Background Tracking longitudinal measurements of growth and decline in lung function in
patients with persistent childhood asthma may reveal links between asthma and subsequent …

Background The response to treatment for asthma is characterized by wide interindividual
variability, with a significant number of patients who have no response. We hypothesized that …

Bronchial asthma is a common inflammatory disease caused by the interaction of genetic
and environmental factors 1, 2. Through a genome-wide association study and a replication …

Corticosteroids mediate a variety of immunological actions and are commonly utilized in the
treatment of a wide range of diseases. Unfortunately, therapy with this class of medications …

Rationale: Interpatient variability in montelukast response may be related to variation in
leukotriene pathway candidate genes. Objective: To determine associations between …

Thymic stromal lymphopoietin (TSLP) triggers dendritic cell–mediated T helper (Th) 2
inflammatory responses. A single-nucleotide polymorphism (SNP), rs3806933, in the promoter …

Background: Low intakes of dietary antioxidants may contribute to increases in asthma and
allergy. Objective: We investigated the association of maternal total intakes (foods + …

TBX21 encodes for the transcription factor T-bet (T-box expressed in T cells), which influences
naïve T lymphocyte development and has been implicated in asthma pathogenesis. …

Background Although inhaled corticosteroids (ICSs) generally protect against severe
exacerbations in asthma, they may result in elevated IgE levels, which are associated with …

Rationale: Airway responsiveness is a prognostic marker for asthma symptoms in later life.
Objectives: To evaluate characteristics responsible for persistence of airway responsiveness …