… a.vanstuyvenbergneerincx@amsterdamumc.nlEsther Herrera Luis, MSc7 …Esther
Herrera-Luiswas supported by a MICIU fellowship (PRE2018-083837). Natalia Hernandez-Pacheco
was supported by a fellowship (FI16/00136) from ISCIII and co-funded by the European Social …

Rationale Substantial variability in response to asthma treatment with inhaled corticosteroids
(ICS) has been described among individuals and populations, suggesting the contribution
of genetic factors. Nonetheless, only a few genes have been identified to date. We aimed to …

Severe asthma exacerbations are a major cause of school absences and healthcare costs in
children, particularly those in high-risk racial/ethnic groups. To identify susceptibility genes
for severe asthma exacerbations in Latino children and adolescents, we conducted a meta-…

To the Editor, Approximately 25% of the asthmatic children suffer from uncontrolled asthma
despite regular use of inhaled corticosteroids (ICS). 1 Variation within the 17q21 locus is the
strongest genetic determinant for childhood-onset asthma. 2 Recently, the influence of this …

Background Severe asthma exacerbations are a major cause of asthma morbidity and
医疗成本增加。几项研究已经年代hown racial and ethnic differences in
asthma exacerbation rates. We aimed to identify genetic variants associated with severe …

Background Pharmacogenetic studies in asthma cohorts, primarily made up of White people
of European descent, have identified loci associated with response to inhaled beta agonists
and corticosteroids (ICSs). Differences exist in how individuals from different ancestral …

Genetic association studies have allowed identifying the 17q21 locus and the ADRB2 gene
as the loci most consistently associated with asthma exacerbations. Future studies should
explore the full spectrum of genetic variation and will require larger sample sizes, a better …

Background Little is known about the genetic determinants of severe asthma exacerbations.
Objectives We aimed to identify genetic variants associated with asthma hospitalizations.
Methods We conducted a genome-wide association study of asthma hospitalizations in 34,167 …

DNA methylation studies have associated methylation levels at different CpG sites or genomic
regions with lung function. Moreover, genetic ancestry has been associated with lung function
in Latinos. However, no epigenome-wide association study (EWAS) of lung function has …

Leukotrienes play a central pathophysiological role in both paediatric and adult asthma.
However, 35% to 78% of asthmatics do not respond to leukotriene inhibitors. In this study we
tested the role of the LTA4H regulatory variant rs2660845 and age of asthma onset in response …