Inert gas washout tests, performed using the single- or multiple-breath washout technique,
were first described over 60 years ago. As measures of ventilation distribution inhomogeneity, …

Background: Airway hyperresponsiveness is the ability of airways to narrow excessively in
response to inhaled stimuli and is a key feature of asthma. Airway inflammation and …

Study objectives To evaluate the use of the FEV 1 /forced expiratory volume at 6 s of exhalation
(FEV 6 ) ratio and FEV 6 as an alternative for FEV 1 /FVC and FVC in the detection of …

It has been shown that structural changes in small airways of smokers with average smoking
histories greater than 35 pack-years could be reflected in the single-breath washout test. …

The ability of the diaphragm to generate pressures at different lung volumes (VLs) in humans
may be determined by the following factors: 1) its in vivo three-dimensional shape, radius …

…Sylvia Verbanck…Sylvia Verbanck…Sylvia Verbanck…

Patients referred for treatment of tracheal stenosis typically are asymptomatic until critical
narrowing of the airway occurs, which then requires immediate intervention. To understand …

We investigated ventilation inhomogeneity in patients with chronic obstructive pulmonary
disease (COPD) through use of the multiple breath N 2 washout test (MBW). From an alveolar …

Objectives To estimate the prevalence of undiagnosed chronic obstructive pulmonary disease
(COPD) in a population of general practice patients at risk for developing COPD. A further …

Rationale Small airways function studies in lung disease have used three promising multiple
breath washout (MBW) derived indices: indices of ventilation heterogeneity in the acinar (S …