Background NVX-CoV2373 is a recombinant severe acute respiratory syndrome
coronavirus 2 (rSARS-CoV-2) nanoparticle vaccine composed of trimeric full-length SARS-CoV-2
spike glycoproteins and Matrix-M1 adjuvant. Methods We initiated a randomized, placebo-…

Background The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants threatens progress toward control of the coronavirus disease 2019 (Covid-19)
pandemic. In a phase 1–2 trial involving healthy adults, the NVX-CoV2373 nanoparticle …

Background Triple-reassortant swine influenza A (H1) viruses — containing genes from avian,
human, and swine influenza viruses — emerged and became enzootic among pig herds in
North America during the late 1990s. Methods We report the clinical features of the first 11 …

This study analyzes data from 19 countries (from April 2009 to Jan 2010), comprising some
70,000 hospitalized patients with severe H1N1 infection, to reveal risk factors for severe
pandemic influenza, which include chronic illness, cardiac disease, chronic respiratory disease, …

Background Respiratory syncytial virus (RSV) is the dominant cause of severe lower
respiratory tract infection in infants, with the most severe cases concentrated among younger
婴儿。方法健康的孕妇,在28日凌晨ks 0 days through 36 weeks 0 days of …

Background Influenza is often not recognized as an important cause of severe or fatal disease
in tropical and subtropical countries in Southeast Asia. The extent to which Oseltamivir
treatment may protect against a fatal outcome in severe influenza infections is not known. …

Background Respiratory syncytial virus (RSV) is an important cause of serious respiratory
illness in older adults. Comparison of RSV and influenza infection in hospitalized older adults
may increase awareness of adult RSV disease burden. Methods Hospitalized adults aged ≥…

… Gonçalo Matias, François Haguinet, andVivek Shindeare employed by the GlaxoSmithKline
group of companies.Vivek Shindehas stock options in the GlaxoSmithKline group of
companies. Robert Taylor has an ownership interest in Sage Analytica, a consultancy in …

Background Influenza is an important cause of morbidity and mortality among older adults.
Even so, effectiveness of influenza vaccine for older adults has been reported to be lower than
for younger adults, and the impact of frailty on vaccine effectiveness (VE) and outcomes is …

Estimates of influenza and respiratory syncytial virus (RSV) burden must be periodically
updated to inform public health strategies. We estimated seasonal influenza- and RSV-attributable
hospitalizations in the US from 1997 to 2009 according to age and risk status (…