Iron is essential for many biological processes, however, too much or too little iron can result
in a wide variety of pathological consequences, depending on the organ system, tissue or …

Nuclear factor κB (NFκB) is a unique protein complex that plays a major role in lung
inflammation and respiratory dysfunction. The NFκB signaling pathway, therefore becomes an …

Pulmonary arterial hypertension (PAH) is a debilitating multifactorial disease characterized
by progressive pulmonary vascular remodeling, elevated pulmonary arterial pressure, and …

Increased iron levels and dysregulated iron homeostasis, or both, occur in several lung
diseases. Here, the effects of iron accumulation on the pathogenesis of pulmonary fibrosis and …

Accumulating evidence highlights links between iron regulation and respiratory disease.
Here, we assessed the relationship between iron levels and regulatory responses in clinical …

Pulmonary Arterial Hypertension (PAH) is a disease of the pulmonary arteries, that is
characterized by progressive narrowing of the pulmonary arterial lumen and increased pulmonary …

Estrogen, a major female sex steroid hormone, has been shown to promote the selection of
mucoid Pseudomonas aeruginosa in the airways of patients with chronic respiratory diseases…

OBJECTIVE: To evaluate the antinociceptive, anti-inflammatory and antidiarrheal activities
of the ethanolic calyx extract of Hibiscus sabdariffa Linn. in mice. METHODS: In the present …

Pulmonary arterial hypertension (PAH) is a debilitating condition of the pulmonary circulatory
system that occurs in patients of all ages and if untreated, eventually leads to right heart …

Right ventricular (RV) function is the predominant determinant of survival in patients with
pulmonary arterial hypertension (PAH). In preclinical models, pharmacological activation of …