(fi)17.3(ca)14.7(nt)-220.2(te)18.5(nd)15.5(en)20.8(-)]TJ
0 -1.0584 TD
[(ci)12.8(es)-509.6(to)18.8(wa)16.9(rd)13.9(s)-519.8(h)0(i)18.9(g)0(h)15.5(e)0(r)-510(p)0(r)14(e)0(v)20.8(a)0(l)18.5(e)0(n)15.1(c)0(e)20.4(s)-525.5(w)12.4(i)0(t)16.5(h)-524.3(in)18.9(cr)19.2(ea)14.7(si)17.7(ng)-508(tr)17.3(af)24.9(fi)17.3(c)]TJ
0 -1.0528 TD
[(ex)15.1(po)15.5(su)20(re)-191.3(we)16.9(re)-197(fo)19.6(un)15.5(d)-199.9(f)0(o)19.6(r)-207.2(bo)21.2(th)-191.7(do)15.5(ct)18.4(or)-196.6(di)18.9(ag)20.8(no)15.5(se)19.6(d)-205.6(a)0(s)19.6(t)0(h)18.9(m)0(a)-192.9(a)0(n)15.1(d)]TJ
T*
[(br)13.9(on)21.2(ch)15.1(it)16.5(is)17.7(,)-267.8(a)0(n)20.8(d)-273.9(no)-257.6(as)19.6(so)14.4(ci)18.4(at)18.4(io)18.9(n)-273.9(w)12.4(as)-264.9(ob)21.2(se)13.9(rv)19.6(ed)-258(wi)14.9(th)-260(pu)15.5(lm)15.7(on)21.2(-)]TJ
0 -1.0584 TD
[(ar)13.5(y)-217(f)0(u)19.6(n)0(c)15.1(t)0(i)16.5(o)0(n)21.2(,)-222.3(B)11.6(H)0(R)12.6(,)-216.6(an)15.1(d)-217(a)0(t)18.4(o)0(p)15.5(y)73.2(.)-216.6(T)0(h)17.1(i)0(s)-210(i)0(s)-210(f)0(a)13.5(i)0(r)17.3(l)0(y)-208.8(c)0(o)15.1(n)0(s)20(i)0(s)17.7(t)0(e)18.5(n)0(t)-208.8(w)0(i)14.9(t)0(h)]TJ
0 -1.0527 TD
[(th)13.2(e)-331.2(d)0(a)15.1(t)0(a)-323(f)0(r)18(o)0(m)-329(t)0(w)14.9(o)-330.8(ot)18.9(he)15.1(r)-332.4(s)0(t)17.7(u)0(d)15.5(i)0(e)18.5(s)0(.)-326.7(T)12.2(he)-326.3(fi)17.3(rs)12.8(t)-333.2(s)0(t)17.7(u)0(d)21.2(y)-336.5([1)48.1(1])-333.2(pre-)]TJ
T*
[(sente)-8.2(d)-296.7(data)-296.5(for)-295.7(chroni)-9(c)-291.4(cough)-300.1(and)-292.9(found)-301.3(a)-291.4(sim)-9(ilar)-294.3(assoc-)]TJ
0 -1.0584 TD
[(iatio)-11.4(n)-251.2(o)0(f)-259.2(this)-259.4(rathe)-8.6(r)-258.4(unspecific)-266.8(symptom)-265.6(with)-256.4(truck)-264.3(traffic)]TJ
0 -1.0527 TD
[(and)-366.9(black)-371.2(smoke)-367.1(exposur)-8.5(e)-359.7(a)0(s)-367.3(with)-370.3(wheeze.)-369(The)-365.3(second)]TJ
T*
[(study)-320.4([15])-313.5(found)-318.4(an)-314.9(associati)-11.9(on)-308.8(of)-316.1(truck)-315.5(traffic)-311.6(exposur)-8.5(e)]TJ
0 -1.0584 TD
[(wi)-7.8(th)-407.9(current)-410.1(whee)-7.8(ze,)-406.7(cough)-408.3(and)-412.4(persisten)-10.7(t)-407.2(phlegm,)-409.2(but)]TJ
0 -1.0528 TD
[(not)-312(with)-313.3(curren)-8.6(t)-304.7(asthma)-313.7(and)-310(not)-312(with)-307.7(whee)-7.8(zing)-307.4(e)-6.9(pisodes)]TJ
T*
[(in)-248.6(the)-244.1(first)-246.3(two)-247.6(years)-246.4(of)-247.8(life.)-243.5(The)-6.8(se)-242.1(author)-9(s)-241(conclu)-7.8(ded)-247.4(that)]TJ
