Blood leukocyte transcriptomes in gram-positive and gram-negative community-acquired pneumonia
- PMID:34446464
- DOI:10.1183/13993003.01856-2021
Blood leukocyte transcriptomes in gram-positive and gram-negative community-acquired pneumonia
Abstract
Background:Gram-positive and Gram-negative bacteria are the most common causative pathogens in community-acquired pneumonia (CAP) on the intensive care unit (ICU). The aim of this study was to determine whether the host immune response differs between Gram-positive and Gram-negative CAP upon ICU admission.
Methods:Sixteen host response biomarkers providing insight in pathophysiological mechanisms implicated in sepsis and blood leukocyte transcriptomes were analysed in patients with CAP upon ICU admission in two tertiary hospitals in the Netherlands.
Results:309 patients with CAP with a definite or probable likelihood (determined by predefined criteria) were included. A causative pathogen was determined in 74.4% of admissions. Patients admitted with Gram-positive CAP (n=90) were not different from those admitted with Gram-negative CAP (n=75) regarding demographics, chronic comorbidities, severity of disease and mortality. Host response biomarkers reflective of systemic inflammation, coagulation activation and endothelial cell function, as well as blood leukocytes transcriptomes, were largely similar between Gram-positive and Gram-negative CAP. Blood leukocyte transcriptomes were also similar in Gram-positive and Gram-negative CAP in two independent validation cohorts. On a pathogen-specific level,Streptococcus pneumoniaeandEscherichia coliinduced the most distinct host immune response.
Conclusion:Outcome and host response are similar in critically ill patients with CAP due to Gram-positive bacteria compared to Gram-negative bacteria.
Copyright ©The authors 2021. For reproduction rights and permissions contact permissions@ersnet.org.
Similar articles
-
Association between delay in intensive care unit admission and the host response in patients with community-acquired pneumonia.Ann Intensive Care. 2021 Sep 28;11(1):142. doi: 10.1186/s13613-021-00930-5. Ann Intensive Care. 2021. PMID:34585271 Free PMC article.
-
Comparative Analysis of the Host Response to Community-acquired and Hospital-acquired Pneumonia in Critically Ill Patients.Am J Respir Crit Care Med. 2016 Dec 1;194(11):1366-1374. doi: 10.1164/rccm.201602-0368OC. Am J Respir Crit Care Med. 2016. PMID:27267747
-
Concurrent Immune Suppression and Hyperinflammation in Patients With Community-Acquired Pneumonia.Front Immunol. 2020 May 6;11:796. doi: 10.3389/fimmu.2020.00796. eCollection 2020. Front Immunol. 2020. PMID:32477337 Free PMC article. Clinical Trial.
-
Current guidelines for the treatment of severe pneumonia and sepsis.化疗. 2005 Aug;51(5):227-33. doi: 10.1159/000087452. 化疗. 2005. PMID:16103664 Review.
-
Optimizing treatment outcomes in severe community-acquired pneumonia.Am J Respir Med. 2003;2(1):39-54. doi: 10.1007/BF03256638. Am J Respir Med. 2003. PMID:14720021 Review.
Cited by1article
-
Multidimensional analysis of the host response reveals prognostic and pathogen-driven immune subtypes among adults with sepsis in Uganda.Crit Care. 2022 Feb 8;26(1):36. doi: 10.1186/s13054-022-03907-3. Crit Care. 2022. PMID:35130948 Free PMC article.
LinkOut - more resources
Full Text Sources
Miscellaneous