[HTML][HTML]Trained immunity: a tool for reducing susceptibility to and the severity of SARS-CoV-2 infection
…,N Curtis, RvanCrevel, FLvan de Veerdonk… - Cell, 2020 - Elsevier
SARS-CoV-2 infection is mild in the majority of individuals but progresses into severe
pneumonia in a small proportion of patients. The increased susceptibility to severe disease in the …
pneumonia in a small proportion of patients. The increased susceptibility to severe disease in the …
The immunopathology of sepsis and potential therapeutic targets
Tvan derPoll, FLvan de Veerdonk… - Nature Reviews …, 2017 - nature.com
Key Points Sepsis is a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. The sepsis-associated host response is characterized by …
host response to infection. The sepsis-associated host response is characterized by …
Candida albicans morphogenesis and host defence: discriminating invasion from colonization
Key Points Candida albicans is the most common fungal pathogen of humans, and also
colonizes the skin and mucosal surfaces of most healthy individuals. Little was known about the …
colonizes the skin and mucosal surfaces of most healthy individuals. Little was known about the …
mTOR-and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity
…, P Willems, FLvan de Veerdonk, JWMvan derMeer… - Science, 2014 - science.org
Epigenetic reprogramming of myeloid cells, also known as trained immunity, confers
nonspecific protection from secondary infections. Using histone modification profiles of human …
nonspecific protection from secondary infections. Using histone modification profiles of human …
Presence of genetic variants among young men with severe COVID-19
…, JC Galbany, VVan DerSchoot, HVan DerHoeven… - Jama, 2020 - jamanetwork.com
… Drsvan
de
Veerdonkand Hoischen contributed equally. … Drvan
de
Veerdonkwas supported
by a ZonMW (The Netherlands Organization for Health Research and Development) Vidi …
by a ZonMW (The Netherlands Organization for Health Research and Development) Vidi …
Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages
…, FLVan De Veerdonk… - Blood, The Journal …, 2009 - ashpublications.org
The processing of pro-interleukin-1β depends on activation of caspase-1. Controversy has
arisen whether Toll-like receptor (TLR) ligands alone can activate caspase-1 for release of …
arisen whether Toll-like receptor (TLR) ligands alone can activate caspase-1 for release of …
Invasive aspergillosis in patients admitted to the intensive care unit with severe influenza: a retrospective cohort study
…, K Lagrou, PE Verweij, FLVan de Veerdonk… - The Lancet Respiratory …, 2018 - Elsevier
Background Invasive pulmonary aspergillosis typically occurs in an immunocompromised
host. For almost a century, influenza has been known to set up for bacterial superinfections, …
host. For almost a century, influenza has been known to set up for bacterial superinfections, …
[PDF][PDF]COVID-19 associated pulmonary aspergillosis (CAPA)—from immunology to treatment
A Arastehfar,A Carvalho, FLvan de Veerdonk… - Journal of Fungi, 2020 - mdpi.com
Like severe influenza, coronavirus disease-19 (COVID-19) resulting in acute respiratory
distress syndrome (ARDS) has emerged as an important disease that predisposes patients to …
distress syndrome (ARDS) has emerged as an important disease that predisposes patients to …
[HTML][HTML]Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome
FLvan de Veerdonk,MG Netea, MvanDeuren… - Elife, 2020 - ncbi.nlm.nih.gov
COVID-19 patients can present with pulmonary edema early in disease. We propose that this
is due to a local vascular problem because of activation of bradykinin 1 receptor (B1R) and …
is due to a local vascular problem because of activation of bradykinin 1 receptor (B1R) and …
Inflammasome is a central player in the induction of obesity and insulin resistance
…,MH Zaki, FLVan De Veerdonk… - Proceedings of the …, 2011 - National Acad Sciences
Inflammation plays a key role in the pathogenesis of obesity. Chronic overfeeding leads to
macrophage infiltration in the adipose tissue, resulting in proinflammatory cytokine production…
macrophage infiltration in the adipose tissue, resulting in proinflammatory cytokine production…