T*
[(air)-444.8(polluti)-9.2(on)-439.7(from)-441.9(truck)-446.4(traffic)-436.8(incre)-8.6(ases)-438.7(the)-443.2(risk)-440.7(for)-443.7(a)]TJ
0 -1.0584 TD
[(wi)-7.8(de)-292.2(range)-296.4(of)-293.3(adve)-9.6(rse)-295.7(respirato)-11.1(ry)-293.3(effects)-292.2(but)-294.9(may)-296.1(have)-294.1(a)]TJ
0 -1.0528 TD
[(more)-349.6(importan)-10.3(t)-344.6(role)-343.2(in)-345.3(respirato)-11.1(ry)-344.6(infec)-8.6(tions)-345.5(than)-347.3(in)-339.7(the)]TJ
T*
[(aeti)-8.6(ology)-319.2(of)-321.8(asthma.)-325.5(None)-326.1(of)-316.1(the)-323.7(studies)-325.9(on)-320.2(truck)-321.2(traffic)]TJ
0 -1.0584 TD
[(exp)-8.4(osure)-655.7(meas)-8.2(ured)-659.5(bronchial)-662.8(hyperr)-8.2(espons)-7.4(iveness)-659.6(or)]TJ
0 -1.0528 TD
[(object)-10.1(ive)-335.1(mark)-8.2(ers)-335.5(of)-333.2(a)-6.9(topy)62.9(.)]TJ
1.0015 -1.0527 TD
[(Th)17.1(e)-530.4(r)0(e)19.2(s)0(u)14.4(l)0(t)22.2(s)-531.2(ar)19.2(e)-530.4(a)0(l)18.5(s)0(o)-514.9(c)0(o)15.1(n)0(s)20(i)0(s)17.7(t)0(e)18.4(n)0(t)-521.8(w)0(i)14.9(t)13.9(h)-530(t)0(h)18.9(e)-530.4(fi)17.3(nd)21.2(in)18.9(gs)-520.6(of)]TJ
-1.0015 -1.0527 TD
(D)Tj
6.974 0 0 6.974 316.403 123.024 Tm
0.0001 Tc
[(OC)18.4(KER)77.8(Y)]TJ
/F6 1 Tf
9.963 0 0 9.963 346.45 123.024 Tm
0 Tc
[(et)-288.8(al)18.9(.)]TJ
/F3 1 Tf
2.2933 0 TD
[([2)19.6(])-309.7(and)-310(B)]TJ
6.974 0 0 6.974 407.622 123.024 Tm
0.0001 Tc
[(RAU)-11.4(N)]TJ
9.963 0 0 9.963 427.351 123.024 Tm
0 Tc
(-F)Tj
6.974 0 0 6.974 435.572 123.024 Tm
0.0001 Tc
(AHRLA)Tj
2.9103 0.2195 TD
0 Tc
(\310)Tj
0.5203 -0.2195 TD
0.0001 Tc
[(ND)-10.9(ER)]TJ
/F6 1 Tf
9.963 0 0 9.963 481.493 123.024 Tm
0 Tc
[(et)-305.9(al.)]TJ
/F3 1 Tf
2.3445 0 TD
[([8])-307.1(who)]TJ
-19.6267 -1.0528 TD
[(show)-8.2(ed)-593.8(a)-593(significan)-12.7(t)-589.3(associ)-10.1(ation)-595.1(between)-599(cough)-596(and)]TJ
ET
1 i 
58.28 758.834 478.205 -0.51 re
f
58.28 732.926 478.205 -0.51 re
f
58.28 583.994 478.205 -0.51 re
f
BT
/F2 1 Tf
8.966 0 0 8.966 58.28 772.667 Tm
[(Table)-331.9(5.)-336.7(\261)-333.2(Association)-245.3(of)-241.9(respiratory)-244.6(symptoms)-247.9(and)-240.8(diseases)-247(with)-248(exposure)-244.4(to)-241.9(inner)-246.2(city)-239.8(air)-250.1(pollutants)-243.7(at)-241.9(home)-248.7(address*)-240.6(in)]TJ
0 -1.0559 TD
[(atopic)-335.6(and)-329.3(nonatopic)-336.2(children)]TJ
/F3 1 Tf
