Background The replication-competent recombinant vesicular stomatitis virus (rVSV)–based
vaccine expressing a Zaire ebolavirus (ZEBOV) glycoprotein was selected for rapid safety …

Background The creation of transmyocardial channels from the epicardium to the left ventricular
cavity with the use of a CO 2 laser is a modern approach in the treatment of patients with …

Predicting vaccine efficacy remains a challenge. We used a systems vaccinology approach
to identify early innate immune correlates of antibody induction in humans receiving the …

Background The recent West African Ebola epidemic led to accelerated efforts to test Ebola
vaccine candidates. As part of the World Health Organisation-led VSV Ebola Consortium (…

A fraction of COVID-19 patients progress to a severe disease manifestation with respiratory
failure and the necessity of mechanical ventilation. Identifying patients at risk is critical for …

Background In the SARS-CoV-2 pandemic, viral genomes are available at unprecedented
speed, but spatio-temporal bias in genome sequence sampling precludes phylogeographical …

In response to the Ebola virus (EBOV) crisis of 2013–2016, a recombinant vesicular
stomatitis virus (VSV)–based EBOV vaccine was clinically tested (NCT02283099). A single-dose …

Human adenoviruses (HAdVs) have developed mechanisms to manipulate cellular antiviral
measures to ensure proper DNA replication, with detailed processes far from being …

Aims Fluid overload is a hallmark in acute heart failure (AHF). Bioelectrical impedance vector
analysis (BIVA) has emerged as a noninvasive method for quantifying patients’ hydration. …

Purpose While more advanced COVID-19 necessitates medical interventions and
hospitalization, patients with mild COVID-19 do not require this. Identifying patients at risk of …