Method for measuring neurotoxicity of aggregating polypeptides with the MTT assay on differentiated neuroblastoma cells
Z Datki, A Juhász, M Gálfi, K Soós, RPapp… - Brain research …, 2003 - Elsevier
Reliable in vitro assays are essential for study of the effects of neurotoxic compounds such
as β-amyloid peptides (Aβ). The MTT assay has been used in cultures of different cells, eg SH…
as β-amyloid peptides (Aβ). The MTT assay has been used in cultures of different cells, eg SH…
TGF-β directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury
…, C Becker, S Herold, RPapp… - Proceedings of the …, 2014 - National Acad Sciences
TGF-β is a pathogenic factor in patients with acute respiratory distress syndrome (ARDS), a
condition characterized by alveolar edema. A unique TGF-β pathway is described, which …
condition characterized by alveolar edema. A unique TGF-β pathway is described, which …
Targeting TMEM16A to reverse vasoconstriction and remodelling in idiopathic pulmonary arterial hypertension
RPapp,C Nagaraj, D Zabini, BM Nagy… - European …, 2019 - Eur Respiratory Soc
Our systematic analysis of anion channels and transporters in idiopathic pulmonary arterial
hypertension (IPAH) showed marked upregulation of the Cl − channel TMEM16A gene. We …
hypertension (IPAH) showed marked upregulation of the Cl − channel TMEM16A gene. We …
Oestrogen upregulates L‐type Ca2+channels via oestrogen‐receptor‐α by a regional genomic mechanism in female rabbit hearts
X Yang, G Chen, RPapp,DB DeFranco… - The Journal of …, 2012 - Wiley Online Library
Non‐technical summary Women during their child‐bearing years have longer QT intervals
in their electrocardiograms than men and are more susceptible to lethal arrhythmias elicited …
in their electrocardiograms than men and are more susceptible to lethal arrhythmias elicited …
In vitro model of neurotoxicity of Aβ 1–42 and neuroprotection by a pentapeptide: irreversible events during the first hour
Z Datki, RPapp,D Zádori, K Soós, L Fülöp… - Neurobiology of …, 2004 - Elsevier
The cell biology of Alzheimer's disease (AD) is characterized mainly by the neurodegeneration
caused by the β-amyloid (Aβ) peptides and by the formation of neurofibrillary tangles. …
caused by the β-amyloid (Aβ) peptides and by the formation of neurofibrillary tangles. …
Reverse rate-dependent changes are determined by baseline action potential duration in mammalian and human ventricular preparations
Class III antiarrhythmic agents exhibit reverse rate-dependent lengthening of the action
potential duration (APD). In spite of the several theories developed so far to explain this reverse …
potential duration (APD). In spite of the several theories developed so far to explain this reverse …
Gap junctional uncoupling plays a trigger role in the antiarrhythmic effect of ischaemic preconditioning
RPapp, M Gönczi,M Kovács,G Seprényi… - Cardiovascular …, 2007 - academic.oup.com
Objective: The aim of this study was to determine whether uncoupling of gap junctions (GJ)
prior to ischaemia would modify the antiarrhythmic effect of ischaemic preconditioning (PC) in …
prior to ischaemia would modify the antiarrhythmic effect of ischaemic preconditioning (PC) in …
Importance of kynurenine in pulmonary hypertension
…, A Meinitzer,N Sharma, RPapp… - … of Physiology-Lung …, 2017 - journals.physiology.org
The tryptophan metabolite kynurenine is significantly increased in pulmonary arterial
hypertension (PAH) patients, and it is a potent vasodilator of systemic arteries. Our aim was to …
hypertension (PAH) patients, and it is a potent vasodilator of systemic arteries. Our aim was to …
[HTML][HTML]任务1调节apoptosis and proliferation in a subset of non-small cell lung cancers
K Leithner, B Hirschmugl, Y Li, B Tang, RPapp… - PLoS …, 2016 - journals.plos.org
Lung cancer is the leading cause of cancer deaths worldwide; survival times are poor
despite therapy. The role of the two-pore domain K+ (K2P) channel TASK-1 (KCNK3) in lung …
despite therapy. The role of the two-pore domain K+ (K2P) channel TASK-1 (KCNK3) in lung …
Ion channels and transporters as therapeutic targets in the pulmonary circulation
A Olschewski, RPapp,C Nagaraj… - Pharmacology & …, 2014 - Elsevier
Pulmonary circulation is a low pressure, low resistance, high flow system. The low resting
vascular tone is maintained by the concerted action of ion channels, exchangers and pumps. …
vascular tone is maintained by the concerted action of ion channels, exchangers and pumps. …