10.2874 -1.7072 TD
(Subjects)Tj
1.4227 -1.0559 TD
(n)Tj
5.6147 1.0559 TD
(SO)Tj
6.725 0 0 5.977 225.014 746.362 Tm
(2)Tj
8.966 0 0 8.966 201.373 738.425 Tm
(+10)Tj
/F9 1 Tf
1.8969 0 TD
(m)Tj
/F3 1 Tf
0.5691 0 TD
(g)Tj
/F10 1 Tf
0.4995 0.2213 TD
(.)Tj
/F3 1 Tf
0.2719 -0.2213 TD
(m)Tj
6.725 0 0 5.977 237.316 742.393 Tm
(3)Tj
8.966 0 0 8.966 283.521 747.893 Tm
(NO)Tj
6.725 0 0 5.977 296.39 746.362 Tm
(2)Tj
8.966 0 0 8.966 271.956 738.425 Tm
(+10)Tj
/F9 1 Tf
1.8969 0 TD
(m)Tj
/F3 1 Tf
0.5754 0 TD
(g)Tj
/F10 1 Tf
0.4995 0.2213 TD
(.)Tj
/F3 1 Tf
0.2719 -0.2213 TD
(m)Tj
6.725 0 0 5.977 307.956 742.393 Tm
(3)Tj
8.966 0 0 8.966 356.031 747.893 Tm
(CO)Tj
-1.625 -1.0559 TD
(+0.2)Tj
/F9 1 Tf
2.1498 0 TD
(m)Tj
/F3 1 Tf
0.5691 0 TD
(g)Tj
/F10 1 Tf
0.4995 0.2213 TD
(.)Tj
/F3 1 Tf
0.2719 -0.2213 TD
(m)Tj
6.725 0 0 5.977 379.672 742.393 Tm
(3)Tj
8.966 0 0 8.966 417.543 747.893 Tm
(Benzene)Tj
-0.2339 -1.0559 TD
(+1)Tj
/F9 1 Tf
1.3974 0 TD
(m)Tj
/F3 1 Tf
0.5691 0 TD
(g)Tj
/F10 1 Tf
0.5058 0.2213 TD
(.)Tj
/F3 1 Tf
0.2656 -0.2213 TD
(m)Tj
6.725 0 0 5.977 446.91 742.393 Tm
(3)Tj
8.966 0 0 8.966 498.557 747.893 Tm
(O)Tj
6.725 0 0 5.977 505.02 746.362 Tm
(3)Tj
8.966 0 0 8.966 483.817 738.425 Tm
(+10)Tj
/F9 1 Tf
1.8969 0 TD
(m)Tj
/F3 1 Tf
0.5754 0 TD
(g)Tj
/F10 1 Tf
0.4995 0.2213 TD
(.)Tj
/F3 1 Tf
0.2656 -0.2213 TD
(m)Tj
6.725 0 0 5.977 519.76 742.393 Tm
(3)Tj
8.966 0 0 8.966 58.28 720.453 Tm
[(Symptoms)-336.9(in)-330.2(the)-335.8(past)]TJ
0 -1.0559 TD
[(12)-334.1(months**)]TJ
0.3351 -1.0559 TD
(Wheeze)Tj
0.3288 -1.0559 TD
[(Atopic)-339.9(children)]TJ
6.725 0 0 5.977 120.472 696.075 Tm
(+)Tj
8.966 0 0 8.966 156.586 692.05 Tm
[(4391)-1825.3(1.03)-330.2(\(0.79\2611.35\))-1147.6(1.05)-336.5(\(0.76\2611.45\))-1147.6(1.00)-330.2(\(0.81\2611.24\))-1147.6(1.02)-336.5(\(0.83\2611.27\))-1147.6(0.81)-330.2(\(0.53\2611.23\))]TJ
-10.3 -1.0496 TD
[(Nonatopic)-338.1(children)]TJ
6.725 0 0 5.977 133.342 686.608 Tm
(#)Tj
8.966 0 0 8.966 156.586 682.639 Tm
[(4379)-1825.3(1.36)-330.2(\(1.01\2611.84\))-1147.6(1.16)-336.5(\(0.79\2611.70\))-1147.6(1.05)-330.2(\(0.83\2611.31\))-1147.6(1.09)-336.5(\(0.87\2611.36\))-1147.6(1.08)-330.2(\(0.68\2611.73\))]TJ
-10.6288 -1.0559 TD
[(Morning)-329.3(cough)]TJ
0.3288 -1.0559 TD
[(Atopic)-339.9(children)]TJ
6.725 0 0 5.977 120.472 667.672 Tm
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