Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
…, ME Pitulescu, TS Schmidt, MLBochenek… - Nature, 2010 - nature.com
In development, tissue regeneration or certain diseases, angiogenic growth leads to the
expansion of blood vessels and the lymphatic vasculature. This involves endothelial cell …
expansion of blood vessels and the lymphatic vasculature. This involves endothelial cell …
[HTML][HTML]Angiogenic endothelial cell signaling in cardiac hypertrophy and heart failure
R Gogiraju, MLBochenek, K Schäfer - Frontiers in Cardiovascular …, 2019 - frontiersin.org
Endothelial cells are, by number, the most frequent cell type in the heart and active players
in cardiac physiology and pathology. Coronary angiogenesis plays a vital role in maintaining …
in cardiac physiology and pathology. Coronary angiogenesis plays a vital role in maintaining …
Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice
R Gogiraju,X Xu, MLBochenek… - Journal of the …, 2015 - Am Heart Assoc
Background Cardiac dysfunction developing in response to chronic pressure overload is
associated with apoptotic cell death and myocardial vessel rarefaction. We examined whether …
associated with apoptotic cell death and myocardial vessel rarefaction. We examined whether …
Ephrin-B2 regulates endothelial cell morphology and motility independently of Eph-receptor binding
MLBochenek, S Dickinson,JW Astin… - Journal of cell …, 2010 - journals.biologists.com
The transmembrane protein ephrin-B2 regulates angiogenesis, ie the formation of new blood
vessels through endothelial sprouting, proliferation and remodeling processes. In addition …
vessels through endothelial sprouting, proliferation and remodeling processes. In addition …
Endothelial cell senescence and thrombosis: Ageing clots
MLBochenek, E Schütz, K Schäfer - Thrombosis research, 2016 - Elsevier
Age is an important cardiovascular risk factor. Among others, age is associated with an
increased risk to develop thrombotic cardiovascular complications, both in the arterial (acute …
increased risk to develop thrombotic cardiovascular complications, both in the arterial (acute …
[HTML][HTML]Role of endothelial cells in acute and chronic thrombosis
MLBochenek, K Schäfer - Hämostaseologie, 2019 - thieme-connect.com
Haemostasis encompasses a set of strictly regulated actions, such as vasoconstriction,
platelet activation and blood coagulation. Endothelial cells play a crucial role in all of these …
platelet activation and blood coagulation. Endothelial cells play a crucial role in all of these …
Activated endothelial TGFβ1 signaling promotes venous thrombus nonresolution in mice via endothelin-1: potential role for chronic thromboembolic pulmonary …
MLBochenek, C Leidinger, NS Rosinus… - Circulation …, 2020 - Am Heart Assoc
Rationale: Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by
defective thrombus resolution, pulmonary artery obstruction, and vasculopathy. TGFβ (…
defective thrombus resolution, pulmonary artery obstruction, and vasculopathy. TGFβ (…
From thrombosis to fibrosis in chronic thromboembolic pulmonary hypertension
MLBochenek, NS Rosinus, M Lankeit… - Thrombosis and …, 2017 - thieme-connect.com
The pathomechanisms underlying the development of thrombofibrotic pulmonary artery
occlusions in Chronic Thromboembolic Pulmonary Hypertension (CTEPH) are largely unknown. …
occlusions in Chronic Thromboembolic Pulmonary Hypertension (CTEPH) are largely unknown. …
选择性删除地蜡tin signaling in endothelial cells enhances neointima formation and phenocopies the vascular effects of diet-induced obesity in mice
A Hubert, MLBochenek, E Schütz… - … , and vascular biology, 2017 - Am Heart Assoc
Objective— Obesity is associated with elevated circulating leptin levels and hypothalamic
leptin resistance. Leptin receptors (LepRs) are expressed on endothelial cells, and leptin …
leptin resistance. Leptin receptors (LepRs) are expressed on endothelial cells, and leptin …
Endothelial deletion of protein tyrosine phosphatase-1B protects against pressure overload-induced heart failure in mice
R Gogiraju, MR Schroeter, MLBochenek… - Cardiovascular …, 2016 - academic.oup.com
Aims Cardiac angiogenesis is an important determinant of heart failure. We examined the
hypothesis that protein tyrosine phosphatase (PTP)-1B, a negative regulator of vascular …
hypothesis that protein tyrosine phosphatase (PTP)-1B, a negative regulator of vascular …