[HTML][HTML]Clinical utility of the neutrophil elastase inhibitor sivelestat for the treatment of acute respiratory distress syndrome

N Aikawa, YKawasaki- Therapeutics and clinical risk …, 2014 - ncbi.nlm.nih.gov
Acute respiratory distress syndrome is a serious condition that can arise following direct or
indirect lung injury. It is heterogeneous and has a high mortality rate. Supportive care is the …

SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models

…, N Arakawa, K Takuma, Y Kishida, YKawasaki… - … of Pharmacology and …, 2001 - ASPET
The effect of the newly synthesized compound 2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline
(SEA0400) on the Na + -Ca 2+ exchanger (NCX) was investigated and …

Ivabradine for the treatment of cardiovascular diseases

T Ide, K Ohtani, T Higo,M Tanaka, YKawasaki… - Circulation …, 2019 - jstage.jst.go.jp
Higher heart rate (HR) is independently related to worse outcomes in various cardiac
diseases, including hypertension, coronary artery disease, and heart failure (HF). HR is …

Efficacy and safety of ivabradine in Japanese patients with chronic heart failure―J-SHIFT study―

…, T Inomata,Y Sakata, T Tanaka, YKawasaki… - Circulation …, 2019 - jstage.jst.go.jp
Background: Increased heart rate (HR) is an independent risk factor for cardiovascular
outcomes in chronic heart failure (HF). Ivabradine, anI f inhibitor, improved outcomes in patients …

Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory …

…, N Taenaka, S Endo, T Ikeda, YKawasaki- Pulmonary …, 2011 - Elsevier
Introduction Sivelestat, a neutrophil elastase inhibitor, has been approved in Japan for the
treatment of patients with acute lung injury (ALI) associated with systemic inflammatory …

[HTML][HTML]A novel binding factor of 14-3-3β functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasis

…, K Katagiri, M Ogawa, A Sugiyama, YKawasaki… - Journal of Biological …, 2008 - ASBMB
The 14-3-3 proteins form a highly conserved family of dimeric proteins that interact with
各种信号转导蛋白并调节细胞周期,凋亡,应激反应和…

[HTML][HTML]Mechanism of action of benzene toxicity: cell cycle suppression in hemopoietic progenitor cells (CFU-GM)

BI Yoon, Y Hirabayashi, YKawasaki, Y Kodama… - Experimental …, 2001 - Elsevier
Objective The aim of this study was to clarify previously reported controversial data and
hypotheses concerning the effect of benzene on the cell cycle of hemopoietic stem cells. …

Aryl hydrocarbon receptor mediates benzene-induced hematotoxicity

BI Yoon, Y Hirabayashi, YKawasaki… - Toxicological …, 2002 - academic.oup.com
Benzene can induce hematotoxicity and leukemia in humans and mice. Since a review of
the literature shows that the CYP2E1 knockout mouse is not known to possess any benzene …

Mechanisms of benzene-induced hematotoxicity and leukemogenicity: cDNA microarray analyses using mouse bone marrow tissue.

BIL Yoon, GX Li, K Kitada, YKawasaki… - Environmental …, 2003 - ehp.niehs.nih.gov
Although the mechanisms underlying benzene-induced toxicity and leukemogenicity are not
yet fully understood, they are likely to be complicated by various pathways, including those …

An Automated, Clip-Type, Small Internet of Things Camera-Based Tomato Flower and Fruit Monitoring and Harvest Prediction System

…, N Kochi, K Tokuda, Y Nakano,H Naito, YKawasaki… - Sensors, 2022 - mdpi.com
Automated crop monitoring using image analysis is commonly used in horticulture. Image-processing
技术已经被使用in several studies to monitor growth, determine …