The study of human macrophages and their ontogeny is an important unresolved issue.
Here, we use a humanized mouse model expressing human cytokines to dissect the …

The immunopathology of coronavirus disease 2019 (COVID-19) remains enigmatic, causing
immunodysregulation and T cell lymphopenia. Monocytic myeloid-derived suppressor cells (…

Every breath we take contains potentially harmful pathogens or allergens. Dendritic cells (DCs),
monocytes, and macrophages are essential in maintaining a delicate balance of …

Disease phenotypes of pulmonary sarcoidosis are distinguished by clinical rather than
immunological criteria. We aimed to characterise patterns of CD4 + T-cell lineage plasticity …

Pulmonary sarcoidosis has unknown etiology, a difficult diagnostic procedure and no curative
treatment. Extracellular vesicles including exosomes are nano-sized entities released from …

Sarcoidosis is a systemic inflammatory disease mainly affecting the lungs. The hallmark of
sarcoidosis are granulomas that are surrounded by activated T cells, likely targeting the …

Sarcoidosis is a T‐cell driven inflammatory disease characterized by granuloma formation.
Mononuclear phagocytes (MNPs)—macrophages, monocytes, and dendritic cells (DCs)—are …

Influenza A viruses (IAV) primarily target respiratory epithelial cells, but can also replicate in
immune cells, including human dendritic cells (DCs). Super-resolution microscopy provides …

Whole-blood fixation provides a rapid and simplified method for cell preservation compared
to isolation of peripheral blood mononuclear cells (PBMCs). This can be especially …

Background Pulmonary sarcoidosis is an inflammatory disease characterised by granuloma
formation and heterogeneous clinical outcome. Tumour necrosis factor (TNF) is a pro-…