文摘

背景:吸烟可能会引起呼吸道炎症和肺功能的损害。确定之间的关系类型和程度的气道炎症和肺功能的下降,白细胞在吸烟者和戒烟的痰液检查。方法:40 6吸烟者和戒烟的平均年龄64年(25%;75%百分位数62;66)吸烟史的40.1(31.7;53)包年进行肺功能测试和问卷调查的15年随访期。痰液被吸入诱导的高渗盐水和微分白细胞数量进行cytospin准备。结果:获得足够的痰样本分布在38个科目(78%)。的比率在一秒钟用力呼气量(FEV1)肺活量(VC) 67.1 (60;72)%和年度FEV1下降为19.4毫升/年(12;30)。气道阻塞患者FEV1 / VC < 63%)有更多的中性粒细胞(77(50,86)%)比那些没有气道阻塞(60 (43;73)%)。中性粒细胞的百分比也显著更大(77(62;85)%)比那些没有慢性咳痰咳痰(57 (45;75)%。 Increased levels of neutrophils in the sputum were correlated with a rapid decline in FEV1 over the 15 year follow up period. CONCLUSIONS: Airways obstruction and chronic expectoration, as well as accelerated decline in lung function, are associated with increased numbers of neutrophils in the sputum of smokers and ex-smokers which suggests that neutrophilic inflammation of the airways may be involved in the pathogenesis of chronic obstructive pulmonary disease.