Background Many patients with asthma have uncontrolled disease despite treatment with
inhaled glucocorticoids. One potential cause of the variability in response to treatment is …

Rationale: T-helper type 2 (Th2) inflammation, mediated by IL-4, IL-5, and IL-13, is considered
the central molecular mechanism underlying asthma, and Th2 cytokines are emerging …

© 2000 Macmillan Magazines Ltd formed from bone-marrow-derived precursor cells in response
to the coordinated actions of several protein factors. The study of one of these proteins, …

Rationale: For many patients with asthma, allergic airway inflammation is primarily a Th2-weighted
process; however, heterogeneity in patterns of inflammation suggests phenotypic …

Trisomy 21 results in Down's syndrome, but little is known about how a 1.5-fold increase in
gene dosage produces the pleiotropic phenotypes of Down's syndrome. Here we report that …

Tumour-necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is the only TRAF family
member that participates in signal transduction of both the TNF receptor (TNFR) superfamily …

TRANCE, a TNF family member, and its receptor, TRANCE-R, are critical regulators of
dendritic cell and osteoclast function. Here, we demonstrate that TRANCE activates the …

Background Eosinophilic airway inflammation is heterogeneous in asthmatic patients. We
recently described a distinct subtype of asthma defined by the expression of genes inducible …

Fibroblasts are non-haematopoietic structural cells that define the architecture of organs,
support the homeostasis of tissue-resident cells and have key roles in fibrosis, cancer, …

Increasing evidence suggests that asthma is a heterogeneous disorder regulated by distinct
molecular mechanisms. In a cross-sectional study of asthmatics of varying severity (n = 51), …