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[(Cell)-327.3(Biology)-329.1(Unit)]TJ 0 -1.0599 TD [(National)-325.1(Heart)-334(and)-327(Lung)-328.6(Institute)]TJ T* [(Imperial)-328(College)-327.1(School)-328(of)-330.3(Medicine)]TJ 0 -1.067 TD [(Dovehou)13.2(se)-337.4(Street)]TJ 0 -1.0599 TD [(London)-324.4(SW3)-329.8(6L)101.1(Y)]TJ 0 -1.067 TD (UK)Tj 0 -1.0599 TD [(Fax:)-325.1(44)-330.1(2073763442)]TJ 0 -2.1268 TD [(Keywords)11.5(:)-334.6(Acute)-326.7(respiratory)-329.9(distress)]TJ 0 -1.0599 TD (syndrome)Tj T* [(granulocyt)11(e)-331.2(colony-stimu)10.3(lating)-335(factor)]TJ 0 -1.067 TD [(granulocyt)11(e)-331.2(macrophage)-323.9(colony-)]TJ 0 -1.0599 TD [(stimulatin)8.6(g)-332.2(factor)]TJ 0 -1.067 TD [(interleukin-)10.2(8)]TJ 0 -1.0599 TD (neutrophils)Tj T* (prognosis)Tj 0 -2.1268 TD [(Received:)-327.9(Decemb)12.9(er)-336.4(9)-332.2(1999)]TJ 0 -1.0599 TD [(Accepted)-325.4(after)-331.6(revision)-329.8(January)-326.1(28)-330.1(2000)]TJ 0 -2.1268 TD [(This)-424.7(study)-427(was)-430.3(supported)-417.7(by)-429.7(the)-429(British)]TJ 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[(filtrate)-258.6(the)-255.5(lungs)-257.8(in)-248.6(large)-247.6(numbe)-7.4(rs)-254.7(and)-253.1(their)-255.3(persisten)-10.7(ce)-252.7(in)]TJ 0 -1.0528 TD [(the)-261.2(lungs)-269.2(is)-261.2(an)-258(imp)-7.8(ortant)-267.4(determin)-10.7(ant)-261.2(of)-259.2(po)-7.2(or)-259.2(surviva)-10.9(l)-259.2([4,)]TJ T* [(5].)-140.1(Elucid)-8.2(ation)-139.9(of)-139.7(the)-141.7(mecha)-8.2(nisms)-142.6(that)-139.1(mai)-8.2(ntain)-139.9(pulm)-8.6(onary)]TJ T* [(neutr)-8.2(ophilia)-365.7(in)-368.1(ARDS)-367.7(may)-364.3(there)-8.6(fore)-365.2(be)-366.1(of)-361.6(consi)-7.8(derabl)-9.4(e)]TJ 0 -1.0471 TD [(prognos)-8.1(tic)-337.5(and)-332.7(thera)-8.6(peuti)-9(c)-331.2(signifi)-9.6(cance.)]TJ 1.0015 -1.0528 TD [(Th)17.1(e)-217.4(m)0(a)17.7(i)0(n)-203.1(c)0(h)15.1(e)0(m)17.7(o)0(t)18.9(a)0(c)14.7(t)0(i)16.5(c)-211.7(fa)13.5(ct)18.4(or)-208(fo)19.6(r)-218.6(n)0(e)20.8(u)0(t)18.9(r)0(o)13.9(p)0(h)21.2(i)0(l)16.5(s)-218.2(i)13.9(n)-217(th)18.9(e)-217.4(b)0(l)18.9(o)0(o)15.5(d)]TJ -1.0015 -1.0527 TD [(an)15.1(d)-308.1(b)0(r)19.6(o)0(n)15.5(c)0(h)15.1(o)0(a)20.8(l)0(v)18.9(e)0(o)15.1(l)0(a)18.4(r)-309.7(la)12.8(va)20.8(ge)-303.5(\(B)14.9(A)12.4(L)0(\))-303.2(f)0(l)17.3(u)0(i)13.2(d)0(s)-298.6(o)0(f)-304.7(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)-301(w)0(i)14.9(t)0(h)]TJ T* [(AR)18.3(DS)-238(ha)20.8(s)-241(b)0(e)15.1(e)0(n)-229.6(s)0(h)14.4(o)0(w)17.3(n)-239.8(to)-231.5(be)-235.2(th)18.9(e)-240.2(c)0(y)15.1(t)0(o)18.9(k)0(i)18.9(n)0(e)-229.6(i)0(n)13.2(t)0(e)18.4(r)0(l)17.3(e)0(u)20.8(k)0(i)13.2(n)-239.8(\(I)18(L\))15.5(-)]TJ 0 -1.0471 TD [(8,)-297.1(an)15.1(d)-308.1(o)0(t)18.9(h)0(e)15.1(r)-309.7(pr)19.6(od)21.2(uc)15.1(ts)-301(of)-299(in)18.9(fl)17.3(am)17.7(ma)12(ti)16.5(on)-297.4(ma)17.7(ke)-297.8(a)-308.5(l)0(e)12.8(s)0(s)18.9(e)0(r)-299.4(c)0(o)15.1(n)0(-)]TJ 0 -1.0528 TD [(tr)17.3(ib)18.9(ut)18.9(io)13.2(n)-393.4([)0(6)19.6(])0(.)-406.8(Higher)-411.2(level)-9.4(s)-400.3(o)-6.5(f)-400.7(I)0(L)-7.2(-)0(8)-401.5(are)-408.7(presen)-8.2(t)-407.2(i)0(n)-402.3(BAL)]TJ 25.1977 21.0266 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[(Da)16.9(ta)-493.7(di)13.2(st)17.7(ri)17.3(bu)21.2(ti)16.5(on)15.5(s)-502.7(w)0(e)16.9(r)0(e)-492.9(n)0(o)15.5(n)0(p)15.5(a)0(r)19.2(a)0(m)17.7(e)0(t)18.4(r)0(i)17.3(c)0(;)-499.4(t)0(h)18.9(u)0(s)-492.1(c)0(o)15.1(m)0(p)18.1(a)0(r)24.9(-)]TJ -1.0015 -1.0527 TD [(is)17.7(on)15.5(s)-400.3(b)0(e)20.8(t)0(w)14.9(e)0(e)14.7(n)-399.1(in)18.9(de)15.1(pe)20.8(nd)15.5(en)20.8(t)-401.5(g)0(r)19.6(o)0(u)15.5(p)0(s)-389.7(w)0(e)16.9(r)0(e)-396.2(m)0(a)17.7(d)0(e)-394.6(u)0(s)20(i)0(n)18.9(g)-399.1(th)13.2(e)]TJ 0 -1.0471 TD [(Ma)18.9(nn)15.5(-W)18.5(hi)13.2(tn)18.9(ey)-240.9(U-)15.7(te)18.4(st)12(.)-250.8(C)11.6(or)14(re)19.2(la)18.4(ti)16.5(on)15.5(s)-252.3(w)0(e)16.9(r)0(e)-242.5(c)0(a)14.7(r)0(r)18(i)0(e)18.4(d)-256.8(ou)21.2(t)-253.5(u)0(s)20(i)0(n)13.2(g)]TJ 0 -1.0528 TD [(th)18.9(e)-325.5(S)11.4(pe)15.1(ar)19.2(ma)12(n)-319.4(r)0(a)13.5(n)0(k)-314.5(c)0(o)20.8(r)0(r)12.4(e)0(l)18.5(a)0(t)18.5(i)0(o)18.9(n)-325.1(co)15.1(ef)30.6(fi)17.3(ci)18.4(en)15.1(t.)]TJ /F6 1 Tf 35.0595 46.0593 TD [(Res)-7.8(ults)]TJ /F4 1 Tf -9.8617 -2.0998 TD [(Br)27.3(onchoal)-8.1(veolar)-390.2(lavage)-394.7(neutr)26.3(ophil)-389.8(counts)-395.5(and)-383.6(cytoki)-10.6(ne)]TJ 0 -1.0471 TD [(level)-9.8(s)]TJ /F3 1 Tf 1.0015 -2.0998 TD [(Th)17.1(e)-200.3(c)0(l)18.5(i)0(n)18.9(i)0(c)12.8(a)0(l)-186.4(c)0(h)15.1(a)0(r)19.2(a)0(c)14.7(t)0(e)18.4(r)0(i)17.3(s)0(t)17.7(i)0(c)18.4(s)-201.1(of)-185.2(th)13.2(e)-194.6(3)0(1)-189.3(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-192.9(w)12.4(it)16.5(h)-199.9(A)0(R)18.3(D)0(S)]TJ -1.0015 -1.0528 TD [(an)15.1(d)-302.4(t)0(h)18.9(e)0(i)18.4(r)-304(BA)12.6(L)-300.8(c)0(e)14.7(l)0(l)-290.8(c)0(o)15.1(u)0(n)21.2(t)0(s)-295.3(a)0(t)-294.5(t)0(h)18.8(e)-308.5(t)13.9(i)0(m)15.7(e)-302.8(of)-299(in)18.8(it)16.5(ia)18.4(l)-304.7(l)0(a)18.4(v)0(a)20.8(g)0(e)-297.8(a)0(r)19.2(e)]TJ 0 -1.0471 TD [(sh)14.4(ow)17.3(n)-319.4(i)0(n)-311.2(t)0(a)18.4(b)0(l)13.2(e)-319.8(1.)-319.8(All)-335.3(the)-329.4(pati)-8.2(ents)-331.4(show)-8.2(ed)-332(increased)-338(per-)]TJ 0 -1.0527 TD [(cen)-8.8(tages)-224.4(of)-219.4(neutr)-8.2(ophils)-226.8(and)-224.6(highly)-225.6(signifi)-9.6(cant)-222.5(incre)-8.6(ases)-222.5(in)]TJ T* [(neu)-8.4(trophil)-292.9(numbe)-7.4(rs)-288.8(per)-288.8(milli)-10.8(litre)-291.8(of)-293.3(BAL)-288.2(flui)-9.4(d)-285.3(recover)-9.8(ed)]TJ 0 -1.0471 TD [(compa)-7.8(red)-414(to)-407.9(healthy)-414.9(controls)-412.4(\(p)]TJ /F8 1 Tf 13.2533 0 TD (<)Tj /F3 1 Tf 0.552 0 TD [(0.00)-8.4(1\).)-407.5(The)-410.8(results)-412.8(of)]TJ -13.8053 -1.0528 TD [(cytoki)-9.7(ne)-360.4(analys)-9(is)-363.6(in)-362.4(the)-363.6(same)-366.7(initial)-370.5(lavage)-366.7(samp)-7.8(les)-364.8(are)]TJ 0 -1.0471 TD [(show)-8.2(n)-558.4(i)0(n)-567.3(figure)-568.2(1.)-558.8(The)-6.8(se)-560.8(confi)-8.2(rm)-563.9(that)-565.9(patients)-567.2(with)]TJ 0 -1.0527 TD [(ARD)-9.2(S)-495.1(have)-498.9(h)-6.5(ighly)-498(signifi)-9.6(cant)-501.3(incre)-8.6(ases)-495.6(in)-499(IL)-7.2(-8)-498.2(level)]TJ 0 -1.0471 TD [(compa)-7.8(red)-459.5(to)-459.2(con)-8.4(trols)-460.9(\(med)-8.2(ian)-460.3(\(range\))-466.2(1,350)-458.7(\(1.00\26149)-7.3(,)]TJ 0 -1.0527 TD [(631)-8(\))]TJ /F4 1 Tf 2.1966 0 TD [(ve)-8(rsus)]TJ /F3 1 Tf 2.9079 0 TD [(9.00)-372.6(pg)]TJ /F11 1 Tf 3.1241 0.2049 TD (.)Tj /F3 1 Tf 0.2731 -0.2049 TD (mL)Tj 7.472 0 0 6.641 407.735 619.143 Tm (-1)Tj 9.963 0 0 9.963 417.6 614.721 Tm [(\(0\26124.50)-7.3(\))-372.2(p)]TJ /F8 1 Tf 4.7744 0 TD (<)Tj /F3 1 Tf 0.552 0 TD [(0.001\),)-376.1(and)-372.6(also)]TJ -16.1953 -1.0471 TD [(show)-400.8(that)-400.9(these)-406.5(patients)-402.2(exhibi)-9.7(t)-395.8(highl)-8.6(y)-393.4(signi)-9.8(ficant)-398.7(incr-)]TJ 0 -1.0528 TD [(eases)-320.4(in)-316.9(G-CSF)-319.8(\(175)-323.3(\(0\2611,000)-7.3(\))]TJ /F4 1 Tf 12.9801 0 TD (versus)Tj /F3 1 Tf 2.8453 0 TD [(4.55)-321.3(pg)]TJ /F11 1 Tf 3.0729 0.2049 TD (.)Tj /F3 1 Tf 0.2675 -0.2049 TD (mL)Tj 7.472 0 0 6.641 513.978 598.223 Tm (-1)Tj 9.963 0 0 9.963 523.275 593.801 Tm (\(0\261)Tj -21.4761 -1.0471 TD [(6.50)-8.4(\))-611.3(p)]TJ /F8 1 Tf 3.1924 0 TD (<)Tj /F3 1 Tf 0.552 0 TD [(0.0025\))-615.4(and)-611.6(GM)-7.4(-CSF)-616.7(levels)-614.5(\(2.20)-613.9(\(0\2618.90\))]TJ /F4 1 Tf -3.7444 -1.0527 TD (versus)Tj /F3 1 Tf 2.8054 0 TD [(0.39)-264.4(pg)]TJ /F11 1 Tf 3.016 0.1992 TD (.)Tj /F3 1 Tf 0.2731 -0.1992 TD (mL)Tj 7.472 0 0 6.641 383.754 577.304 Tm (-1)Tj 9.963 0 0 9.963 392.542 572.882 Tm [(\(0.32\2610.)-6.9(71\))-271.3(p)]TJ /F8 1 Tf 5.4231 0 TD (<)Tj /F3 1 Tf 0.552 0 TD [(0.001\).)-267.9(The)-6.8(re)-265.3(was)-269.6(no)]TJ -14.3288 -1.0471 TD [(signi)-9.8(ficant)-296.3(dif)10.8(ference)-300.4(in)-294.1(the)-289.6(cytoki)-9.7(ne)-286.5(level)-9.4(s)-286.5(o)0(r)-293.3(neutr)-8.2(ophil)]TJ 0 -1.0528 TD [(cou)-8.4(nts)-256.2(between)-263.3(the)-261.2(15)-257.6(patients)-265.6(with)-256.4(infec)-8.6(tion)-258.2(\(pri)-8.6(mary)-258.6(or)]TJ 0 -1.0471 TD [(seconda)-7.7(ry\))-449.3(and)-440.9(the)-443.2(16)-445.4(without)-448.9(infec)-8.6(tion.)-446.4(However)24.2(,)-444.2(G)0(-)]TJ 0 -1.0527 TD [(CSF)-324.1(level)-9.4(s)-314.9(wer)-8.2(e)-319.8(significantl)-13.3(y)-319.4(higher)-321.9(in)-322.6(the)-318.1(nine)-324.5(patien)-10.2(ts)]TJ 0 -1.0471 TD [(who)-376.1(fail)-9.8(ed)-371.8(to)-373.8(survi)-9(ve)-371.8(than)-375.7(in)-373.8(the)-375(22)-377.1(survivors)-379(\(p)]TJ /F8 1 Tf 20.2242 0 TD (<)Tj /F3 1 Tf 0.552 0 TD (0.05;)Tj -20.7762 -1.0528 TD [(tabl)-8.2(e)-274.3(2\).)-276.6(Lev)-6.8(els)-273.7(of)-276.3(IL)-7.2(-8)-276.3(and)-275.8(neutr)-8.2(ophils)-278(in)-277.1(the)-278.2(same)-281.3(sam-)]TJ 0 -1.0471 TD [(ples)-337.1(also)-337.1(tended)-332.1(to)-334(be)-332(higher)-339(in)-334(the)-329.4(nonsur)-7.4(vivor)-7.8(s.)-332.4(There)]TJ 0 -1.0527 TD [(was)-201.3(no)-200.7(relations)-11.9(hip)-198.2(between)-206.3(GM-C)-9.6(SF)-193.4(level)-9.4(s)-195.4(and)-201.9(survival.)]TJ /F4 1 Tf 0 -3.0103 TD [(Cor)-8.2(r)32.2(elation)-434(between)-440.4(levels)-432.8(of)-430.7(cytokines)-435.5(and)-429.1(neutr)26.4(ophil)]TJ 0 -1.0471 TD [(cou)-8.4(nts)]TJ /F3 1 Tf 1.0015 -2.0998 TD [(Th)17.1(e)-484.9(c)0(o)20.8(r)0(r)12.3(e)0(l)18.5(a)0(t)18.4(i)0(o)18.8(n)-484.5(be)20.8(tw)14.9(ee)20.4(n)-484.5(n)0(u)21.2(m)0(b)12.4(e)0(r)19.2(s)-480(of)-475.4(ne)20.8(ut)18.9(ro)13.9(ph)21.2(il)16.5(s)-480(a)0(n)15.1(d)]TJ -1.0015 -1.0527 TD [(co)15.1(nc)15.1(en)20.8(tr)17.3(at)18.5(io)13.2(ns)-253.1(of)-259.2(ea)14.7(ch)-258(cy)20.8(to)13.2(ki)18.9(ne)-258(in)-260(th)18.9(e)-268.6(s)0(a)19.6(m)0(e)-261.2(B)11.6(AL)-260(sa)14(mp)18.1(le)18.4(s)]TJ 0 -1.0471 TD [(fr)12.4(om)-351.8(th)18.9(e)-359.7(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-352.2(i)0(s)-352.2(s)0(h)14.4(o)0(w)17.3(n)-359.3(in)-351(ta)18.4(bl)13.2(e)-359.7(3)0(.)-359.7(The)-6.8(re)-367.7(wer)-8.2(e)-371.1(signi-)]TJ 0 -1.0527 TD [(fican)-8.6(t)-407.2(correl)-11(ations)-415(between)-416.9(both)-415.2(concentrati)-13.1(ons)-407.5(of)-412.8(IL-8)]TJ 0 -1.0471 TD [(and)-475(G-CSF)-479.1(and)-475(neutr)-8.2(ophil)-475.2(percentag)-12.5(es)-469.8(and)-475(neutr)-8.2(ophil)]TJ 0 -1.0528 TD [(numbe)-7.4(rs)-379.9(per)-379.9(milli)-10.8(litre.)-383.2(By)-376.1(contr)-8.2(ast,)-382.2(there)-384.2(was)-377.7(no)-377.1(corre-)]TJ 0 -1.0471 TD [(latio)-11.4(n)-234.1(between)-240.5(concent)-8.9(rations)-240.9(of)-236.4(GM)-7.4(-CSF)-241.1(and)-236(neutr)-8.2(ophil)]TJ 0 -1.0527 TD [(cou)-8.4(nts.)