Background— Tumor necrosis factor-α (TNF-α) and angiotensin II (Ang II) are implicated in
the development and further progression of heart failure, which might be, at least in part, …

Background— Short-term administration of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)
reductase inhibitors, statins, has been shown to attenuate ischemia-reperfusion injury. …

Matrix metalloproteinase-2 (MMP-2) is prominently overexpressed both after myocardial
infarction (MI) and in heart failure. However, its pathophysiological significance in these …

目的::转换growth factor (TGF)-β promotes the deposition of extracellular matrix
protein and also acts as an anti-inflammatory cytokine. These biological effects might be …

Background— Increased expression of monocyte chemoattractant protein-1 (MCP-1) has
recently been described in clinical and experimental failing heart. However, its …

Background— Oxidative stress plays an important role in the pathophysiology of heart
failure. We determined whether the overexpression of glutathione peroxidase (GSHPx) could …

Background— Peroxisome proliferator–activated receptor-γ activators have recently been
implicated as regulators of cellular proliferation and inflammatory response such as cytokine …

To evaluate the ability of high-resolution computed tomography (HRCT) to detect longitudinal
changes in structural abnormalities caused by smoking, HRCT and pulmonary function …

Platelet activating factor (PAF) is immediately degraded and inactivated in the bloodstream
by plasma PAF acetylhydrolase (PAF-AH). Although plasma PAF-AH-like activity was …

Objectives : The aim of the present study was to determine whether streptozotocin (STZ)-induced
hyperglycemia exacerbates progressive left ventricular (LV) dilation and dysfunction …