Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives
…,C Guignabert,S Bonnet, PDorfmüller… - European …, 2019 - Eur Respiratory Soc
临床and translational research has played a major role in advancing our understanding
of pulmonary hypertension (PH), including pulmonary arterial hypertension and other forms …
of pulmonary hypertension (PH), including pulmonary arterial hypertension and other forms …
Relevant issues in the pathology and pathobiology of pulmonary hypertension
RM Tuder,SL Archer, PDorfmüller, SC Erzurum… - Journal of the American …, 2013 - jacc.org
Knowledge of the pathobiology of pulmonary hypertension (PH) continues to accelerate.
However, fundamental gaps remain in our understanding of the underlying pathological …
However, fundamental gaps remain in our understanding of the underlying pathological …
Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension
F Perros,D Montani, PDorfmüller… - American journal of …, 2008 - atsjournals.org
Rationale: Platelet-derived growth factor (PDGF) promotes the proliferation and migration of
pulmonary artery smooth muscle cells (PASMCs), and may play a role in the progression of …
pulmonary artery smooth muscle cells (PASMCs), and may play a role in the progression of …
Inflammation in pulmonary arterial hypertension
LC Price, SJ Wort, F Perros, PDorfmüller, A Huertas… - Chest, 2012 - Elsevier
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling
of the precapillary pulmonary arteries, with excessive proliferation of vascular cells. Although …
of the precapillary pulmonary arteries, with excessive proliferation of vascular cells. Although …
Endothelial-to-mesenchymal transition in pulmonary hypertension
…, A Hautefort, C Péchoux, HJ Bogaard, PDorfmüller… - Circulation, 2015 - Am Heart Assoc
Background— The vascular remodeling responsible for pulmonary arterial hypertension (PAH)
involves predominantly the accumulation of α-smooth muscle actin–expressing …
involves predominantly the accumulation of α-smooth muscle actin–expressing …
Fibrous remodeling of the pulmonary venous system in pulmonary arterial hypertension associated with connective tissue diseases
PDorfmüller,M Humbert, F Perros, O Sanchez… - Human pathology, 2007 - Elsevier
Pulmonary arterial hypertension is a severe complication of connective tissue diseases. It is
currently well established that pulmonary arterial hypertension associated with connective …
currently well established that pulmonary arterial hypertension associated with connective …
Right ventricular diastolic impairment in patients with pulmonary arterial hypertension
…,WJ Paulus, CAC Ottenheijm, JT Marcus, PDorfmüller… - Circulation, 2013 - Am Heart Assoc
Background— The role of right ventricular (RV) diastolic stiffness in pulmonary arterial
hypertension (PAH) is not well established. Therefore, we investigated the presence and possible …
hypertension (PAH) is not well established. Therefore, we investigated the presence and possible …
CX3C Chemokine Fractalkine in Pulmonary Arterial Hypertension
K Balabanian, A Foussat, PDorfmüller… - American journal of …, 2002 - atsjournals.org
Perivascular infiltrates composed of macrophages and lymphocytes have been described in
lung biopsies of patients displaying pulmonary arterial hypertension (PAH), suggesting that …
lung biopsies of patients displaying pulmonary arterial hypertension (PAH), suggesting that …
EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension
Pulmonary veno-occlusive disease (PVOD) is a rare and devastating cause of pulmonary
hypertension that is characterized histologically by widespread fibrous intimal proliferation of …
hypertension that is characterized histologically by widespread fibrous intimal proliferation of …
Chemokine RANTES in severe pulmonary arterial hypertension
PDorfmuller, V Zarka, I Durand-Gasselin… - American journal of …, 2002 - atsjournals.org
The recent discovery that sporadic and familial primary pulmonary hypertension can be
associated with germline mutations of genes encoding receptor members of the transforming …
associated with germline mutations of genes encoding receptor members of the transforming …