A comparison of obese and nonobese people with asthma: exploring an asthma-obesity interaction
- PMID:20154078
- DOI:10.1378/chest.09-2491
A comparison of obese and nonobese people with asthma: exploring an asthma-obesity interaction
Abstract
Objective:The objectives of our study were to compare patient characteristics and severity of disease in obese and normal-weight-confirmed people with asthma and to explore reasons for misdiagnosis of asthma, including potential interactions with obesity.
Methods:我们随机选择physician-diagn患者osed asthma from eight Canadian cities. Asthma diagnosis was confirmed via a sequential lung function testing algorithm. Logistic analysis was conducted to compare obese and normal-weight-confirmed people with asthma and to assess characteristics associated with misdiagnosis of asthma. Interaction with obesity was investigated.
Results:Complete assessments were obtained on 496 subjects who reported physician-diagnosed asthma (242 obese and 254 normal-weight subjects); 346 had asthma confirmed with sequential lung testing, and in 150 subjects a diagnosis of asthma was ruled out. Obese subjects with asthma were significantly more likely to be men, have a history of hypertension and gastroesophageal reflux disease, and have a lower FEV(1) compared with normal-weight subjects with asthma. Older subjects, men, and subjects with higher FEV(1) were more likely to have received misdiagnoses of asthma. Obesity was not an independent predictor of misdiagnosis, however there was an interaction between obesity and urgent visits for respiratory symptoms. The odds ratio for receiving a misdiagnosis of asthma for obese individuals as compared with normal-weight individuals was 4.08 (95% CI, 1.23-13.5) for those with urgent visits in the past 12 months.
Conclusions:Obese people with asthma have lower lung function and more comorbidities compared with normal-weight people with asthma. Obese individuals who make urgent visits for respiratory symptoms are more likely to receive a misdiagnosis of asthma.
Comment in
-
推荐Reading from the University of Chicago Pulmonary and Critical Care Fellows: John F. McConville, M.D., Program Director.Am J Respir Crit Care Med. 2010 Dec 1;182(11):1453-1454. doi: 10.1164/rccm.201007-1085RR. Am J Respir Crit Care Med. 2010. PMID:21757426 Free PMC article. No abstract available.
Similar articles
-
Overdiagnosis of asthma in obese and nonobese adults.CMAJ. 2008 Nov 18;179(11):1121-31. doi: 10.1503/cmaj.081332. CMAJ. 2008. PMID:19015563 Free PMC article.
-
Obesity and asthma morbidity in a community-based adult cohort in a large urban area: the Chicago Initiative to Raise Asthma Health Equity (CHIRAH).J Asthma. 2010 Jun;47(5):491-5. doi: 10.3109/02770901003801980. J Asthma. 2010. PMID:20560823 Free PMC article.
-
Gastro-oesophageal reflux and worse asthma control in obese children: a case of symptom misattribution?Thorax. 2016 Mar;71(3):238-46. doi: 10.1136/thoraxjnl-2015-207662. Epub 2016 Feb 1. Thorax. 2016. PMID:26834184 Free PMC article.
-
Underdiagnosis and overdiagnosis of asthma in the morbidly obese.Respir Med. 2013 Sep;107(9):1356-64. doi: 10.1016/j.rmed.2013.05.007. Epub 2013 Jun 10. Respir Med. 2013. PMID:23764128
-
Asthma and obesity: a known association but unknown mechanism.Respirology. 2012 Apr;17(3):412-21. doi: 10.1111/j.1440-1843.2011.02080.x. Respirology. 2012. PMID:21992497 Review.
Cited by24articles
-
Asthma in Children and Adults-What Are the Differences and What Can They Tell us About Asthma?Front Pediatr. 2019 Jun 25;7:256. doi: 10.3389/fped.2019.00256. eCollection 2019. Front Pediatr. 2019. PMID:31294006 Free PMC article. Review.
-
Asthma and obesity in the Middle East region: An overview.Ann Thorac Med. 2019 Apr-Jun;14(2):116-121. doi: 10.4103/atm.ATM_115_18. Ann Thorac Med. 2019. PMID:31007762 Free PMC article. Review.
-
Asthma: Overdiagnosed, Underdiagnosed, and Ineffectively Treated.J Allergy Clin Immunol Pract. 2018 May-Jun;6(3):801-802. doi: 10.1016/j.jaip.2018.02.023. J Allergy Clin Immunol Pract. 2018. PMID:29747983 Free PMC article. No abstract available.
-
Targeting patients with asthma for omalizumab therapy: choosing the right patient to get the best value for money.Ther Adv Chronic Dis. 2017 Feb;8(2-3):31-45. doi: 10.1177/2040622317690494. Epub 2017 Feb 1. Ther Adv Chronic Dis. 2017. PMID:28348726 Free PMC article. Review.
-
Association of systemic inflammation, adiposity, and metabolic dysregulation with asthma burden among Hispanic adults.Respir Med. 2017 Apr;125:72-81. doi: 10.1016/j.rmed.2017.03.003. Epub 2017 Mar 6. Respir Med. 2017. PMID:28340865 Free PMC article.
Publication types
MeSH terms
Grant support
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous