Nonallergic bronchial hyperexcitability in chronic bronchitis
- PMID:6364903
Nonallergic bronchial hyperexcitability in chronic bronchitis
Abstract
本研究的目的是评估响应能力to inhaled histamine and methacholine using PC20, the concentration causing a 20% fall in forced expiratory volume in one second (FEV1) in 28 subjects with chronic bronchitis excluding asthma. Eighteen subjects had airway hyperexcitability, as demonstrated by a PC20 less than 16 mg/ml. The response to histamine and methacholine was not significantly different and the correlation coefficient was 0.75. Baseline airway caliber was related to the level of hyperexcitability, as 14 of 14 subjects with a FEV1 to forced vital capacity ratio less than 95% pred and/or a forced expiratory flow during the middle half of the FVC less than 80% pred, and only 4 of 10 subjects with normal spirometry, had a PC20 less than 16 mg/ml (x2 = 15.6, p less than 0.001). There was no correlation between blood or sputum eosinophilia, total IgE levels, or atopy and the level of airway hyperexcitability. Spontaneous daily variations of peak expiratory flow rates were significantly (t = 2.43, p less than 0.05) more pronounced in subjects with PC20 less than 16 mg/ml. We conclude that airway hyperexcitability assessed with PC20 is often present in chronic bronchitis and more often so in the presence of airway obstruction.
Similar articles
-
Pulmonary function tests and airway responsiveness to methacholine in chronic bronchiectasis of the adult.Bull Eur Physiopathol Respir. 1984 Jul-Aug;20(4):375-80. Bull Eur Physiopathol Respir. 1984. PMID:6383502
-
Slope of the dose-response curve to inhaled histamine and methacholine and PC20 in subjects with symptoms of airway hyperexcitability and in normal subjects.Am Rev Respir Dis. 1985 Sep;132(3):644-7. doi: 10.1164/arrd.1985.132.3.644. Am Rev Respir Dis. 1985. PMID:3898944
-
Circadian variations of airway response to histamine in asthmatic subjects.Bull Eur Physiopathol Respir. 1983 Sep-Oct;19(5):465-9. Bull Eur Physiopathol Respir. 1983. PMID:6640165
-
Combination therapy with anticholinergic agents for airflow obstruction.Postgrad Med J. 1987;63 Suppl 1:69-74. Postgrad Med J. 1987. PMID:3122192 Review.
-
Calcium channel blockers for lung function improvement in asthma: A systematic review and meta-analysis.Ann Allergy Asthma Immunol. 2017 Dec;119(6):518-523.e3. doi: 10.1016/j.anai.2017.08.013. Epub 2017 Oct 9. Ann Allergy Asthma Immunol. 2017. PMID:29032888 Review.
Cited by13articles
-
[Recommendations for implementing bronchial provocation tests with pharmacologic substances. German Society of Pneumology--Scientific "Bronchial Provocation Tests" Study Group].Med Klin (Munich). 1997 Aug 15;92(8):458-63. doi: 10.1007/BF03044912. Med Klin (Munich). 1997. PMID:9340468 German. No abstract available.
-
Adenosine, methacholine, and exercise challenges in children with asthma or paediatric chronic obstructive pulmonary disease.Thorax. 1995 May;50(5):511-6. doi: 10.1136/thx.50.5.511. 胸腔》1995。 PMID:7597663 Free PMC article. Clinical Trial.
-
Bronchial responsiveness to methacholine in chronic bronchitis: relationship to airflow obstruction and cold air responsiveness.Thorax. 1984 Dec;39(12):912-8. doi: 10.1136/thx.39.12.912. Thorax. 1984. PMID:6393416 Free PMC article.
-
Airway responsiveness to histamine in man: effect of atropine on in vivo and in vitro comparison.Thorax. 1985 Apr;40(4):261-7. doi: 10.1136/thx.40.4.261. Thorax. 1985. PMID:4023976 Free PMC article.
-
Differences in responsiveness to hyperventilation and methacholine in asthma and chronic bronchitis.Thorax. 1985 Jun;40(6):422-6. doi: 10.1136/thx.40.6.422. Thorax. 1985. PMID:3895554 Free PMC article.