Nrf2 regulates expression of genes encoding enzymes with antioxidant (eg. heme oxygenase-1
(HO-1)) or xenobiotic detoxification (eg. NAD(P)H:quinone oxidoreductase, glutathione S…

Necroptosis is a genetically regulated form of necrotic cell death that has emerged as an
important pathway in human disease. The necroptosis pathway is induced by a variety of …

Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Diabetic nephropathy (DN) is the most common cause of end-stage kidney disease worldwide,
and is associated with increased morbidity and mortality in patients with both type 1 and …

Both acute kidney injury (AKI) and chronic kidney disease (CKD) that lead to diminished
kidney function are interdependent risk factors for increased mortality. If untreated over time, …

Autophagy is a highly conserved cellular process regulating turnover of cytoplasmic proteins
via a lysosome-dependent pathway. Here we show that kidneys from mice deficient in …

Autophagy is an evolutionarily conserved process that cells use to degrade and recycle
cellular proteins and remove damaged organelles. During the past decade, there has been a …

Transforming growth factor-β 1 (TGF-β 1 ) is a potent inducer of extracellular matrix protein
synthesis and a key mediator of renal fibrosis. However, the intracellular signaling …

Transforming growth factor-β (TGF-β) is generally considered as a central mediator of fibrotic
diseases. Indeed, much focus has been placed on inhibiting TGF-β and its downstream …

Autophagy is a highly conserved homoeostatic mechanism for cell survival under conditions
of stress, and is widely implicated as an important pathway in many biological processes …