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T*
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T*
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T*
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[(th)18.9(od)15.5(s.)-269.8(Ad)17.3(di)18.9(ti)16.5(on)15.5(al)18.5(ly)81.4(,)-279.2(s)0(e)13.9(r)0(u)19.6(m)-282.8(le)18.4(ve)15.1(ls)-272.6(of)-270.6(to)18.9(ta)18.4(l)-282(i)0(m)15.7(m)0(u)18.1(n)0(o)15.5(g)0(l)18.9(o)0(b)15.5(u)0(l)18.9(i)0(n)]TJ
0 -1.0528 TD
[(\(I)18(g\))13.9(E)-238.2(\()0(P)20.4(h)0(a)15.1(r)0(m)16.5(a)0(c)14.7(i)13.9(a,)-234.9(U)12.4(p)0(p)15.5(s)0(a)19.6(l)0(a)12.8(,)-233.7(Sw)12.4(ed)20.8(en)15.1(\))-241.4(a)0(n)20.8(d)-239.8(sp)20(ec)14.7(if)17.3(ic)-231.9(Ig)19.6(E)-238.2(a)0(n)15.1(t)0(i)16.5(-)]TJ
0 -1.0471 TD
[(bo)15.5(di)18.9(es)-304.7(fo)13.9(r)-315.3(l)0(a)18.4(b)0(o)21.2(r)0(a)13.5(t)0(o)18.9(r)0(y)-304.7(a)0(n)15.1(i)0(m)15.7(a)0(l)-305.9(a)0(l)18.5(l)0(e)18.4(r)14.7(ge)20.8(ns)-310(by)-303.1(ra)19.2(di)13.2(oa)20.8(ll)16.5(er)24.9(go)21.2(so)14.4(r)20.4(-)]TJ
0 -1.0528 TD
[(be)15.1(nt)-311.2(te)12.8(st)-312.4(\(R)14.9(AS)18.1(T)63.4(;)-327.5(P)11.4(h)0(a)15.1(r)0(m)16.5(a)0(c)14.7(i)13.9(a\))-316.5(we)16.9(re)-316.5(ev)15.1(al)18.4(ua)15.1(te)18.4(d.)]TJ
1.0015 -1.0471 TD
[(Al)14.9(l)-321.8(c)0(h)15.1(i)0(l)16.5(d)0(r)19.6(e)0(n)-314.9(a)0(n)20.8(d)-325.1(th)18.9(ei)18.4(r)-326.7(p)0(a)15.1(r)0(e)19.2(n)0(t)18.9(s)-326.3(w)12.4(e)0(r)13.5(e)-319.8(in)13.2(fo)19.6(rm)16.5(ed)-314.9(ab)15.1(ou)21.2(t)-321.8(t)0(h)13.2(e)]TJ
-1.0015 -1.0528 TD
[(ex)15.1(pe)20.8(ri)17.3(me)17.7(nt)-385.2(an)15.1(d)-393.4(t)0(h)18.9(e)-393.8(te)18.4(st)17.7(s)-394.6(w)0(e)16.9(r)0(e)-384.8(p)0(e)20.8(r)0(f)12.4(o)0(r)19.6(m)0(e)17.7(d)-393.4(af)19.2(te)12.8(r)-389.3(o)0(b)15.5(t)0(a)18.4(i)0(n)18.9(i)0(n)13.2(g)]TJ
0 -1.0471 TD
[(th)18.9(ei)18.4(r)-429.2(c)0(o)20.8(n)0(s)14.4(e)0(n)20.8(t)-424.2(to)-419.3(pa)20.8(rt)17.3(ic)18.4(ip)13.2(at)18.4(e)-422.3(i)0(n)-419.3(t)13.9(he)-417.3(st)17.7(ud)15.5(y)73.2(.)-421.5(Th)17.1(e)-428(s)0(t)17.7(u)0(d)21.2(y)-427.6(w)12.4(a)0(s)]TJ
0 -1.0527 TD
[(ap)15.1(pr)19.6(ov)15.5(ed)-314.9(by)-314.5(th)18.9(e)-325.5(l)0(o)18.9(c)0(a)20.4(l)-327.5(me)17.7(di)18.9(ca)14.7(l)-321.8(e)0(t)12.8(h)0(i)18.9(c)0(a)20.4(l)-327.5(co)20.8(mm)14.9(it)16.5(te)18.4(e.)]TJ
/F3 1 Tf
0 -3.0331 TD
[(Defini)-10.4(tions)]TJ
/F7 1 Tf
1.0015 -2.1055 TD
[(In)-310.4(th)13.2(e)-319.8(a)0(n)20.8(a)0(l)12.8(y)0(s)20(i)0(s)-312.4(o)0(f)-310.4(t)0(h)13.2(e)-319.8(da)15.1(t)13.9(a)0(,)-314.5(t)0(h)18.9(e)-319.8(fo)13.9(ll)16.5(ow)17.3(in)18.9(g)-319.4(d)0(e)15.1(f)0(i)17.3(n)0(i)18.9(t)0(i)16.5(o)0(n)21.2(s)-326.3(of)]TJ
-1.0015 -1.0471 TD
[(se)19.6(ns)14.4(it)16.5(iz)18.4(ed)-349.1(an)20.8(d)-359.3(a)0(l)18.5(l)0(e)18.4(r)14.7(gi)18.9(c)-354(s)0(u)14.4(b)0(j)18.9(e)0(c)20.4(t)0(s)-352.2(w)0(e)16.9(r)0(e)-350.7(u)0(s)20(e)0(d)15.1(.)-353.2(An)-352.6(i)13.9(n)0(d)15.5(i)0(v)18.8(i)0(d)18.9(u)0(a)15.1(l)]TJ
0 -1.0528 TD
[(wa)16.9(s)-229.6(c)0(o)20.8(n)0(s)20(i)0(d)13.2(e)0(r)19.2(e)0(d)-218.2(s)0(e)19.6(n)0(s)14.4(i)0(t)16.5(i)0(z)18.4(e)0(d)-218.2(t)0(o)-214.5(l)0(a)12.8(b)0(o)21.2(r)0(a)19.2(t)0(o)13.2(r)0(y)-213.7(a)0(n)15.1(i)0(m)15.7(a)0(l)18.5(s)-229.6(i)13.9(f)-230(th)18.9(ey)-218.2(ha)15.1(d)]TJ
0 -1.0471 TD
[(a)-479.2(p)0(o)21.2(s)0(i)17.7(t)0(i)16.5(v)0(e)-468.6(s)0(k)14.4(i)0(n)-470.5(p)0(r)19.6(i)0(c)18.4(k)-478.8(te)18.4(st)-471.7(or)-469.7(sp)20(ec)14.7(if)17.3(ic)-470.9(se)19.6(ru)19.6(m)-481.9(I)0(g)19.6(E)-482.9(to)-464.8(th)13.2(e)]TJ
0 -1.0527 TD
[(al)18.4(le)18.4(r)14.7(g)0(e)20.8(n)0(.)-399.5(S)0(u)16.3(b)0(j)18.9(e)0(c)14.7(t)0(s)-397.7(w)0(e)16.9(r)0(e)-401.9(c)0(o)15.1(n)0(s)20(i)0(d)18.9(e)0(r)13.5(e)0(d)-400.3(a)0(l)18.5(l)0(e)18.4(r)20.4(gi)13.2(c)-405.2(t)0(o)-402.3(l)0(a)18.4(b)0(o)15.5(r)0(a)19.2(t)0(o)13.2(r)0(y)]TJ
0 -1.0471 TD
[(an)15.1(im)21.4(al)12.8(s)-388.9(i)0(f)-381.1(t)0(h)13.2(e)0(y)-377.5(w)0(e)11.2(r)0(e)-379.1(s)0(e)13.9(n)0(s)20(i)0(t)16.5(i)0(z)18.4(e)0(d)-383.2(a)0(n)20.8(d)-393.4(sh)20(ow)17.3(ed)-383.2(ev)15.1(id)18.9(en)15.1(ce)-383.6(of)]TJ
0 -1.0527 TD
[(re)19.2(sp)14.4(ir)17.3(at)18.5(or)19.6(y)-228.4(s)0(y)20(m)0(p)12.4(t)0(o)18.9(m)0(s)16.9(,)-228(su)20(ch)-218.2(as)-219.4(rh)19.6(in)18.9(it)16.5(is)17.7(,)-228(w)0(h)17.3(e)0(e)20.4(z)0(i)12.8(n)0(g)21.2(,)-228(ti)16.5(gh)21.2(tn)18.9(es)13.9(s)]TJ
0 -1.0471 TD
[(of)-549.4(th)18.8(e)-553.2(c)0(h)15.1(e)0(s)19.6(t)-555.1(or)-549.4(co)20.8(ug)15.5(hi)18.9(ng)-547.8(th)18.9(at)-550.6(w)12.4(e)0(r)13.5(e)-553.2(cl)18.5(ea)14.7(rl)17.3(y)-552.7(r)0(e)13.5(l)0(a)18.4(t)0(e)18.4(d)-558.4(to)]TJ
0 -1.0528 TD
[(la)18.4(bo)15.5(ra)19.2(to)18.9(ry)-316.1(an)15.1(im)15.7(al)18.5(s.)]TJ
/F3 1 Tf
25.1977 29.2722 TD
[(Stat)-7.8(istical)-340.8(analys)-8.6(is)]TJ
/F7 1 Tf
1.0015 -2.0998 TD
[(St)14(at)18.5(is)17.7(ti)16.5(ca)14.7(l)-572.2(a)0(n)15.1(a)0(l)18.5(y)0(s)20(e)0(s)-566.5(w)0(e)16.9(r)0(e)-566.9(p)0(e)15.1(r)0(f)18(o)0(r)19.6(m)0(e)17.7(d)-575.5(us)14.4(in)18.8(g)-575.5(S)11.4(tu)18.9(de)15.1(nt)]TJ
/F6 1 Tf
20.964 0 TD
(')Tj
/F7 1 Tf
0.2105 0 TD
(s,)Tj
-22.1761 -1.0527 TD
[(Ch)16.5(i-)17.3(sq)14.4(ua)20.8(re)13.5(d)-296.7(o)0(r)-293.3(F)0(i)14(s)0(h)20(e)0(r)]TJ
/F6 1 Tf
8.5814 0 TD
(')Tj
/F7 1 Tf
0.2105 0 TD
[(s)-303.6(e)0(x)20.8(a)0(c)14.7(t)-299.1(te)18.4(st)17.7(.)-302(T)69.1(o)-296.7(e)0(v)15.1(a)0(l)18.5(u)0(a)15.1(t)0(e)-288.8(w)0(h)17.3(i)0(c)12.8(h)-296.7(va)15.1(r)20.4(-)]TJ
-8.7919 -1.0471 TD
[(ia)12.8(bl)18.9(es)-253.5(we)16.9(re)-259.6(re)19.2(la)18.4(te)12.8(d)-262.5(t)0(o)-254.3(r)0(e)13.5(s)0(p)20(i)0(r)17.3(a)0(t)18.5(o)0(r)13.9(y)-262.5(sy)20(mp)12.4(t)13.9(o)0(m)12.4(s)0(,)-252.7(l)0(u)18.9(n)0(g)-257.6(f)0(u)19.6(n)0(c)15.1(t)0(i)16.5(o)0(n)]TJ
0 -1.0528 TD
