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临床试验
。 2007年7月26日（7）：732-8。
DOI：10.1016 / J.Healun.2007.04.013。 EPUB 2007年6月13日。

创建模型比较6分钟步行试验对评估肺动脉高压治疗效果的代谢相当

Mardi Gomberg-Maitland1那 Dezheng Huo那 Raymond L Benza.那 vallerie v mclaughlin.那 Victor F Tapson那 Robyn J Barst.
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临床试验

创建模型比较6分钟步行试验对评估肺动脉高压治疗效果的代谢相当

Mardi Gomberg-Maitland等等。 J Heart Lung Transplant。 2007 Jul。

抽象的

背景：The 6-minute walk test (6MWT) is the current standard to assess exercise capacity in pulmonary arterial hypertension (PAH). We compared the Naughton-Balke treadmill test reported in exercise metabolic equivalents (METs) with the 6MWT to evaluate whether MET could be a useful tool to assess exercise capacity.

方法：Serial 6MWTs followed by Naughton-Balke treadmill tests were performed in 47 PAH patients initiating a change in PAH therapy at baseline (i.e., Time 0) and Weeks 6, 12, 24 and 48; New York Heart Association (NYHA) functional class (FC) was also assessed. Hemodynamics data were recorded at baseline and Weeks 12 and 48. Treadmill time was converted to MET. Generalized estimating equation models, receiver-operating characteristic curves and fixed-effect linear models were utilized to create a model comparing 6MWT to MET.

结果：满足6MWT（r = 0.62）。分段线性函数描述了6MWT之间的关系并满足。6MWT并达到Fc（p <0.001）与鉴别Fc的能力相似。血流动力学的变化响应PAH治疗的变化与6MWT的变化相关并满足。在较少的病人（即，FC II）的较少，6MWT的变化比满足不那么明显。

结论：遇到似乎是PAH中运动能力的可靠度量，并与6MWT相关。满足可用于临床评估，有助于展示在较少病患者的运动能力方面的改善。

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