-347.7(Con)-7(sistent)-356.7(with)-353.2(these)-355.3(findings,)-355.5(IL-8)-357.5(and)-349.8(G-CSF)]TJ 0 -1.0471 TD [(level)-9.4(s)-491.3(correlated)-500.9(close)-8.2(ly)-487.6(wi)-7.8(th)-487.6(ea)-8(ch)-491.3(other)-491.9(\(r)]TJ 7.97 0 0 7.97 491.244 344.183 Tm (S)Tj /F8 1 Tf 9.963 0 0 9.963 495.609 344.183 Tm (=)Tj /F3 1 Tf 0.5577 0 TD [(0.86,)-492.4(p)]TJ /F8 1 Tf 2.9932 0 TD (<)Tj /F3 1 Tf -22.2501 -1.0527 TD [(0.00)-8.4(1\))-378.7(but)-380.2(less)-378.1(close)-8.2(ly)-379.5(with)-381.6(GM-CS)-9.5(F)-375.6(concent)-8.9(rations)-383.2(in)]TJ 0 -1.0471 TD [(the)-517.2(same)-514.7(lavage)-514.6(samples)-514.8(\(r)]TJ 7.97 0 0 7.97 425.99 323.263 Tm (S)Tj /F8 1 Tf 9.963 0 0 9.963 430.412 323.263 Tm (=)Tj /F3 1 Tf 0.552 0 TD [(0.449,)-510.3(p)]TJ /F8 1 Tf 3.5111 0 TD (<)Tj /F3 1 Tf 0.5577 0 TD [(0.025)-509.9(and)-514.9(r)]TJ 7.97 0 0 7.97 526.564 323.263 Tm (S)Tj /F8 1 Tf 9.963 0 0 9.963 530.986 323.263 Tm (=)Tj /F3 1 Tf -22.2501 -1.0528 TD [(0.39)-8.4(4,)-331.2(p)]TJ /F8 1 Tf 3.3404 0 TD (<)Tj /F3 1 Tf 0.552 0 TD [(0.05,)-338.8(respec)-8.6(tively\).)]TJ ET 0 0 0 1 K 0 J 0 j 0.5 w 3.864 M []0 d /GS3 gs 1 i 109.464 288.833 m 109.464 161.326 l 109.728 288.641 m 106.987 288.641 l 109.728 262.565 m 106.987 262.565 l 109.728 236.896 m 106.987 236.896 l 109.728 211.963 m 106.987 211.963 l 109.728 185.932 m 106.987 185.932 l 109.728 161.57 m 106.987 161.57 l S BT /F16 1 Tf 10 0 0 10 100.357 158.033 Tm 0 0 0 1 k /GS4 gs (0)Tj ET /GS3 gs 109.238 156.52 m 226.408 156.52 l 109.394 156.659 m 109.394 154.838 l 152.68 156.659 m 152.68 154.838 l 206.734 156.659 m 206.734 154.838 l S BT 10 0 0 10 139.905 144.495 Tm /GS4 gs (Control)Tj ET 0 0 0 0 k 3.864 M /GS3 gs 140.612 160.632 m 140.612 161.806 141.563 162.757 142.737 162.757 c 143.91 162.757 144.862 161.806 144.862 160.632 c 144.862 159.459 143.91 158.507 142.737 158.507 c 141.563 158.507 140.612 159.459 140.612 160.632 c b 144.033 160.632 m 144.033 161.806 144.984 162.757 146.158 162.757 c 147.332 162.757 148.283 161.806 148.283 160.632 c 148.283 159.459 147.332 158.507 146.158 158.507 c 144.984 158.507 144.033 159.459 144.033 160.632 c b 147.533 160.632 m 147.533 161.806 148.485 162.757 149.658 162.757 c 150.832 162.757 151.783 161.806 151.783 160.632 c 151.783 159.459 150.832 158.507 149.658 158.507 c 148.485 158.507 147.533 159.459 147.533 160.632 c b 150.533 160.632 m 150.533 161.806 151.485 162.757 152.658 162.757 c 153.832 162.757 154.783 161.806 154.783 160.632 c 154.783 159.459 153.832 158.507 152.658 158.507 c 151.485 158.507 150.533 159.459 150.533 160.632 c b 154.033 160.632 m 154.033 161.806 154.984 162.757 156.158 162.757 c 157.332 162.757 158.283 161.806 158.283 160.632 c 158.283 159.459 157.332 158.507 156.158 158.507 c 154.984 158.507 154.033 159.459 154.033 160.632 c b 157.283 160.632 m 157.283 161.806 158.234 162.757 159.408 162.757 c 160.582 162.757 161.533 161.806 161.533 160.632 c 161.533 159.459 160.582 158.507 159.408 158.507 c 158.234 158.507 157.283 159.459 157.283 160.632 c b 160.783 160.632 m 160.783 161.806 161.734 162.757 162.908 162.757 c 164.082 162.757 165.033 161.806 165.033 160.632 c 165.033 159.459 164.082 158.507 162.908 158.507 c 161.734 158.507 160.783 159.459 160.783 160.632 c b 204.783 160.632 m 204.783 161.806 205.734 162.757 206.908 162.757 c 208.081 162.757 209.033 161.806 209.033 160.632 c 209.033 159.459 208.081 158.507 206.908 158.507 c 205.734 158.507 204.783 159.459 204.783 160.632 c b 204.783 161.199 m 204.783 162.373 205.734 163.324 206.908 163.324 c 208.081 163.324 209.033 162.373 209.033 161.199 c 209.033 160.026 208.081 159.074 206.908 159.074 c 205.734 159.074 204.783 160.026 204.783 161.199 c b 204.783 161.766 m 204.783 162.94 205.734 163.891 206.908 163.891 c 208.081 163.891 209.033 162.94 209.033 161.766 c 209.033 160.592 208.081 159.641 206.908 159.641 c 205.734 159.641 204.783 160.592 204.783 161.766 c b 204.783 162.333 m 204.783 163.507 205.734 164.458 206.908 164.458 c 208.081 164.458 209.033 163.507 209.033 162.333 c 209.033 161.159 208.081 160.208 206.908 160.208 c 205.734 160.208 204.783 161.159 204.783 162.333 c b 204.783 162.9 m 204.783 164.074 205.734 165.025 206.908 165.025 c 208.081 165.025 209.033 164.074 209.033 162.9 c 209.033 161.726 208.081 160.775 206.908 160.775 c 205.734 160.775 204.783 161.726 204.783 162.9 c b 204.783 163.467 m 204.783 164.64 205.734 165.592 206.908 165.592 c 208.081 165.592 209.033 164.64 209.033 163.467 c 209.033 162.293 208.081 161.342 206.908 161.342 c 205.734 161.342 204.783 162.293 204.783 163.467 c b 204.783 164.034 m 204.783 165.207 205.734 166.159 206.908 166.159 c 208.081 166.159 209.033 165.207 209.033 164.034 c 209.033 162.86 208.081 161.909 206.908 161.909 c 205.734 161.909 204.783 162.86 204.783 164.034 c b 204.783 164.601 m 204.783 165.774 205.734 166.726 206.908 166.726 c 208.081 166.726 209.033 165.774 209.033 164.601 c 209.033 163.427 208.081 162.476 206.908 162.476 c 205.734 162.476 204.783 163.427 204.783 164.601 c b 204.783 165.168 m 204.783 166.341 205.734 167.293 206.908 167.293 c 208.081 167.293 209.033 166.341 209.033 165.168 c 209.033 163.994 208.081 163.043 206.908 163.043 c 205.734 163.043 204.783 163.994 204.783 165.168 c b 204.783 165.735 m 204.783 166.908 205.734 167.86 206.908 167.86 c 208.081 167.86 209.033 166.908 209.033 165.735 c 209.033 164.561 208.081 163.609 206.908 163.609 c 205.734 163.609 204.783 164.561 204.783 165.735 c b 204.783 166.301 m 204.783 167.475 205.734 168.426 206.908 168.426 c 208.081 168.426 209.033 167.475 209.033 166.301 c 209.033 165.127 208.081 164.176 206.908 164.176 c 205.734 164.176 204.783 165.127 204.783 166.301 c b 204.783 166.868 m 204.783 168.042 205.734 168.993 206.908 168.993 c 208.081 168.993 209.033 168.042 209.033 166.868 c 209.033 165.694 208.081 164.743 206.908 164.743 c 205.734 164.743 204.783 165.694 204.783 166.868 c b 204.783 167.435 m 204.783 168.609 205.734 169.56 206.908 169.56 c 208.081 169.56 209.033 168.609 209.033 167.435 c 209.033 166.261 208.081 165.31 206.908 165.31 c 205.734 165.31 204.783 166.261 204.783 167.435 c b 204.783 168.002 m 204.783 169.175 205.734 170.127 206.908 170.127 c 208.081 170.127 209.033 169.175 209.033 168.002 c 209.033 166.828 208.081 165.877 206.908 165.877 c 205.734 165.877 204.783 166.828 204.783 168.002 c b 204.783 168.569 m 204.783 169.742 205.734 170.694 206.908 170.694 c 208.081 170.694 209.033 169.742 209.033 168.569 c 209.033 167.395 208.081 166.444 206.908 166.444 c 205.734 166.444 204.783 167.395 204.783 168.569 c b 204.783 169.136 m 204.783 170.309 205.734 171.261 206.908 171.261 c 208.081 171.261 209.033 170.309 209.033 169.136 c 209.033 167.962 208.081 167.011 206.908 167.011 c 205.734 167.011 204.783 167.962 204.783 169.136 c b 204.783 169.702 m 204.783 170.876 205.734 171.828 206.908 171.828 c 208.081 171.828 209.033 170.876 209.033 169.702 c 209.033 168.529 208.081 167.577 206.908 167.577 c 205.734 167.577 204.783 168.529 204.783 169.702 c b 204.783 170.269 m 204.783 171.443 205.734 172.394 206.908 172.394 c 208.081 172.394 209.033 171.443 209.033 170.269 c 209.033 169.096 208.081 168.144 206.908 168.144 c 205.734 168.144 204.783 169.096 204.783 170.269 c b 204.783 170.836 m 204.783 172.01 205.734 172.961 206.908 172.961 c 208.081 172.961 209.033 172.01 209.033 170.836 c 209.033 169.663 208.081 168.711 206.908 168.711 c 205.734 168.711 204.783 169.663 204.783 170.836 c b 204.783 171.403 m 204.783 172.577 205.734 173.528 206.908 173.528 c 208.081 173.528 209.033 172.577 209.033 171.403 c 209.033 170.23 208.081 169.278 206.908 169.278 c 205.734 169.278 204.783 170.23 204.783 171.403 c b 204.783 175.903 m 204.783 177.077 205.734 178.028 206.908 178.028 c 208.081 178.028 209.033 177.077 209.033 175.903 c 209.033 174.73 208.081 173.778 206.908 173.778 c 205.734 173.778 204.783 174.73 204.783 175.903 c b 203.649 181.403 m 203.649 182.577 204.6 183.528 205.774 183.528 c 206.948 183.528 207.899 182.577 207.899 181.403 c 207.899 180.229 206.948 179.278 205.774 179.278 c 204.6 179.278 203.649 180.229 203.649 181.403 c b 207.149 181.403 m 207.149 182.577 208.1 183.528 209.274 183.528 c 210.448 183.528 211.399 182.577 211.399 181.403 c 211.399 180.229 210.448 179.278 209.274 179.278 c 208.1 179.278 207.149 180.229 207.149 181.403 c b 207.149 192.403 m 207.149 193.577 208.1 194.528 209.274 194.528 c 210.448 194.528 211.399 193.577 211.399 192.403 c 211.399 191.229 210.448 190.278 209.274 190.278 c 208.1 190.278 207.149 191.229 207.149 192.403 c b 203.748 192.403 m 203.748 193.577 204.699 194.528 205.873 194.528 c 207.046 194.528 207.998 193.577 207.998 192.403 c 207.998 191.229 207.046 190.278 205.873 190.278 c 204.699 190.278 203.748 191.229 203.748 192.403 c b 204.783 239.653 m 204.783 240.827 205.734 241.778 206.908 241.778 c 208.081 241.778 209.033 240.827 209.033 239.653 c 209.033 238.479 208.081 237.528 206.908 237.528 c 205.734 237.528 204.783 238.479 204.783 239.653 c b 204.783 286.153 m 204.783 287.326 205.734 288.277 206.908 288.277 c 208.081 288.277 209.033 287.326 209.033 286.153 c 209.033 284.979 208.081 284.028 206.908 284.028 c 205.734 284.028 204.783 284.979 204.783 286.153 c b BT 10 0 0 10 82.159 285.083 Tm 0 0 0 1 k /GS4 gs (50000)Tj 0 -2.625 TD (40000)Tj 0 -2.55 TD (30000)Tj 0 -2.525 TD (20000)Tj 0 -2.6 TD (10000)Tj 0 10 -10 0 76.183 206.809 Tm (IL-8 pg\341mL)Tj 0 8 -8 0 73.348 246.009 Tm (-1)Tj 10 0 0 10 63.357 289.533 Tm (a\))Tj 13.2315 -14.5038 TD (ARDS)Tj ET 3.864 M /GS3 gs 212.38 162.457 m 218.852 162.457 l 152.908 292.9 m 206.929 292.9 l 152.768 293.156 m 152.768 290.672 l 206.783 293.156 m 206.783 290.672 l S BT /F18 1 Tf 10 0 0 10 173.091 293.566 Tm /GS4 gs (***)Tj ET 0 0 0 0 k 3.864 M /GS3 gs 509.876 180.629 m 509.876 181.803 510.828 182.754 512.001 182.754 c 513.175 182.754 514.126 181.803 514.126 180.629 c 514.126 179.456 513.175 178.504 512.001 178.504 c 510.828 178.504 509.876 179.456 509.876 180.629 c b 509.876 184.597 m 509.876 185.771 510.828 186.722 512.001 186.722 c 513.175 186.722 514.126 185.771 514.126 184.597 c 514.126 183.424 513.175 182.472 512.001 182.472 c 510.828 182.472 509.876 183.424 509.876 184.597 c b 509.876 183.464 m 509.876 184.637 510.828 185.589 512.001 185.589 c 513.175 185.589 514.126 184.637 514.126 183.464 c 514.126 182.29 513.175 181.339 512.001 181.339 c 510.828 181.339 509.876 182.29 509.876 183.464 c b 509.876 172.732 m 509.876 173.906 510.828 174.857 512.001 174.857 c 513.175 174.857 514.126 173.906 514.126 172.732 c 514.126 171.559 513.175 170.607 512.001 170.607 c 510.828 170.607 509.876 171.559 509.876 172.732 c b 509.876 172.732 m 509.876 173.906 510.828 174.857 512.001 174.857 c 513.175 174.857 514.126 173.906 514.126 172.732 c 514.126 171.559 513.175 170.607 512.001 170.607 c 510.828 170.607 509.876 171.559 509.876 172.732 c b 509.876 173.299 m 509.876 174.473 510.828 175.424 512.001 175.424 c 513.175 175.424 514.126 174.473 514.126 173.299 c 514.126 172.126 513.175 171.174 512.001 171.174 c 510.828 171.174 509.876 172.126 509.876 173.299 c b 3.864 M 417.959 248.222 m 417.959 161.326 l 418.223 248.052 m 415.482 248.052 l 418.223 213.533 m 415.482 213.533 l 418.223 195.874 m 415.482 195.874 l 418.223 161.57 m 415.482 161.57 l S BT /F16 1 Tf 10 0 0 10 408.852 158.033 Tm 0 0 0 1 k /GS4 gs (0)Tj ET /GS3 gs 417.733 156.52 m 531.903 156.52 l 417.889 156.659 m 417.889 154.838 l S BT 0 10 -10 0 402.037 173.224 Tm /GS4 gs (GM-CSF pg\341mL)Tj 0 8 -8 0 399.203 230.634 Tm (-1)Tj 10 0 0 10 386.04 250.213 Tm (c\))Tj ET /GS3 gs 418.223 230.792 m 415.482 230.792 l 418.223 178.198 m 415.482 178.198 l S BT 10 0 0 10 408.852 174.299 Tm /GS4 gs (2)Tj 0 1.7833 TD (4)Tj 0 1.7894 TD (6)Tj 0 1.6848 TD (8)Tj -0.4374 1.7261 TD (10)Tj ET /GS3 gs 460.041 156.659 m 460.041 154.838 l S BT 10 0 0 10 447.266 144.495 Tm /GS4 gs (Control)Tj ET /GS3 gs 511.827 156.659 m 511.827 154.838 l S 0 0 0 0 k 3.864 M 509.876 161.199 m 509.876 162.373 510.828 163.324 512.001 163.324 c 513.175 163.324 514.126 162.373 514.126 161.199 c 514.126 160.026 513.175 159.074 512.001 159.074 c 510.828 159.074 509.876 160.026 509.876 161.199 c b BT 10 0 0 10 500.766 144.495 Tm 0 0 0 1 k /GS4 gs (ARDS)Tj ET 0 0 0 0 k /GS3 gs 447.973 165.168 m 447.973 166.341 448.924 167.293 450.098 167.293 c 451.271 167.293 452.223 166.341 452.223 165.168 c 452.223 163.994 451.271 163.043 450.098 163.043 c 448.924 163.043 447.973 163.994 447.973 165.168 c b 451.394 168.591 m 451.394 169.765 452.346 170.716 453.519 170.716 c 454.693 170.716 455.644 169.765 455.644 168.591 c 455.644 167.418 454.693 166.466 453.519 166.466 c 452.346 166.466 451.394 167.418 451.394 168.591 c b 454.894 165.168 m 454.894 166.341 455.846 167.293 457.019 167.293 c 458.193 167.293 459.144 166.341 459.144 165.168 c 459.144 163.994 458.193 163.043 457.019 163.043 c 455.846 163.043 454.894 163.994 454.894 165.168 c b 457.894 166.858 m 457.894 168.032 458.846 168.983 460.019 168.983 c 461.193 168.983 462.144 168.032 462.144 166.858 c 462.144 165.685 461.193 164.734 460.019 164.734 c 458.846 164.734 457.894 165.685 457.894 166.858 c b 461.394 165.168 m 461.394 166.341 462.346 167.293 463.519 167.293 c 464.693 167.293 465.644 166.341 465.644 165.168 c 465.644 163.994 464.693 163.043 463.519 163.043 c 462.346 163.043 461.394 163.994 461.394 165.168 c b 464.394 166.168 m 464.394 167.341 465.346 168.292 466.519 168.292 c 467.693 168.292 468.644 167.341 468.644 166.168 c 468.644 164.994 467.693 164.043 466.519 164.043 c 465.346 164.043 464.394 164.994 464.394 166.168 c b 468.144 165.168 m 468.144 166.341 469.096 167.293 470.269 167.293 c 471.443 167.293 472.394 166.341 472.394 165.168 c 472.394 163.994 471.443 163.043 470.269 163.043 c 469.096 163.043 468.144 163.994 468.144 165.168 c b 509.876 162.278 m 509.876 163.451 510.828 164.403 512.001 164.403 c 513.175 164.403 514.126 163.451 514.126 162.278 c 514.126 161.104 513.175 160.153 512.001 160.153 c 510.828 160.153 509.876 161.104 509.876 162.278 c b 509.876 165.064 m 509.876 166.238 510.828 167.189 512.001 167.189 c 513.175 167.189 514.126 166.238 514.126 165.064 c 514.126 163.891 513.175 