Background Bronchial thermoplasty (BT) has previously been shown to improve asthma
control out to 2 years in patients with severe persistent asthma. Objective We sought to assess …

Background Eosinophilic airway inflammation is often present in asthma, and reduction of
such inflammation results in improved clinical outcomes. We hypothesised that fevipiprant (…

Objective To determine the prevalence of systemic corticosteroid-induced morbidity in severe
asthma. Design Cross-sectional observational study. Setting The primary care Optimum …

Background Few genetic studies that focus on moderate-to-severe asthma exist. We aimed
to identity novel genetic variants associated with moderate-to-severe asthma, see whether …

Severe refractory asthma poses a substantial burden in terms of healthcare costs but relatively
little is known about the factors which drive these costs. This study uses data from the …

Background Clinical outcomes are worse in current smokers and exsmokers with mild-to-moderate
asthma compared with never smokers, but little is known about the influence of …

Rationale: Poor adherence is common in difficult-to-control asthma. Distinguishing patients
with difficult-to-control asthma who respond to inhaled corticosteroids (ICS) from refractory …

Objective. The aim of this study was to evaluate the “real world” effects of the monoclonal
antibody omalizumab (OMB) when used to treat severe persistent allergic asthma in UK clinical …

Background Asthma treatment guidelines recommend increasing corticosteroid dose to
control symptoms and reduce exacerbations. This approach is potentially flawed because …

BACKGROUND Systematic assessment of severe asthma can be used to confirm the
diagnosis identify comorbidities, and address adherence to therapy. However, the prospective …