[(an)15.1(d)-444.6(s)0(e)19.6(n)0(s)14.4(i)13.9(ti)16.5(za)14.7(ti)16.5(on)21.2(,)-444.2(a)0(n)-434.4(a)0(n)15.1(a)0(l)18.5(y)0(s)20(i)0(s)-437.6(o)0(f)-435.6(l)0(o)18.9(g)0(i)18.9(s)0(t)17.7(i)0(c)-436.8(r)0(e)19.2(g)0(r)13.9(e)0(s)19.6(s)0(i)17.7(o)0(n)-434(w)0(a)16.9(s)]TJ
0 -1.0471 TD
[(us)14.4(ed)20.8(.)]TJ
/F5 1 Tf
9.8617 -2.5607 TD
[(Res)-7.8(ults)]TJ
/F7 1 Tf
-8.8602 -1.747 TD
[(A)-238(p)0(o)21.2(s)0(i)17.7(t)0(i)16.5(v)0(e)-223.9(f)0(a)19.2(m)0(i)15.7(l)0(y)-225.8(h)0(i)18.9(s)0(t)17.7(o)0(r)19.6(y)-234.1(of)-225.1(at)18.4(op)21.2(y)-234.1(o)0(r)-225.1(a)0(s)19.6(t)0(h)18.8(m)0(a)-227(w)0(a)16.9(s)-229.6(re)13.5(po)21.2(rt)17.3(-)]TJ
-1.0015 -1.0527 TD
[(ed)-218.2(mo)18.1(re)-214.1(fr)12.4(eq)20.8(ue)15.1(nt)18.9(ly)-214.5(by)-217.8(ch)20.8(il)16.5(dr)19.6(en)-218.2(of)-213.7(pa)15.1(re)19.2(nt)18.9(s)-223.9(w)0(i)14.9(t)0(h)-214.5(o)0(c)15.1(c)0(u)20.8(p)0(a)15.1(t)0(i)16.5(o)0(n)21.2(-)]TJ
0 -1.0471 TD
[(al)-266.1(ex)20.8(po)15.5(su)20(re)-259.6(th)13.2(an)-258(by)-263.3(ch)20.8(il)16.5(dr)19.6(en)-263.7(of)-259.2(pa)15.1(re)19.2(nt)18.9(s)-269.4(n)0(o)15.5(t)-270.6(oc)20.8(cu)15.1(pa)20.8(ti)16.5(on)15.5(al)18.4(ly)]TJ
0 -1.0528 TD
[(ex)15.1(po)15.5(se)19.6(d)-495.8(t)0(o)-493.3(l)0(a)18.4(b)0(o)15.5(r)0(a)19.2(t)0(o)18.9(r)0(y)-492.5(a)0(n)20.8(i)0(m)15.7(a)0(l)12.8(s)-497(\(4)19.6(8.)15.9(6)]TJ
/F3 1 Tf
15.4954 0 TD
[(ve)14.7(rs)18.9(us)]TJ
/F7 1 Tf
2.9875 0 TD
[(20)21.2(.4)15.9(%,)-492.9(p)]TJ
/F9 1 Tf
3.7671 0 TD
(<)Tj
/F7 1 Tf
-22.2501 -1.0471 TD
[(0.)15.9(00)15.5(1,)-365.3(F)11.4(i)0(s)17.7(h)0(e)15.1(r)]TJ
/F6 1 Tf
5.2467 0 TD
(')Tj
/F7 1 Tf
0.2105 0 TD
[(s)-377.5(e)0(x)20.8(a)0(c)14.7(t)-373(te)18.4(st)17.7(,)-376(f)0(i)11.6(g)0(.)-365.3(1\).)-379.1(T)63.4(e)0(n)-388.9(children)-394.5(from)-390.7(oc-)]TJ
-5.4572 -1.0528 TD
[(cup)-8.4(ationally)-358.6(exposed)-360.2(parent)-9.4(s)-349.1(\(20%\))-362.2(and)-349.8(seven)-358.6(from)-356.5(the)]TJ
0 -1.0471 TD
[(non)-8(exposed)-337.4(parent)-9.4(s)-332(\(17.5%)-8.2(\))-332.4(report)-10.6(ed)-337.7(previous)-341.7(recurrent)]TJ
0 -1.0527 TD
[(bronchi)-9.7(tis,)-293.2(chroni)-9(c)-291.4(sputu)-7.4(m)-288.4(product)-9.7(ion)-294.9(or)-287.7(pneu)-9.1(monia)-294.3(\(p)]TJ
/F9 1 Tf
22.2501 0 TD
(>)Tj
/F7 1 Tf
-22.2501 -1.0471 TD
[(0.1\),)-215.2(but)-215.2(there)-213.5(was)-212.7(no)-212.1(signi)-9.8(ficant)-216.6(difference)-209.9(betw)-9.8(een)-208(these)]TJ
0 -1.0527 TD
[(groups)-7.4(.)-501.2(There)-505.4(was)-502.9(a)-501.9(signifi)-9.6(cant)-501.3(difference)-505.8(in)-499(the)-500.2(fre-)]TJ
0 -1.0471 TD
[(que)-8.4(ncy)-355.5(of)-355.9(symp)-7.4(toms)-356.9(sugges)-7.4(tive)-361(of)-355.9(airways)-362.4(alle)-8.6(rgi)10.8(c)-359.7(dis-)]TJ
0 -1.0528 TD
[(ease,)-290.4(such)-289.2(as)-287.7(asthm)-10.9(a)-285.7(and)-287.2(rhiniti)-10.8(s)-286.5(between)-291.7(the)-289.6(children)-292.1(of)]TJ
0 -1.0471 TD
[(occ)-8.8(upationally)-217.9(exposed)-217.9(and)-213.2(nonexpos)-7.7(ed)-212.5(parent)-9.4(s)-212.5(\()0(8)]TJ
/F3 1 Tf
20.264 0 TD
(versus)Tj
/F7 1 Tf
-20.264 -1.0527 TD
[(2%)-339.6(p)]TJ
/F9 1 Tf
2.1624 0 TD
(<)Tj
/F7 1 Tf
0.552 0 TD
[(0.05,)-338.8(Fisher)]TJ
/F6 1 Tf
4.8085 0 TD
(')Tj
/F7 1 Tf
0.2219 0 TD
[(s)-332(exact)-343.2(test,)-334.2(fig.)-342.4(1\).)]TJ
-6.7433 -1.0471 TD
[(Th)17.1(er)13.5(e)-297.1(w)0(a)16.9(s)-303.6(no)-286.1(si)12(gn)21.2(if)17.3(ic)18.4(an)15.1(t)-299.1(d)0(i)18.9(f)14.7(fe)19.2(re)19.2(nc)15.1(e)-297.1(i)0(n)-294.1(t)0(h)18.9(e)-302.8(fr)18(eq)20.8(ue)15.1(nc)20.8(y)-302.4(o)0(f)]TJ
-1.0015 -1.0528 TD
[(pa)15.1(re)19.2(nt)13.2(al)-243.3(sm)16.9(ok)21.2(in)18.9(g)-251.2(h)0(a)15.1(b)0(i)18.9(t)-253.5(be)20.8(tw)14.9(ee)14.7(n)-251.1(t)0(h)18.8(e)-251.5(tw)14.9(o)-251.2(g)0(r)19.6(o)0(u)15.5(p)0(s)-241.7(\()0(1)19.6(7)]TJ
/F3 1 Tf
20.3153 0 TD
[(ve)14.7(rs)18.8(us)]TJ
/F7 1 Tf
-20.3153 -1.0471 TD
[(20)15.5(%)-327.5(p)]TJ
/F9 1 Tf
2.6233 0 TD
(>)Tj
/F7 1 Tf
0.5406 0 TD
[(0.)15.9(05)21.2(,)-324.7(F)0(i)13.9(s)0(h)20(e)0(r)]TJ
/F6 1 Tf
4.7004 0 TD
(')Tj
/F7 1 Tf
0.2105 0 TD
[(s)-326.3(e)0(x)20.8(a)0(c)14.7(t)-321.8(te)12.8(st)17.7(,)-319.1(f)0(i)17.3(g)0(.)-314.1(1\).)]TJ
-7.0734 -1.0528 TD
[(Th)17.1(er)13.5(e)-257.2(w)0(a)16.9(s)-263.7(no)-246.2(di)18.9(f)14.7(f)0(e)19.2(r)0(e)19.2(n)0(c)15.1(e)-257.2(in)-254.3(F)11.4(V)0(C)-254.9(a)0(n)20.8(d)-262.5(F)11.4(E)0(V)]TJ
7.97 0 0 7.97 483.137 342.652 Tm
(1)Tj
9.963 0 0 9.963 489.713 342.652 Tm
[(be)20.8(tw)14.9(ee)20.4(n)-262.5(t)0(h)18.9(e)]TJ
-18.1073 -1.0471 TD
-0.0163 Tc
[(t)-16.3(w)-1.4(o)-426.8(g)-16.3(ro)-16.3(u)4.9(p)-16.3(s)-417.4(o)-16.3(f)-417.8(c)-16.3(hi)-16.3(ld)-16.3(re)-16.3(n)-416.6(\()-16.3(St)-16.3(ud)-16.3(en)-16.3(t)]TJ
/F6 1 Tf
13.0484 0 TD
0 Tc
(')Tj
/F7 1 Tf
0.2105 0 TD
0.406 Tc
[(st)406(e)418.8(s)406(t)423.7(,)-4.1(p)]TJ
/F9 1 Tf
3.2721 0 TD
0 Tc
(>)Tj
/F7 1 Tf
0.5406 0 TD
[(0.)15.9(05)21.2(,)-410.1(t)0(a)12.8(b)0(l)18.9(e)-410.9(1\).)]TJ
-17.0716 -1.0528 TD
[(Simi)-10.2(larly)57.7(,)-319.1(serum)-323.1(levels)-324.3(of)-321.8(total)-324.3(IgE)-321(were)-322.4(not)-317.7(different)-318.8(in)]TJ
0 -1.0471 TD
[(chil)-8.2(dren)-374.9(from)-373.6(both)-375.3(groups)-371.6(\(Stude)-8.2(nt)]TJ
/F6 1 Tf
14.4938 0 TD
(')Tj
/F7 1 Tf
0.2162 0 TD
[(s)-371.8(test,)-374(p)]TJ
/F9 1 Tf
3.2436 0 TD
(>)Tj
/F7 1 Tf
0.5577 0 TD
[(0.05,)-372.9(table)]TJ
-18.5114 -1.0527 TD
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[(te)12.8(st)17.7(\).)]TJ
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[(Th)17.1(er)19.2(e)-371.1(w)0(a)16.9(s)-371.8(a)-371.1(s)0(i)17.7(g)0(n)21.2(i)0(f)17.3(i)0(c)18.4(a)0(n)15.1(t)-367.3(as)13.9(so)20(ci)18.4(at)12.8(io)18.9(n)-370.7(\()0(p)]TJ
/F9 1 Tf
15.2564 0 TD
(<)Tj
/F7 1 Tf
0.5406 0 TD
[(0.)15.9(05)15.5(,)-364.6(P)0(e)15.9(a)0(r)19.2(s)0(o)14.4(n)]TJ
/F6 1 Tf
5.406 0 TD
(')Tj
/F7 1 Tf
0.2105 0 TD
(s)Tj
/F17 1 Tf
-22.4151 -1.0471 TD
(x)Tj
/F7 1 Tf
7.472 0 0 6.641 63.666 414.425 Tm
(2)Tj
9.963 0 0 9.963 72.227 410.003 Tm
