Activation of the NALP3 inflammasome induces interleukin 1β production and inflammation.
Latz and colleagues show that silica uptake followed by lysosome disruption and cathepsin …

MicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or
translation of fully or partially sequence-complementary target mRNAs. In order to identify …

The structural basis for the distinction of viral RNA from abundant self RNA in the cytoplasm
of virally infected cells is largely unknown. We demonstrated that the 5′-triphosphate end of …

Innate immunity sensor Cytoplasmic DNA is an important trigger for the innate immune
system. The downstream signalling pathways involved in this process have been extensively …

The inflammatory nature of atherosclerosis is well established but the agent (s) that incite
inflammation in the artery wall remain largely unknown. Germ-free animals are susceptible to …

The events leading to the inflammation and tissue damage associated with Alzheimer's
disease are unclear. Golenbock and colleagues now show that amyloid-β activates the …

The IL-1 family cytokines are regulated on transcriptional and posttranscriptional levels.
Pattern recognition and cytokine receptors control pro-IL-1β transcription whereas …

The Toll-like receptor (TLR)9 is critical for the recognition of immunostimulatory CpG motifs
but may cooperate with other TLRs. We analyzed TLR1–10 mRNA expression by using …

Short interfering RNA (siRNA) is used in RNA interference technology to avoid non-target-related
induction of type I interferon (IFN) typical for long double-stranded RNA. Here we show …

The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes (STING)…