162.939 512.001 162.939 c 510.828 162.939 509.876 163.891 509.876 165.064 c b 511.944 165.963 m 511.944 167.137 512.895 168.088 514.069 168.088 c 515.242 168.088 516.194 167.137 516.194 165.963 c 516.194 164.79 515.242 163.838 514.069 163.838 c 512.895 163.838 511.944 164.79 511.944 165.963 c b 509.876 167.401 m 509.876 168.575 510.828 169.526 512.001 169.526 c 513.175 169.526 514.126 168.575 514.126 167.401 c 514.126 166.228 513.175 165.277 512.001 165.277 c 510.828 165.277 509.876 166.228 509.876 167.401 c b 513.292 171.716 m 513.292 172.89 514.244 173.841 515.417 173.841 c 516.591 173.841 517.542 172.89 517.542 171.716 c 517.542 170.542 516.591 169.591 515.417 169.591 c 514.244 169.591 513.292 170.542 513.292 171.716 c b 512.123 171.806 m 512.123 172.98 513.075 173.931 514.249 173.931 c 515.422 173.931 516.373 172.98 516.373 171.806 c 516.373 170.632 515.422 169.681 514.249 169.681 c 513.075 169.681 512.123 170.632 512.123 171.806 c b 509.876 172.165 m 509.876 173.339 510.828 174.29 512.001 174.29 c 513.175 174.29 514.126 173.339 514.126 172.165 c 514.126 170.992 513.175 170.04 512.001 170.04 c 510.828 170.04 509.876 170.992 509.876 172.165 c b 509.876 174.323 m 509.876 175.496 510.828 176.448 512.001 176.448 c 513.175 176.448 514.126 175.496 514.126 174.323 c 514.126 173.149 513.175 172.198 512.001 172.198 c 510.828 172.198 509.876 173.149 509.876 174.323 c b 509.876 175.491 m 509.876 176.665 510.828 177.616 512.001 177.616 c 513.175 177.616 514.126 176.665 514.126 175.491 c 514.126 174.318 513.175 173.366 512.001 173.366 c 510.828 173.366 509.876 174.318 509.876 175.491 c b 509.876 177.019 m 509.876 178.193 510.828 179.144 512.001 179.144 c 513.175 179.144 514.126 178.193 514.126 177.019 c 514.126 175.846 513.175 174.894 512.001 174.894 c 510.828 174.894 509.876 175.846 509.876 177.019 c b 509.876 177.649 m 509.876 178.822 510.828 179.774 512.001 179.774 c 513.175 179.774 514.126 178.822 514.126 177.649 c 514.126 176.475 513.175 175.523 512.001 175.523 c 510.828 175.523 509.876 176.475 509.876 177.649 c b 509.876 182.33 m 509.876 183.503 510.828 184.455 512.001 184.455 c 513.175 184.455 514.126 183.503 514.126 182.33 c 514.126 181.156 513.175 180.205 512.001 180.205 c 510.828 180.205 509.876 181.156 509.876 182.33 c b 509.876 181.196 m 509.876 182.37 510.828 183.321 512.001 183.321 c 513.175 183.321 514.126 182.37 514.126 181.196 c 514.126 180.022 513.175 179.071 512.001 179.071 c 510.828 179.071 509.876 180.022 509.876 181.196 c b 509.876 189.002 m 509.876 190.176 510.828 191.127 512.001 191.127 c 513.175 191.127 514.126 190.176 514.126 189.002 c 514.126 187.828 513.175 186.877 512.001 186.877 c 510.828 186.877 509.876 187.828 509.876 189.002 c b 509.876 192.328 m 509.876 193.501 510.828 194.453 512.001 194.453 c 513.175 194.453 514.126 193.501 514.126 192.328 c 514.126 191.154 513.175 190.203 512.001 190.203 c 510.828 190.203 509.876 191.154 509.876 192.328 c b 509.876 193.946 m 509.876 195.119 510.828 196.071 512.001 196.071 c 513.175 196.071 514.126 195.119 514.126 193.946 c 514.126 192.772 513.175 191.821 512.001 191.821 c 510.828 191.821 509.876 192.772 509.876 193.946 c b 509.876 197.451 m 509.876 198.625 510.828 199.576 512.001 199.576 c 513.175 199.576 514.126 198.625 514.126 197.451 c 514.126 196.278 513.175 195.326 512.001 195.326 c 510.828 195.326 509.876 196.278 509.876 197.451 c b 509.876 200.418 m 509.876 201.591 510.828 202.543 512.001 202.543 c 513.175 202.543 514.126 201.591 514.126 200.418 c 514.126 199.244 513.175 198.293 512.001 198.293 c 510.828 198.293 509.876 199.244 509.876 200.418 c b 509.876 207.339 m 509.876 208.513 510.828 209.464 512.001 209.464 c 513.175 209.464 514.126 208.513 514.126 207.339 c 514.126 206.165 513.175 205.214 512.001 205.214 c 510.828 205.214 509.876 206.165 509.876 207.339 c b 509.876 207.698 m 509.876 208.872 510.828 209.823 512.001 209.823 c 513.175 209.823 514.126 208.872 514.126 207.698 c 514.126 206.525 513.175 205.573 512.001 205.573 c 510.828 205.573 509.876 206.525 509.876 207.698 c b 509.876 214.08 m 509.876 215.254 510.828 216.206 512.001 216.206 c 513.175 216.206 514.126 215.254 514.126 214.08 c 514.126 212.907 513.175 211.955 512.001 211.955 c 510.828 211.955 509.876 212.907 509.876 214.08 c b 509.876 218.844 m 509.876 220.018 510.828 220.969 512.001 220.969 c 513.175 220.969 514.126 220.018 514.126 218.844 c 514.126 217.671 513.175 216.72 512.001 216.72 c 510.828 216.72 509.876 217.671 509.876 218.844 c b 509.876 236.103 m 509.876 237.276 510.828 238.228 512.001 238.228 c 513.175 238.228 514.126 237.276 514.126 236.103 c 514.126 234.929 513.175 233.978 512.001 233.978 c 510.828 233.978 509.876 234.929 509.876 236.103 c b 509.876 238.8 m 509.876 239.973 510.828 240.925 512.001 240.925 c 513.175 240.925 514.126 239.973 514.126 238.8 c 514.126 237.626 513.175 236.674 512.001 236.674 c 510.828 236.674 509.876 237.626 509.876 238.8 c b 3.864 M 460.04 251.4 m 511.621 251.4 l 459.9 251.656 m 459.9 249.172 l 511.403 251.656 m 511.403 249.172 l S BT /F18 1 Tf 10 0 0 10 480.223 252.066 Tm 0 0 0 1 k /GS4 gs (***)Tj ET /GS3 gs 520.13 179.561 m 526.572 179.561 l 268.661 269.718 m 268.661 161.326 l 268.925 269.448 m 266.183 269.448 l 268.925 250.824 m 266.183 250.824 l 268.925 232.869 m 266.183 232.869 l 268.925 196.611 m 266.183 196.611 l 268.925 161.57 m 266.183 161.57 l S BT /F16 1 Tf 10 0 0 10 259.554 158.033 Tm /GS4 gs (0)Tj ET /GS3 gs 268.435 156.52 m 378.604 156.52 l 268.591 156.659 m 268.591 154.838 l S BT 10 0 0 10 246.154 265.708 Tm /GS4 gs (2000)Tj 0 10 -10 0 241.379 193.809 Tm (G-CSF pg\341mL)Tj 0 8 -8 0 238.545 244.389 Tm (-1)Tj 10 0 0 10 229.054 269.533 Tm (b\))Tj 1.71 -2.2499 TD (1000)Tj 0.4607 -1.7919 TD (800)Tj ET /GS3 gs 268.925 214.834 m 266.183 214.834 l S BT 10 0 0 10 250.76 210.887 Tm /GS4 gs (600)Tj 0 -1.805 TD (400)Tj ET /GS3 gs 268.925 178.942 m 266.183 178.942 l S BT 10 0 0 10 250.76 175.36 Tm /GS4 gs (200)Tj ET /GS3 gs 308.475 156.659 m 308.475 154.838 l S BT 10 0 0 10 295.7 144.495 Tm /GS4 gs (Control)Tj ET 0 0 0 0 k 3.864 M /GS3 gs 296.407 160.632 m 296.407 161.806 297.358 162.757 298.532 162.757 c 299.705 162.757 300.657 161.806 300.657 160.632 c 300.657 159.459 299.705 158.507 298.532 158.507 c 297.358 158.507 296.407 159.459 296.407 160.632 c b 299.828 161.766 m 299.828 162.94 300.78 163.891 301.953 163.891 c 303.127 163.891 304.078 162.94 304.078 161.766 c 304.078 160.592 303.127 159.641 301.953 159.641 c 300.78 159.641 299.828 160.592 299.828 161.766 c b 303.328 160.632 m 303.328 161.806 304.28 162.757 305.453 162.757 c 306.627 162.757 307.578 161.806 307.578 160.632 c 307.578 159.459 306.627 158.507 305.453 158.507 c 304.28 158.507 303.328 159.459 303.328 160.632 c b 306.328 161.766 m 306.328 162.94 307.28 163.891 308.453 163.891 c 309.627 163.891 310.578 162.94 310.578 161.766 c 310.578 160.592 309.627 159.641 308.453 159.641 c 307.28 159.641 306.328 160.592 306.328 161.766 c b 309.828 160.632 m 309.828 161.806 310.78 162.757 311.953 162.757 c 313.127 162.757 314.078 161.806 314.078 160.632 c 314.078 159.459 313.127 158.507 311.953 158.507 c 310.78 158.507 309.828 159.459 309.828 160.632 c b 313.078 161.766 m 313.078 162.94 314.029 163.891 315.203 163.891 c 316.377 163.891 317.328 162.94 317.328 161.766 c 317.328 160.592 316.377 159.641 315.203 159.641 c 314.029 159.641 313.078 160.592 313.078 161.766 c b 3.864 M 359.694 156.659 m 359.694 154.838 l S 3.864 M 357.743 160.632 m 357.743 161.806 358.695 162.757 359.869 162.757 c 361.042 162.757 361.993 161.806 361.993 160.632 c 361.993 159.459 361.042 158.507 359.869 158.507 c 358.695 158.507 357.743 159.459 357.743 160.632 c b BT 10 0 0 10 348.633 144.495 Tm 0 0 0 1 k /GS4 gs (ARDS)Tj ET 0 0 0 0 k /GS3 gs 357.743 161.278 m 357.743 162.452 358.695 163.403 359.869 163.403 c 361.042 163.403 361.993 162.452 361.993 161.278 c 361.993 160.105 361.042 159.153 359.869 159.153 c 358.695 159.153 357.743 160.105 357.743 161.278 c b 357.743 161.924 m 357.743 163.098 358.695 164.049 359.869 164.049 c 361.042 164.049 361.993 163.098 361.993 161.924 c 361.993 160.751 361.042 159.799 359.869 159.799 c 358.695 159.799 357.743 160.751 357.743 161.924 c b 357.743 162.57 m 357.743 163.744 358.695 164.695 359.869 164.695 c 361.042 164.695 361.993 163.744 361.993 162.57 c 361.993 161.397 361.042 160.445 359.869 160.445 c 358.695 160.445 357.743 161.397 357.743 162.57 c b 357.743 163.216 m 357.743 164.39 358.695 165.341 359.869 165.341 c 361.042 165.341 361.993 164.39 361.993 163.216 c 361.993 162.043 361.042 161.091 359.869 161.091 c 358.695 161.091 357.743 162.043 357.743 163.216 c b 357.743 163.862 m 357.743 165.036 358.695 165.987 359.869 165.987 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[(pati)-8.2(ents)-337.1(also)-331.4(have)-333.9(incre)-8.6(ased)-335.1(concent)-8.9(rations)-337.7(of)-333.2(G-CSF)-336.8(in)]TJ 0 -1.0641 TD [(BAL)-9.4(,)-364.6(which)-369(correlate)-374.9(close)-8.2(ly)-362.4(with)-370.2(the)-369.3(levels)-369.8(of)-367.3(neutro-)]TJ 0 -1.0698 TD [(phil)-7.8(s)-417.4(and)-423.8(IL-8.)-426.1(Moreo)-7.8(ver)29.9(,)-421.5(the)-420.5(level)-9.4(s)-417.4(o)0(f)-424.2(G-CSF)-427.9(were)-424.8(a)]TJ T* [(stro)-8.2(nger)-460.3(predi)-8.2(ctor)-457(of)-458.4(poor)-459.9(ou)-7.2(tcome)-459.7(than)-461.1(that)-463.5(of)-458.4(either)]TJ T* [(neu)-8.4(trophils)-323.3(or)-321.8(IL-8.)-323.7(This)-323.7(provi)-7.8(des)-322.6(the)-318.1(firs)-9.8(t)-316.1(direc)-8.6(t)]TJ /F4 1 Tf 20.0649 0 TD [(in)-316.9(vivo)]TJ /F3 1 Tf -20.0649 -1.0641 TD [(eviden)-7.8(ce)-395(in)-396.6(patients)-402.2(with)-398.7(ARDS)-396.1(that)-400.9(this)-396(factor)23.2(,)-393(which)]TJ 0 -1.0698 TD [(has)-356.7(the)-357.9(ability)-362.4(to)-351(prolo)-7.8(ng)-354.3(the)-352.2(survi)-9(val)-352.2(of)-355.9(neutr)-8.2(ophils)-357.7(by)]TJ T* [(delayi)-10.1(ng)-530.8(apoptosis)-537.9([12],)-530.2(may)-529.4(also)-536.3(play)-529.4(a)-530.4(role)-531(in)-527.4(the)]TJ 0 -1.0641 TD [(pathog)-7.4(enesi)-8.2(s)-332(o)0(f)-338.9(ARDS.)]TJ 1.0015 -1.0528 TD [(Th)17.1(er)13.5(e)-319.8(h)0(a)20.8(s)-320.6(be)15.1(en)-309.2(on)15.5(e)-319.8(p)0(r)19.6(e)0(v)15.1(i)0(o)18.8(u)0(s)-310(s)0(t)17.7(u)0(d)15.5(y)-319.4(of)-310.4(G-)15.7(CS)17.3(F)-318.7(l)0(e)12.8(v)0(e)20.8(l)0(s)-312.4(i)0(n)]TJ -1.0015 -1.0641 TD [(BA)12.6(L)-323.6(f)0(l)17.3(u)0(i)18.9(d)-325.1(fr)18(om)-312(pa)15.1(ti)16.5(en)20.8(ts)-318.1(wi)20.6(th)-316.9(AR)18.3(DS)-317.7([1)48.1(1].)-322.2(The)-6.8(y)-330.8(wer)-8.2(e)-331.2(o)0(n)]TJ 0 -1.0698 TD [(ave)-8.8(rage)-369.7(10)-7.2(-fold)-373.6(higher)-378.8(than)-370(those)-377.7(in)-373.8(BAL)-373.6(from)-379.3(normal)]TJ T* [(volunt)-9.3(eers)-535.9(\(median)-536.8(\(range)-8.6(\))-531.6(238)-531.5(pg)]TJ /F11 1 Tf 14.8523 0.1992 TD (.)Tj /F3 1 Tf 0.2675 -0.1992 TD (mL)Tj 7.472 0 0 6.641 473.669 138.217 Tm (-1)Tj 9.963 0 0 9.963 485.121 133.795 Tm [(\(19.5\2615,)-6.9(241\))]TJ /F4 1 Tf -17.6464 -1.0641 TD (versus)Tj /F3 1 Tf 2.9989 0 TD (mean\213)Tj 6.974 0 0 6.974 366.009 123.194 Tm 0.0001 Tc (SEM)Tj 9.963 0 0 9.963 384.831 123.194 Tm 0 Tc [(25\213)-6.8(20)-462.5(pg)]TJ /F11 1 Tf 4.0118 0.1992 TD (.)Tj /F3 1 Tf 0.2675 -0.1992 TD (mL)Tj 7.472 0 0 6.641 441.184 127.616 Tm (-1)Tj 9.963 0 0 9.963 447.364 123.194 Tm [(\),)-463.7(but)-459.9(wer)-8.2(e)-456.4(meas)-8.2(ured)]TJ -13.8565 -1.0698 TD [(only)-557.4(on)-553.5(the)-557.1(first)-559.2(day)-554.7(after)-556.5(onset)-559.8(of)-555.1(ARDS,)-555.8(and)-554.7(the)]TJ ET 1 i 58.28 749.367 227.168 -0.51 re f 58.28 732.926 227.168 -0.51 re f 58.28 621.864 227.168 -0.51 re f BT /F2 1 Tf 8.966 0 0 8.966 58.28 772.667 Tm [(Table)-331.9(2.)