[(t)13.9(e)0(s)13.9(t)0(\))-472.1(b)0(e)20.8(t)0(w)14.9(e)0(e)14.7(n)-478.8(po)21.2(si)17.7(ti)16.5(ve)-474.2(sk)20(in)-470.5(pr)19.6(ic)12.8(k)-478.8(t)0(e)18.4(s)0(t)17.7(s)-480(to)-470.5(la)18.4(bo)15.5(ra)19.2(to)13.2(ry)]TJ
-1.3999 -1.0527 TD
[(an)15.1(im)21.4(al)12.8(s)-269.4(i)0(n)-265.7(c)0(h)20.8(i)0(l)16.5(d)0(r)13.9(e)0(n)-263.7(a)0(n)20.8(d)-273.9(th)18.9(e)-274.3(o)0(c)20.8(c)0(u)15.1(p)0(a)20.8(t)0(i)16.5(o)0(n)15.5(a)0(l)-260.4(e)0(x)15.1(p)0(o)21.2(s)0(u)14.4(r)0(e)-265.3(o)0(f)-259.2(t)0(h)13.2(e)0(i)18.4(r)]TJ
0 -1.0471 TD
[(pa)15.1(re)19.2(nt)18.9(s.)]TJ
1.0015 -1.0528 TD
[(Fu)16.3(rt)17.3(he)20.8(rm)16.5(or)13.9(e,)-502.3(th)18.9(er)13.5(e)-513.3(w)0(a)16.9(s)-514.1(a)-513.3(s)0(i)17.7(g)0(n)15.5(i)0(f)17.3(i)0(c)18.4(a)0(n)15.1(t)-509.6(as)13.9(so)20(ci)18.5(at)12.8(io)18.9(n)-512.9(\()0(p)]TJ
/F9 1 Tf
21.2428 0 TD
(<)Tj
/F7 1 Tf
-22.2444 -1.0471 TD
[(0.)15.9(05)21.2(,)-341.8(P)11.4(ea)14.7(rs)18.4(on)]TJ
/F6 1 Tf
5.3776 0 TD
(')Tj
/F7 1 Tf
0.2049 0 TD
(s)Tj
/F17 1 Tf
0.7284 0 TD
(x)Tj
/F7 1 Tf
7.472 0 0 6.641 126.539 372.586 Tm
(2)Tj
9.963 0 0 9.963 133.682 368.164 Tm
[(te)18.4(st)17.7(\))-343.8(b)0(e)20.8(t)0(w)14.9(e)0(e)14.7(n)-336.5(a)-342.6(p)0(o)15.5(s)0(i)17.7(t)0(i)16.5(v)0(e)-332(R)11.6(AS)12.4(T)-340.6(t)0(o)-328.3(h)0(a)15.1(i)0(r)]TJ
-7.5684 -1.0528 TD
[(al)18.4(le)18.4(r)14.7(g)0(e)20.8(n)0(s)-378.3(o)0(f)-378.7(l)0(a)18.4(b)0(o)21.2(r)0(a)13.5(t)0(o)18.9(r)0(y)-378.7(a)0(n)20.8(i)0(m)15.7(a)0(l)18.4(s)-388.9(an)20.8(d)-387.7(t)0(h)18.9(e)-388.1(oc)20.8(cu)15.1(pa)20.8(ti)16.5(on)15.5(al)-374.2(ex)15.1(-)]TJ
0 -1.0471 TD
[(po)15.5(su)20(re)19.2(.)]TJ
1.0015 -1.0528 TD
[(No)-335.5(as)19.6(so)14.4(ci)18.4(at)18.5(io)18.9(n)-342.2(b)0(e)15.1(t)0(w)14.9(e)0(e)20.4(n)-342.2(a)-348.3(p)0(o)21.2(s)0(i)17.7(t)0(i)16.5(v)0(e)-332(R)0(A)12.6(S)11.4(T)-346.3(t)0(o)-334(h)0(a)20.8(i)0(r)-335.6(a)0(l)18.4(l)0(e)12.8(r)20.4(-)]TJ
-1.0015 -1.0471 TD
[(ge)15.1(ns)-310(of)-316.1(la)18.4(bo)15.5(ra)19.2(to)18.9(ry)-316.1(an)15.1(im)15.7(al)18.4(s)-320.6(a)0(n)15.1(d)-319.4(sm)11.2(ok)21.2(in)18.9(g)-325.1(s)0(t)17.7(a)0(t)18.4(u)0(s)-315.7(o)0(f)-316.1(p)0(a)20.8(r)0(e)13.5(n)0(t)18.9(s)]TJ
0 -1.0527 TD
[(in)-373.8(bo)21.2(th)-373.8(gr)19.6(ou)15.5(ps)-372.6(\(p)]TJ
/F9 1 Tf
7.1132 0 TD
(>)Tj
/F7 1 Tf
0.5463 0 TD
[(0.)21.6(05)15.5(,)-376(P)0(e)15.9(a)0(r)19.2(s)0(o)14.4(n)]TJ
/F6 1 Tf
5.4117 0 TD
(')Tj
/F7 1 Tf
0.2106 0 TD
(s)Tj
/F17 1 Tf
0.7625 0 TD
(x)Tj
/F7 1 Tf
7.472 0 0 6.641 203.641 320.258 Tm
(2)Tj
9.963 0 0 9.963 211.181 315.836 Tm
[(te)18.4(st)17.7(\))-377.9(w)0(a)16.9(s)-383.2(ob)15.5(se)19.6(rv)19.6(ed)]TJ
-15.3474 -1.0471 TD
[(\(t)17.3(ab)15.1(le)-311.6(2\).)]TJ
/F5 1 Tf
34.3652 24.697 TD
[(Discu)-10.9(ssion)]TJ
/F7 1 Tf
-8.1659 -1.6446 TD
[(Th)17.1(e)-228.8(r)0(e)19.2(l)0(a)12.8(t)13.9(iv)13.2(e)-223.1(r)0(i)17.3(s)0(k)-219(o)0(f)19.6(,)-228(an)20.8(d)-228.4(t)0(h)18.9(e)-228.8(te)18.4(nd)21.2(en)15.1(cy)-218.2(to)-214.5(de)15.1(ve)20.8(lo)13.2(p)-222.7(a)0(l)18.5(l)0(e)12.8(r)20.4(gi)18.8(c)]TJ
-1.0015 -1.0641 TD
[(di)13.2(se)19.6(as)19.6(e)-228.8(e)0(a)14.7(r)0(l)17.3(y)-222.7(in)-220.2(li)16.5(fe)-219.8(ar)19.2(e)-228.8(b)0(o)21.2(t)0(h)-220.2(s)0(t)17.7(r)0(o)19.6(n)0(g)15.5(l)0(y)-220.2(i)0(n)18.9(f)0(l)17.3(u)0(e)15.1(n)0(c)20.8(e)0(d)-218.2(b)0(y)-217.8(g)0(e)15.1(n)0(e)20.8(t)0(i)16.5(c)]TJ
0 -1.0584 TD
[(fa)13.5(ct)18.4(or)19.6(s)-223.9(a)0(n)20.8(d)-222.7(a)-217.4(f)0(a)13.5(m)0(i)15.7(l)0(y)-208.8(h)0(i)18.9(s)0(t)12(o)0(r)19.6(y)-217(of)-213.7(al)18.5(le)12.8(r)20.4(g)0(i)18.9(c)-223.1(di)18.9(se)19.6(as)13.9(e)-217.4([)0(2)14(,)-228(3].)-231.1(In)-230.8(the)]TJ
0 -1.0641 TD
[(author)-9(s)-480(opini)-8.6(on,)-479.9(parent)-9.4(al)-482.3(occupat)-8.9(ion)-482.7(appears)-487.3(to)-481.9(be)-479.9(an)]TJ
0 -1.0584 TD
[(imp)-7.8(ortant)-563.3(risk)-565.9(facto)-8.6(r)-560(for)-557.5(the)-562.7(develo)-7.8(pment)-567.4(of)-560.8(allergic)]TJ
0 -1.0641 TD
[(disea)-8.2(se.)]TJ
1.0015 -1.0471 TD
[(Th)17.1(is)-266.9(st)17.7(ud)21.2(y)-273.9(o)0(f)-264.9(c)0(h)15.1(i)0(l)22.2(d)0(r)13.9(e)0(n)-263.7(w)0(h)17.3(o)0(s)20(e)-274.3(pa)15.1(re)19.2(nt)18.9(s)-275.1(h)0(a)20.8(d)-273.9(be)15.1(en)-263.7(ex)20.8(po)15.5(se)19.6(d)]TJ
-1.0015 -1.0584 TD
[(to)-191.7(la)18.4(bo)15.5(ra)19.2(to)18.8(ry)-190.9(an)15.1(im)15.7(al)18.5(s)-195.4(a)0(t)-192.1(w)0(o)17.3(r)0(k)-190.9(s)0(h)20(o)0(w)17.3(e)0(d)-189.7(t)0(h)18.9(a)0(t)-192.1(t)0(h)18.9(e)-200.3(in)18.8(ci)18.4(de)15.1(nc)20.8(es)-190.9(of)]TJ
0 -1.0641 TD
[(po)15.5(si)17.7(ti)16.5(ve)-366.1(sk)14.4(in)-368.1(pr)19.6(ic)12.8(k)-376.3(t)0(e)18.4(s)0(t)17.7(s)-377.5(to)-368.1(an)15.1(im)15.7(al)-368.5(al)18.4(le)18.4(r)14.7(g)0(e)20.8(n)0(s)-366.9(a)0(n)15.1(d)-376.3(po)15.5(si)17.7(ti)16.5(ve)]TJ
0 -1.0584 TD
[(RA)12.6(S)11.4(T)69.1(s)-360.5(h)0(a)15.1(d)-359.3(be)15.1(en)-349.1(hi)13.2(gh)21.2(er)-356.3(th)18.9(an)-354.7(ch)20.8(il)16.5(dr)19.6(en)-354.7(of)-355.9(pa)20.8(re)13.5(nt)18.9(s)-360.5(n)0(o)15.5(t)-361.6(oc)20.8(-)]TJ
0 -1.0641 TD
[(cu)15.1(pa)15.1(t)13.9(i)0(o)13.2(n)0(a)20.8(l)0(l)16.5(y)-325.1(ex)20.8(po)15.5(se)19.6(d)-325.1(t)0(o)-316.9(l)0(a)18.4(b)0(o)15.5(r)0(a)19.2(t)0(o)18.9(r)0(y)-316.1(a)0(n)15.1(i)0(m)15.7(a)0(l)18.5(s)0(.)]TJ
1.0015 -1.0471 TD
[(Th)17.1(e)-359.7(d)0(i)18.9(a)0(g)15.1(n)0(o)21.2(s)0(i)17.7(s)-354.8(of)-350.2(se)19.6(ns)14.4(it)22.2(iz)12.8(at)18.5(io)18.8(n)-353.6(w)0(a)11.2(s)-354.8(ba)20.8(se)13.9(d)-353.6(b)0(o)15.5(t)0(h)-345.3(o)0(n)-348.7(s)0(k)20(i)0(n)]TJ
-1.0015 -1.0641 TD
[(pr)13.9(ic)18.4(k)-285.3(t)0(e)12.8(s)0(t)17.7(s)-286.5(ag)20.8(ai)12.8(ns)20(t)-287.7(h)0(a)15.1(i)0(r)-278.7(a)0(l)18.5(l)0(e)18.5(r)14.7(ge)20.8(ns)-281.6(fr)18(om)-277.8(th)13.2(e)-285.7(c)0(o)20.8(m)0(m)14.9(o)0(n)15.5(l)0(y)-277.1(u)0(s)14.3(e)0(d)]TJ
0 -1.0584 TD
