We isolated and identified an endogenous 24-kDa human basement membrane-derived
inhibitor of angiogenesis and tumor growth, termed canstatin. Canstatin, a fragment of the α2 …

Vascular basement membrane is an important structural component of blood vessels and
has been shown to interact with and modulate vascular endothelial behavior during …

Vascular basement membrane is an important structural component of blood vessels.
During angiogenesis this membrane undergoes many alterations and these changes are …

Type IV collagen is a major component of basement membranes and it provides structural
and functional support to various cell types. Type IV collagen exists in a highly complex …

Vascular basement membrane is an important regulator of angiogenesis and undergoes
many alterations during angiogenesis and these changes are speculated to influence …

Riociguat is a soluble guanylate cyclase stimulator approved for the treatment of inoperable
and persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH). In the …

Background Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare, debilitating,
and life-threatening disease. We investigated associations between markers of disease …

A proportion of pulmonary arterial hypertension (PAH) patients do not reach treatment goals
with phosphodiesterase-5 inhibitors (PDE5i). RESPITE investigated the safety, feasibility …

Physiological and pathological turnover of basement membranes liberates biologically active
cryptic molecules. Several collagen-derived fragments possess anti-angiogenic activity. …

Background Riociguat was well tolerated and improved exercise and functional capacity in
patients with pulmonary arterial hypertension (PAH) and inoperable chronic thromboembolic …