A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases
Clinical and epidemiological data suggest that asthma and allergic diseases are associated
and may share a common genetic etiology. We analyzed genome-wide SNP data for asthma
and allergic diseases in 33,593 cases and 76,768 controls of European ancestry from UK …
and may share a common genetic etiology. We analyzed genome-wide SNP data for asthma
and allergic diseases in 33,593 cases and 76,768 controls of European ancestry from UK …
Association of obesity and its genetic predisposition with the risk of severe COVID-19: Analysis of population-based cohort data
Objective We aimed to examine the associations of obesity-related traits (body mass index
[BMI], central obesity) and their genetic predisposition with the risk of developing severe
COVID-19 in a population-based data. Research design and methods We analyzed data …
[BMI], central obesity) and their genetic predisposition with the risk of developing severe
COVID-19 in a population-based data. Research design and methods We analyzed data …
[HTML][HTML]Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders
…,V Anttila, H Won, YCA Feng,J Rosenthal, ZZhu… - Cell, 2019 - Elsevier
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these
pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 …
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these
pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 …
[HTML][HTML]Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China
…, B Huang, X Ding, X Wang, P Niu, J Meng,ZZhu… - Cell host & …, 2020 - Elsevier
An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has
revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or
SARS-like coronaviruses. A systematic comparison identified 380 amino acid substitutions …
revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or
SARS-like coronaviruses. A systematic comparison identified 380 amino acid substitutions …
Shared genetic architecture between metabolic traits and Alzheimer's disease: A large-scale genome-wide cross-trait analysis
A growing number of studies clearly demonstrate a substantial link between metabolic
dysfunction and the risk of Alzheimer's disease (AD), especially glucose-related dysfunction;
one hypothesis for this comorbidity is the presence of a common genetic etiology. We …
dysfunction and the risk of Alzheimer's disease (AD), especially glucose-related dysfunction;
one hypothesis for this comorbidity is the presence of a common genetic etiology. We …
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis
Epidemiological studies demonstrate an association between asthma and mental health
disorders, although little is known about the shared genetics and causality of this
association. Thus, we aimed to investigate shared genetics and the causal link between …
disorders, although little is known about the shared genetics and causality of this
association. Thus, we aimed to investigate shared genetics and the causal link between …
哮喘协会及其遗传predisposition with the risk of severe COVID-19
To the Editor: In individuals with severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) infection, the severity of illness ranges from asymptomatic to fatal. 1 The Centers for
Disease Control and Prevention currently list asthma as a risk factor for severe illness from …
CoV-2) infection, the severity of illness ranges from asymptomatic to fatal. 1 The Centers for
Disease Control and Prevention currently list asthma as a risk factor for severe illness from …
[HTML][HTML]Predicting the receptor-binding domain usage of the coronavirus based on kmer frequency on spike protein
Deltacoronavirus, based on serological and genetic studies (Li, 2016). The
Alphacoronavirus and Betacoronavirus mainly infect mammals, whereas the
Gammacoronavirus and Deltacoronavirus mainly infect avians (Tang et al., 2015). The …
Alphacoronavirus and Betacoronavirus mainly infect mammals, whereas the
Gammacoronavirus and Deltacoronavirus mainly infect avians (Tang et al., 2015). The …
Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank
Background Clinical and epidemiologic studies have shown that obesity is associated with
asthma and that these associations differ by asthma subtype. Little is known about the
shared genetic components between obesity and asthma. Objective We sought to identify …
asthma and that these associations differ by asthma subtype. Little is known about the
shared genetic components between obesity and asthma. Objective We sought to identify …
[HTML][HTML]Nematode-encoded RALF peptide mimics facilitate parasitism of plants through the FERONIA receptor kinase
X Zhang, H Peng,SZhu, J Xing, X Li, ZZhu, J Zheng… - Molecular Plant, 2020 - Elsevier
The molecular mechanism by which plants defend against plant root-knot nematodes
(RKNs) is largely unknown. The plant receptor kinase FERONIA and its peptide ligands,
rapid alkalinization factors (RALFs), regulate plant immune responses and cell expansion …
(RKNs) is largely unknown. The plant receptor kinase FERONIA and its peptide ligands,
rapid alkalinization factors (RALFs), regulate plant immune responses and cell expansion …