-336.7(\261)-333.2(Bronchoalveolar)-321(lavage)-323.9(\(BAL\))-320.5(findings)-324.4(in)-323.9(non-)]TJ 0 -1.0559 TD [(survivors)-267.2(compared)-265.4(with)-266.9(survivors)-267.2(in)-266.9(the)-265.2(acute)-262.8(respiratory)]TJ T* [(distress)-332.3(syndrome)-336.4(group)-329.5(at)-336.7(initial)-335.3(lavage)]TJ /F3 1 Tf 0 -1.7072 TD [(BAL)-332.4(marker)-3673.9(Nonsurvivors)-2065.1(Survivors)-1947(p-value)]TJ 0 -2.0044 TD [(Patients)-337.5(n)-7270.9(9)-5949.4(22)]TJ 0 -1.0559 TD [(Neutrophils)-335.5(%)-4527.2(91.27)]TJ 8.6624 -1.0559 TD (\(32.85\26194.90\))Tj 8.3905 1.0559 TD (43.72)Tj -1.7009 -1.0559 TD (\(14.01\26198.40\))Tj 6.276 0 0 6.276 265.323 710.986 Tm 0.0001 Tc (NS)Tj 8.966 0 0 8.966 58.28 692.05 Tm 0 Tc (Neutrophils)Tj /F9 1 Tf 0.3351 -1.0496 TD (3)Tj /F3 1 Tf 0.8283 0 TD (10)Tj 6.725 0 0 5.977 77.726 686.608 Tm (4)Tj 8.966 0 0 8.966 84.076 682.639 Tm (cells)Tj /F11 1 Tf 1.802 0.2213 TD (.)Tj /F3 1 Tf 0.2656 -0.2213 TD (mL)Tj 6.725 0 0 5.977 114.973 686.608 Tm (-1)Tj 8.966 0 0 8.966 151.143 692.05 Tm (24.96)Tj -1.6945 -1.0496 TD (\(4.93\261203.45\))Tj 8.3905 1.0496 TD (10.86)Tj -1.7009 -1.0496 TD (\(0.82\261141.30\))Tj 6.276 0 0 6.276 265.323 692.05 Tm 0.0001 Tc (NS)Tj 8.966 0 0 8.966 58.28 673.171 Tm 0 Tc [(IL-8)-332.2(pg)]TJ /F11 1 Tf 3.0856 0.2213 TD (.)Tj /F3 1 Tf 0.2656 -0.2213 TD (mL)Tj 6.725 0 0 5.977 100.687 677.14 Tm (-1)Tj 8.966 0 0 8.966 146.665 673.171 Tm (2617.60)Tj -0.9484 -1.0559 TD (\(133\26112352\))Tj 7.657 1.0559 TD [(1)32.1(170.00)]TJ -0.4616 -1.0559 TD (\(1\26149631\))Tj 6.276 0 0 6.276 265.323 673.171 Tm 0.0001 Tc (NS)Tj 8.966 0 0 8.966 58.28 654.236 Tm 0 Tc [(G-CSF)-332.4(pg)]TJ /F11 1 Tf 4.1478 0.2213 TD (.)Tj /F3 1 Tf 0.2656 -0.2213 TD (mL)Tj 6.725 0 0 5.977 110.211 658.205 Tm (-1)Tj 8.966 0 0 8.966 154.488 654.236 Tm (457)Tj -1.6945 -1.0559 TD (\(4.34\2611000\))Tj 8.6434 1.0559 TD (80)Tj -1.0749 -1.0559 TD (\(0\261866\))Tj 5.7728 1.0559 TD (<0.05)Tj -22.3768 -2.1119 TD [(GM-CSF)-332.6(pg)]TJ /F11 1 Tf 5.033 0.2213 TD (.)Tj /F3 1 Tf 0.2656 -0.2213 TD (mL)Tj 6.725 0 0 5.977 118.148 639.269 Tm (-1)Tj 8.966 0 0 8.966 153.411 635.301 Tm (2.63)Tj -1.4479 -1.0559 TD (\(0.49\2618.90\))Tj 8.1376 1.0559 TD (1.87)Tj -0.822 -1.0559 TD (\(0\2618.60\))Tj 6.276 0 0 6.276 265.323 635.301 Tm 0.0001 Tc (NS)Tj 8.966 0 0 8.966 58.28 608.371 Tm 0 Tc [(Data)-401.5(are)-403.7(presented)-403.9(as)-404.6(median)-405.4(\(range\).)-400.1(IL-8:)-403.6(interleukin-8;)-410.9(G-)]TJ T* [(CSF:)-406.9(granulocyte)-410.4(colony-stimulating)-407(factor;)-413.7(GM-CSF:)-404(granu-)]TJ T* [(locyte-macrophage)-340(colony-stimulating)-337.5(factor)49.8(.)]TJ ET 58.28 221.272 227.168 -0.51 re f 139.408 196.838 66.671 -0.283 re f 216.113 196.838 69.335 -0.283 re f 58.28 180.397 227.168 -0.454 re f 58.28 145.077 227.168 -0.51 re f BT /F2 1 Tf 8.966 0 0 8.966 58.28 235.105 Tm [(Table)-331.9(3.)-336.7(\261)-333.2(Correlation)-532.2(between)-527.8(levels)-532.8(of)-532.7(cytokines)-530.1(and)]TJ T* [(neutrophils)-335.2(in)-330.2(the)-334.8(31)-331.3(patients)-337.2(at)-330.4(initial)-335.3(lavage)]TJ /F3 1 Tf 10.4265 -1.7072 TD (Neutrophils)Tj 1.9285 -1.0559 TD (%)Tj 6.7782 1.0559 TD (Neutrophils)Tj /F9 1 Tf -0.9674 -1.0559 TD (3)Tj /F3 1 Tf 0.8346 0 TD (10)Tj 6.725 0 0 5.977 237.6 204.831 Tm (4)Tj 8.966 0 0 8.966 243.95 200.863 Tm (cells)Tj /F11 1 Tf 1.802 0.2213 TD (.)Tj /F3 1 Tf 0.2719 -0.2213 TD (mL)Tj 6.725 0 0 5.977 274.847 204.831 Tm (-1)Tj 8.966 0 0 8.966 146.665 185.896 Tm (r)Tj 7.173 0 0 7.173 149.556 185.896 Tm (S)Tj 8.966 0 0 8.966 175.124 185.896 Tm [(p-value)-2572.8(r)]TJ 7.173 0 0 7.173 227.679 185.896 Tm (S)Tj 8.966 0 0 8.966 254.608 185.896 Tm (p-value)Tj -21.8962 -1.998 TD [(IL-8)-332.2(pg)]TJ /F11 1 Tf 3.0856 0.2213 TD (.)Tj /F3 1 Tf 0.2656 -0.2213 TD (mL)Tj 6.725 0 0 5.977 100.687 171.95 Tm (-1)Tj 8.966 0 0 8.966 142.242 167.981 Tm (0.62)Tj /F8 1 Tf 3.7495 0 TD (<)Tj /F3 1 Tf 0.5564 0 TD [(0.001)-2157(0.43)]TJ /F8 1 Tf 8.3083 0 TD (<)Tj /F3 1 Tf 0.5501 0 TD (0.025)Tj -22.5285 -1.0559 TD [(G-CSF)-332.4(pg)]TJ /F11 1 Tf 4.1478 0.2213 TD (.)Tj /F3 1 Tf 0.2656 -0.2213 TD (mL)Tj 6.725 0 0 5.977 110.211 162.482 Tm (-1)Tj 8.966 0 0 8.966 142.242 158.513 Tm (0.54)Tj /F8 1 Tf 3.5029 0 TD (<)Tj /F3 1 Tf 0.5501 0 TD [(0.0025)-1909.9(0.42)]TJ /F8 1 Tf 8.5612 0 TD (<)Tj /F3 1 Tf 0.5501 0 TD (0.025)Tj -22.5285 -1.0559 TD [(GM-CSF)-332.6(pg)]TJ /F11 1 Tf 5.033 0.2213 TD (.)Tj /F3 1 Tf 0.2656 -0.2213 TD (mL)Tj 6.725 0 0 5.977 118.148 153.014 Tm (-1)Tj 8.966 0 0 8.966 142.242 149.046 Tm (0.22)Tj 6.276 0 0 6.276 184.479 149.046 Tm 0.0001 Tc (NS)Tj 8.966 0 0 8.966 220.365 149.046 Tm 0 Tc (0.23)Tj 6.276 0 0 6.276 263.905 149.046 Tm 0.0001 Tc (NS)Tj 8.966 0 0 8.966 58.28 131.584 Tm 0 Tc [(IL-8:)-675.5(interleukin-8;)-682.8(G-CSF:)-682(granulocyte)-676(colony-stimulating)]TJ 0 -1.0559 TD [(factor;)-495.9(GM-CSF:)-498.8(granulocyte-macrophage)-502.5(colony-stimulating)]TJ T* [(factor)49.8(.)]TJ ET 0 0 0 1 K 0 J 0 j 0.5 w 3.864 M []0 d /GS3 gs 348.264 639.015 m 532.423 639.015 l 348.603 490.75 m 532.923 490.75 l 360.797 490.925 m 360.797 488.632 l S 0 0 0 0 k 3.864 M 355.468 494.529 m 355.468 495.702 356.419 496.654 357.592 496.654 c 358.766 496.654 359.717 495.702 359.717 494.529 c 359.717 493.355 358.766 492.404 357.592 492.404 c 356.419 492.404 355.468 493.355 355.468 494.529 c b 355.836 494.529 m 355.836 495.702 356.787 496.654 357.961 496.654 c 359.135 496.654 360.086 495.702 360.086 494.529 c 360.086 493.355 359.135 492.404 357.961 492.404 c 356.787 492.404 355.836 493.355 355.836 494.529 c b 356.573 494.529 m 356.573 495.702 357.524 496.654 358.698 496.654 c 359.872 496.654 360.823 495.702 360.823 494.529 c 360.823 493.355 359.872 492.404 358.698 492.404 c 357.524 492.404 356.573 493.355 356.573 494.529 c b 356.205 494.529 m 356.205 495.702 357.156 496.654 358.329 496.654 c 359.503 496.654 360.455 495.702 360.455 494.529 c 360.455 493.355 359.503 492.404 358.329 492.404 c 357.156 492.404 356.205 493.355 356.205 494.529 c b 356.942 494.529 m 356.942 495.702 357.893 496.654 359.066 496.654 c 360.24 496.654 361.191 495.702 361.191 494.529 c 361.191 493.355 360.24 492.404 359.066 492.404 c 357.893 492.404 356.942 493.355 356.942 494.529 c b 357.678 494.529 m 357.678 495.702 358.63 496.654 359.803 496.654 c 360.977 496.654 361.928 495.702 361.928 494.529 c 361.928 493.355 360.977 492.404 359.803 492.404 c 358.63 492.404 357.678 493.355 357.678 494.529 c b 358.047 494.529 m 358.047 495.702 358.998 496.654 360.172 496.654 c 361.346 496.654 362.297 495.702 362.297 494.529 c 362.297 493.355 361.346 492.404 360.172 492.404 c 358.998 492.404 358.047 493.355 358.047 494.529 c b 357.31 494.529 m 357.31 495.702 358.261 496.654 359.435 496.654 c 360.608 496.654 361.56 495.702 361.56 494.529 c 361.56 493.355 360.608 492.404 359.435 492.404 c 358.261 492.404 357.31 493.355 357.31 494.529 c b 358.415 494.529 m 358.415 495.702 359.367 496.654 360.54 496.654 c 361.714 496.654 362.665 495.702 362.665 494.529 c 362.665 493.355 361.714 492.404 360.54 492.404 c 359.367 492.404 358.415 493.355 358.415 494.529 c b 359.152 494.529 m 359.152 495.702 360.104 496.654 361.277 496.654 c 362.451 496.654 363.402 495.702 363.402 494.529 c 363.402 493.355 362.451 492.404 361.277 492.404 c 360.104 492.404 359.152 493.355 359.152 494.529 c b 358.784 494.529 m 358.784 495.702 359.735 496.654 360.909 496.654 c 362.082 496.654 363.034 495.702 363.034 494.529 c 363.034 493.355 362.082 492.404 360.909 492.404 c 359.735 492.404 358.784 493.355 358.784 494.529 c b 360.626 494.529 m 360.626 495.702 361.578 496.654 362.751 496.654 c 363.925 496.654 364.876 495.702 364.876 494.529 c 364.876 493.355 363.925 492.404 362.751 492.404 c 361.578 492.404 360.626 493.355 360.626 494.529 c b 360.258 494.529 m 360.258 495.702 361.209 496.654 362.383 496.654 c 363.556 496.654 364.508 495.702 364.508 494.529 c 364.508 493.355 363.556 492.404 362.383 492.404 c 361.209 492.404 360.258 493.355 360.258 494.529 c b 362.837 494.529 m 362.837 495.702 363.789 496.654 364.962 496.654 c 366.136 496.654 367.087 495.702 367.087 494.529 c 367.087 493.355 366.136 492.404 364.962 492.404 c 363.789 492.404 362.837 493.355 362.837 494.529 c b 361.363 494.529 m 361.363 495.702 362.315 496.654 363.488 496.654 c 364.662 496.654 365.613 495.702 365.613 494.529 c 365.613 493.355 364.662 492.404 363.488 492.404 c 362.315 492.404 361.363 493.355 361.363 494.529 c b 360.995 494.529 m 360.995 495.702 361.946 496.654 363.12 496.654 c 364.293 496.654 365.245 495.702 365.245 494.529 c 365.245 493.355 364.293 492.404 363.12 492.404 c 361.946 492.404 360.995 493.355 360.995 494.529 c b 361.732 494.529 m 361.732 495.702 362.683 496.654 363.857 496.654 c 365.03 496.654 365.982 495.702 365.982 494.529 c 365.982 493.355 365.03 492.404 363.857 492.404 c 362.683 492.404 361.732 493.355 361.732 494.529 c h 362.1 494.529 m 362.1 495.702 363.051 496.654 364.225 496.654 c 365.399 496.654 366.35 495.702 366.35 494.529 c 366.35 493.355 365.399 492.404 364.225 492.404 c 363.051 492.404 362.1 493.355 362.1 494.529 c h 359.889 494.529 m 359.889 495.702 360.841 496.654 362.014 496.654 c 363.188 496.654 364.139 495.702 364.139 494.529 c 364.139 493.355 363.188 492.404 362.014 492.404 c 360.841 492.404 359.889 493.355 359.889 494.529 c h 359.521 494.529 m 359.521 495.702 360.472 496.654 361.646 496.654 c 362.819 496.654 363.771 495.702 363.771 494.529 c 363.771 493.355 362.819 492.404 361.646 492.404 c 360.472 492.404 359.521 493.355 359.521 494.529 c h 362.469 494.529 m 362.469 495.702 363.42 496.654 364.594 496.654 c 365.767 496.654 366.719 495.702 366.719 494.529 c 366.719 493.355 365.767 492.404 364.594 492.404 c 363.42 492.404 362.469 493.355 362.469 494.529 c s BT /F16 1 Tf 10 0 0 10 347.69 478.6 Tm 0 0 0 1 k /GS4 gs (Control)Tj ET 3.864 M /GS3 gs 369.684 494.573 m 377.614 494.573 l 348.158 622.131 m 348.158 494.131 l 348.421 596.512 m 345.688 596.512 l 348.421 570.774 m 345.688 570.774 l 348.421 545.366 m 345.688 545.366 l 348.421 520.02 m 345.688 520.02 l 348.421 494.35 m 345.688 494.35 l 348.421 622.131 m 345.688 622.131 l S BT 10 0 0 10 330.472 618.465 Tm /GS4 gs (250)Tj 0 -2.575 TD (200)Tj T* (150)Tj 0 -2.525 TD (100)Tj 0.45 -2.525 TD (50)Tj 0.4535 -2.55 TD (0)Tj 0 10 -10 0 326.999 507.104 Tm (Neutrophils )Tj /F13 1 Tf 4.375 0 TD (\264)Tj /F16 1 Tf 0.549 0 TD (10)Tj 0 8 -8 0 324.164 565.463 Tm (4)Tj 0 10 -10 0 326.999 569.111 Tm ( cells\341mL)Tj 0 8 -8 0 324.164 601.461 Tm (-1)Tj 10 0 0 10 314.247 622.465 Tm (b\))Tj ET /GS3 gs 348.166 769.131 m 348.166 643.058 l 348.43 768.939 m 345.688 768.939 l 348.43 744.212 m 345.688 744.212 l 348.43 719.28 m 345.688 719.28 l 348.43 693.674 m 345.688 693.674 l 348.43 668.185 m 345.688 668.185 l 348.43 643.321 m 345.688 643.321 l S BT 10 0 0 10 339.471 639.465 Tm /GS4 gs (0)Tj -0.4542 2.4688 TD (20)Tj 0 2.5789 TD (40)Tj 0 2.5806 TD (60)Tj 0 2.4534 TD (80)Tj -0.4673 2.4826 TD (100)Tj -1.601 0.3856 TD (a\))Tj 0 10 -10 0 326.999 685.339 Tm (Neutrophils %)Tj ET 3.864 M /GS3 gs 361.598 644.131 m 361.598 645.305 362.55 646.256 363.723 646.256 c 364.897 646.256 365.848 645.305 365.848 644.131 c 365.848 642.958 364.897 642.006 363.723 642.006 c 362.55 642.006 361.598 642.958 361.598 644.131 c s 0 0 0 0 k 360.465 644.131 m 360.465 645.305 361.416 646.256 362.589 646.256 c 363.763 646.256 364.715 645.305 364.715 644.131 c 364.715 642.958 363.763 642.006 362.589 642.006 c 361.416 642.006 360.465 642.958 360.465 644.131 c b 359.898 644.698 m 359.898 645.872 360.849 646.823 362.023 646.823 c 363.196 646.823 364.148 645.872 364.148 644.698 c 364.148 643.525 363.196 642.573 362.023 642.573 c 360.849 642.573 359.898 643.525 359.898 644.698 c b 354.549 643.506 m 354.549 644.68 355.5 645.631 356.674 645.631 c 357.848 645.631 358.799 644.68 358.799 643.506 c 358.799 642.333 357.848 641.381 356.674 641.381 c 355.5 641.381 354.549 642.333 354.549 643.506 c b 359.174 647.756 m 359.174 648.93 360.125 649.881 361.299 649.881 c 362.473 649.881 363.424 648.93 363.424 647.756 c 363.424 646.583 362.473 645.631 361.299 645.631 c 360.125 645.631 359.174 646.583 359.174 647.756 c b 363.299 644.131 m 363.299 645.305 364.25 646.256 365.424 646.256 c 366.598 646.256 367.549 645.305 367.549 644.131 c 367.549 642.958 366.598 642.006 365.424 642.006 c 364.25 642.006 363.299 642.958 363.299 644.131 c b 362.732 644.698 m 362.732 645.872 363.684 646.823 364.857 646.823 c 366.031 646.823 366.982 645.872 366.982 644.698 c 366.982 643.525 366.031 642.573 364.857 642.573 c 363.684 642.573 362.732 643.525 362.732 644.698 c b 362.165 644.698 m 362.165 645.872 363.117 646.823 364.29 646.823 c 365.464 646.823 366.415 645.872 366.415 644.698 c 366.415 643.525 365.464 642.573 364.29 642.573 c 363.117 642.573 362.165 643.525 362.165 644.698 c b 361.598 644.698 m 361.598 645.872 362.55 646.823 363.723 646.823 c 364.897 646.823 365.848 645.872 365.848 644.698 c 365.848 643.525 364.897 642.573 363.723 642.573 c 362.55 642.573 361.598 643.525 361.598 644.698 c b 361.031 644.698 m 361.031 