The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis

T Rosenow, LCMok,LTurkovic… - European …, 2019 - Eur Respiratory Soc
Introduction Pulmonary inflammation and infection are important clinical and prognostic
markers of lung disease in cystic fibrosis (CF). However, whether in young children they are …

Air trapping in early cystic fibrosis lung disease—Does CT tell the full story?

…,LTurkovic,CP Murray, LCMok… - Pediatric …, 2017 - Wiley Online Library
Introduction Mosaic attenuation on expiratory chest computed tomography (CT) is common
在生命的早期,囊性纤维化(CF)and often referred to as “air trapping”. It is presumed to be …

The effect of CFTR modulators on CT outcomes in cystic fibrosis

LCMok,AGU Juárez, M Kemner-Van De Corput… - 2019 - Eur Respiratory Soc
Background: There is a lack of sensitive clinical trial outcome measures to monitor the effect
of novel therapies in children with cystic fibrosis (CF). Aim: To assess the effect of CFTR …

Combining chemotherapy and checkpoint blockade in thoracic cancer: how to proceed?

WJ Aston,SA Fisher, A Khong, CMok… - Lung Cancer …, 2014 - Future Medicine
Given the impressive efficacy of immune checkpoint blockade in thoracic malignancies, and
the recently discovered immune-stimulating properties of many cytotoxic drugs, a logical …

Examining the effects of the Gly551Asp mutation on CT outcomes in children with cystic fibrosis

LCMok, T Rosenow,S Stick,LTurkovic - 2017 - Eur Respiratory Soc
Background: The clinical course of cystic fibrosis (CF) patients with the Gly551Asp mutation (class
III) is not well characterised, particularly in terms of structural lung disease. Data on …

End-expiratory lung volume is not associated with gas trapping on CT in early cystic fibrosis lung disease

T Rosenow, CMok, KA Ramsey,C Murray… - C60. ALL ABOUT …, 2016 - atsjournals.org
Methods: Children in the Australian Respiratory Early Surveillance Team for Cystic Fibrosis
cohort aged below 7 years with paired volumetric inspiration/expiration CT scans and age-…

Chronic Inflammation And Infection Leads To Worse Structural Lung Disease In Young Children With Cystic Fibrosis

T Rosenow, CMok,LTurkovic,CP Murray… - B108. CYSTIC …, 2017 - atsjournals.org
Methods: All annual surveillance CT scans from the AREST CF cohort since 2010 were
analysed with the PRAGMA-CF method, which determines the extent of structural lung disease …

Longitudinal Assessment of Chest CT Regions of Low Attenuation Reversibility in Early Cystic Fibrosis Lung Disease

LCMok,ER Andrinopoulou,M de Bruijne… - A72. WHAT'S NEW IN …, 2018 - atsjournals.org
Rationale: Chest computed tomography (CT) regions of low attenuation (LAR) are an important
feature of end-stage lung disease and reflect small airways disease in cystic fibrosis (CF)…

[HTML][HTML]Dysregulated metabolism underpins Zika-virus-infection-associated impairment in fetal development

…,JZH Low,ES Gan,SS Kwek,LCui, HC Tan,DZLMok… - Cell Reports, 2021 - Elsevier
… : drying gas temperature 300C with a flow of 10L/min, nebulizer gas pressure 40 psi, sheath
gas temperature 350C with a flow of 11L/min, nozzle voltage 500 V, and capillary voltage …