Objective: Pulmonary arterial hypertension (PAH) is a fatal disease characterized by the
narrowing of pulmonary arteries (PAs). It is now established that this phenotype is associated …

Rationale: Pulmonary arterial hypertension (PAH) is a life-threatening condition characterized
通过异常elevated pulmonary pressures and right ventricular failure. Excessive …

Rationale: The MSTs (mammalian Ste20-like kinases) 1/2 are members of the HIPPO
pathway that act as growth suppressors in adult proliferative diseases. Pulmonary arterial …

Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by a sustained
elevation of pulmonary artery (PA) pressure, right ventricular failure, and premature death. …

Background Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterised by
exuberant tissue remodelling and associated with high unmet medical needs. Outcomes are …

The authors show that increased poly(adenosine diphosphate–ribose) polymerase 1 (PARP1)
and pyruvate kinase muscle isozyme 2 (PKM2) expression is a common feature of a …

… Charifa Awada,Yann Grobs, Wen-Hui Wu, Karima Habbout, Charlotte Romanet, Sandra
Breuils-Bonnet, Eve Tremblay, Sandra Martineau, Roxane Paulin, Sébastien Bonnet …

Trifluoperazine (TFP), an antipsychotic drug approved by the Food and Drug Administration,
has been show to exhibit anti-cancer effects. Pulmonary arterial hypertension (PAH) is a …

Experimental procedures using human tissues or cells conformed to the principles outlined
in the Declaration of Helsinki and were performed with the approval of Laval University and …

Pulmonary arterial hypertension (PAH) is characterized by progressive obstruction and
decreased compliance of pulmonary arteries (PA), leading to right ventricular (RV) failure and …