Mammalian rRNA genes are preceded by a terminator element that is recognized by the
transcription termination factor TTF-I. In exploring the functional significance of the promoter-…

The human endothelial nitric-oxide synthase gene (heNOS) is constitutively expressed in
endothelial cells, and its expression is induced under hypoxia. The goal of this study was to …

Endothelium-derived relaxing factor (EDRF)/nitric oxide (NO) is synthesized from L-Arginine
by the endothelial, constitutive, NO synthase. To facilitate genetic studies, we have cloned …

Physiological adaptation of normal blood vessels to acute or chronic changes in blood flow
is endothelium dependent. In vitro studies have shown that, among other genes, NO …

Pregnancy-induced hypertension may be regarded as a manifestation of endothelial-cell
dysfunction. The role of the eNOS gene in the development of a familial pregnancy-induced …

Aims Our aim was to identify new microRNAs (miRNAs) implicated in pathological vascular
smooth muscle cells (VSMCs) proliferation and characterize their mechanism of action. …

Florent Soubrier and colleagues report a genome-wide association study of pulmonary
arterial hypertension. They identify a susceptibility locus near CBLN2 associated with a …

Aging is the main risk factor for cardiovascular diseases, but the associated molecular
mechanisms are poorly understood. The Wnt signaling pathway was shown to be induced during …

Background The basal release of nitric oxide by the endothelium plays an important role in
regulating blood flow and pressure and mediates most of the endothelium-dependent …

The prevalence of germline mutations in paediatric pulmonary hypertension (PH) is poorly
documented. The objective of this study was to determine the mutation frequency in PH genes …