[(la)12.8(bo)21.2(ra)13.5(t)13.9(o)0(r)14(y)-342.2(an)15.1(im)15.7(al)18.5(s,)-338.1(an)20.8(d)-347.9(s)0(u)20(p)0(p)15.5(l)0(e)18.4(m)0(e)17.7(n)0(t)18.9(e)0(d)-337.7(b)0(y)-337.3(m)0(e)17.7(a)0(s)19.6(u)0(r)13.9(i)0(n)18.8(g)-347.9(sp)20(e-)]TJ
T*
[(ci)12.8(fi)17.3(c)-490.6(I)0(g)19.6(E)-494.3(in)-481.9(se)19.6(ru)13.9(m.)-482.3(On)17.3(ly)-481.9(fi)17.3(ve)-485.6(ch)20.8(il)16.5(dr)13.9(en)-479.9(fr)18(om)-488.4(th)18.9(e)-490.6(o)0(c)15.1(c)0(u)20.8(-)]TJ
0 -1.0641 TD
[(pa)15.1(ti)16.5(on)21.2(al)12.8(ly)-220.2(ex)15.1(po)21.2(se)14(d)-234.1(g)0(r)19.6(o)0(u)15.5(p)-228.4(ha)15.1(d)-234.1(b)0(o)21.2(t)0(h)-225.8(p)0(o)15.5(s)0(i)17.7(t)13.9(iv)13.2(e)-228.8(s)0(k)14.4(i)0(n)-225.8(p)0(r)19.6(i)0(c)18.4(k)-234.1(te)18.5(st)17.7(s)]TJ
0 -1.0584 TD
[(an)15.1(d)-273.9(p)0(o)21.2(s)0(i)17.7(t)0(i)16.5(v)0(e)-269.4(R)11.6(AS)18.1(T)69.1(s)-275.1(ag)20.8(ai)12.8(ns)20(t)-270.6(h)0(a)15.1(i)0(r)-267.3(a)0(l)18.4(l)0(e)18.4(r)20.4(ge)15.1(ns)20(.)-273.5(S)0(e)15.9(v)0(e)20.8(r)0(a)13.5(l)-270.6(st)17.7(ud)15.5(ie)18.4(s)]TJ
0 -1.0641 TD
[(sh)14.4(ow)79.9(,)-336.1(h)0(o)21.2(w)0(e)16.9(v)0(e)15.1(r)37.5(,)-336.1(t)13.9(ha)15.1(t)-338.9(s)0(p)20(e)0(c)14.7(i)13.9(fi)17.3(c)-336.9(I)0(g)13.9(E)-334.9(ca)14.7(nn)21.2(ot)-328.3(be)-326.3(de)15.1(mo)18.1(ns)20(tr)11.6(at)18.4(ed)]TJ
0 -1.0584 TD
[(wi)14.9(th)-499(th)13.2(e)-507.6(m)0(e)17.7(t)0(h)18.9(o)0(d)15.5(s)-508.4(av)20.8(ai)12.8(la)18.4(bl)18.9(e)-507.6(i)0(n)-499(m)0(a)12(n)0(y)-496.6(s)0(u)14.4(b)0(j)18.9(e)0(c)20.4(t)0(s)-500.2(w)0(h)17.3(o)-512.9(ex)20.8(-)]TJ
T*
[(pe)15.1(ri)17.3(en)15.1(ce)-588.5(sy)20(mp)18.1(to)18.9(ms)11.2(.)-592.2(T)0(h)17.1(e)0(s)13.9(e)-593(fi)11.6(ve)-588.1(ch)20.8(il)16.5(dr)19.6(en)-593.8(vi)18.8(si)17.7(ti)16.5(ng)-587.7(th)18.8(ei)18.4(r)]TJ
0 -1.0641 TD
[(pa)15.1(re)19.2(nt)13.2(s)]TJ
/F6 1 Tf
2.7941 0 TD
(')Tj
/F7 1 Tf
0.4211 0 TD
[(wo)17.3(rk)-202.3(at)-197.8(le)18.4(as)19.6(t)-208(t)0(h)18.9(r)0(e)13.5(e)-206(ti)16.5(me)17.7(s)-206.8(p)0(e)20.8(r)-207.2(ye)15.1(ar)-197(\(r)18(an)15.1(ge)-195.4(2\261)15.5(6)-205.6(v)0(i)18.9(s)0(i)17.7(t)0(s)17.7(\))]TJ
-3.2152 -1.0584 TD
[(ha)15.1(d)-313.8(b)0(e)15.1(e)0(n)-303.5(i)0(n)-305.5(c)0(o)15.1(n)0(t)18.9(a)0(c)14.7(t)-316.1(w)12.4(i)0(t)16.5(h)-319.4(l)13.9(a)0(b)15.1(o)0(r)19.6(a)0(t)12.8(o)0(r)19.6(y)-313.7(an)15.1(im)15.7(al)18.5(s)-314.9(f)0(o)19.6(r)-315.3(at)-311.6(l)13.9(e)0(a)14.7(s)0(t)-306.7(5)]TJ
0 -1.0641 TD
[(mi)15.7(n)-382(\()0(r)12.4(a)0(n)20.8(g)0(e)-377.5(5)0(\261)21.2(1)0(5)-371.4(m)0(i)15.7(n)0(\))13.9(.)-381.6(T)12.2(h)0(e)-377.5(o)0(t)18.9(h)0(e)15.1(r)-377.9(fi)17.3(ve)-377.5(ch)20.8(il)16.5(dr)13.9(en)20.8(,)-381.7(t)0(h)18.8(a)0(t)-374.2(h)0(a)15.1(d)]TJ
0 -1.0584 TD
[(on)15.5(ly)-425(po)15.5(si)17.7(ti)22.2(ve)-428.7(sk)20(in)-425(pr)13.9(ic)18.4(k)-433.3(t)0(e)18.4(s)0(t)17.7(s)-434.4(to)-425(la)18.4(bo)15.5(ra)19.2(to)13.2(ry)-424.2(an)20.8(im)15.7(al)12.8(s)-428.7(h)0(a)15.1(d)]TJ
0 -1.0641 TD
[(ne)15.1(ve)15.1(r)-292.6(s)0(e)19.6(e)0(n)-286.5(t)0(h)18.8(e)0(i)18.5(r)-292.6(pa)15.1(re)19.2(nt)18.9(s)]TJ
/F6 1 Tf
9.3325 0 TD
(')Tj
/F7 1 Tf
0.5065 0 TD
[(wo)17.3(rk)13.9(pl)18.9(ac)14.7(e.)-280.4(Al)14.9(l)-293.4(c)0(h)20.8(i)0(l)16.5(d)0(r)13.9(e)0(n)-280.8(f)0(r)12.4(o)0(m)-283.5(t)0(h)18.9(e)]TJ
-9.839 -1.0584 TD
[(oc)15.1(cu)15.1(pa)20.8(ti)16.5(on)21.2(al)12.8(ly)-425(ex)20.8(po)15.5(se)19.6(d)-433.3(g)0(r)14(o)0(u)21.2(p)-433.3(ha)15.1(d)-433.2(b)0(e)20.8(e)0(n)-423(i)0(n)-425(c)0(o)15.1(n)0(t)18.9(a)0(c)14.7(t)-429.9(wi)14.9(th)]TJ
T*
[(th)13.2(ei)18.4(r)-281.2(p)0(a)15.1(r)0(e)19.2(n)0(t)13.2(s)]TJ
/F6 1 Tf
4.8427 0 TD
(')Tj
/F7 1 Tf
0.5008 0 TD
[(cl)18.5(ot)18.9(he)15.1(s,)-275.5(wh)17.3(ic)18.4(h)-285.3(h)0(a)20.8(d)-285.3(be)15.1(en)-275.1(br)19.6(ou)15.5(gh)21.2(t)-287.7(h)0(o)21.2(m)0(e)-278.2(f)0(r)18(o)0(m)]TJ
-5.3434 -1.0641 TD
[(th)13.2(e)-405.2(w)0(o)17.3(r)0(k)13.9(p)0(l)18.9(a)0(c)20.4(e)-410.9(ma)17.7(ny)-399.9(ti)16.5(me)17.7(s)-411.7(p)0(e)20.8(r)-406.4(ye)15.1(ar)-401.9(\(r)18(an)20.8(ge)-400.3(4\261)15.5(10)-399.9(ti)16.5(me)17.7(s\))18.5(.)]TJ
0 -1.0584 TD
[(Th)17.1(re)13.5(e)-308.5(c)0(h)15.1(i)13.9(ld)13.2(re)19.2(n)-308.1(w)0(i)14.9(t)0(h)-299.8(p)0(o)15.5(s)0(i)17.7(t)0(i)16.5(v)0(e)-297.8(s)0(k)14.4(i)0(n)-299.8(p)0(r)19.6(i)0(c)12.8(k)-308.1(te)18.4(st)17.7(s)-309.2(t)0(o)-305.5(l)0(a)18.4(b)0(o)21.2(r)0(a)13.5(t)0(o)18.9(r)0(y)]TJ
0 -1.0641 TD
[(an)15.1(im)15.7(al)18.5(s)-280.8(a)0(n)15.1(d)-285.3(w)12.4(i)0(t)16.5(h)-285.3(sp)20(ec)14.7(if)17.3(ic)-271.8(Ig)13.9(E)12.2(,)-284.9(an)20.8(d)-285.3(t)0(h)18.9(e)-285.7(th)18.9(re)19.2(e)-285.7(t)0(h)18.9(a)0(t)-271.8(h)0(a)15.1(d)-285.3(on)21.2(ly)]TJ
0 -1.0584 TD
[(po)15.5(si)17.7(ti)16.5(ve)-394.6(sk)20(in)-396.6(pr)19.6(ic)18.5(k)-404.8(t)0(e)18.4(s)0(t)17.7(s)-406(t)13.9(o)-404.8(la)18.4(bo)15.5(ra)19.2(to)18.9(ry)-395.8(an)15.1(im)15.7(al)18.5(s)-400.3(w)0(i)14.9(t)0(h)18.8(o)0(u)15.5(t)-401.5(a)]TJ
T*
[(po)15.5(si)17.7(ti)16.5(ve)-218.2(R)11.6(A)0(S)12.4(T)-221.1(po)15.5(ss)18.9(es)13.9(se)19.6(d)-228.4(a)-223.1(ca)14.7(t)-225.1(a)0(t)-214.9(h)0(o)15.5(m)0(e)17.7(.)-228(T)74.8(w)0(o)-221.7(c)0(h)20.8(i)0(l)16.5(d)0(r)13.9(e)0(n)-212.5(w)0(i)14.9(t)0(h)]TJ
0 -1.0641 TD
[(on)15.5(ly)-390.9(po)15.5(si)17.7(ti)16.5(ve)-388.9(sk)14.4(in)-390.9(pr)19.6(ic)12.8(k)-399.1(t)0(e)18.4(s)0(t)17.7(s)-400.3(to)-396.6(la)18.5(bo)15.5(ra)19.2(to)18.8(ry)-395.8(an)20.8(im)15.7(al)18.5(s)-400.3(p)0(o)15.5(s)0(-)]TJ
0 -1.0584 TD
[(se)13.9(ss)18.9(ed)-212.5(a)-223.1(d)0(o)15.5(g)-222.7(at)-214.9(ho)21.2(me)17.7(.)-222.3(R)0(e)16.1(c)0(e)14.7(n)0(t)18.9(l)0(y)81.4(,)-222.3(so)20(me)-215.6(au)15.1(th)18.9(or)13.9(s)-218.2(h)0(a)15.1(v)0(e)-212.5(n)0(o)15.5(t)0(i)16.5(c)0(e)20.4(d)]TJ
0 -1.0641 TD
[(th)13.2(at)-260.4(al)18.4(le)18.4(r)14.7(g)0(y)-257.6(t)0(o)-265.7(c)0(a)20.4(t)0(s)-261.2(o)0(r)-264.9(d)0(o)21.2(g)0(s)-264.5(s)0(e)19.6(e)0(m)17.7(e)0(d)-263.7(t)0(o)-260(b)0(e)-263.7(a)0(n)-263.7(i)0(m)15.7(p)0(o)21.2(r)0(t)17.3(a)0(n)15.1(t)-270.6(ri)17.3(sk)]TJ
