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。 1995年3月; 151（3 Pt 1）：669-74。
DOI：10.1164 / AJRCCM / 151.3_pt_1.669。

颗粒气体污染作为美国成年人预期研究中死亡率的预测因子

c a pope 3rd1那 M J Thun.那 m m namboodiri那 D W码头那 J S Evans.那 F E Speizer那 c w heath jr
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颗粒气体污染作为美国成年人预期研究中死亡率的预测因子

c a pope 3rd等等。 am j respir crit care med。 1995年3月。

抽象的

时间序列，横截面和预期队列研究已经观察到死亡率和微粒空气污染之间的关联，但受到生态设计或少量受试者或研究领域的限制。本研究评估了颗粒状空气污染对死亡率的影响，使用来自许多研究领域的大群组的数据。We linked ambient air pollution data from 151 U.S. metropolitan areas in 1980 with individual risk factor on 552,138 adults who resided in these areas when enrolled in a prospective study in 1982. Deaths were ascertained through December, 1989. Exposure to sulfate and fine particulate air pollution, which is primarily from fossil fuel combustion, was estimated from national data bases. The relationships of air pollution to all-cause, lung cancer, and cardiopulmonary mortality was examined using multivariate analysis which controlled for smoking, education, and other risk factors. Although small compared with cigarette smoking, an association between mortality and particulate air pollution was observed. Adjusted relative risk ratios (and 95% confidence intervals) of all-cause mortality for the most polluted areas compared with the least polluted equaled 1.15 (1.09 to 1.22) and 1.17 (1.09 to 1.26) when using sulfate and fine particulate measures respectively. Particulate air pollution was associated with cardiopulmonary and lung cancer mortality but not with mortality due to other causes. Increased mortality is associated with sulfate and fine particulate air pollution at levels commonly found in U.S. cities. The increase in risk is not attributable to tobacco smoking, although other unmeasured correlates of pollution cannot be excluded with certainty.

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