645.872 361.983 646.823 363.156 646.823 c 364.33 646.823 365.281 645.872 365.281 644.698 c 365.281 643.525 364.33 642.573 363.156 642.573 c 361.983 642.573 361.031 643.525 361.031 644.698 c b 360.465 644.698 m 360.465 645.872 361.416 646.823 362.589 646.823 c 363.763 646.823 364.715 645.872 364.715 644.698 c 364.715 643.525 363.763 642.573 362.589 642.573 c 361.416 642.573 360.465 643.525 360.465 644.698 c b 359.898 644.698 m 359.898 645.872 360.849 646.823 362.023 646.823 c 363.196 646.823 364.148 645.872 364.148 644.698 c 364.148 643.525 363.196 642.573 362.023 642.573 c 360.849 642.573 359.898 643.525 359.898 644.698 c b 359.331 644.698 m 359.331 645.872 360.282 646.823 361.456 646.823 c 362.629 646.823 363.581 645.872 363.581 644.698 c 363.581 643.525 362.629 642.573 361.456 642.573 c 360.282 642.573 359.331 643.525 359.331 644.698 c s 357.063 644.698 m 357.063 645.872 358.014 646.823 359.188 646.823 c 360.362 646.823 361.313 645.872 361.313 644.698 c 361.313 643.525 360.362 642.573 359.188 642.573 c 358.014 642.573 357.063 643.525 357.063 644.698 c b 357.063 644.131 m 357.063 645.305 358.014 646.256 359.188 646.256 c 360.362 646.256 361.313 645.305 361.313 644.131 c 361.313 642.958 360.362 642.006 359.188 642.006 c 358.014 642.006 357.063 642.958 357.063 644.131 c b 357.063 643.564 m 357.063 644.738 358.014 645.689 359.188 645.689 c 360.362 645.689 361.313 644.738 361.313 643.564 c 361.313 642.391 360.362 641.439 359.188 641.439 c 358.014 641.439 357.063 642.391 357.063 643.564 c b 357.063 642.997 m 357.063 644.171 358.014 645.123 359.188 645.123 c 360.362 645.123 361.313 644.171 361.313 642.997 c 361.313 641.824 360.362 640.872 359.188 640.872 c 358.014 640.872 357.063 641.824 357.063 642.997 c b 357.63 642.431 m 357.63 643.604 358.581 644.556 359.755 644.556 c 360.929 644.556 361.88 643.604 361.88 642.431 c 361.88 641.257 360.929 640.306 359.755 640.306 c 358.581 640.306 357.63 641.257 357.63 642.431 c b 358.197 642.431 m 358.197 643.604 359.148 644.556 360.322 644.556 c 361.496 644.556 362.447 643.604 362.447 642.431 c 362.447 641.257 361.496 640.306 360.322 640.306 c 359.148 640.306 358.197 641.257 358.197 642.431 c b 358.764 642.431 m 358.764 643.604 359.715 644.556 360.889 644.556 c 362.063 644.556 363.014 643.604 363.014 642.431 c 363.014 641.257 362.063 640.306 360.889 640.306 c 359.715 640.306 358.764 641.257 358.764 642.431 c b 359.898 642.431 m 359.898 643.604 360.849 644.556 362.023 644.556 c 363.196 644.556 364.148 643.604 364.148 642.431 c 364.148 641.257 363.196 640.306 362.023 640.306 c 360.849 640.306 359.898 641.257 359.898 642.431 c h 360.465 642.431 m 360.465 643.604 361.416 644.556 362.589 644.556 c 363.763 644.556 364.715 643.604 364.715 642.431 c 364.715 641.257 363.763 640.306 362.589 640.306 c 361.416 640.306 360.465 641.257 360.465 642.431 c h 361.031 642.431 m 361.031 643.604 361.983 644.556 363.156 644.556 c 364.33 644.556 365.281 643.604 365.281 642.431 c 365.281 641.257 364.33 640.306 363.156 640.306 c 361.983 640.306 361.031 641.257 361.031 642.431 c h 361.598 642.431 m 361.598 643.604 362.55 644.556 363.723 644.556 c 364.897 644.556 365.848 643.604 365.848 642.431 c 365.848 641.257 364.897 640.306 363.723 640.306 c 362.55 640.306 361.598 641.257 361.598 642.431 c h 361.598 642.997 m 361.598 644.171 362.55 645.123 363.723 645.123 c 364.897 645.123 365.848 644.171 365.848 642.997 c 365.848 641.824 364.897 640.872 363.723 640.872 c 362.55 640.872 361.598 641.824 361.598 642.997 c h 361.598 643.564 m 361.598 644.738 362.55 645.689 363.723 645.689 c 364.897 645.689 365.848 644.738 365.848 643.564 c 365.848 642.391 364.897 641.439 363.723 641.439 c 362.55 641.439 361.598 642.391 361.598 643.564 c s 3.864 M 360.924 639.224 m 360.924 636.483 l 369.684 643.333 m 377.614 643.333 l 455.56 490.925 m 455.56 488.632 l S 3.864 M 454.094 566.831 m 454.094 568.005 455.046 568.956 456.219 568.956 c 457.393 568.956 458.344 568.005 458.344 566.831 c 458.344 565.657 457.393 564.706 456.219 564.706 c 455.046 564.706 454.094 565.657 454.094 566.831 c b 454.094 531.581 m 454.094 532.755 455.046 533.706 456.219 533.706 c 457.393 533.706 458.344 532.755 458.344 531.581 c 458.344 530.407 457.393 529.456 456.219 529.456 c 455.046 529.456 454.094 530.407 454.094 531.581 c b 454.094 506.331 m 454.094 507.505 455.046 508.456 456.219 508.456 c 457.393 508.456 458.344 507.505 458.344 506.331 c 458.344 505.157 457.393 504.206 456.219 504.206 c 455.046 504.206 454.094 505.157 454.094 506.331 c b 454.094 494.017 m 454.094 495.19 455.046 496.142 456.219 496.142 c 457.393 496.142 458.344 495.19 458.344 494.017 c 458.344 492.843 457.393 491.892 456.219 491.892 c 455.046 491.892 454.094 492.843 454.094 494.017 c b 454.094 499.828 m 454.094 501.002 455.046 501.953 456.219 501.953 c 457.393 501.953 458.344 501.002 458.344 499.828 c 458.344 498.655 457.393 497.703 456.219 497.703 c 455.046 497.703 454.094 498.655 454.094 499.828 c b 454.094 498.998 m 454.094 500.172 455.046 501.123 456.219 501.123 c 457.393 501.123 458.344 500.172 458.344 498.998 c 458.344 497.825 457.393 496.873 456.219 496.873 c 455.046 496.873 454.094 497.825 454.094 498.998 c b 454.094 498.168 m 454.094 499.341 455.046 500.293 456.219 500.293 c 457.393 500.293 458.344 499.341 458.344 498.168 c 458.344 496.994 457.393 496.043 456.219 496.043 c 455.046 496.043 454.094 496.994 454.094 498.168 c b 454.094 497.338 m 454.094 498.511 455.046 499.463 456.219 499.463 c 457.393 499.463 458.344 498.511 458.344 497.338 c 458.344 496.164 457.393 495.213 456.219 495.213 c 455.046 495.213 454.094 496.164 454.094 497.338 c b 454.094 496.507 m 454.094 497.681 455.046 498.632 456.219 498.632 c 457.393 498.632 458.344 497.681 458.344 496.507 c 458.344 495.334 457.393 494.382 456.219 494.382 c 455.046 494.382 454.094 495.334 454.094 496.507 c b 454.094 495.677 m 454.094 496.851 455.046 497.802 456.219 497.802 c 457.393 497.802 458.344 496.851 458.344 495.677 c 458.344 494.504 457.393 493.552 456.219 493.552 c 455.046 493.552 454.094 494.504 454.094 495.677 c b 454.094 494.847 m 454.094 496.02 455.046 496.972 456.219 496.972 c 457.393 496.972 458.344 496.02 458.344 494.847 c 458.344 493.673 457.393 492.722 456.219 492.722 c 455.046 492.722 454.094 493.673 454.094 494.847 c b 3.864 M 461.263 497.65 m 468.399 497.65 l S BT 10 0 0 10 435.421 478.515 Tm 0 0 0 1 k /GS4 gs [(W)30(eeks 2\3203)]TJ ET /GS3 gs 387.22 475.632 m 530.219 475.632 l S BT 10 0 0 10 446.386 463.1 Tm /GS4 gs (ARDS)Tj ET 0 0 0 0 k 3.864 M /GS3 gs 506.141 499.101 m 506.141 500.274 507.092 501.226 508.266 501.226 c 509.439 501.226 510.391 500.274 510.391 499.101 c 510.391 497.927 509.439 496.976 508.266 496.976 c 507.092 496.976 506.141 497.927 506.141 499.101 c b 3.864 M 507.736 490.925 m 507.736 488.632 l S 3.864 M 506.141 500.331 m 506.141 501.505 507.092 502.456 508.266 502.456 c 509.439 502.456 510.391 501.505 510.391 500.331 c 510.391 499.158 509.439 498.206 508.266 498.206 c 507.092 498.206 506.141 499.158 506.141 500.331 c b 506.141 493.612 m 506.141 494.786 507.092 495.737 508.266 495.737 c 509.439 495.737 510.391 494.786 510.391 493.612 c 510.391 492.439 509.439 491.487 508.266 491.487 c 507.092 491.487 506.141 492.439 506.141 493.612 c b 506.141 494.179 m 506.141 495.353 507.092 496.304 508.266 496.304 c 509.439 496.304 510.391 495.353 510.391 494.179 c 510.391 493.005 509.439 492.054 508.266 492.054 c 507.092 492.054 506.141 493.005 506.141 494.179 c b 506.141 495.409 m 506.141 496.583 507.092 497.535 508.266 497.535 c 509.439 497.535 510.391 496.583 510.391 495.409 c 510.391 494.236 509.439 493.284 508.266 493.284 c 507.092 493.284 506.141 494.236 506.141 495.409 c b 506.141 496.64 m 506.141 497.813 507.092 498.765 508.266 498.765 c 509.439 498.765 510.391 497.813 510.391 496.64 c 510.391 495.466 509.439 494.515 508.266 494.515 c 507.092 494.515 506.141 495.466 506.141 496.64 c b 506.141 497.87 m 506.141 499.044 507.092 499.995 508.266 499.995 c 509.439 499.995 510.391 499.044 510.391 497.87 c 510.391 496.697 509.439 495.745 508.266 495.745 c 507.092 495.745 506.141 496.697 506.141 497.87 c b BT 10 0 0 10 487.284 478.6 Tm 0 0 0 1 k /GS4 gs [(W)30(eeks 4\3209)]TJ ET 3.864 M /GS3 gs 513.019 493.733 m 520.949 493.733 l 402.926 490.925 m 402.926 488.632 l S 0 0 0 0 k 3.864 M 401.095 494.163 m 401.095 495.336 402.046 496.288 403.22 496.288 c 404.393 496.288 405.345 495.336 405.345 494.163 c 405.345 492.989 404.393 492.038 403.22 492.038 c 402.046 492.038 401.095 492.989 401.095 494.163 c b 401.095 496.488 m 401.095 497.662 402.046 498.614 403.22 498.614 c 404.393 498.614 405.345 497.662 405.345 496.488 c 405.345 495.315 404.393 494.363 403.22 494.363 c 402.046 494.363 401.095 495.315 401.095 496.488 c b 401.095 501.14 m 401.095 502.314 402.046 503.265 403.22 503.265 c 404.393 503.265 405.345 502.314 405.345 501.14 c 405.345 499.967 404.393 499.015 403.22 499.015 c 402.046 499.015 401.095 499.967 401.095 501.14 c b 401.612 502.088 m 401.612 503.261 402.563 504.213 403.736 504.213 c 404.91 504.213 405.862 503.261 405.862 502.088 c 405.862 500.914 404.91 499.963 403.736 499.963 c 402.563 499.963 401.612 500.914 401.612 502.088 c b 400.836 503.369 m 400.836 504.542 401.788 505.494 402.961 505.494 c 404.135 505.494 405.086 504.542 405.086 503.369 c 405.086 502.195 404.135 501.243 402.961 501.243 c 401.788 501.243 400.836 502.195 400.836 503.369 c b 402.042 503.196 m 402.042 504.37 402.994 505.321 404.167 505.321 c 405.341 505.321 406.292 504.37 406.292 503.196 c 406.292 502.023 405.341 501.071 404.167 501.071 c 402.994 501.071 402.042 502.023 402.042 503.196 c b 401.095 505.178 m 401.095 506.351 402.046 507.303 403.22 507.303 c 404.393 507.303 405.345 506.351 405.345 505.178 c 405.345 504.004 404.393 503.053 403.22 503.053 c 402.046 503.053 401.095 504.004 401.095 505.178 c b 401.095 506.986 m 401.095 508.16 402.046 509.111 403.22 509.111 c 404.393 509.111 405.345 508.16 405.345 506.986 c 405.345 505.813 404.393 504.862 403.22 504.862 c 402.046 504.862 401.095 505.813 401.095 506.986 c b 401.095 509.129 m 401.095 510.302 402.046 511.254 403.22 511.254 c 404.393 511.254 405.345 510.302 405.345 509.129 c 405.345 507.955 404.393 507.004 403.22 507.004 c 402.046 507.004 401.095 507.955 401.095 509.129 c b 401.095 510.68 m 401.095 511.853 402.046 512.805 403.22 512.805 c 404.393 512.805 405.345 511.853 405.345 510.68 c 405.345 509.506 404.393 508.555 403.22 508.555 c 402.046 508.555 401.095 509.506 401.095 510.68 c b 401.095 512.402 m 401.095 513.576 402.046 514.527 403.22 514.527 c 404.393 514.527 405.345 513.576 405.345 512.402 c 405.345 511.229 404.393 510.277 403.22 510.277 c 402.046 510.277 401.095 511.229 401.095 512.402 c b 401.095 513.608 m 401.095 514.782 402.046 515.733 403.22 515.733 c 404.393 515.733 405.345 514.782 405.345 513.608 c 405.345 512.435 404.393 511.483 403.22 511.483 c 402.046 511.483 401.095 512.435 401.095 513.608 c b 401.095 515.331 m 401.095 516.505 402.046 517.456 403.22 517.456 c 404.393 517.456 405.345 516.505 405.345 515.331 c 405.345 514.157 404.393 513.206 403.22 513.206 c 402.046 513.206 401.095 514.157 401.095 515.331 c b 3.864 M 408.398 504.701 m 414.158 504.701 l S 3.864 M 401.095 538.331 m 401.095 539.505 402.046 540.456 403.22 540.456 c 404.393 540.456 405.345 539.505 405.345 538.331 c 405.345 537.157 404.393 536.206 403.22 536.206 c 402.046 536.206 401.095 537.157 401.095 538.331 c b 401.095 598.831 m 401.095 600.004 402.046 600.956 403.22 600.956 c 404.393 600.956 405.345 600.004 405.345 598.831 c 405.345 597.657 404.393 596.706 403.22 596.706 c 402.046 596.706 401.095 597.657 401.095 598.831 c b BT 10 0 0 10 389.305 478.6 Tm 0 0 0 1 k /GS4 gs [(W)30(eek 1)]TJ ET 0 0 0 0 k /GS3 gs 506.036 642.631 m 506.036 643.805 506.987 644.756 508.161 644.756 c 509.334 644.756 510.286 643.805 510.286 642.631 c 510.286 641.458 509.334 640.506 508.161 640.506 c 506.987 640.506 506.036 641.458 506.036 642.631 c b 506.036 659.631 m 506.036 660.805 506.987 661.756 508.161 661.756 c 509.334 661.756 510.286 660.805 510.286 659.631 c 510.286 658.458 509.334 657.506 508.161 657.506 c 506.987 657.506 506.036 658.458 506.036 659.631 c b 506.036 670.881 m 506.036 672.055 506.987 673.006 508.161 673.006 c 509.334 673.006 510.286 672.055 510.286 670.881 c 510.286 669.708 509.334 668.756 508.161 668.756 c 506.987 668.756 506.036 669.708 506.036 670.881 c b 506.036 672.756 m 506.036 673.93 506.987 674.881 508.161 674.881 c 509.334 674.881 510.286 673.93 510.286 672.756 c 510.286 671.583 509.334 670.631 508.161 670.631 c 506.987 670.631 506.036 671.583 506.036 672.756 c b 506.036 678.881 m 506.036 680.055 506.987 681.006 508.161 681.006 c 509.334 681.006 510.286 680.055 510.286 678.881 c 510.286 677.708 509.334 676.756 508.161 676.756 c 506.987 676.756 506.036 677.708 506.036 678.881 c b 506.036 683.631 m 506.036 684.805 506.987 685.756 508.161 685.756 c 509.334 685.756 510.286 684.805 510.286 683.631 c 510.286 682.458 509.334 681.506 508.161 681.506 c 506.987 681.506 506.036 682.458 506.036 683.631 c b 506.036 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[(ce)14.7(nt)18.9(ra)13.5(t)13.9(i)0(o)13.2(n)0(s)-236(o)0(f)-242.1(G)0(M)15.3(-)0(C)14.9(S)11.4(F)-250.4(i)0(n)-242.9(B)11.6(AL)-242.9(fl)17.3(ui)18.9(d)-251.2(a)0(n)15.1(d)-245.5(le)18.4(ve)15.1(ls)-238.4(of)-242.1(ne)15.1(ut)18.8(ro)19.6(-)]TJ 0 -1.0471 TD [(ph)15.5(il)16.5(s,)-281.2(no)15.5(r)-292.6(p)0(r)19.6(o)0(g)15.5(n)0(o)21.2(s)0(i)17.7(s)0(,)-281.2(w)0(a)11.2(s)-292.2(fo)19.6(un)21.2(d)-296.7(i)0(n)-282.7(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)-283.9(w)0(i)20.6(t)0(h)-288.4(A)12.4(RD)12.6(S)-290.2(i)0(n)]TJ 0 -1.0528 TD [(th)13.2(e)-325.5(p)0(r)19.6(e)0(s)13.9(e)0(n)20.8(t)-327.5(st)12(ud)21.2(y)73.2(.)