Experimental liver cirrhosis induced by alcohol and iron.

…, W Horne, S Kamimura, ONiemelä… - The Journal of …, 1995 - Am Soc Clin Investig
To determine if alcoholic liver fibrogenesis is exacerbated by dietary iron supplementation,
carbonyl iron (0.25% wt/vol) was intragastrically infused with or without ethanol to rats for 16 …

Biomarkers in alcoholism

ONiemelä- Clinica chimica acta, 2007 - Elsevier
Alcoholism ranks as one of the main current threats to the health and safety of people in
大多数西方国家。Therefore, a high priority should be given to aims at reducing its …

Effects of head and extracranial injuries on serum protein S100B levels in trauma patients

…, TK Leino, S Siitonen, ONiemelä… - Journal of Trauma …, 2004 - journals.lww.com
Background: Serum protein S100B determinations have been recently suggested as markers
of traumatic brain injury. However, little is known about the effects of extracranial injuries …

Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig

…, JA Villanueva,AM Devlin, ONiemelä… - Proceedings of the …, 2002 - National Acad Sciences
Alcoholic liver disease is associated with abnormal hepatic methionine metabolism and folate
deficiency. Because folate is integral to the methionine cycle, its deficiency could promote …

Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases

ONiemelä,S Parkkila, RO Juvonen, K Viitala… - Journal of …, 2000 - Elsevier
Background/Aims: Interaction between CYP2E1, ethanol metabolites, and enhanced lipid
peroxidation is linked to the pathogenesis of alcoholic liver disease. This study was conducted …

Monoclonal and polyclonal antibodies against acetaldehyde-containing epitopes in acetaldehyde-protein adducts

Y Israel, E Hurwitz, ONiemelä… - Proceedings of the …, 1986 - National Acad Sciences
Immunization of mice with acetaldehyde conjugated to human plasma proteins resulted in
the production of polyclonal antibodies that reacted with erythrocyte protein-acetaldehyde …

Distribution of ethanol-induced protein adducts in vivo: relationship to tissue injury

ONiemelä- Free Radical Biology and Medicine, 2001 - Elsevier
Generation of oxygen free radicals and reactive aldehydes as a result of excessive ethanol
consumption has been well established. Recent studies in human alcoholics and in …

Timing of infant feeding in relation to childhood asthma and allergic diseases

BI Nwaru, HM Takkinen, ONiemelä, M Kaila… - Journal of Allergy and …, 2013 - Elsevier
Background Emerging evidence questions current recommendations on the timing of infant
feeding for the prevention of childhood allergies. The evidence for asthma is inconclusive. …

Comparison of the combined marker GGT–CDT and the conventional laboratory markers of alcohol abuse in heavy drinkers, moderate drinkers and abstainers

…, H Koivisto, P Anttila, ONiemelä- Alcohol and …, 2006 - academic.oup.com
Aims: A combined index based on γ-glutamyltransferase (GGT) and carbohydrate-deficient
transferrin (CDT) measurements (GGT–CDT) has been recently suggested to improve the …

Alcohol intake and the pattern of trauma in young adults and working aged people admitted after trauma

O Savola, ONiemelä, M Hillbom - Alcohol and alcoholism, 2005 - academic.oup.com
Aims: To investigate the relationship of different patterns of alcohol intake to various types of
trauma. Methods: We examined the associations of alcohol consumption in a series of 385 …