摘要

目的:调查类风湿关节炎患者和未选择的对照组吸入甲胆碱后气道阻塞和支气管反应的发生率。对照组由患有轻微退行性关节问题的风湿病科患者组成。方法—100例类风湿性关节炎(RA)患者[72例(72%)女性，28例(28%)男性;平均(SD)年龄58(10)岁]和50对照组[30(60%)女性，20(40%)男性;平均(SD)年龄56(9)岁。详细记录了病史、吸烟史和吸毒史;进行了皮肤刺刺试验以评估特异反应，并进行了胸部和手部x光片。进行了肺活量测定、流量容积回路和气体转移因子测量，以检测气流阻塞，并进行了甲胆碱吸入试验，以评估支气管反应性。结果:类风湿关节炎患者与对照组在年龄、性别、吸烟状况和皮肤刺痛试验特异反应方面差异无统计学意义(p < 0.05)。RA患者有喘息史的比例明显高于对照组(18% vs 4%， p < 0.05)。 FEV1, FVC, FEV1/FVC, FEF25-75%, FEF25%, FEF50% and FEF75% were all significantly lower in the rheumatoid arthritis group (p < 0.05). A significantly higher number of patients with RA compared with controls showed bronchial reactivity to inhaled methacholine [55 (55%) v 8 (16%), p < 0.05]. FEV1, FVC, FEV1/FVC, FEF25-75%, FEF25%, FEF50% and FEF75% were all significantly lower among the patients with RA achieving PD20 FEV1 to inhaled methacholine (p < 0.05). CONCLUSION--In unselected rheumatoid arthritis patients both airflow obstruction and bronchial reactivity are significantly increased compared with controls.