-330.4(It)17.3(s)-326.3(r)0(o)13.9(l)13.9(e)-331.2(in)-316.9(th)18.9(e)-331.2(p)0(a)15.1(t)13.9(ho)15.5(ge)15.1(ne)20.8(si)17.7(s)-326.3(i)0(s)-323.8(t)0(h)18.9(e)0(r)19.2(e)0(f)13.5(o)0(r)19.6(e)]TJ 0 -1.0471 TD [(le)12.8(ss)-316.9(cl)18.5(ea)20.4(r)60.2(.)-324.7(Th)17.1(e)-325.5(i)0(n)13.2(c)0(r)19.2(e)0(a)14.7(s)0(e)19.6(s)-326.3(in)-316.9(GM)15.3(-C)14.9(S)11.4(F)-324.3(le)18.4(ve)15.1(ls)-318.1(in)-316.9(BA)18.3(L)-329.3(w)0(e)16.9(r)0(e)]TJ 0 -1.0527 TD [(mu)12.4(ch)-485.6(lo)18.9(we)16.9(r)-491.8(\()0(m)10.8(e)0(d)20.8(i)0(a)18.5(n)-495.8(\(r)18(an)15.1(ge)20.8(\))-497.4(2)0(.)21.6(2)-495.8(pg)]TJ /F11 1 Tf 15.0572 0.1992 TD (.)Tj /F3 1 Tf 0.2675 -0.1992 TD (mL)Tj 7.472 0 0 6.641 475.54 430.809 Tm (-1)Tj 9.963 0 0 9.963 486.482 426.387 Tm [(\(0)13.9(\2618)21.2(.9)15.9(\))-497.4(t)13.9(ha)15.1(n)]TJ -17.783 -1.0471 TD [(th)13.2(os)20(e)-274.3(o)0(f)-264.9(G)0(-)15.7(C)11.6(SF)85.4(,)-267.8(a)0(n)15.1(d)0(,)-262.9(a)0(l)18.5(t)0(h)13.2(o)0(u)21.2(g)0(h)]TJ /F4 1 Tf 12.2574 0 TD [(in)-265.7(vi)18.4(vo)]TJ /F3 1 Tf 2.9306 0 TD [(co)20.8(nc)15.1(en)20.8(tr)17.3(at)12.8(i)13.9(o)0(n)15.5(s)-275.1(ma)17.7(y)]TJ -15.1881 -1.0527 TD [(be)-394.6(up)-388.5(to)-390.9(18)15.5(0-)19.6(fo)13.9(l)13.9(d)-404.8(hi)18.9(gh)21.2(er)-396.2(be)20.8(ca)14.7(us)20(e)-399.5(o)0(f)-390.1(t)0(h)13.2(e)-399.5(di)18.9(lu)18.9(ti)16.5(on)-388.5(du)15.5(e)-399.5(t)0(o)]TJ 0 -1.0471 TD [(BA)12.6(L)12.2(,)-290.6(it)-285.1(is)-278.2(no)15.5(t)-287.7(k)0(n)15.5(o)0(w)17.3(n)-291(w)12.4(h)0(e)15.1(t)0(h)18.8(e)0(r)-282.4(s)0(u)20(c)0(h)-280.8(l)0(o)13.2(w)-289.2(co)20.8(nc)15.1(en)15.1(tr)17.3(at)18.5(io)18.9(ns)-281.6(of)]TJ 0 -1.0528 TD [(GM)15.3(-C)14.9(SF)-352.8(wi)14.9(th)18.8(in)-356.7(th)18.8(e)-365.4(l)0(u)18.9(n)0(g)15.5(s)-360.5(wo)17.3(ul)18.9(d)-365(h)0(a)15.1(v)0(e)-354.8(a)0(n)20.8(y)-365(pa)15.1(t)13.9(h)0(o)15.5(p)0(h)15.5(y)0(s)20(i)0(o)18.8(-)]TJ T* [(lo)13.2(gi)18.9(ca)20.4(l)-225.1(e)0(f)24.9(f)0(e)19.2(c)0(t)18.4(.)-222.3(Th)17.1(e)-223.1(m)0(e)17.7(d)0(i)18.9(a)0(n)-218.2(t)13.9(ol)13.2(er)19.2(at)18.5(ed)-212.5(do)15.5(se)-213.7(of)-213.7(in)18.8(tr)17.3(av)15.1(en)15.1(ou)21.2(s)-223.9(r)0(e)19.2(-)]TJ 0 -1.0471 TD [(co)15.1(mb)18.1(in)18.9(an)15.1(t)-242.1(G)0(M)15.3(-)0(C)14.9(S)11.4(F)-244.7(i)0(s)-238.4(1)0(5)]TJ /F8 1 Tf 10.3853 0 TD (m)Tj /F3 1 Tf 0.5634 0 TD (g)Tj /F11 1 Tf 0.4894 0.1992 TD (.)Tj /F3 1 Tf 0.2731 -0.1992 TD [(kg)-234.8(bo)21.2(dy)-234.8(we)16.9(ig)18.8(ht)]TJ 7.472 0 0 6.641 486.708 368.05 Tm -0.0185 Tc (-1)Tj /F11 1 Tf 9.963 0 0 9.963 492.661 365.612 Tm 0 Tc (.)Tj /F3 1 Tf 0.2675 -0.1992 TD [(da)15.1(y)]TJ 7.472 0 0 6.641 509.386 368.05 Tm (-1)Tj 9.963 0 0 9.963 517.89 363.628 Tm [([1)19.6(7].)]TJ -20.9355 -1.0527 TD [(The)-302.7(present)-301.5(findings)-303.9(sugges)-7.4(t)-293.4(that)-298.4(the)-301(numbe)-7.4(rs)-294.5(of)-299(neutro-)]TJ 0 -1.0471 TD [(phil)-7.8(s)-275.1(i)0(n)-277.1(the)-278.2(lungs)-274.8(in)-277.1(ARD)-9.2(S)-273.1(are)-277.8(infl)-9.4(uenced)-278.9(more)-281.3(by)-274.7(intra-)]TJ 0 -1.0527 TD [(pulm)-8.6(onary)-318.8(level)-9.4(s)-314.9(o)0(f)-316.1(the)-318.1(medi)-9(ators)-322.4(G-CSF)-319.8(and)-321.4(IL-8)-317.7(than)]TJ 0 -1.0471 TD [(by)-337.3(GM-C)-9.6(SF)74(.)]TJ 1.0015 -1.0528 TD [(Un)11.6(l)13.9(i)0(k)13.2(e)-308.5(G)12.4(-)0(C)14.9(S)0(F)91.1(,)-307.7(th)18.8(e)-308.5(c)0(o)15.1(l)0(o)18.8(n)0(y)21.2(-)0(s)12.8(t)0(i)22.2(m)0(u)12.4(l)0(a)18.4(t)0(i)16.5(n)0(g)-297.4(a)0(n)20.8(d)-308.1(an)15.1(ti)16.5(-a)19.2(po)15.5(pt)18.9(o-)]TJ -1.0015 -1.0471 TD [(ti)16.5(c)-359.7(e)0(f)24.9(f)0(e)19.2(c)0(t)12.8(s)-360.5(of)-350.2(GM)15.3(-C)14.9(S)11.4(F)-358.5(ar)13.5(e)-359.7(l)0(e)18.4(s)0(s)-351(s)0(p)14.4(e)0(c)20.4(i)0(f)17.3(i)0(c)-351.4(t)0(o)-351(n)0(e)15.1(u)0(t)18.8(r)0(o)14(p)0(h)21.2(i)0(l)16.5(s)0(.)-349.5(I)0(t)]TJ 0 -1.0528 TD [(pr)13.9(o-)19.6(lo)18.9(ng)15.5(s)-229.6(t)0(h)13.2(e)-228.8(su)20(rv)13.9(iv)18.9(al)-226.2(of)-219.4(eo)15.1(si)17.7(no)21.2(ph)15.5(il)16.5(s)-229.6(a)0(s)-225.1(w)0(e)16.9(l)0(l)-222.5(a)0(s)-225.1(n)0(e)20.8(u)0(t)18.9(r)0(o)13.9(p)0(h)21.2(i)0(l)16.5(s)]TJ 0 -1.0471 TD [(fr)12.4(om)-272.1(th)13.2(e)-280(b)0(l)18.9(o)0(o)15.5(d)-285.3(of)-276.3(no)21.2(rm)16.5(al)-277.5(vo)21.2(lu)13.2(nt)18.9(ee)20.4(rs)]TJ /F4 1 Tf 14.6304 0 TD [(in)-277.1(vi)18.5(tr)46.1(o)]TJ /F3 1 Tf 3.1241 0 TD [(by)-274.7(in)18.8(hi)13.2(bi)18.9(ti)16.5(ng)]TJ -17.7545 -1.0528 TD [(ap)15.1(op)15.5(t)13.9(o)0(s)14.4(i)0(s)-335.2([)0(1)19.6(8],)-350.6(promotes)-361.9(the)-357.9(release)-359.2(o)-6.5(f)-349.5(monoc)-7.4(ytes,)-360.2(neu-)]TJ T* [(troph)-7.8(ils)-543.2(and)-543.3(eosino)-8.6(phils)-544.7(from)-544.3(bone)-544.1(marrow)-544.5([19])-546.8(and)]TJ 0 -1.0471 TD [(enh)-8.4(ances)-324.9(many)-331(of)-321.8(the)-329.4(biolog)-9.3(ical)-327.3(functions)-333.5(of)-321.8(these)-332.6(cells)]TJ 0 -1.0528 TD [([18].)-370.8(However)18.5(,)-364.6(ARDS)-367.7(is)-369.3(a)-359.7(disor)-9(der)-368.5(that)-366.7(speci)-8.2(fically)-367.7(in-)]TJ 0 -1.0471 TD [(volves)-236.2(incre)-8.6(ases)-228.2(on)-7.2(ly)-225.8(in)-231.5(neutr)-8.2(ophil)-230.5(numbe)-7.4(rs.)-232.3(The)-228.7(absence)]TJ 0 -1.0528 TD [(of)-287.7(incre)-8.6(ases)-290.8(in)-288.4(numbe)-7.4(rs)-283.1(of)-287.7(eo)-7.6(sinophil)-8.7(s)-286.5(and)-287.2(monoc)-7.4(ytes)-285.9(in)]TJ 0 -1.0471 TD [(ARD)-9.2(S)-307.3(sugges)-7.4(ts)-306.7(that)-309.8(the)-312.4(low)-310.2(levels)-312.9(of)-310.4(GM-CS)-9.5(F)-301.6(d)-6.5(etected)]TJ 0 -1.0527 TD [(in)-379.5(the)-375(lungs)]TJ /F4 1 Tf 5.2638 0 TD [(in)-373.8(vivo)]TJ /F3 1 Tf 3.1639 0 TD [(may)-375.7(not)-374.6(have)-379.4(a)-371.1(signi)-9.8(ficant)-375.9(colony)-7.4(-)]TJ -8.4277 -1.0471 TD [(sti)-8.2(mulatin)-10.3(g)-365(effect.)-364.6(The)-371(levels)-369.8(wer)-8.2(e)-365.4(o)0(n)-371.4(average)-372.7(five-fold)]TJ 0 -1.0527 TD [(higher)-219.5(than)-210.7(norm)-7.8(al,)-209.6(where)-10.1(as)-208(those)-212.7(of)-213.7(G-CSF)-211.7(wer)-8.2(e)-211.7(38-fold)]TJ 0 -1.0471 TD [(higher)-265(and)-258.8(those)-258.2(of)-259.2(IL-8)-260.7(150-fo)-7.8(ld)-254.3(higher)42.3(.)-256.5(Other)-262.5(functions)]TJ 0 -1.0527 TD [(of)-253.5(GM-CSF)-254.2(may)-250.5(be)-246.6(more)-252.9(relev)-8.6(ant)-249.8(to)-248.6(its)-247.2(role)-252.1(in)-248.6(the)-249.8(mech-)]TJ T* [(anism)-341(of)-338.9(ARDS,)-339.6(which)-340.6(remains)-338.8(to)-339.7(be)-332(eluci)-9.4(dated.)]TJ 1.0015 -1.0471 TD [(Ex)17.1(pe)15.1(ri)17.3(me)17.7(nt)18.9(al)-140.9(st)17.7(ud)15.5(ie)18.4(s)-144.2(h)0(a)15.1(v)0(e)-138.5(p)0(r)19.6(o)0(v)15.5(i)0(d)18.9(e)0(d)-138.5(e)0(v)20.8(i)0(d)13.2(e)0(n)20.8(c)0(e)-138.9(t)0(h)18.9(a)0(t)-140.9(G)0(-)15.7(C)11.6(SF)]TJ -1.0015 -1.0528 TD [(pl)13.2(ay)20.8(s)-201.1(a)-206(mo)18.1(re)-191.3(im)15.7(po)15.5(rt)17.3(an)20.8(t)-202.3(r)0(o)13.9(l)13.9(e)-206(th)18.9(an)-189.7(GM)15.3(-C)14.9(SF)-193.4(in)-191.7(th)18.8(e)-206(r)0(e)19.2(g)0(u)15.5(l)0(a)18.4(t)0(i)16.5(o)0(n)]TJ 0 -1.0471 TD [(of)-190.9(bl)18.9(oo)15.5(d)-194.2(n)0(e)15.1(u)0(t)18.9(r)0(o)19.6(p)0(h)15.5(i)0(l)-188.4(n)0(u)15.5(m)0(b)18.1(e)0(r)19.2(s)0(.)-190.1(D)0(o)17.3(g)0(s)-184.8(d)0(e)15.1(p)0(l)18.8(e)0(t)18.5(e)0(d)-189.7(o)0(f)-190.9(G)12.4(-C)14.9(SF)-187.7(by)-189.3(a)]TJ ET 0 0 0 1 K 0 J 0 j 0.5 w 3.864 M []0 d /GS3 gs 1 i 107.636 635.881 m 281.397 635.881 l S 0 0 0 0 k 3.864 M 121.148 494.152 m 121.148 495.326 122.099 496.277 123.273 496.277 c 124.447 496.277 125.398 495.326 125.398 494.152 c 125.398 492.979 124.447 492.027 123.273 492.027 c 122.099 492.027 121.148 492.979 121.148 494.152 c b 121.715 494.152 m 121.715 495.326 122.666 496.277 123.84 496.277 c 125.013 496.277 125.965 495.326 125.965 494.152 c 125.965 492.979 125.013 492.027 123.84 492.027 c 122.666 492.027 121.715 492.979 121.715 494.152 c b 122.282 494.152 m 122.282 495.326 123.233 496.277 124.407 496.277 c 125.58 496.277 126.532 495.326 126.532 494.152 c 126.532 492.979 125.58 492.027 124.407 492.027 c 123.233 492.027 122.282 492.979 122.282 494.152 c b 122.849 494.152 m 122.849 495.326 123.8 496.277 124.974 496.277 c 126.147 496.277 127.099 495.326 127.099 494.152 c 127.099 492.979 126.147 492.027 124.974 492.027 c 123.8 492.027 122.849 492.979 122.849 494.152 c b 123.982 494.152 m 123.982 495.326 124.934 496.277 126.107 496.277 c 127.281 496.277 128.232 495.326 128.232 494.152 c 128.232 492.979 127.281 492.027 126.107 492.027 c 124.934 492.027 123.982 492.979 123.982 494.152 c b 124.549 494.152 m 124.549 495.326 125.501 496.277 126.674 496.277 c 127.848 496.277 128.799 495.326 128.799 494.152 c 128.799 492.979 127.848 492.027 126.674 492.027 c 125.501 492.027 124.549 492.979 124.549 494.152 c b 125.116 494.152 m 125.116 495.326 126.068 496.277 127.241 496.277 c 128.415 496.277 129.366 495.326 129.366 494.152 c 129.366 492.979 128.415 492.027 127.241 492.027 c 126.068 492.027 125.116 492.979 125.116 494.152 c b 3.864 M 131.898 493.987 m 136.898 493.987 l 107.636 489.382 m 281.397 489.382 l 125.398 489.591 m 125.398 486.85 l S 3.864 M 123.429 353.355 m 123.429 354.529 124.38 355.48 125.554 355.48 c 126.728 355.48 127.679 354.529 127.679 353.355 c 127.679 352.181 126.728 351.23 125.554 351.23 c 124.38 351.23 123.429 352.181 123.429 353.355 c b 3.864 M 107.636 340.882 m 280.897 340.882 l 125.398 341.092 m 125.398 338.35 l S 3.864 M 123.429 351.965 m 123.429 353.139 124.38 354.09 125.554 354.09 c 126.728 354.09 127.679 353.139 127.679 351.965 c 127.679 350.792 126.728 349.84 125.554 349.84 c 124.38 349.84 123.429 350.792 123.429 351.965 c b 123.429 351.072 m 123.429 352.246 124.38 353.197 125.554 353.197 c 126.728 353.197 127.679 352.246 127.679 351.072 c 127.679 349.899 126.728 348.947 125.554 348.947 c 124.38 348.947 123.429 349.899 123.429 351.072 c b 123.429 350.775 m 123.429 351.948 124.38 352.899 125.554 352.899 c 126.728 352.899 127.679 351.948 127.679 350.775 c 127.679 349.601 126.728 348.65 125.554 348.65 c 124.38 348.65 123.429 349.601 123.429 350.775 c b 123.429 350.179 m 123.429 351.353 124.38 352.304 125.554 352.304 c 126.728 352.304 127.679 351.353 127.679 350.179 c 127.679 349.005 126.728 348.054 125.554 348.054 c 124.38 348.054 123.429 349.005 123.429 350.179 c b 123.429 349.484 m 123.429 350.658 124.38 351.609 125.554 351.609 c 126.728 351.609 127.679 350.658 127.679 349.484 c 127.679 348.311 126.728 347.359 125.554 347.359 c 124.38 347.359 123.429 348.311 123.429 349.484 c b 123.429 348.591 m 123.429 349.765 124.38 350.716 125.554 350.716 c 126.728 350.716 127.679 349.765 127.679 348.591 c 127.679 347.417 126.728 346.466 125.554 346.466 c 124.38 346.466 123.429 347.417 123.429 348.591 c b 123.429 348.095 m 123.429 349.268 124.38 350.22 125.554 350.22 c 126.728 350.22 127.679 349.268 127.679 348.095 c 127.679 346.921 126.728 345.97 125.554 345.97 c 124.38 345.97 123.429 346.921 123.429 348.095 c b 123.429 347.638 m 123.429 348.811 124.38 349.763 125.554 349.763 c 126.728 349.763 127.679 348.811 127.679 347.638 c 127.679 