0 -1.0584 TD
[(fa)13.5(ct)18.4(or)-503.9(fo)19.6(r)-514.5(l)0(a)18.4(b)0(o)15.5(r)0(a)19.2(t)0(o)18.9(r)0(y)-503.9(a)0(n)15.1(i)0(m)15.7(a)0(l)-505.1(a)0(l)18.5(l)0(e)18.4(r)20.4(gy)-508(fr)18(om)-505.4(th)18.9(e)-513.3(r)0(e)19.2(s)0(u)20(l)0(t)-507.1(o)0(f)]TJ
T*
[(ad)15.1(ve)15.1(rs)18.4(e)-382.4(r)0(e)13.5(a)0(c)20.4(t)0(i)16.5(o)0(n)15.5(s)-383.2(be)15.1(tw)20.6(ee)14.7(n)-387.7(t)0(h)18.9(e)0(s)19.6(e)-388.1(al)18.5(le)18.4(r)14.7(g)0(e)20.8(n)0(s)-378.3([)0(4)19.6(])0(.)-395.4(A)0(l)-7.8(bumins)]TJ
0 -1.0641 TD
[(occ)-8.8(ur)-441.3(at)-448.2(high)-443.6(concent)-8.9(rations)-451.5(in)-442.1(anim)-9(al)-442.5(hair/dand)-14(er)-441.7(ex-)]TJ
0 -1.0584 TD
[(tract)-11(s)-263.7(and)-264.5(represent)-270.9(imp)-7.8(ortant)-267.4(cross)-8.2(-reactive)-272.5(allergens)-260.3(for)]TJ
0 -1.0641 TD
[(~30%)-515(of)-509.6(pati)-8.2(ents)-513.5(with)-512.5(anim)-9(al)-510.8(allergy)-501.9([5,)-515.7(6].)-510(Patients)]TJ
0 -1.0584 TD
[(alle)-8.6(rgic)-439.9(to)-453.5(animals)-459.1(frequen)-9.3(tly)-450.9(display)-455.6(IgE)-451.9(reactivit)-13.5(y)-444.6(t)0(o)]TJ
/F19 1 Tf
9.6 0 0 9.6 76.388 771.498 Tm
0 0 0 1 k
(35)Tj
-0.0295 -1.6649 TD
(30)Tj
0 9.6 -9.6 0 68.708 671.242 Tm
[(Positive)-228.1(skin)-228(prick)-228(tests)-456.1(%)]TJ
ET
0 0 0 1 K
0 J 0 j 0.48 w 2.613 M []0 d
1 i 
92.004 775.966 m
88.404 775.966 l
91.741 759.825 m
88.141 759.825 l
91.78 742.665 m
88.18 742.665 l
91.759 725.385 m
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91.628 708.225 m
88.028 708.225 l
91.732 690.465 m
88.132 690.465 l
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91.868 656.625 l
282.787 656.625 l
91.852 673.665 m
88.252 673.665 l
91.857 656.637 m
88.257 656.637 l
S
BT
9.6 0 0 9.6 76.463 738.378 Tm
(25)Tj
-0.0337 -1.8001 TD
(20)Tj
-0.0125 -3.7876 TD
(10)Tj
0.4616 -1.5918 TD
(5)Tj
-0.0607 -1.8208 TD
(0)Tj
-0.3486 5.3429 TD
(15)Tj
ET
107.867 656.625 m
107.867 653.625 l
139.753 656.625 m
139.753 653.625 l
171.421 656.625 m
171.421 653.625 l
202.845 656.625 m
202.845 653.625 l
234.323 656.625 m
234.323 653.625 l
265.747 656.625 m
265.747 653.625 l
S
BT
9.6 0 0 9.6 97.988 643.431 Tm
[(T)29.8(rees)-1171.4(Grass)-938(Moulds)-407(Feathers)-826.5(HDM)-1483.1(D.p.)]TJ
ET
98.518 718.137 m
107.878 718.137 l
107.878 656.577 l
98.518 656.577 l
98.518 718.137 l
S
q
107.828 735.804 8.88 -79.2 re
W* n
0.346 w 
165.988 698.909 m
109.569 642.491 l
163.3 701.597 m
106.881 645.179 l
160.612 704.286 m
104.193 647.867 l
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90.752 661.308 l
144.483 720.414 m
88.064 663.996 l
141.795 723.103 m
85.376 666.684 l
139.107 725.791 m
82.688 669.372 l
136.418 728.479 m
80 672.06 l
133.73 731.167 m
77.312 674.748 l
131.042 733.855 m
74.623 677.436 l
128.354 736.543 m
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125.666 739.231 m
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122.978 741.919 m
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120.29 744.608 m
63.871 688.189 l
117.601 747.296 m
61.183 690.877 l
114.913 749.984 m
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112.225 752.672 m
55.807 696.253 l
S
Q
107.828 735.804 8.88 -79.2 re
130.268 766.905 m
139.678 766.905 l
139.678 656.67 l
130.268 656.67 l
130.268 766.905 l
S
q
139.682 749.663 8.28 -93.02 re
W* n
0.346 w 
207.222 705.821 m
141.122 639.721 l
204.534 708.509 m
138.434 642.41 l
201.846 711.198 m
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199.158 713.886 m
133.058 647.786 l
196.47 716.574 m
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193.782 719.262 m
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183.029 730.015 m
116.929 663.915 l
180.341 732.703 m
114.241 666.603 l
177.653 735.391 m
111.553 669.291 l
174.965 738.079 m
108.865 671.979 l
172.277 740.767 m
106.177 674.667 l
169.588 743.455 m
103.489 677.355 l
166.9 746.143 m
100.8 680.043 l
164.212 748.831 m
98.112 682.732 l
161.524 751.52 m
95.424 685.42 l
158.836 754.208 m
92.736 688.108 l
156.148 756.896 m
90.048 690.796 l
153.46 759.584 m
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150.771 762.272 m
84.672 696.172 l
148.083 764.96 m
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145.395 767.648 m
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142.707 770.336 m
76.607 704.237 l
S
Q
139.682 749.663 8.28 -93.02 re
161.948 701.369 m
171.478 701.369 l
171.478 656.654 l
161.948 656.654 l
161.948 701.369 l
S
q
171.428 704.648 8.88 -48.02 re
W* n
0.346 w 
207.79 683.323 m
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194.35 696.763 m
159.753 662.167 l
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157.065 664.855 l
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151.689 670.231 l
183.597 707.516 m
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180.909 710.204 m
146.313 675.608 l
178.221 712.892 m
143.625 678.296 l
175.533 715.58 m
140.936 680.984 l
S
Q
171.428 704.648 8.88 -48.02 re
193.678 673.78 m
202.867 673.78 l
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193.678 656.666 l
193.678 673.78 l
S
q
202.824 666.832 8.88 -10.22 re
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0.346 w 
214.207 664.419 m
204.574 654.786 l
211.519 667.107 m
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199.198 660.162 l
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S
Q
202.824 666.832 8.88 -10.22 re
224.827 743.265 m
234.357 743.265 l
234.357 656.67 l
224.827 656.67 l
224.827 743.265 l
S
q
234.307 735.815 8.88 -79.199 re
W* n
0.346 w 
292.477 698.909 m
236.058 642.491 l
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273.66 717.726 m
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270.972 720.414 m
