Recurrent cough: natural history and significance in infancy and early childhood
- PMID:9811075
- DOI:10.1002/(SICI)1099-0496(199810)26:4 <256 :: aid-ppul4> 3.0.co; 2-o
Recurrent cough: natural history and significance in infancy and early childhood
抽象的
我们调查了在学龄前报告的儿童样本中的结果,以确定1)他们是否共享了毒性变异性哮喘的特征,以及2)在期间在随访中发展了经典喘息哮喘的比例早期学年。在学前班期间,一群被确定为在学龄前时期咳嗽的儿童队列在早期的学期重新评估。先前发现的无症状学龄前儿童,他们仍然无症状的儿童提供了相对组,该组就当前的呼吸道症状,肺功能,对吸入甲醛的支气管反应性,特应性状态,峰值流量变异性和记录的夜间咳嗽提供了比较组。回应率适中,有41%的人参加了后续研究。有关当前症状的信息可从16%获得。当前症状的确定表明,在随访中,有70个(56.0%[95%CI 47.3-64.5%])在随访中无症状,46(36.8%[28.7-45.5%])在缺席的情况下继续进行咳嗽。感冒和9(7.2%[3.6-12.8%])报告了最近的喘息攻击。当比较46名儿童从学龄前期间一直持续咳嗽到与无症状比较组的受试者进行后续咳嗽时,前者的夜间咳嗽明显更多(50.0%vs. 16.8%; P <0.01),更有可能接受治疗(10.9%比1.7%; P = 0.01),或被诊断为哮喘(26.1%vs. 5.7%; P <0.001)。 They also showed greater bronchial reactivity than their asymptomatic counterparts (1.23 mg/ml vs. 3.35 mg/ml; P=0.002). Atopic status and other indices of lung function were similar between groups. We conclude that there are a group of children with long-term recurrent cough who display features consistent with a diagnosis of cough variant asthma, but at 2-4 years of follow-up, few progress to develop asthma characterized by wheeze.
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