Suboptimal treatment response to anti-IL-5 monoclonal antibodies in severe eosinophilic asthmatics with airway autoimmune phenomena
…, H Al-Hayyan, A Ayoub, SDRevill… - European …, 2020 - Eur Respiratory Soc
Background In clinical trials, the two anti-interleukin (IL)-5 monoclonal antibodies (mAbs:
mepolizumab and reslizumab) approved to treat severe eosinophilic asthma reduce …
mepolizumab and reslizumab) approved to treat severe eosinophilic asthma reduce …
A robust protocol for decellularized human lung bioink generation amenable to 2D and 3D lung cell culture
…,M Babi、Chandiramohan Noble, SDRevill… - Cells, 2021 - mdpi.com
Decellularization efforts must balance the preservation of the extracellular matrix (ECM)
components while eliminating the nucleic acid and cellular components. Following effective …
components while eliminating the nucleic acid and cellular components. Following effective …
Monocyte and macrophage derived myofibroblasts: Is it fate? A review of the current evidence
…, S Naiel, P Yazdanshenas, SDRevill… - Wound Repair and …, 2021 - Wiley Online Library
Since the discovery of the myofibroblast over 50 years ago, much has been learned about
its role in wound healing and fibrosis. Its origin, however, remains controversial, with a …
its role in wound healing and fibrosis. Its origin, however, remains controversial, with a …
FK506-binding protein 13 expression is upregulated in interstitial lung disease and correlated with clinical severity. a potentially protective role
…, S Abed, O Mekhael, K Tandon, SDRevill… - American Journal of …, 2021 - atsjournals.org
Pulmonary fibrosis is a progressive lung disease characterized by myofibroblast accumulation
and excessive extracellular matrix deposition. We sought to investigate the role of …
and excessive extracellular matrix deposition. We sought to investigate the role of …
Cigarette smoke augments CSF3 expression in neutrophils to compromise alveolar-capillary barrier function during influenza infection
…, SDRevill, A Tabuchi,DZabini… - European …, 2022 - Eur Respiratory Soc
Background Cigarette smokers are at increased risk of acquiring influenza, developing
severe disease, and requiring hospitalization/ICU admission following infection. However, …
severe disease, and requiring hospitalization/ICU admission following infection. However, …
Mouse Models of Lung Fibrosis
O Mekhael, S Naiel, M Vierhout, AI Hayat, SDRevill… - Myofibroblasts, 2021 - Springer
The drug discovery pipeline, from discovery of therapeutic targets through preclinical and
clinical development phases, to an approved product by health authorities, is a time-…
clinical development phases, to an approved product by health authorities, is a time-…
[HTML][HTML]Increased Monocyte-Derived CD11b+ Macrophage Subpopulations Following Cigarette Smoke Exposure Are Associated With Impaired Bleomycin-Induced …
…,DThayaparan, JJC McGrath, SDRevill… - Frontiers in …, 2021 - ncbi.nlm.nih.gov
Methods Using a whole-body cigarette smoke exposure system, we investigated the impact
of cigarette smoke on macrophage subpopulations in C57BL/6 mice using flow cytometry-…
of cigarette smoke on macrophage subpopulations in C57BL/6 mice using flow cytometry-…
[HTML][HTML]Inhalation: A means to explore and optimize nintedanib's pharmacokinetic/pharmacodynamic relationship
…, S Pham, S Beck, S Naiel, O Mekhael, SRevill… - Pulmonary …, 2020 - Elsevier
Oral nintedanib is marketed for the treatment of idiopathic pulmonary fibrosis (IPF). While
effective slowing fibrosis progression, as an oral medicine nintedanib is limited. To reduce side …
effective slowing fibrosis progression, as an oral medicine nintedanib is limited. To reduce side …
Depression in rheumatoid arthritis patients: demographic, clinical, and psychological predictors
T Covic,G Tyson,D Spencer, G Howe - Journal of psychosomatic research, 2006 - Elsevier
Objective To confirm the prevalence of depression in a sample of rheumatoid arthritis (RA)
patients; to identify the most significant predictors of depression in RA and to explore patients …
patients; to identify the most significant predictors of depression in RA and to explore patients …
A preliminary investigation of cognitive function in rheumatoid arthritis patients on long-term methotrexate treatment
…, S Cumming, L Hallab,D Spencer… - Journal of health …, 2013 - journals.sagepub.com
Some studies suggest that cognitive function is impaired in rheumatoid arthritis patients.
One possible influence may be commonly used rheumatoid arthritis treatment, methotrexate. …
One possible influence may be commonly used rheumatoid arthritis treatment, methotrexate. …