Background Elucidating the role of T cell responses in COVID-19 is of utmost importance to
understand the clearance of SARS-CoV-2 infection. Methods 30 hospitalized COVID-19 …

Given the pathophysiological key role of the host response to an infection rather than the
infection per se, an ideal therapeutic strategy would also target this response. This study was …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the so-called
coronavirus disease (COVID-19), which is characterized by a broad spectrum of clinical …

Purpose Life-threatening complications of CD-19 Chimeric antigen receptor - T (CAR-T) cells
such as the cytokine release syndrome (CRS)) have been reported. Treatment is limited to …

Background Multi‐organ dysfunction in acute liver failure (ALF) has been attributed to a
systemic inflammatory response directly triggered by the injured liver. High‐volume therapeutic …

A dysbalanced coagulation system is part of the pathological host response to infection in
sepsis. Activation of pro-coagulant pathways and attenuation of anti-coagulant activity …

Despite the pandemic status of COVID-19, there is limited information about host risk factors
and treatment beyond supportive care. Immunoglobulin G (IgG) could be a potential …

To the Editor: With great interest, we read the article by Keith et al.[1] suggesting adjunctive
therapeutic plasma exchange (TPE) as a potential novel treatment approach for severe …

The endothelial glycocalyx and its regulated shedding are important to vascular health.
Endo-β-D-glucuronidase heparanase-1 (HPSE1) is the only enzyme that can shed heparan …

Dear Editor, The hallmark of sepsis is a pathological host response to an infection that may
lead to organ dysfunction, shock and high mortality. Besides numerous circulating mediators …