Changing demographics, epidemiology, and survival of incident pulmonary arterial hypertension: results from the pulmonary hypertension registry of the United …

…, CA Elliot, JSR Gibbs,LSHoward… - American journal of …, 2012 - atsjournals.org
Rationale: Incident pulmonary arterial hypertension was underrepresented in most pulmonary
hypertension registries and may have a different disease profile to prevalent disease. …

Treatment goals of pulmonary hypertension

…,LSHoward, HH Leuchte, MA Mathier,SMehta… - Journal of the American …, 2013 - jacc.org
With significant therapeutic advances in the field of pulmonary arterial hypertension, the
need to identify clinically relevant treatment goals that correlate with long-term outcome has …

Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension

GP Diller,Svan Eijl, DO Okonko,LSHoward, O Ali… - Circulation, 2008 - Am Heart Assoc
Background— Impaired endothelial homeostasis underlies the pathophysiology of pulmonary
arterial hypertension (PAH). We speculated that PAH patients are deficient in circulating …

Macitentan for the treatment of inoperable chronic thromboembolic pulmonary hypertension (MERIT-1): results from the multicentre, phase 2, randomised, double …

…, AM D'Armini, P Fedullo,LSHoward… - The Lancet Respiratory …, 2017 - Elsevier
Background Macitentan is beneficial for long-term treatment of pulmonary arterial
hypertension. The microvasculopathy of chronic thromboembolic pulmonary hypertension (CTEPH) …

Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension: clinical prevalence, outcomes, and mechanistic insights

CJ Rhodes,LSHoward, M Busbridge,D Ashby… - Journal of the American …, 2011 - jacc.org
Objectives : This study sought to understand the prevalence and clinical relevance of iron
缺乏在特发性肺患者rterial hypertension (IPAH). Background : Iron …

Red cell distribution width outperforms other potential circulating biomarkers in predicting survival in idiopathic pulmonary arterial hypertension

CJ Rhodes,J Wharton,LSHoward, JSR Gibbs… - Heart, 2011 - heart.bmj.com
Luke S Howard2, … If you wish to reuse any or all of this article please use the link below
which will take you to the Copyright Clearance Center’sRightsLink service. You will be able to …

Echocardiographic assessment of pulmonary hypertension: standard operating procedure

LSHoward,J Grapsa, D Dawson… - European …, 2012 - Eur Respiratory Soc
Patients with suspected pulmonary hypertension (PH) should be evaluated using a multimodality
approach to ensure that they receive a correct diagnosis. The series of investigations …

Reduced microRNA-150 is associated with poor survival in pulmonary arterial hypertension

…, A Chakrabarti,LSHoward… - American journal of …, 2013 - atsjournals.org
Rationale: MicroRNAs (miRNAs or miRs) are implicated in the pathogenesis of various
cardiovascular diseases, including pulmonary arterial hypertension (PAH). Objectives: We …

Understanding the impact of pulmonary arterial hypertension on patients' and carers' lives

…, I Armstrong, R Aldrighetti,LSHoward… - European …, 2013 - Eur Respiratory Soc
Pulmonary arterial hypertension (PAH) is a rare, debilitating and rapidly progressive disease.
尽管有important medical advances in PAH management, the search …

Plasma metabolomics implicates modified transfer RNAs and altered bioenergetics in the outcomes of pulmonary arterial hypertension

…, M Haimel, G Coghlan, PA Corris,LSHoward… - Circulation, 2017 - Am Heart Assoc
Background: Pulmonary arterial hypertension (PAH) is a heterogeneous disorder with high
mortality. Methods: We conducted a comprehensive study of plasma metabolites using …