Introduction There are no determined treatment agents for severe COVID-19. It is suggested
that methylprednisolone, as an immunosuppressive treatment, can reduce the inflammation …

Rheumatoid arthritis (RA) is characterized by immune dysfunctions and chronic inflammation
that mainly affects diarthrodial joints. Genetics has long been surveyed in searching for the …

Swelling and the progressive destruction of articular cartilage are major characteristics of
rheumatoid arthritis (RA), a systemic autoimmune disease that directly affects the synovial …

Inequalities in features and severity of ankylosing spondylitis (AS) have been noticed
between men and women, suggesting a possible influence of gender on disease phenotypes. …

Ankylosing spondylitis (AS) is a highly heritable immune-mediated arthritis common in Turkish
and Iranian populations. Familial Mediterranean Fever (FMF) is an autosomal recessive …

Objective We sought to test the hypothesis that Polygenic Risk Scores (PRSs) have strong
capacity to discriminate cases of ankylosing spondylitis (AS) from healthy controls and …

The nuclear factor-κB (NF-κB) signaling pathway regulates multiple processes in innate and
adaptive immune cells. This pathway is involved in inflammation through the regulation of …

Ankylosing Spondylitis (AS) is an inflammatory arthritis, which affects mainly spine and sacroiliac
joints. According to recent studies, ERAP1 is the second most common candidate gene …

… Sasan Fallahi1, 2, Mahdi Mahmoudi2, Mohammad Hossein Nicknam3, Farhad
Gharibdoost2,ElhamFarhadi4, Azad Saei5, Keramat Nourijelyani6, Noushin Ahmadzadeh2 …

P53 is a transcription factor that regulates many signaling pathways like apoptosis, cell cycle,
DNA repair, and cellular stress responses. P53 is involved in inflammatory responses …