Alveolar macrophages orchestrate the response to viral infections. Age-related changes in
these cells may underlie the differential severity of pneumonia in older patients. We …

Ontologically distinct populations of macrophages differentially contribute to organ fibrosis
through unknown mechanisms. We applied lineage tracing, single-cell RNA sequencing and …

Pulmonary fibrosis is a relentlessly progressive and often fatal disease with a paucity of
available therapies. Genetic evidence implicates disordered epithelial repair, which is normally …

Alveolar epithelial cell (AEC) apoptosis, arising from mitochondrial dysfunction and
mitophagy defects, is important in mediating idiopathic pulmonary fibrosis (IPF). Our group …

Regulatory T (Treg) cells orchestrate resolution and repair of acute lung inflammation and
injury after viral pneumonia. Compared with younger patients, older individuals experience …

Skeletal muscle dysfunction in survivors of pneumonia disproportionately affects older
individuals in whom it causes substantial morbidity. We found that skeletal muscle recovery was …

Numerous studies have established that acute or chronic exposure to environmental
pollutants like particulate matter (PM) leads to the development of accelerated aging related …

…劳尔 Piseaux-Aillonc …

Although in the ionizing radiation field many concepts and processes are currently recognized
as radiobiological, there are also probabilistic ones, and a probabilistic treatment makes a …

Aging is among the most important risk factors for the development of pulmonary fibrosis.
We found that a small molecule that specifically inhibits translational inhibition induced by …