346.464 126.728 345.513 125.554 345.513 c 124.38 345.513 123.429 346.464 123.429 347.638 c b 3.864 M 131.898 349.22 m 136.898 349.22 l S BT /F16 1 Tf 10 0 0 10 112.091 325.878 Tm 0 0 0 1 k /GS4 gs (Control)Tj ET /GS3 gs 107.63 472.132 m 107.63 345.279 l 107.894 471.94 m 105.152 471.94 l 107.894 446.649 m 105.152 446.649 l 107.894 420.384 m 105.152 420.384 l 107.894 395.435 m 105.152 395.435 l 107.894 369.989 m 105.152 369.989 l 107.894 345.488 m 105.152 345.488 l S BT 10 0 0 10 98.935 341.332 Tm /GS4 gs (0)Tj -0.4579 12.7134 TD (10)Tj 0 10 -10 0 85.46 383.058 Tm (GM-CSF pg\341mL)Tj 0 8 -8 0 82.625 440.467 Tm (-1)Tj 10 0 0 10 64.435 473.832 Tm (c\))Tj 3.4205 -3.108 TD (9)Tj 0 -2.6003 TD (8)Tj 0 -2.5204 TD (4)Tj 0 -2.5028 TD (2)Tj ET /GS3 gs 107.63 618.39 m 107.63 493.779 l 107.894 618.17 m 105.152 618.17 l 107.894 597.126 m 105.152 597.126 l 107.894 576.285 m 105.152 576.285 l 107.894 555.219 m 105.152 555.219 l 107.894 534.827 m 105.152 534.827 l 107.894 513.873 m 105.152 513.873 l 107.894 493.987 m 105.152 493.987 l S BT 10 0 0 10 98.935 489.832 Tm /GS4 gs (0)Tj -1.3858 12.4527 TD (1200)Tj 0 10 -10 0 79.21 536.557 Tm (G-CSF pg\341mL)Tj 0 8 -8 0 76.375 587.137 Tm (-1)Tj 10 0 0 10 64.435 622.331 Tm (b\))Tj 2.0642 -2.8714 TD (1000)Tj 0.4517 -2.1056 TD (800)Tj 0 -2.0854 TD (600)Tj 0 -2.0719 TD (400)Tj T* (200)Tj ET /GS3 gs 107.63 767.131 m 107.63 640.278 l 107.894 766.939 m 105.152 766.939 l 107.894 745.76 m 105.152 745.76 l 107.894 724.582 m 105.152 724.582 l 107.894 703.403 m 105.152 703.403 l 107.894 682.225 m 105.152 682.225 l 107.894 661.046 m 105.152 661.046 l 107.894 640.486 m 105.152 640.486 l S BT 10 0 0 10 98.935 636.331 Tm /GS4 gs (0)Tj -1.8352 12.7134 TD (60000)Tj 0 -2.1502 TD (50000)Tj 0 -2.1176 TD (40000)Tj 0 -2.1214 TD (30000)Tj 0 -2.0874 TD (20000)Tj 0 -2.1213 TD (10000)Tj 0 10 -10 0 72.21 686.556 Tm (IL-8 pg\341mL)Tj 0 8 -8 0 69.375 725.756 Tm (-1)Tj 10 0 0 10 64.435 768.83 Tm (a\))Tj ET 0 0 0 0 k 3.864 M /GS3 gs 250.344 640.299 m 250.344 641.473 251.295 642.425 252.469 642.425 c 253.642 642.425 254.594 641.473 254.594 640.299 c 254.594 639.126 253.642 638.174 252.469 638.174 c 251.295 638.174 250.344 639.126 250.344 640.299 c b 250.344 640.866 m 250.344 642.04 251.295 642.991 252.469 642.991 c 253.642 642.991 254.594 642.04 254.594 640.866 c 254.594 639.693 253.642 638.741 252.469 638.741 c 251.295 638.741 250.344 639.693 250.344 640.866 c b 250.344 641.433 m 250.344 642.607 251.295 643.558 252.469 643.558 c 253.642 643.558 254.594 642.607 254.594 641.433 c 254.594 640.26 253.642 639.308 252.469 639.308 c 251.295 639.308 250.344 640.26 250.344 641.433 c b 250.344 642 m 250.344 643.174 251.295 644.125 252.469 644.125 c 253.642 644.125 254.594 643.174 254.594 642 c 254.594 640.827 253.642 639.875 252.469 639.875 c 251.295 639.875 250.344 640.827 250.344 642 c b 250.344 642.567 m 250.344 643.741 251.295 644.692 252.469 644.692 c 253.642 644.692 254.594 643.741 254.594 642.567 c 254.594 641.394 253.642 640.442 252.469 640.442 c 251.295 640.442 250.344 641.394 250.344 642.567 c b 250.344 643.134 m 250.344 644.307 251.295 645.259 252.469 645.259 c 253.642 645.259 254.594 644.307 254.594 643.134 c 254.594 641.96 253.642 641.009 252.469 641.009 c 251.295 641.009 250.344 641.96 250.344 643.134 c b 250.344 643.701 m 250.344 644.875 251.295 645.826 252.469 645.826 c 253.642 645.826 254.594 644.875 254.594 643.701 c 254.594 642.527 253.642 641.576 252.469 641.576 c 251.295 641.576 250.344 642.527 250.344 643.701 c b 250.344 643.701 m 250.344 644.875 251.295 645.826 252.469 645.826 c 253.642 645.826 254.594 644.875 254.594 643.701 c 254.594 642.527 253.642 641.576 252.469 641.576 c 251.295 641.576 250.344 642.527 250.344 643.701 c b 3.864 M 256.875 640.486 m 261.875 640.486 l 252.625 636.091 m 252.625 633.349 l S 3.864 M 204.83 666.401 m 204.83 667.575 205.782 668.526 206.955 668.526 c 208.129 668.526 209.08 667.575 209.08 666.401 c 209.08 665.228 208.129 664.276 206.955 664.276 c 205.782 664.276 204.83 665.228 204.83 666.401 c b 204.83 657.901 m 204.83 659.075 205.782 660.026 206.955 660.026 c 208.129 660.026 209.08 659.075 209.08 657.901 c 209.08 656.728 208.129 655.776 206.955 655.776 c 205.782 655.776 204.83 656.728 204.83 657.901 c b 204.83 656.651 m 204.83 657.825 205.782 658.776 206.955 658.776 c 208.129 658.776 209.08 657.825 209.08 656.651 c 209.08 655.478 208.129 654.526 206.955 654.526 c 205.782 654.526 204.83 655.478 204.83 656.651 c b 204.83 655.151 m 204.83 656.325 205.782 657.276 206.955 657.276 c 208.129 657.276 209.08 656.325 209.08 655.151 c 209.08 653.978 208.129 653.026 206.955 653.026 c 205.782 653.026 204.83 653.978 204.83 655.151 c b 204.83 647.151 m 204.83 648.325 205.782 649.276 206.955 649.276 c 208.129 649.276 209.08 648.325 209.08 647.151 c 209.08 645.978 208.129 645.027 206.955 645.027 c 205.782 645.027 204.83 645.978 204.83 647.151 c b 204.83 646.366 m 204.83 647.539 205.782 648.491 206.955 648.491 c 208.129 648.491 209.08 647.539 209.08 646.366 c 209.08 645.192 208.129 644.241 206.955 644.241 c 205.782 644.241 204.83 645.192 204.83 646.366 c b 204.83 645.58 m 204.83 646.754 205.782 647.705 206.955 647.705 c 208.129 647.705 209.08 646.754 209.08 645.58 c 209.08 644.407 208.129 643.455 206.955 643.455 c 205.782 643.455 204.83 644.407 204.83 645.58 c b 204.83 644.795 m 204.83 645.968 205.782 646.92 206.955 646.92 c 208.129 646.92 209.08 645.968 209.08 644.795 c 209.08 643.621 208.129 642.669 206.955 642.669 c 205.782 642.669 204.83 643.621 204.83 644.795 c b 204.83 644.009 m 204.83 645.182 205.782 646.134 206.955 646.134 c 208.129 646.134 209.08 645.182 209.08 644.009 c 209.08 642.835 208.129 641.884 206.955 641.884 c 205.782 641.884 204.83 642.835 204.83 644.009 c b 204.83 643.223 m 204.83 644.397 205.782 645.348 206.955 645.348 c 208.129 645.348 209.08 644.397 209.08 643.223 c 209.08 642.05 208.129 641.098 206.955 641.098 c 205.782 641.098 204.83 642.05 204.83 643.223 c b 204.83 642.438 m 204.83 643.611 205.782 644.563 206.955 644.563 c 208.129 644.563 209.08 643.611 209.08 642.438 c 209.08 641.264 208.129 640.313 206.955 640.313 c 205.782 640.313 204.83 641.264 204.83 642.438 c b 204.83 641.652 m 204.83 642.826 205.782 643.777 206.955 643.777 c 208.129 643.777 209.08 642.826 209.08 641.652 c 209.08 640.478 208.129 639.527 206.955 639.527 c 205.782 639.527 204.83 640.478 204.83 641.652 c b 204.83 640.866 m 204.83 642.04 205.782 642.991 206.955 642.991 c 208.129 642.991 209.08 642.04 209.08 640.866 c 209.08 639.693 208.129 638.741 206.955 638.741 c 205.782 638.741 204.83 639.693 204.83 640.866 c b 3.864 M 210.862 643.381 m 215.862 643.381 l 207.112 636.091 m 207.112 633.349 l S 3.864 M 158.375 705.651 m 158.375 706.825 159.326 707.776 160.5 707.776 c 161.673 707.776 162.625 706.825 162.625 705.651 c 162.625 704.478 161.673 703.526 160.5 703.526 c 159.326 703.526 158.375 704.478 158.375 705.651 c b 158.375 666.651 m 158.375 667.825 159.326 668.776 160.5 668.776 c 161.673 668.776 162.625 667.825 162.625 666.651 c 162.625 665.478 161.673 664.526 160.5 664.526 c 159.326 664.526 158.375 665.478 158.375 666.651 c b 158.375 657.401 m 158.375 658.575 159.326 659.526 160.5 659.526 c 161.673 659.526 162.625 658.575 162.625 657.401 c 162.625 656.228 161.673 655.276 160.5 655.276 c 159.326 655.276 158.375 656.228 158.375 657.401 c b 158.375 652.901 m 158.375 654.075 159.326 655.026 160.5 655.026 c 161.673 655.026 162.625 654.075 162.625 652.901 c 162.625 651.728 161.673 650.776 160.5 650.776 c 159.326 650.776 158.375 651.728 158.375 652.901 c b 158.375 650.401 m 158.375 651.575 159.326 652.526 160.5 652.526 c 161.673 652.526 162.625 651.575 162.625 650.401 c 162.625 649.228 161.673 648.276 160.5 648.276 c 159.326 648.276 158.375 649.228 158.375 650.401 c b 158.375 647.401 m 158.375 648.575 159.326 649.526 160.5 649.526 c 161.673 649.526 162.625 648.575 162.625 647.401 c 162.625 646.228 161.673 645.276 160.5 645.276 c 159.326 645.276 158.375 646.228 158.375 647.401 c b 158.375 645.651 m 158.375 646.825 159.326 647.776 160.5 647.776 c 161.673 647.776 162.625 646.825 162.625 645.651 c 162.625 644.478 161.673 643.527 160.5 643.527 c 159.326 643.527 158.375 644.478 158.375 645.651 c b 158.375 643.902 m 158.375 645.075 159.326 646.026 160.5 646.026 c 161.673 646.026 162.625 645.075 162.625 643.902 c 162.625 642.728 161.673 641.776 160.5 641.776 c 159.326 641.776 158.375 642.728 158.375 643.902 c b 158.375 642.006 m 158.375 643.18 159.326 644.131 160.5 644.131 c 161.673 644.131 162.625 643.18 162.625 642.006 c 162.625 640.833 161.673 639.882 160.5 639.882 c 159.326 639.882 158.375 640.833 158.375 642.006 c b 158.375 641.256 m 158.375 642.43 159.326 643.381 160.5 643.381 c 161.673 643.381 162.625 642.43 162.625 641.256 c 162.625 640.083 161.673 639.132 160.5 639.132 c 159.326 639.132 158.375 640.083 158.375 641.256 c b 158.375 640.506 m 158.375 641.68 159.326 642.631 160.5 642.631 c 161.673 642.631 162.625 641.68 162.625 640.506 c 162.625 639.333 161.673 638.382 160.5 638.382 c 159.326 638.382 158.375 639.333 158.375 640.506 c b 158.375 639.756 m 158.375 640.93 159.326 641.881 160.5 641.881 c 161.673 641.881 162.625 640.93 162.625 639.756 c 162.625 638.583 161.673 637.632 160.5 637.632 c 159.326 637.632 158.375 638.583 158.375 639.756 c b 3.864 M 164.656 644.381 m 169.656 644.381 l S 3.864 M 158.375 745.151 m 158.375 746.325 159.326 747.276 160.5 747.276 c 161.673 747.276 162.625 746.325 162.625 745.151 c 162.625 743.977 161.673 743.026 160.5 743.026 c 159.326 743.026 158.375 743.977 158.375 745.151 c b 3.864 M 160.656 636.091 m 160.656 633.349 l S 3.864 M 121.148 640.651 m 121.148 641.825 122.099 642.777 123.273 642.777 c 124.447 642.777 125.398 641.825 125.398 640.651 c 125.398 639.478 124.447 638.526 123.273 638.526 c 122.099 638.526 121.148 639.478 121.148 640.651 c b 121.715 640.651 m 121.715 641.825 122.666 642.777 123.84 642.777 c 125.013 642.777 125.965 641.825 125.965 640.651 c 125.965 639.478 125.013 638.526 123.84 638.526 c 122.666 638.526 121.715 639.478 121.715 640.651 c b 122.282 640.651 m 122.282 641.825 123.233 642.777 124.407 642.777 c 125.58 642.777 126.532 641.825 126.532 640.651 c 126.532 639.478 125.58 638.526 124.407 638.526 c 123.233 638.526 122.282 639.478 122.282 640.651 c b 122.849 640.651 m 122.849 641.825 123.8 642.777 124.974 642.777 c 126.147 642.777 127.099 641.825 127.099 640.651 c 127.099 639.478 126.147 638.526 124.974 638.526 c 123.8 638.526 122.849 639.478 122.849 640.651 c b 123.982 640.651 m 123.982 641.825 124.934 642.777 126.107 642.777 c 127.281 642.777 128.232 641.825 128.232 640.651 c 128.232 639.478 127.281 638.526 126.107 638.526 c 124.934 638.526 123.982 639.478 123.982 640.651 c b 124.549 640.651 m 124.549 641.825 125.501 642.777 126.674 642.777 c 127.848 642.777 128.799 641.825 128.799 640.651 c 128.799 639.478 127.848 638.526 126.674 638.526 c 125.501 638.526 124.549 639.478 124.549 640.651 c b 125.116 640.651 m 125.116 641.825 126.068 642.777 127.241 642.777 c 128.415 642.777 129.366 641.825 129.366 640.651 c 129.366 639.478 128.415 638.526 127.241 638.526 c 126.068 638.526 125.116 639.478 125.116 640.651 c b 3.864 M 131.898 640.486 m 136.898 640.486 l 125.398 636.091 m 125.398 633.349 l S 3.864 M 250 493.05 m 250 494.224 250.952 495.175 252.125 495.175 c 253.299 495.175 254.25 494.224 254.25 493.05 c 254.25 491.877 253.299 490.925 252.125 490.925 c 250.952 490.925 250 491.877 250 493.05 c b 250 494.367 m 250 495.541 250.952 496.492 252.125 496.492 c 253.299 496.492 254.25 495.541 254.25 494.367 c 254.25 493.194 253.299 492.242 252.125 492.242 c 250.952 492.242 250 493.194 250 494.367 c b 250 494.934 m 250 496.108 250.952 497.059 252.125 497.059 c 253.299 497.059 254.25 496.108 254.25 494.934 c 254.25 493.76 253.299 492.809 252.125 492.809 c 250.952 492.809 250 493.76 250 494.934 c b 250 495.501 m 250 496.674 250.952 497.626 252.125 497.626 c 253.299 497.626 254.25 496.674 254.25 495.501 c 254.25 494.327 253.299 493.376 252.125 493.376 c 250.952 493.376 250 494.327 250 495.501 c b 250 497.568 m 250 498.741 250.952 499.693 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500.081 c 208.052 500.081 209.003 499.13 209.003 497.956 c 209.003 496.782 208.052 495.831 206.878 495.831 c 205.704 495.831 204.753 496.782 204.753 