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193.048 685.501 l
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241.403 749.984 m
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238.715 752.672 m
182.296 696.253 l
S
Q
234.307 735.815 8.88 -79.199 re
S
0.528 w 
256.507 767.369 m
265.736 767.369 l
265.736 656.654 l
256.507 656.654 l
256.507 767.369 l
S
q
265.686 753.22 8.822 -96.608 re
W* n
0.346 w 
336.071 707.618 m
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333.383 710.307 m
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317.254 726.435 m
248.587 657.769 l
314.566 729.124 m
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311.878 731.812 m
243.211 663.145 l
309.189 734.5 m
240.523 665.833 l
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229.771 676.586 l
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279.62 764.069 m
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202.889 703.467 l
268.867 774.822 m
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S
Q
265.686 753.22 8.822 -96.608 re
S
BT
/F7 1 Tf
7.97 0 0 7.97 58.28 628.384 Tm
0 g
[(Fig.)-327.1(2.)-331.2(\261)-332.2(Frequency)-687.3(of)-693.1(positive)-694.7(skin)-692.3(prick)-695.3(tests)-692.7(against)-693.4(common)]TJ
0 -1.067 TD
[(aller)14.7(gens)-575.1(in)-567.3(children)-569.4(of)-572.1(parents)-570.3(with)-567.9(\()]TJ
/F10 1 Tf
16.723 0 TD
(h)Tj
/F7 1 Tf
0.8322 0 TD
[(\))-574.3(and)-568.9(children)-569.4(of)-572.1(parents)]TJ
-17.5552 -1.0599 TD
[(without)-293.7(\()]TJ
/F11 1 Tf
3.6419 0 TD
(u)Tj
/F7 1 Tf
0.7967 0 TD
[(\))-296.8(occupational)-290.8(exposure)-288.4(to)-297(laboratory)-287.9(animals.)-294.3(HDM:)-289.7(house)]TJ
-4.4386 -1.0599 TD
[(dust)-329.5(mite;)-330.2(D.p.:)]TJ
/F3 1 Tf
6.6508 0 TD
[(Dermatoph)11.4(agoides)-322.2(pter)27.2(onyssinu)13.1(s)]TJ
/F7 1 Tf
13.3442 0 TD
(.)Tj
/F21 1 Tf
0 10 -10 0 67.53 176.586 Tm
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[(Positive)-228(skin)-228(prick)-228(tests)-456(%)]TJ
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(15)Tj
-0.138 -4.0681 TD
(10)Tj
0.4988 -8.08 TD
(0)Tj
3.458 -1.4461 TD
[(Mouse)-4972.1(Rat)-4786.9(Hamster)]TJ
11.65 0 0 11.65 76.448 197.477 Tm
(5)Tj
ET
0.539 w 
89.113 160.858 m
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89.113 201.561 m
84.127 201.561 l
89.113 242.263 m
84.127 242.263 l
89.113 282.966 m
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S
0.511 w 
89.113 282.953 m
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122.927 160.812 m
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191.182 160.812 m
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103.342 209.234 m
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103.342 160.857 l
103.342 209.234 l
S
q
122.959 164.62 19.544 -3.808 re
W* n
0.36 w 
144.062 165.519 m
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141.262 168.319 m
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138.462 171.119 m
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132.861 176.719 m
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S
Q
122.959 164.62 19.544 -3.808 re
171.531 240.667 m
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S
q
191.147 164.697 19.544 -3.808 re
W* n
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212.246 165.591 m
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S
Q
191.147 164.697 19.544 -3.808 re
239.606 273.081 m
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239.606 160.814 l
239.606 273.081 l
S
q
259.082 169.184 18.633 -8.319 re
W* n
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280.086 167.823 m
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277.286 170.623 m
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S
Q
259.082 169.184 18.633 -8.319 re
S
BT
/F14 1 Tf
11.283 0 0 11.283 120.063 217.052 Tm
(*)Tj
ET
0.5 w 
113.648 213.661 m
113.648 217.994 l
131.981 217.994 l
131.981 213.661 l
S
BT
11.283 0 0 11.283 187.897 249.868 Tm
(*)Tj
ET
181.648 246.328 m
181.648 250.661 l
199.981 250.661 l
199.981 246.328 l
S
BT
11.283 0 0 11.283 256.028 282.602 Tm
(*)Tj
ET
249.981 279.161 m
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268.314 283.494 l
268.314 279.161 l
S
BT
/F7 1 Tf
7.97 0 0 7.97 58.28 129.883 Tm
0 g
[(Fig.)-327.1(3.)-331.2(\261)-332.2(Frequency)-445.5(of)-451.2(positive)-452.9(skin)-450.4(prick)-453.4(tests)-450.9(to)-453.4(laboratory)-451.5(animal)]TJ
0 -1.0599 TD
[(aller)14.7(gens)-311.9(in)-311.2(children)-306.2(of)-309(parents)-307.1(with)-304.7(\()]TJ
/F10 1 Tf
15.151 0 TD
(h)Tj
/F7 1 Tf
0.8322 0 TD
[(\))-311.1(and)-312.8(withou)12.4(t)-313.3(\()]TJ
/F11 1 Tf
6.0391 0 TD
(u)Tj
/F7 1 Tf
0.7967 0 TD
[(\))-311.1(occupation)12.2(al)]TJ
-22.8189 -1.067 TD
[(exposure)-323.9(to)-332.5(laboratory)-323.5(animals.)-329.9(*:)-332.5(p)]TJ
/F9 1 Tf
14.6388 0 TD
(<)Tj
/F7 1 Tf
0.5477 0 TD
[(0.05,)-325.9(Fisher)]TJ
/F6 1 Tf
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(')Tj
/F7 1 Tf
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[(s)-333.4(exact)-330.3(test.)]TJ
/F23 1 Tf
0 9.8 -9.8 0 318.615 651.419 Tm
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[(Positive)-228(skin)-228(prick)-228(tests)-456(%)]TJ
9.8 0 0 9.8 321.023 760.387 Tm
(12)Tj
-0.0135 -2.1618 TD
(10)Tj
0.4429 -2.2629 TD
(8)Tj
0.0035 -2.1033 TD
(6)Tj
-0.0005 -2.154 TD
(4)Tj
0.0032 -2.2168 TD
(2)Tj
0.0069 -2.1126 TD
(0)Tj
15.6044 -1.4467 TD
(Dog)Tj
-10.0334 0 TD
(Cat)Tj
ET
0.616 w 
335.711 764.323 m
335.711 636.868 l
535.629 636.868 l
335.711 764.323 m
333.384 764.323 l
335.711 742.708 m
333.384 742.708 l
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(H)Tj
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0.0001 Tc
(OLLANDER)Tj
/F3 1 Tf
