文摘
目的:估计Churg-Strauss综合症的发病率(CSS)在哮喘吸毒者的庞大的人口。方法:回顾性研究中患者该药哮喘药物3保健管理组织。成年人收到>或= 3配药治疗哮喘的药物之间的任何连续12个月期间1月1日,1995年和2000年6月30日被确定。信息对病人的年龄、性别、入学状态,哮喘药物分发,住院病人和门诊病人诊断和程序是获得自动化数据库。图表进行评论人被诊断的组合和计费代码的CSS的说明。风湿病审查抽象信息在所有科目;那些遇到>或美国风湿病学院= 2的标准CSS 2临床专家进行了综述。每个临床专家独立评级的情况下;有分歧的解决共识。案件列为“可能/明确的”CSS包含在这些分析。 The incidence of CSS was estimated overall and according to patient gender, age, and calendar year. RESULTS: From a population of 184,667 asthma drug users contributing 606,184 person-years of exposure, 21 incident cases of CSS were identified (overall incidence of 34.6 per million person-years; 95% confidence interval 21.4 to 53.0). Incidence rates did not differ by gender and age group. The incidence rates for 1995, 1996, 1997, 1998, 1999, and the first 6 months of 2000 were 0, 22, 52, 75, 14, and 14 per million person-years respectively. CONCLUSIONS: Results from this population-based study suggest a somewhat lower incidence of CSS in asthma drug users than previously reported and provides important information as to the risk of developing CSS from a population-based perspective.