497.956 c b 204.753 496.295 m 204.753 497.469 205.704 498.42 206.878 498.42 c 208.052 498.42 209.003 497.469 209.003 496.295 c 209.003 495.122 208.052 494.17 206.878 494.17 c 205.704 494.17 204.753 495.122 204.753 496.295 c b 204.753 493.26 m 204.753 494.433 205.704 495.385 206.878 495.385 c 208.052 495.385 209.003 494.433 209.003 493.26 c 209.003 492.086 208.052 491.135 206.878 491.135 c 205.704 491.135 204.753 492.086 204.753 493.26 c b 3.864 M 210.785 513.882 m 215.785 513.882 l 207.035 489.591 m 207.035 486.85 l S 3.864 M 204.753 517.152 m 204.753 518.326 205.704 519.277 206.878 519.277 c 208.052 519.277 209.003 518.326 209.003 517.152 c 209.003 515.979 208.052 515.027 206.878 515.027 c 205.704 515.027 204.753 515.979 204.753 517.152 c b 205.378 514.902 m 205.378 516.076 206.329 517.027 207.503 517.027 c 208.677 517.027 209.628 516.076 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TD [(are)-266.5(now)-268(needed)-267.6(to)-265.7(ident)-9(ify)-262.3(the)-266.8(mai)-8.2(n)-262.5(source)-8.2(s)-263.7(o)0(f)-264.9(G-CSF)-268.6(in)]TJ 0 -1.0471 TD [(the)-283.9(lungs)-286.2(of)-282(pati)-8.2(ents)-280.2(wi)-7.8(th)-282.7(ARDS)-288(and)-281.5(to)-282.7(clarify)-292.9(its)-281.4(role)-286.3(in)]TJ 0 -1.0528 TD [(pathog)-7.4(enesi)-8.2(s.)]TJ 1.0015 -1.0471 TD [(Th)17.1(e)-206(p)0(o)21.2(t)0(e)12.8(n)0(t)18.9(i)0(a)18.4(l)-202.3(of)-196.6(G-)15.7(CS)17.3(F)-204.8(t)0(o)-197.4(c)0(o)20.8(n)0(t)13.2(r)0(i)17.3(b)0(u)21.2(t)0(e)-197.8(t)0(o)-197.4(t)0(h)18.9(e)-206(pa)20.8(th)18.9(og)15.5(en)15.1(es)19.6(is)]TJ -1.0015 -1.0527 TD [(of)-264.9(AR)12.6(DS)-266.4(is)-266.9(su)14.4(pp)21.2(or)13.9(te)18.4(d)-273.9(b)0(y)-269(r)0(e)19.2(p)0(o)15.5(r)0(t)17.3(s)-275.1(of)-264.9(de)15.1(ve)20.8(lo)13.2(pm)18.1(en)20.8(t)-276.3(o)0(f)-270.6(a)0(c)20.4(u)0(t)13.2(e)]TJ 0 -1.0471 TD [(lu)18.9(ng)-416.9(in)18.9(ju)13.2(ry)-412.8(in)-419.3(pa)15.1(t)13.9(i)0(e)12.8(n)0(t)18.9(s)-423.1(tr)17.3(ea)14.7(te)18.4(d)-427.6(w)0(i)14.9(t)0(h)-413.6(r)0(e)13.5(c)0(o)20.8(m)0(b)18.1(i)0(n)13.2(a)0(n)20.8(t)-424.2(G-)15.7(CS)17.3(F)]TJ 0 -1.0528 TD [([2)19.6(8\26130].)-335.8(In)-344.6(addition,)-349.8(experiment)-12.6(al)-340.1(model)-9.7(s)-337.7(show)-343.9(that)-344(in-)]TJ 0 -1.0471 TD [(trave)-8.6(nous)-311.5(instillation)-317.6(of)-310.4(recom)-9.4(binant)-311.3(G-CSF)-319.8(can)-310.4(exacer-)]TJ 0 -1.0527 TD [(bate)-268(pre-ex)-8.6(ist)-8.2(ing)-266.4(acute)-269.2(lung)-272.9(injury)-272.7([31\26133])-8.5(.)-262.1(F)0(u)-6.4(rthermor)-11.1(e,)]TJ 0 -1.0471 TD [(it)-233.9(has)-237.2(recent)-9.8(ly)-231.5(been)-237.2(report)-10.6(ed)-235.2(that)-235.8(G-CSF)-240.1(alone)-240.3(can)-236.4(induce)]TJ 0 -1.0528 TD [(acute)-286.2(lung)-284.3(injury)-284.1(when)-280.5(intr)-9.4(oduced)-284.2(direc)-8.6(tly)-280.2(into)-281(the)-283.9(lungs)]TJ 0 -1.0471 TD [(of)-310.4(rats)-315.9([34].)-313.9(Doses)-312.1(of)-316.1(300\2613,00)-5.7(0)-308.1(n)0(g)-308.8(recom)-9.4(binant)-317(human)]TJ 0 -1.0528 TD [(G-CSF)-188.9(introduced)-185.5(intr)-9.4(atracheall)-12.7(y)-177.2(caused)-189.1(hypoxi)-7(a,)-178(mark)-8.2(ed)]TJ 0 -1.0471 TD [(pulmo)-9.3(nary)-613.9(oedem)-7.8(a)-615.7(and)-617.3(pulmonary)-623.3(neutrophil)-11.1(ia.)-613.6(The)]TJ 0 -1.0527 TD [(maximum)-359(level)-350.8(of)-344.6(G-CSF)-353.9(found)-352.5(in)-345.3(the)-346.5(presen)-8.2(t)-350.3(study)-348.8(in)]TJ 0 -1.0471 TD [(BAL)-191.5(fluid)-192.3(from)-191.5(pati)-8.2(ents)-189.1(with)-193.8(ARDS)-191.2(was)-189.9(2.5)-189.7(ng)]TJ /F11 1 Tf 18.5739 0.1992 TD (.)Tj /F3 1 Tf 0.2731 -0.1992 TD (mL)Tj 7.472 0 0 6.641 259.767 420.435 Tm (-1)Tj 9.963 0 0 9.963 265.89 416.012 Tm [(,)-188.2(but,)]TJ -20.8388 -1.0527 TD [(since)-218.7(the)-221.3(dilutio)-9.2(n)-217(factor)-221.5(due)-218.9(to)-220.2(BAL)-219.9(could)-217.2(reach)-222.9(180-fo)-7.8(ld,)]TJ /F4 1 Tf 0 -1.0471 TD [(in)-157.6(vivo)]TJ /F3 1 Tf 2.7372 0 TD [(concent)-8.9(rations)-161.2(of)-162.5(G-CSF)-166.1(in)-157.6(lung)-164.8(lining)-159.7(flui)-9.4(d)-154.4(may)-165.2(be)]TJ -2.7372 -1.0528 TD [(up)-206.4(to)-208.8(450)-201.5(n)-6.5(g)]TJ /F11 1 Tf 4.8939 0.1992 TD (.)Tj /F3 1 Tf 0.2675 -0.1992 TD (mL)Tj 7.472 0 0 6.641 123.42 389.027 Tm (-1)Tj 9.963 0 0 9.963 129.6 384.605 Tm [(,)-205.2(sufficient)-207.7(to)-203.1(have)-208.7(a)-206(pathop)-7.4(hysiologi)-9.5(cal)]TJ -7.1587 -1.0471 TD (effect.)Tj 1.0015 -1.0528 TD [(In)-276.3(co)20.8(nc)15.1(lu)18.9(si)17.7(on)15.5(,)-279.2(t)0(h)18.9(i)0(s)-278.2(s)0(t)17.7(u)0(d)21.2(y)-285.3(sh)20(ow)17.3(s)-286.5(t)0(h)18.9(a)0(t)-271.8(i)0(n)18.9(c)0(r)13.5(e)0(a)20.4(s)0(e)13.9(s)-280.8(in)-277.1(gr)19.6(an)15.1(u-)]TJ -1.0015 -1.0471 TD [(lo)18.9(cy)15.1(te)-442.5(co)20.8(lo)13.2(ny)21.2(-s)18.4(ti)16.5(mu)12.4(l)13.9(a)0(t)12.8(i)0(n)18.9(g)-450.3(fa)19.2(ct)12.8(or)-441.3(an)20.8(d)-456(g)0(r)19.6(a)0(n)15.1(u)0(l)18.9(o)0(c)20.8(y)0(t)13.2(e)0(-)19.2(m)0(a)17.7(c)0(r)13.5(o)0(-)]TJ 0 -1.0527 TD [(ph)15.5(ag)20.8(e)-200.3(c)0(o)15.1(l)13.9(on)15.5(y-)19.6(st)17.7(im)15.7(ul)13.2(at)18.5(io)18.9(n)-199.9(f)0(a)19.2(c)0(t)18.5(o)0(r)-190.9(l)0(e)18.4(v)0(e)15.1(l)0(s)-192.9(o)0(c)20.8(c)0(u)15.1(r)-195.8(in)-191.7(th)18.9(e)-200.3(l)0(u)18.9(n)0(g)15.5(s)-201.1(of)]TJ T* [(pa)15.1(ti)22.2(en)15.1(ts)-449(wi)14.9(th)-447.8(ac)14.7(ut)18.9(e)-456.4(r)0(e)13.5(s)0(p)20(i)0(r)17.3(a)0(t)18.4(o)0(r)13.9(y)-456(di)18.9(st)17.7(re)13.5(ss)-447.8(sy)20(nd)15.5(ro)19.6(me)17.7(.)-461.3(T)12.2(he)15.1(ir)]TJ 0 -1.0471 TD [(ro)19.6(le)-351.4(in)-351(th)18.9(e)-359.7(p)0(a)20.8(t)0(h)13.2(o)0(g)21.2(e)0(n)15.1(e)0(s)19.6(i)0(s)-352.2(a)0(n)20.8(d)-359.3(wh)17.3(et)18.4(he)15.1(r)-360.9(s)0(u)20(c)0(h)-349.1(i)0(n)18.9(c)0(r)13.5(e)0(a)20.4(s)0(e)13.9(s)-354.8(al)18.4(so)]TJ 0 -1.0527 TD [(oc)15.1(cu)20.8(r)-326.7(i)0(n)-311.2(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-318.1(a)0(t)-317.3(r)0(i)17.3(s)0(k)20(,)-324.7(no)21.2(w)-329.1(n)0(e)20.8(e)0(d)15.1(s)-326.3(t)13.9(o)-325.1(be)-314.9(cl)12.8(ar)19.2(if)17.3(ie)18.4(d.)]TJ /F6 1 Tf 8.966 0 0 8.966 151.257 272.409 Tm [(Referenc)8.7(es)]TJ /F3 1 Tf -10.3696 -2.2762 TD [(1.)-1766.5(Bernard)-521.1(GR,)-528.4(Artigas)-524.9(A,)-524.2(Brigham)-524.6(KL,)]TJ /F4 1 Tf 19.3924 0 TD [(et)-519.6(al)]TJ /F3 1 Tf 1.998 0 TD [(.)-527.7(and)-523.1(the)]TJ -18.8739 -1.1128 TD [(Consensus)-231.1(Committee.)-241.1(Report)-232.4(of)-233.9(the)-234.6(American-European)]TJ 0 -1.1065 TD [(Consensus)-566.2(Conference)-576(on)-568.1(Acute)-571.7(Respiratory)-569.3(Distress)]TJ 0 -1.1128 TD [(Syndrome:)-403.6(definitions,)-407.1(mechanisms,)-410.3(relevant)-405.6(outcomes,)]TJ T* [(and)-206.9(clinical)-213.4(trial)-207.7(coordination.)]TJ /F4 1 Tf 11.9946 0 TD [(J)-207.9(Crit)-211(Car)27.2(e)]TJ /F3 1 Tf 4.6157 0 TD [(1994;)-208.5(9:)-210(72\26181.)]TJ -19.1268 -1.1128 TD [(2.)-1766.5(Murray)-625.3(JF)70.8(,)-628.9(Matthay)-633.7(MA,)-625.5(Luce)-633.3(JM,)-629.7(Flick)-626.6(MR.)-633.3(An)]TJ 2.5165 -1.1065 TD [(expanded)-317.7(definition)-315(of)-322.4(the)-316.8(adult)-318.1(respiratory)-325.3(distress)-321.2(syn-)]TJ 0 -1.1128 TD (drome.)Tj /F4 1 Tf 3.1109 0 TD [(Am)-334.6(Rev)-330.3(Respir)-340.1(Dis)]TJ /F3 1 Tf 8.0933 0 TD [(1988;)-328.6(138:)-335.5(720\261723.)]TJ -13.7207 -1.1128 TD [(3.)-1766.5(McNee)-215.7(W)77.1(,)-217.9(Selby)-219.5(C.)-222.1(Neutrophil)-221.1(traffic)-218.6(in)-216.4(the)-221.9(lungs:)-224.2(role)-222.4(of)]TJ 2.5165 -1.1128 TD [(haemodynamics,)-261.9(cell)-261.5(adhesion)-264.6(and)-257.5(deformability)57(.)]TJ /F4 1 Tf 19.9425 0 TD (Thorax)Tj /F3 1 Tf -19.9425 -1.1065 TD [(1993,)-329.7(48:)-336(79\26188.)]TJ -2.5165 -1.1128 TD [(4.)-1766.5(Steinber)12.9(g)-574.9(K)0(P)106.6(,)-572(Milberg)-565.4(JA,)-575.4(Martin)-572.2(TR,)-572.8(Maunder)-573(RJ,)]TJ 2.5165 -1.1128 TD [(Cockrill)-350(BA,)-351.3(Hudson)-349.2(LD.)-350.1(Evolution)-347.5(of)-354(bronchoalveolar)]TJ 0 -1.1065 TD [(cell)-552.4(populations)-558.9(in)-551.5(the)-557.1(adult)-552.1(respiratory)-559.2(distress)-561.4(syn-)]TJ 0 -1.1128 TD (drome.)Tj /F4 1 Tf 3.0666 0 TD [(Am)-296.6(J)-290.1(Respir)-295.8(Crit)-293.2(Car)33.6(e)-296.5(Med)]TJ /F3 1 Tf 11.4065 0 TD [(1994;)-290.7(150:)-297.5(1)32.1(13\261122.)]TJ 11.0082 73.5671 TD [(5.)-1766.5(Baughman)-387.8(RP)105.2(,)-388.6(Gunther)-388.5(KL,)-388(Rashkin)-390.2(MC,)-386.7(Keeton)-387.9(DA,)]TJ 2.5165 -1.1381 TD [(Pattishall)-360.2(EN.)-362.8(Changes)-362.3(in)-355.5(the)-361(inflammatory)-366.7(response)-359.2(of)]TJ T* [(the)-228.3(lung)-234.3(during)-227.9(acute)-233.1(respiratory)-230.4(distress)-232.6(syndrome:)-235.5(prog-)]TJ T* [(nostic)-293.5(indicators.)]TJ /F4 1 Tf 7.088 0 TD [(Am)-290.3(J)-296.5(Respir)-289.5(Crit)-293.2(Car)27.2(e)-290.1(Med)]TJ /F3 1 Tf 11.4002 0 TD [(1996;)-290.7(154:)]TJ -18.4882 -1.1444 TD (76\26181.)Tj -2.5165 -1.1065 TD [(6.)-1766.5(Kunkel)-533.5(SL,)-535.1(Standiford)-537.4(TJ,)-537.7(Kasahara)-537.9(K,)-530.5(Strieter)-540.6(RM.)]TJ 2.5165 -1.1381 TD [(Interleukin-8)-534.1(\(IL-8\):)-531(the)-531.8(major)-533.6(neutrophil)-533.9(chemotactic)]TJ 0 -1.1444 TD [(factor)-335.9(in)-330.2(the)-335.8(lung.)]TJ /F4 1 Tf 7.6191 0 TD [(Exp)-336.9(Lung)-331.7(Res)]TJ /F3 1 Tf 6.0194 0 TD [(1991;)-334.9(17:)-336(17\26123.)]TJ -16.155 -1.1065 TD [(7.)-1766.5(Miller)-321.7(EJ,)-316.4(Cohen)-318.1(AB,)-319.7(Nagao)-316.4(S,)]TJ /F4 1 Tf 15.7567 0 TD [(et)-317.3(al)]TJ /F3 1 Tf 1.7957 0 TD [(.)-319.1(Elevated)-319.6(levels)-318.6(of)]TJ -15.0359 -1.1381 TD [(NAP-1/interleukin-8)-420.8(are)-416.3(present)-417.8(in)-418.7(the)-418(airspaces)-417.5(of)-417.3(pa-)]TJ 0 -1.1444 TD [(tients)-245.3(with)-246.3(the)-247.2(adult)-248.6(respiratory)-249.4(distress)-251.6(syndrome)-246.3(and)-244.9(are)]TJ 0 -1.1381 TD [(associated)-393.2(with)-385.4(increased)-391.1(mortality)55.7(.)]TJ /F4 1 Tf 14.8968 0 TD [(Am)-391.5(Rev)-387.2(Respir)-390.7(Dis)]TJ /F3 1 Tf -14.8968 -1.1381 TD [(1992;)-334.9(146:)-329.1(427\261432.)]TJ -2.5165 -1.1128 TD [(8.)-1766.5(Donnelly)-218.7(SC,)-220.2(Strieter)-224.4(RM,)-222.3(Kunkel)-217.4(SL,)]TJ /F4 1 Tf 18.014 0 TD [(et)-222.5(al)]TJ /F3 1 Tf 1.7009 0 TD [(.)-217.9(Interleukin-8)]TJ -17.1983 -1.1381 TD [(and)-219.6(development)-221.6(of)-221.3(adult)-223.3(respiratory)-224.1(distress)-226.3(syndrome)-221(in)]TJ T* [(at)-336.3(risk)-331.3(patient)-338.2(groups.)]TJ /F4 1 Tf 9.1619 0 TD (Lancet)Tj /F3 1 Tf 3.035 0 TD [(1993;)-328.6(341:)-335.5(643\261647.)]TJ -14.7134 -1.1128 TD [(9.)-1766.5(Goodman)-481.9(RB,)-479.2(Strieter)-490(RM,)-475.2(Martin)-483.7(DP)100.3(,)]TJ /F4 1 Tf 19.6959 0 TD [(et)-481.7(al)]TJ /F3 1 Tf 1.9601 0 TD [(.)-483.5(Inflam-)]TJ -19.1395 -1.1381 TD [(matory)-267.5(cytokines)-266.5(in)-266.9(patients)-263.1(with)-265.3(persistence)-273.5(of)-265.5(the)-266.2(acute)]TJ T* [(respiratory)-224.1(distress)-226.3(syndrome.)]TJ /F4 1 Tf 12.0578 0 TD [(Am)-220.8(J)-220.6(Respir)-226.3(Crit)-223.6(Car)33.6(e)-226.9(Med)]TJ /F3 1 Tf -12.0578 -1.1381 TD [(1996;)-334.9(154:)-329.1(602\26161)28.3(1.)]TJ -2.5165 -1.1128 TD [(10.)-1266.5(Haslett)-368(C.)-361.2(Granulocyte)-369.5(apoptosis)-362.7(and)-365(inflammatory)-366.7(dis-)]TJ 2.5165 -1.1381 TD (ease.)Tj /F4 1 Tf 2.2826 0 TD [(Br)-332.5(Med)-333.8(Bull)]TJ /F3 1 Tf 5.3934 0 TD [(1997;)-328.6(53:)-336(669\261683.)]TJ -10.1925 -1.1065 TD [(1)25.8(1)0(.)-1292.3(Matute-Bello)-306.3(G,)-302.9(Liles)-303.9(WC,)-296.7(Radell)-309.5(F)-301.6(II,)]TJ /F4 1 Tf 18.7158 0 TD [(et)-298.3(al)]TJ /F3 1 Tf 1.7767 0 TD [(.)-300.1(Neutrophil)]TJ -17.976 -1.1445 TD [(apoptosis)-331.1(in)-323.8(the)-329.4(acute)-328(respiratory)-337.9(distress)-327.5(syndrome.)]TJ /F4 1 Tf 21.4979 0 TD (Am)Tj -21.4979 -1.1381 TD [(Respir)-333.8(Crit)-337.4(Car)33.6(e)-334.4(Med)]TJ /F3 1 Tf 9.2251 0 TD [(1997;)-334.9(156:)-335.5(1969\2611977.)]TJ -11.7416 -1.1065 TD [(12.)-1266.5(Cox)-401.5(G,)-404(Gauldie)-402.4(J,)-401.9(Jordana)-402.8(M.)-401.4(Bronchial)-403.7(epithelial)-404.5(cell)]TJ 2.5165 -1.1445 TD [(derived)-492.5(cytokines)-494.1(\(G-CSF)-497.2(and)-491.4(GM-CSF\))-491.1(promote)-494.6(the)]TJ 0 -1.1381 TD [(survival)-438.9(of)-429.9(peripheral)-437.2(blood)-436.1(neutrophils)]TJ /F4 1 Tf 16.9075 0 TD [(in)-431.3(vitr)27.9(o)]TJ /F3 1 Tf 3.035 0 TD (.)Tj /F4 1 Tf 0.6829 0 TD [(Am)-435.7(J)]TJ -20.6253 -1.1381 TD [(Respir)-333.8(Cell)-336(Mol)-336.4(Biol)]TJ /F3 1 Tf 8.8015 0 TD [(1992,)-329.7(7:)-336.5(507\261513.)]TJ -11.318 -1.1128 TD 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