9.963 0 0 9.963 356.258 771.647 Tm
0 Tc
[(et)-237.6(al.)]TJ
/F7 1 Tf
2.2079 0 TD
[([4])-238.8(described)-246.6(total)-244.7(IgE)-235.6(as)-242.1(a)-234.5(risk)-241.5(facto)-8.6(r)-235.7(o)0(f)]TJ
-6.9197 -1.0471 TD
[(labor)-8.2(atory)-338.2(anim)-9(al)-334.4(allergy)67.2(.)]TJ
1.0015 -1.0528 TD
[(Th)17.1(e)-291.4(p)0(r)19.6(e)0(s)19.6(e)0(n)15.1(t)-287.7(st)17.7(ud)21.2(y)-285.3(f)0(o)13.9(u)0(n)21.2(d)-291(th)18.8(at)-277.5(bo)21.2(th)-282.7(up)21.2(pe)15.1(r)-286.9(a)0(n)20.8(d)-285.3(lo)13.2(w)12.4(e)0(r)-282.4(r)0(e)19.2(s)0(-)]TJ
-1.0015 -1.0471 TD
[(pi)13.2(ra)19.2(to)18.8(ry)-242.1(di)18.9(se)13.9(as)19.6(es)-242.1(we)16.9(re)-242.5(mo)18.1(re)-242.5(li)22.2(ke)15.1(ly)-242.9(to)-237.2(oc)15.1(cu)20.8(r)-252.8(i)0(n)-237.2(t)0(h)13.2(e)-245.9(gr)13.9(ou)21.2(p)-251.2(o)0(f)]TJ
0 -1.0528 TD
[(ch)15.1(il)16.5(dr)19.6(en)-349.1(wh)17.3(os)20(e)-359.7(p)0(a)20.8(r)0(e)13.5(n)0(t)18.9(s)-354.8(ha)20.8(d)-359.3(b)0(e)20.8(e)0(n)-349.1(o)0(c)15.1(c)0(u)20.8(p)0(a)15.1(t)0(i)22.2(o)0(n)15.5(a)0(l)18.4(l)0(y)-351(e)0(x)20.8(p)0(o)15.5(s)0(e)19.6(d)]TJ
T*
[(to)-277.1(la)18.4(bo)15.5(ra)19.2(to)18.9(ry)-276.3(an)15.1(im)15.7(al)18.5(s.)-275.5(It)-273(wa)16.9(s)-286.5(a)0(l)18.5(s)0(o)-275.9(a)0(s)19.6(s)0(u)14.3(m)0(e)17.7(d)-285.3(th)18.9(at)-271.8(th)13.2(es)19.6(e)-285.7(c)0(h)20.8(i)0(l)16.5(-)]TJ
0 -1.0471 TD
[(dr)13.9(en)-576.7(we)16.9(re)-578.3(mo)18.1(re)-578.3(fr)18(eq)15.1(ue)20.8(nt)18.9(ly)-578.7(ex)15.1(po)21.2(se)13.9(d)-581.2(t)0(o)-578.7(h)0(i)18.9(g)0(h)15.5(e)0(r)-578.3(a)0(n)20.8(i)0(m)15.7(a)0(l)]TJ
0 -1.0527 TD
[(al)12.8(le)18.4(r)20.4(g)0(e)15.1(n)-279.6(le)12.8(ve)20.8(ls)-278.2(th)18.9(ro)19.6(ug)15.5(h)-285.3(t)13.9(he)15.1(ir)-273(pa)15.1(re)19.2(nt)13.2(s)]TJ
/F6 1 Tf
14.0898 0 TD
(')Tj
/F7 1 Tf
0.5008 0 TD
[(oc)15.1(cu)20.8(pa)15.1(ti)22.2(on)15.5(,)-284.9(a)0(l)18.5(t)0(h)18.9(o)0(u)15.5(g)0(h)]TJ
-14.5906 -1.0471 TD
-0.0167 Tc
[(t)-16.7(h)-3.5(e)-444.7(a)-16.7(ir)-16.7(bo)-16.7(rn)-16.7(e)-439.7(a)-16.7(ni)-16.7(ma)-16.7(l)-436.4(c)-16.7(on)-16.7(c)4.1(e)-16.7(nt)-16.7(ra)-16.7(ti)-16.7(on)-16.7(s)-440.5(b)-16.7(ot)-16.7(h)-436(a)-16.7(t)-442.1(w)-16.7(or)-16.7(k)-440.9(a)-16.7(n)4.1(d)-450(i)-16.7(n)]TJ
0 -1.0527 TD
0 Tc
[(th)13.2(ei)18.4(r)-400.7(h)0(o)21.2(m)0(e)17.7(s)-400.3(we)16.9(re)-396.2(no)21.2(t)-401.5(d)0(e)20.8(t)0(e)12.8(r)0(m)16.5(i)0(n)18.8(e)0(d)20.8(.)-398.7(E)]TJ
6.974 0 0 6.974 455.414 677.48 Tm
0.0001 Tc
[(GGL)24.1(ES)18(T)18.8(O)0(N)]TJ
/F3 1 Tf
9.963 0 0 9.963 495.439 677.48 Tm
0 Tc
[(et)-391.3(al)18.9(.)]TJ
/F7 1 Tf
2.5038 0 TD
[([1)19.6(5])]TJ
-21.1859 -1.0471 TD
[(noti)-7.8(ced)-486.8(that)-486.2(bo)-7.2(th)-481.9(nasal)-491.9(and)-486.4(bronchi)-9.7(al)-488(symptom)-9.5(s)-485.6(were)]TJ
0 -1.0528 TD
[(signi)-9.8(ficantly)-419.7(dependen)-7.3(t)-412.9(o)0(n)-416.9(the)-414.8(concent)-8.9(ration)-415.4(of)-418.5(airborn)]TJ
0 -1.0471 TD
[(rat)-279.8(allergens.)-272.1(Nasal)-273.9(symp)-7.4(toms)-277.2(were)-276.8(signifi)-9.6(cantly)-277.6(increas-)]TJ
0 -1.0527 TD
[(ed)-286.5(at)-283.1(a)-285.7(rat)-285.5(alle)-8.6(rgen)-272.5(concen)-11.5(tration)-287.6(of)-287.7(166\21328)-287.9(ng)]TJ
/F12 1 Tf
18.8243 0.1992 TD
(.)Tj
/F7 1 Tf
0.2731 -0.1992 TD
(m)Tj
7.472 0 0 6.641 507.231 640.063 Tm
(-3)Tj
9.963 0 0 9.963 516.189 635.641 Tm
(com-)Tj
-20.7648 -1.0471 TD
[(pared)-233.8(with)-233.7(9.6\2133)-229.9(ng)]TJ
/F12 1 Tf
7.944 0.1992 TD
(.)Tj
/F7 1 Tf
0.2731 -0.1992 TD
(m)Tj
7.472 0 0 6.641 398.891 629.631 Tm
(-3)Tj
9.963 0 0 9.963 405.014 625.209 Tm
[(,)-228(but)-226.6(the)-232.7(pulmonary)-236.3(respon)-7.8(se)-230.7(was)]TJ
-9.6056 -1.0527 TD
[(sim)-9(ilar)-482.1(in)-481.9(terms)-484.8(of)-486.8(symptom)-9.5(s,)-480.3(cough)-482.2(or)-481.1(FEV)]TJ
7.97 0 0 7.97 502.242 614.721 Tm
(1)Tj
9.963 0 0 9.963 506.211 614.721 Tm
[(.)-484.1(Three)]TJ
-19.7633 -1.0527 TD
[(chil)-8.2(dren)-215.6(from)-219.9(the)-209.9(firs)-9.8(t)-213.7(group)-216(with)-216.6(a)-211.7(positive)-219.7(skin)-217.2(prick)-218.8(test)]TJ
0 -1.0471 TD
[(and)-258.8(RAST)-197.1(confirmed)-261.1(that)-258.6(nasal)-258.6(symp)-7.4(toms)-260.2(such)-255(as)-253.5(sneez-)]TJ
0 -1.0527 TD
[(ing,)-312.3(itching)-308.8(a)-6.9(n)0(d)-303.1(rhino)-7.8(rrhea)-309.4(had)-310(appeared)-310.9(before)-315.9(the)-306.7(dev-)]TJ
0 -1.0471 TD
[(elopm)-9.8(ent)-255.5(of)-259.2(chest)-258.6(symp)-7.4(toms)-260.2(\(asthma\))-267.2([14].)-257(Some)-261.9(studies)]TJ
0 -1.0527 TD
[(found)-363.9(that)-361(asthm)-10.9(a)-354(w)0(i)-7.8(thout)-361.4(rhinitis)-365.5(was)-360.6(rare)-365.6(among)-360.2(sub-)]TJ
0 -1.0471 TD
[(ject)-8.6(s)-377.5(occupat)-8.9(ional)-9(ly)-379.5(exposed)-382.9(to)-385.2(laboratory)-386.3(anim)-9(als,)-382.2(and)]TJ
0 -1.0527 TD
[(that)-417.9(most)-419.5(often)-423.6(it)-410.3(was)-417.5(associ)-10.1(ated)-416(wi)-7.8(th)-413.6(nasal)-417.9(symp)-7.4(toms)]TJ
0 -1.0471 TD
([16].)Tj
1.0015 -1.0527 TD
[(As)-416.4(no)-411.3(si)17.7(gn)15.5(if)17.3(ic)18.4(an)20.8(t)-424.2(d)0(i)18.9(f)20.4(fe)13.5(re)19.2(nc)15.1(e)-422.3(w)12.4(as)-412.8(ob)15.5(se)19.6(rv)13.9(ed)-411.7(in)-413.6(th)18.8(e)-422.3(f)0(r)18(e)0(-)]TJ
-1.0015 -1.0471 TD
[(qu)15.5(en)15.1(cy)-383.2(of)-384.4(po)15.5(si)17.7(t)13.9(i)0(v)13.2(e)-393.8(sk)20(in)-385.2(pr)19.6(ic)12.8(k)-393.4(t)0(e)18.4(s)0(t)17.7(s)-394.6(re)19.2(sp)14.4(on)21.2(se)-384.4(to)-385.2(co)15.1(mm)14.9(on)]TJ
0 -1.0528 TD
[(al)12.8(le)18.4(r)20.4(g)0(e)15.1(n)0(s)-310(b)0(e)15.1(t)13.9(we)11.2(en)-309.2(th)18.9(e)-325.5(t)0(w)20.6(o)-325.1(gr)19.6(ou)15.5(ps)-310(of)-310.4(ch)15.1(il)16.5(dr)19.6(en)15.1(,)-319.1(i)0(t)-313.6(c)0(o)20.8(u)0(l)18.8(d)-325.1(be)]TJ
T*
[(su)14.4(pp)21.2(os)14.3(ed)-206.8(th)18.8(at)-203.5(al)12.8(l)13.9(e)0(r)24.9(g)0(y)-206.4(t)0(o)-203.1(c)0(o)15.1(m)0(m)14.9(o)0(n)-206.4(a)0(l)18.5(l)0(e)18.4(r)20.4(ge)15.1(ns)-207.6(do)21.2(es)-208(no)15.5(t)-213.7(a)0(p)20.8(p)0(e)15.1(a)0(r)]TJ
