Adult differentiated cells can be reprogrammed into pluripotent stem cells or lineage-restricted
proliferating precursors in culture; however, this has not been demonstrated in vivo. Here, …

Cell fate can be reprogrammed by modifying intrinsic and extrinsic cues. Here we show that
two small molecules (forskolin and dorsomorphin) enable the transcription factor …

Adult neurogenesis plays critical roles in maintaining brain homeostasis and responding to
neurogenic insults. However, the adult mammalian spinal cord lacks an intrinsic capacity for …

Glial cells can be in vivo reprogrammed into functional neurons in the adult CNS; however,
the process by which this reprogramming occurs is unclear. Here, we show that a distinct …

Fragile X syndrome (FXS), the most common genetic form of mental retardation and autism,
is caused by loss-of-function mutations in an RNA-binding protein, Fragile X Mental …

Various combinations of cardiogenic transcription factors, including Gata4 (G), Hand2 (H),
Mef2c (M) and Tbx5 (T), can reprogram fibroblasts into induced cardiac-like myocytes (iCLMs) …

Subtype-specific neurons obtained from adult humans will be critical to modeling
neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). Here, we show that adult …

In vitro generation of motor neurons (MNs) is a promising approach for modeling motor neuron
diseases such as amyotrophic lateral sclerosis (ALS). As aging is a leading risk factor for …

Adult neurogenesis persists in the rodent dentate gyrus and is stimulated by chronic treatment
with conventional antidepressants through BDNF/TrkB signaling. Ketamine in low doses …

The amyloid-β protein (Aβ) oligomers are believed to be the main culprits in the cytoxicity of
Alzheimer’s disease (AD) and p3 peptides (Aβ17–42 fragments) are present in AD amyloid …