User profiles forAkylbek Sydykov
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Akylbek Sydykov
MD, PhD
Verified email at innere.med.uni-giessen.de
Cited by 3307 |
[HTML][HTML]Reversal of experimental pulmonary hypertension by PDGF inhibition
Progression of pulmonary hypertension is associated with increased proliferation and migration
of pulmonary vascular smooth muscle cells. PDGF is a potent mitogen and involved in …
of pulmonary vascular smooth muscle cells. PDGF is a potent mitogen and involved in …
[HTML][HTML]Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice
…, A Turowska, B Fuchs, S Nikam, M Roth,ASydykov… - Cell, 2011 - Elsevier
Chronic obstructive pulmonary disease (COPD) is one of the most common causes of death
worldwide. We report in an emphysema model of mice chronically exposed to tobacco …
worldwide. We report in an emphysema model of mice chronically exposed to tobacco …
[HTML][HTML]Inflammatory mediators drive adverse right ventricular remodeling and dysfunction and serve as potential biomarkers
ASydykov,A Mamazhakypov, A Petrovic… - Frontiers in …, 2018 - frontiersin.org
Adverse right ventricular (RV) remodeling leads to ventricular dysfunction and failure that
represents an important determinant of outcome in patients with pulmonary hypertension. …
represents an important determinant of outcome in patients with pulmonary hypertension. …
[HTML][HTML]Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice
N Weissmann,ASydykov, H Kalwa, U Storch… - Nature …, 2012 - nature.com
Lung ischaemia–reperfusion-induced oedema (LIRE) is a life-threatening condition that
causes pulmonary oedema induced by endothelial dysfunction. Here we show that lungs from …
causes pulmonary oedema induced by endothelial dysfunction. Here we show that lungs from …
[HTML][HTML]The role of transient receptor potential channel 6 channels in the pulmonary vasculature
…,A Dietrich, N Weissmann,ASydykov- Frontiers in …, 2017 - frontiersin.org
瞬时受体的ial channel 6 (TRPC6) is a Ca2+-permeable non-selective cation
channel that is widely expressed in the heart, lung and vascular tissues. The use of TRPC6-…
channel that is widely expressed in the heart, lung and vascular tissues. The use of TRPC6-…
Pulmonary hypertension in acute and chronic high altitude maladaptation disorders
ASydykov,A Mamazhakypov, A Maripov… - International Journal of …, 2021 - mdpi.com
Alveolar hypoxia is the most prominent feature of high altitude environment with well-known
consequences for the cardio-pulmonary system, including development of pulmonary …
consequences for the cardio-pulmonary system, including development of pulmonary …
Mitochondrial complex IV subunit 4 isoform 2 is essential for acute pulmonary oxygen sensing
Rationale: Acute pulmonary oxygen sensing is essential to avoid life-threatening hypoxemia
via hypoxic pulmonary vasoconstriction (HPV) which matches perfusion to ventilation. …
via hypoxic pulmonary vasoconstriction (HPV) which matches perfusion to ventilation. …
Mitochondrial hyperpolarization in pulmonary vascular remodeling. Mitochondrial uncoupling protein deficiency as disease model
…, T Hoeres, A Bakr, S Waisbrod,ASydykov… - American journal of …, 2013 - atsjournals.org
Alterations of mitochondrial membrane potential (MMP), reactive oxygen species (ROS),
and mitochondrial respiration are possible triggers of pulmonary vascular remodeling in …
and mitochondrial respiration are possible triggers of pulmonary vascular remodeling in …
Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing
Mitochondria play an important role in sensing both acute and chronic hypoxia in the
pulmonary vasculature, but their primary oxygen-sensing mechanism and contribution to …
pulmonary vasculature, but their primary oxygen-sensing mechanism and contribution to …
Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension
…, A Esfandiary, M Gierhardt,ASydykov… - European …, 2018 - Eur Respiratory Soc
Increased mitochondrial reactive oxygen species (ROS), particularly superoxide, have been
suggested to mediate hypoxic pulmonary vasoconstriction (HPV), chronic hypoxia-induced …
suggested to mediate hypoxic pulmonary vasoconstriction (HPV), chronic hypoxia-induced …