0 -1.0471 TD
[(to)-220.2(be)-212.5(an)-218.2(im)15.7(po)21.2(rt)17.3(an)15.1(t)-225.1(r)0(i)17.3(s)0(k)-213.3(f)0(a)13.5(c)0(t)18.4(o)0(r)-213.7(f)0(o)13.9(r)-224.3(se)19.6(ns)14.4(i)13.9(t)0(i)16.5(z)0(a)14.7(t)0(i)16.5(o)0(n)-212.1(t)0(o)-220.2(l)0(a)18.4(b)0(o)21.2(r)0(a)13.5(t)0(o)18.9(r)0(y)]TJ
0 -1.0528 TD
[(an)15.1(im)15.7(al)18.5(s.)-247(H)]TJ
6.974 0 0 6.974 351.439 468.227 Tm
0.0001 Tc
[(OLL)23.9(AN)21.6(DER)]TJ
/F3 1 Tf
9.963 0 0 9.963 390.954 468.227 Tm
0 Tc
[(et)-249(al)18.9(.)]TJ
/F7 1 Tf
2.2136 0 TD
[([1)19.6(7])-259.2(noti)-7.8(ced)-264.9(that)-275.7(allergy)-262.9(to)-265.7(ca)-8(ts)]TJ
-10.408 -1.0471 TD
[(or)-418.5(dogs)-419.7(seem)-8.2(ed)-417.3(to)-413.6(be)-417.3(an)-417.3(imp)-7.8(ortant)-421.1(risk)-417.9(facto)-8.6(r)-417.8(for)-415.2(lab-)]TJ
0 -1.0528 TD
[(orato)-8.2(ry)-242.1(a)-6.9(nimal)-245.4(alle)-8.6(rgy)70.1(,)-239.4(wher)-9(eas)-243.3(alle)-8.6(rgy)-231.5(to)-248.6(pollen)-248.8(or)-242.1(house)]TJ
0 -1.0471 TD
[(dust)-268.4(mite,)-262.1(in)-265.7(the)-261.2(absence)-269.9(of)-259.2(cat)-261.6(a)-6.9(n)0(d)-257.6(dog)-264.1(allergy)67.2(,)-262.1(appeared)]TJ
0 -1.0527 TD
[(to)-339.7(be)-332(insig)-9.8(nificant.)]TJ
1.0015 -1.0471 TD
[(Sm)13.2(ok)21.2(in)13.2(g)-319.4(i)13.9(s)-320.6(b)0(y)-308.8(f)0(a)13.5(r)-315.3(th)13.2(e)-319.8(m)0(o)18.1(s)0(t)-306.7(d)0(o)15.5(c)0(u)15.1(m)0(e)17.7(n)0(t)18.8(e)0(d)-309.2(r)0(i)17.3(s)0(k)-310(f)0(a)13.5(c)0(t)18.4(o)0(r)-310.4(f)0(o)19.6(r)]TJ
-1.0015 -1.0527 TD
[(th)13.2(e)-240.2(d)0(e)15.1(v)0(e)20.8(l)0(o)13.2(p)0(m)18.1(e)0(n)20.8(t)-247.8(of)-236.4(al)18.5(le)18.4(r)20.4(g)0(i)13.2(c)-240.2(di)13.2(se)19.6(as)19.6(es)13.9(.)-239.4(N)0(u)11.6(m)13.2(er)13.5(ou)21.2(s)-246.7(e)0(p)15.1(i)13.9(de)15.1(mi)15.7(o-)]TJ
0 -1.0471 TD
[(lo)13.2(gi)18.9(ca)20.4(l)-378.7(s)0(t)17.7(u)0(d)15.5(i)0(e)18.4(s)-377.5(ha)20.8(ve)-371.8(fo)19.6(un)21.2(d)-382(a)0(n)-366.1(a)0(s)19.6(s)0(o)14.4(c)0(i)18.4(a)0(t)18.4(i)0(o)18.8(n)-376.3(be)15.1(tw)20.6(ee)14.7(n)-376.3(e)0(x)15.1(p)0(o)21.2(-)]TJ
0 -1.0528 TD
[(su)14.4(re)-316.5(to)-322.6(t)13.9(o)0(b)15.5(a)0(c)14.7(c)0(o)-314.9(s)0(m)16.9(o)0(k)15.5(e)-325.5(an)15.1(d)-325.1(r)0(e)13.5(c)0(u)20.8(r)0(r)18(e)0(n)15.1(t)-327.5(wh)17.3(ee)14.7(zi)18.5(ng)21.2(,)-330.4(b)0(r)19.6(o)0(n)15.5(c)0(h)20.8(i)0(a)18.5(l)]TJ
T*
[(hy)15.5(pe)15.1(rr)18(ea)20.4(ct)18.4(iv)13.2(it)16.5(y)-336.5(a)0(n)15.1(d)-342.2(th)18.9(e)-342.6(d)0(i)18.8(a)0(g)15.1(n)0(o)21.2(s)0(i)17.7(s)-343.4(of)-333.2(as)19.6(th)13.2(ma)-335.1([1)19.6(8,)-342.6(19].)-351.4(An)]TJ
0 -1.0471 TD
[(associ)-10.1(ation)-441.5(between)-445.3(passive)-443.4(smok)-7.4(ing)-437.2(and)-440.9(an)-434.4(incre)-8.6(ased)]TJ
0 -1.0527 TD
[(risk)-372.4(of)-367.3(sensi)-9(tization)-374.9(to)-368.1(envir)-8.2(onmen)-7.4(tal)-366(alle)-8.6(rgens)-359.8(has)-368.1(also)]TJ
0 -1.0471 TD
[(bee)-8.8(n)-365(shown,)-373.5(in)-368.1(both)-369.6(clinical)-375.3(studies)-377.1(and)-366.9(anima)-10.2(l)-367.3(experi-)]TJ
0 -1.0527 TD
[(ment)-9(s.)-343.8(T)57.7(obacco)-352.9(smoke)-350(has)-345.3(a)-348.3(direc)-8.6(t)-344.6(irritant)-355(effect)-347.1(on)-343(the)]TJ
0 -1.0471 TD
[(mucou)-7.4(s)-599.5(mem)-9(brane)-603.7(and)-605.9(thereby)-607.6(damag)-7.8(es)-600.6(its)-600.1(surfa)-8.6(ce,)]TJ
0 -1.0528 TD
[(allo)-8.2(wing)-396.3(penetrati)-11.1(on)-388.5(of)-390.1(a)-6.9(llergens.)-384.7(Fu)-6.4(rthermor)-11.1(e,)-388.5(tobacc)-8.2(o)]TJ
0 -1.0471 TD
[(smok)-7.4(e)-280(may)-284.7(have)-282.7(a)-285.7(direct)-284.9(immunom)-11.5(odulat)-9.7(ing)-277.8(effect)-278.8([20].)]TJ
0 -1.0528 TD
[(How)-10.2(ever)28.7(,)-364.6(severa)-8.6(l)-361.7(studie)-10.9(s)-360.5(have)-368.1(report)-10.5(ed)-366.1(the)-363.6(opposi)-8.1(te)-362.8(re-)]TJ
0 -1.0471 TD
[(sult)-9(s)-332([21,)-340(22].)]TJ
1.0015 -1.0528 TD
[(Si)14(nc)20.8(e)-245.9(n)0(o)-234.8(a)0(s)19.6(s)0(o)20(c)0(i)12.8(a)0(t)18.5(i)0(o)18.8(n)-245.5(w)12.4(a)0(s)-236.4(f)0(o)19.6(u)0(n)15.5(d)-239.8(be)15.1(tw)14.9(ee)20.4(n)-245.5(p)0(o)21.2(s)0(i)17.7(t)0(i)16.5(v)0(e)-235.2(R)11.6(AS)12.4(T)]TJ
-1.0015 -1.0471 TD
[(to)-277.1(ha)20.8(ir)-273(al)18.4(le)12.8(r)20.4(g)0(e)20.8(n)0(s)-275.9(o)0(f)-270.6(l)0(a)18.4(b)0(o)15.5(r)0(a)19.2(t)0(o)13.2(r)0(y)-270.6(a)0(n)15.1(i)13.9(ma)12(ls)-272.6(an)20.8(d)-285.3(s)0(m)16.9(o)0(k)21.2(i)0(n)18.9(g)-285.3(st)17.7(at)18.4(us)]TJ
0 -1.0528 TD
[(of)-344.6(pa)20.8(re)13.5(nt)18.9(s,)-338.1(an)15.1(d)-347.9(b)0(e)15.1(t)13.9(we)11.2(en)-337.7(sm)16.9(ok)15.5(in)18.9(g)-347.9(a)0(n)15.1(d)-347.9(po)21.2(si)17.7(ti)16.5(ve)-343.4(sk)20(in)-339.7(pr)13.9(ic)18.4(k)]TJ
T*
[(te)12.8(st)17.7(s)-269.4(t)0(o)-265.7(l)0(a)18.4(b)0(o)15.5(r)0(a)19.2(t)0(o)13.2(r)0(y)-264.9(a)0(n)20.8(i)0(m)15.7(a)0(l)-266.1(a)0(l)18.5(l)0(e)18.4(r)14.7(ge)20.8(ns)-264.5(an)15.1(d)-273.9(a)0(l)18.4(l)0(e)18.4(r)20.4(gi)18.9(c)-274.3(s)0(y)14.4(m)0(p)18.1(t)0(o)18.8(m)0(s)]TJ
0 -1.0471 TD
[(in)-322.6(bo)15.5(th)-316.9(gr)14(ou)21.2(ps)14.4(,)-324.7(i)0(t)-325(i)0(s)-318.1(c)0(o)15.1(n)0(c)15.1(l)13.9(ud)15.5(ed)-320.6(th)18.9(at)-323(th)18.9(er)13.5(e)-325.5(i)0(s)-323.8(n)0(o)21.2(t)-333.2(su)20(f)14.7(f)0(i)17.3(c)0(i)18.4(e)0(n)20.8(t)]TJ
0 -1.0528 TD
[(ev)15.1(id)18.8(en)15.1(ce)-212.9(th)18.8(at)-214.9(sm)16.9(ok)21.2(in)18.9(g)-222.7(i)0(s)-215.7(a)-217.4(ri)17.3(sk)-213.3(fa)13.5(ct)18.5(or)-213.7(fo)19.6(r)-218.6(l)0(a)12.8(b)0(o)21.2(r)0(a)13.5(t)0(o)18.9(r)0(y)-213.7(a)0(n)20.8(i)0(m)15.7(a)0(l)]TJ
0 -1.0471 TD
[(al)12.8(le)18.4(r)20.4(g)0(y)78.1(.)]TJ
1.0015 -1.0527 TD
[(In)-447(su)20(mm)14.9(ar)13.5(y)73.2(,)-449.9(it)-444.5(ca)14.7(n)-450.3(b)0(e)-445.8(c)0(o)20.8(n)0(c)15.1(l)0(u)18.9(d)0(e)15.1(d)-450.3(th)18.9(at)-448.2(pa)20.8(re)13.5(nt)18.9(al)-442.5(oc)15.1(cu)20.8(-)]TJ
-1.0015 -1.0471 TD
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