文摘

背景:提高静息能量消耗(REE)通常发生在慢性阻塞性肺疾病(COPD)患者的原因还未可知。本研究的目的是评估稀土元素之间的关系,急性期蛋白,并在COPD患者炎症介质。方法:30例进行了研究和26个健康年龄对象作为控制。稀土元素被间接量热法测量和调整的无脂质量(FFM)通过生物电阻抗分析。肿瘤坏死因子-α(tnf),可溶性肿瘤坏死受体(sTNF-R) 55 sTNF-R75,白介素6 (IL),引发和脂多糖结合蛋白(LBP)由ELISA测定。结果:14例正常REE和16个。平均身体质量指数和脂肪量在后者已经大大降低,但肺功能在两组数据是相似的。在30 COPD患者(SD) sTNF-R75均值为1.7(1.0)相比1.1 ng / ml (0.4) ng / ml控制;c反应蛋白(CRP)检测(> 5微克/毫升)在8个病人与对照组的相比,和枸杞多糖是13.2(7.7)微克/毫升(3.1)只有8.6微克/毫升的控制。患者提高稀土元素增加了意味着患者的CRP水平比正常的REE(中位数5.5微克/毫升(范围5 - 193)和<分别5微克/毫升); the same was true for LBP (median 12.4 micrograms/ml (range 8.1-39.1) and 9.5 micrograms/ml (range 5.0-16.6), respectively), but sTNF-R55 and R75 and IL-8 were similar in the two groups. Of the 16 patients with a raised REE, the CRP level was increased in eight and normal in eight. In those with an increased level of CRP the FFM was decreased and LBP, IL-8, and sTNF-R55 and R75 were increased compared with those with normal CRP levels. CONCLUSIONS: A subset of patients with COPD with an increased REE and decreased FFM have increased levels of acute phase reactant proteins and inflammatory cytokines in their serum; these phenomena may be causally related.