Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor–activating mutations
…, H Ogino, S Kakiuchi, M Hanibuchi, YNishioka… - Cancer research, 2008 - AACR
肺癌与epidermal growth factor receptor (EGFR)–activating mutations responds
favorably to the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. However, 25% to 30% …
favorably to the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. However, 25% to 30% …
Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: possible involvement of TNFα and IL‐1α
…, Y Ohmoto, J Nakayama, YNishioka… - … journal of cancer, 2000 - Wiley Online Library
We examined whether macrophage infiltration is associated with angiogenesis in cutaneous
melanoma. The numbers of macrophages and microvessels increased significantly with …
melanoma. The numbers of macrophages and microvessels increased significantly with …
Imatinib as a novel antifibrotic agent in bleomycin-induced pulmonary fibrosis in mice
Y Aono, YNishioka, M Inayama, M Ugai… - American journal of …, 2005 - atsjournals.org
Imatinib mesylate is a potent and specific tyrosine kinase inhibitor against c-ABL, BCR-ABL,
and c-KIT, and has been demonstrated to be highly active in chronic myeloid leukemia and …
and c-KIT, and has been demonstrated to be highly active in chronic myeloid leukemia and …
Induction of systemic and therapeutic antitumor immunity using intratumoral injection of dendritic cells genetically modified to express interleukin 12
YNishioka, M Hirao, PD Robbins, MT Lotze, H Tahara - Cancer research, 1999 - AACR
Bone marrow-derived dendritic cells (BM-DCs) retrovirally transduced with genes encoding
murine interleukin (IL)-12 stably expressed bioactive IL-12 protein at high levels. …
murine interleukin (IL)-12 stably expressed bioactive IL-12 protein at high levels. …
[HTML][HTML]Surfactant protein A suppresses lung cancer progression by regulating the polarization of tumor-associated macrophages
…, S Yano,JG Ledford, S Sone, YNishioka- The American journal of …, 2013 - Elsevier
Surfactant protein A (SP-A) is a large multimeric protein found in the lungs. In addition to its
immunoregulatory function in infectious respiratory diseases, SP-A is also used as a marker …
immunoregulatory function in infectious respiratory diseases, SP-A is also used as a marker …
A novel IκB kinase-β inhibitor ameliorates bleomycin-induced pulmonary fibrosis in mice
M Inayama, YNishioka, M Azuma, S Muto… - American journal of …, 2006 - atsjournals.org
Rationale: IκB kinase-β is a critical regulator in the activation of nuclear factor-κB (NF-κB), a
transcription factor related to the expression and regulation of proinflammatory cytokines. …
transcription factor related to the expression and regulation of proinflammatory cytokines. …
Crosstalk to Stromal Fibroblasts Induces Resistance of Lung Cancer to Epidermal Growth Factor Receptor Tyrosine Kinase InhibitorsFibroblasts Induce EGFR-TKI …
…, M Oda, G Watanabe, Y Kayano, YNishioka… - Clinical Cancer …, 2009 - AACR
Purpose: Lung cancers with epidermal growth factor receptor (EGFR)–activating mutations
show good clinical response to gefitinib and erlotinib, selective tyrosine kinase inhibitors (TKI…
show good clinical response to gefitinib and erlotinib, selective tyrosine kinase inhibitors (TKI…
Hepatocyte Growth Factor Reduces Susceptibility to an Irreversible Epidermal Growth Factor Receptor Inhibitor inEGFR-T790M Mutant Lung Cancer
…, K Matsumoto, W Wang, Q Li, YNishioka… - Clinical Cancer …, 2010 - AACR
Purpose: The secondary T790M mutation in epidermal growth factor receptor (EGFR) is the
most frequent cause of acquired resistance to the reversible EGFR tyrosine kinase inhibitors (…
most frequent cause of acquired resistance to the reversible EGFR tyrosine kinase inhibitors (…
A novel mutant allele of the CYP2A6 gene (CYP2A6* 11) found in a cancer patient who showed poor metabolic phenotype towards tegafur
…, S Nagayama, K Ikeda, YNishioka… - Pharmacogenetics …, 2002 - journals.lww.com
In a clinical study, a newly developed anticancer drug, TS-1 capsule, which contained tegafur
（ft）和5-氯-2、4-二羟基吡啶，二氢吡啶二氢化胺的抑制剂…
（ft）和5-氯-2、4-二羟基吡啶，二氢吡啶二氢化胺的抑制剂…
Transient PI3K Inhibition Induces Apoptosis and Overcomes HGF-Mediated Resistance to EGFR-TKIs in EGFR Mutant Lung CancerTransient PI3K Inhibition …
…, S Takeuchi, K Matsumoto,T Yamori, YNishioka… - Clinical Cancer …, 2011 - AACR
Purpose: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), such as
Gefitinib和Erlotinib对EGFR突变肺癌显示出良好的反应。但是，那 …
Gefitinib和Erlotinib对EGFR突变肺癌显示出良好的反应。但是，那 …